Patents by Inventor Nigel Clarke

Nigel Clarke has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20240329763
    Abstract: In one embodiment, an apparatus includes a controller trigger that includes an input surface configured to receive input based on movement of a finger of a user, the trigger having a range of motion along a trigger path. The apparatus further includes a mode selector configured to actuate movement of an intermediate switching component between a discrete-input mode and a variable-input mode. The intermediate switching component includes a moveable arm, and in the discrete input mode the moveable arm occupies at least a portion of the trigger path, thereby limiting the range of motion of the trigger; and in the variable input mode the moveable arm does not occupy the trigger path. The apparatus further includes a switch configured to receive input, in the discrete-input mode, based on a movement of the intermediate switching component, in response to a physical contact by the trigger.
    Type: Application
    Filed: December 4, 2023
    Publication date: October 3, 2024
    Inventors: Ivan France, Nigel Clarke, Curtis Aumiller, Tara Sriram, Shafae Ali
  • Patent number: 12066446
    Abstract: Provided are methods of detecting the presence or amount of a dihydroxyvitamin D metabolite in a sample using mass spectrometry. The methods generally comprise ionizing a dihydorxyvitamin D metabolite in a sample and detecting the amount of the ion to determine the presence or amount of the vitamin D metabolite in the sample. In certain preferred embodiments the methods include immunopurifying the dihydroxyvitamin D metabolites prior to mass spectrometry. Also provided are methods to detect the presence or amount of two or more dihydroxyvitamin D metabolites in a single assay.
    Type: Grant
    Filed: May 2, 2023
    Date of Patent: August 20, 2024
    Assignee: Quest Diagnostics Investments Incorporated
    Inventors: Brett Holmquist, Nigel Clarke, Anne Caston, Richard E. Reitz
  • Patent number: 12056295
    Abstract: In one embodiment, an apparatus includes a human-interface-device (HID) controller that includes at least one of an extended reality (XR) controller or a mouse controller. The apparatus further includes an undetachable, fully retractable stylus pointed tip configured to extend from the HID controller, configured so that the stylus tip does not protrude beyond an exterior of the HID controller when in a fully retracted position.
    Type: Grant
    Filed: July 26, 2023
    Date of Patent: August 6, 2024
    Assignee: Samsung Electronics Co., Ltd.
    Inventors: Ivan France, Nigel Clarke, Stefan van der Hoff, Tara Sriram, Curtis Aumiller
  • Publication number: 20240248550
    Abstract: In one embodiment, an apparatus includes a human-interface-device (HID) controller that includes at least one of an extended reality (XR) controller or a mouse controller. The apparatus further includes an undetachable, fully retractable stylus pointed tip configured to extend from the HID controller, configured so that the stylus tip does not protrude beyond an exterior of the HID controller when in a fully retracted position.
    Type: Application
    Filed: July 26, 2023
    Publication date: July 25, 2024
    Inventors: Ivan France, Nigel Clarke, Stefan van der Hoff, Tara Sriram, Curtis Aumiller
  • Patent number: 12031888
    Abstract: Various examples are provided related to methane detection in harsh environments. In one example, a method includes drawing a sample of air from at least one first location; delivering the sample to a volume within a sensor block at a second location, where the sensor block includes a gas concentration sensor in communication with the volume; and where a vacuum is applied to the volume within the sensor block to facilitate delivery of the sample to the second location. In another example, a system includes a sampling unit that houses a sensor block, where a sample tube is coupled to an inlet of the sensor block, which includes a gas concentration sensor; an ejector that facilitates delivery of a sample of air from the first location via the sample tube; and a control unit that can receive a gas concentration sensor output from the sampling unit for processing.
    Type: Grant
    Filed: May 5, 2021
    Date of Patent: July 9, 2024
    Assignee: WEST VIRGINIA UNIVERSITY
    Inventors: Derek Johnson, Nigel Clark, Amber Barr, Brian Cappellini
  • Publication number: 20240222102
    Abstract: Provided are methods for determining the apolipoprotein E (ApoE) phenotype in a sample by mass spectrometry; wherein the ApoE allele(s) present in the sample is determined from the identity of the ions detected by mass spectrometry. In another aspect, provided herein are methods for diagnosis or prognosis of Alzheimer's disease or dementia.
    Type: Application
    Filed: January 23, 2024
    Publication date: July 4, 2024
    Applicant: Quest Diagnostics Investments LLC
    Inventors: Darren Weber, Nigel Clarke
  • Publication number: 20240169497
    Abstract: In one embodiment, a method includes accessing an image captured by an imaging system that includes an aperture and an optical sensor, wherein the imaging system blurs the image; and de-blurring the image by applying an Airy-disk correction that attributes at least part of the blurring in the image to a circular aperture rather than to a pinhole aperture.
    Type: Application
    Filed: November 23, 2022
    Publication date: May 23, 2024
    Inventors: Kushal Kardam Vyas, Ernest Rehmatulla Post, Changgeng Liu, Gustavo Alejandro Guayaquil Sosa, Sajid Sadi, Nigel Clarke
  • Publication number: 20240168504
    Abstract: In one embodiment, a method includes accessing a temperature map of a food item in a cooking apparatus, where the temperature map comprises a plurality of regions of the food item and associates a temperature with each region, and the cooking apparatus cooks according to an initial heating technique. The method includes determining, by a computing device, whether a temperature associated with at least one region of the food item violates a predetermined temperature constraint, and in response to a determination that the temperature associated with at least one region of the food item violates a predetermined temperature constraint, then determining an optimal heating technique and instructing the cooking apparatus to cook according to the optimal heating technique. In response to a determination that the temperature of each region does not violate a predetermined temperature constraint, the method includes determining that the initial heating technique should not be changed.
    Type: Application
    Filed: November 10, 2022
    Publication date: May 23, 2024
    Inventors: Musa Maharramov, Brian Patton, Pedro Martinez Lopez, Nigel Clarke
  • Publication number: 20240153092
    Abstract: In one embodiment, a method includes accessing, by a computing device, a thermal image of a space within a cooking apparatus, wherein the space contains a food item. The method further includes segmenting, by a computing device and based on the thermal image, the food item in the space from the food item's environment.
    Type: Application
    Filed: November 8, 2022
    Publication date: May 9, 2024
    Inventors: Pedro Martinez Lopez, Brian Patton, Nigel Clarke, William Augustus Workman, Megan Rowe
  • Publication number: 20240131563
    Abstract: In one embodiment, a system includes a sensor and an airflow generator coupled to an airflow guide configured to direct airflow from the airflow generator toward and past the sensor. The system includes one or more processors and a non-transitory computer readable storage media embodying instructions coupled to the one or more processors, the one or more processors operable to execute the instructions to acquire data about an operational state of the system, wherein the operational state is related to at least one air contaminant generated by the system; and to control the airflow from the airflow generator based on the data about the operational state of the system.
    Type: Application
    Filed: November 22, 2022
    Publication date: April 25, 2024
    Inventors: Yufeng Wu, Nigel Clarke, Brian Patton, Pedro Martinez Lopez, Forrest Gia-Bao Tran
  • Patent number: 11953507
    Abstract: Methods are provided for determining the amount of an IGF-I and/or IGF-II protein in a sample using high resolution/high accuracy mass spectrometry. The methods generally comprise enriching an IGF-I and/or IGF-II protein in a sample, ionizing an IGF-I and/or IGF-II protein from the sample to generate IGF-I and/or IGF-II protein ions, and determining the amount of IGF-I and/or IGF-II protein ions with high resolution/high accuracy mass spectrometry.
    Type: Grant
    Filed: September 21, 2022
    Date of Patent: April 9, 2024
    Assignee: Quest Diagnostics Investments Incorporated
    Inventors: Cory Bystrom, Shijun Sheng, Nigel Clarke, Richard Reitz
  • Publication number: 20240110899
    Abstract: A method for determining the amount of chromogranin A (CgA) in a sample includes: (a) purifying CgA in the sample; (b) adding an internal standard; (c) ionizing CgA and the internal standard to produce one or more CgA ion(s) and one or more internal standard ion(s) detectable by mass spectrometry; (d) determining the amount of the ion(s) from step (c) by mass spectrometry; and (e) correlating the amount of CgA in the sample to the amount of ion(s) measured in step (d).
    Type: Application
    Filed: December 12, 2023
    Publication date: April 4, 2024
    Applicant: Quest Diagnostics Investments LLC
    Inventors: Darren Weber, Michael P. Caufield, Michael McPhaul, Scott Goldman, Nigel Clarke
  • Patent number: 11929243
    Abstract: Provided are methods for determining the apolipoprotein E (ApoE) phenotype in a sample by mass spectrometry; wherein the ApoE allele(s) present in the sample is determined from the identity of the ions detected by mass spectrometry. In another aspect, provided herein are methods for diagnosis or prognosis of Alzheimer's disease or dementia.
    Type: Grant
    Filed: June 13, 2022
    Date of Patent: March 12, 2024
    Assignee: QUEST DIAGNOSTICS INVESTMENTS LLC
    Inventors: Darren Weber, Nigel Clarke
  • Publication number: 20240077503
    Abstract: The invention relates to the detection of non-metabolized vitamin D. In a particular aspect, the invention relates to methods for detecting underivatized non-metabolized vitamin D by mass spectrometry.
    Type: Application
    Filed: November 7, 2023
    Publication date: March 7, 2024
    Inventors: Brett Holmquist, Nigel Clarke
  • Publication number: 20240060950
    Abstract: Provided are methods for determining the amount of tamoxifen and its metabolites in a sample by mass spectrometry. In some aspects, the methods provided herein determine the amount of N-Desmethyl Tamoxifen. In some aspects, the methods provided herein determine the amount of N-Desmethyl Tamoxifen and other tamoxifen metabolites. In some aspects, the methods provided herein determine the amount of tamoxifen, N-Desmethyl Tamoxifen, and other tamoxifen metabolites.
    Type: Application
    Filed: October 25, 2023
    Publication date: February 22, 2024
    Applicant: Quest Diagnostics Investments LLC
    Inventor: Nigel Clarke
  • Patent number: 11885780
    Abstract: Provided are methods for detecting chromogranin A by mass spectrometry. In another aspect, provided herein are methods for quantitating chromogranin A by mass spectrometry. In another aspect, provided herein are methods for prognosis of or measuring the size of neuroendocrine tumors by mass spectrometry.
    Type: Grant
    Filed: January 24, 2022
    Date of Patent: January 30, 2024
    Assignee: Quest Diagnostics Investments LLC
    Inventors: Darren Weber, Michael P. Caufield, Michael McPhaul, Scott Goldman, Nigel Clarke
  • Publication number: 20240007730
    Abstract: In one embodiment, an apparatus includes a head unit that includes one or more image sensors and one or more illumination sources. Both an intensity level of the one or more illumination sources and a position or an orientation of the head unit are adjustable. The apparatus also includes one or more processors and one or more memory elements that can execute instructions to capture, by the one or more image sensors, an image of a user's physical workspace, and provide the captured image for display to one or more users.
    Type: Application
    Filed: June 29, 2022
    Publication date: January 4, 2024
    Inventors: Nigel Clarke, Fulya Yilmaz, Curtis Aumiller, Mohammad Abu Saude
  • Publication number: 20230417760
    Abstract: Methods are described for measuring the amount of C peptide in a sample. More specifically, mass spectrometric methods are described for detecting and quantifying C peptide in a sample utilizing on-line extraction methods coupled with tandem mass spectrometric or high resolution/high accuracy mass spectrometric techniques.
    Type: Application
    Filed: September 12, 2023
    Publication date: December 28, 2023
    Inventors: Nigel Clarke, Zhaohui Chen
  • Patent number: 11852636
    Abstract: The invention relates to the detection of non-metabolized vitamin D. In a particular aspect, the invention relates to methods for detecting underivatized non-metabolized vitamin D by mass spectrometry.
    Type: Grant
    Filed: December 30, 2022
    Date of Patent: December 26, 2023
    Assignee: QUEST DIAGNOSTICS INVESTMENTS INCORPORATED
    Inventors: Brett Holmquist, Nigel Clarke
  • Patent number: 11835505
    Abstract: Provided are methods for determining the amount of tamoxifen and its metabolites in a sample by mass spectrometry. In some aspects, the methods provided herein determine the amount of N-Desmethyl Tamoxifen. In some aspects, the methods provided herein determine the amount of N-Desmethyl Tamoxifen and other tamoxifen metabolites. In some aspects, the methods provided herein determine the amount of tamoxifen, N-Desmethyl Tamoxifen, and other tamoxifen metabolites.
    Type: Grant
    Filed: August 23, 2022
    Date of Patent: December 5, 2023
    Assignee: QUEST DIAGNOSTICS INVESTMENTS INCORPORATED
    Inventor: Nigel Clarke