Abstract: The present disclosure pertains to compositions comprising anti-VEGF proteins.

Abstract: Systems and methods comprising a metering device located on an electricity distribution grid, the metering device comprising one or more processors and memory. The metering device can detect a drop in characteristic of electricity below a threshold indicating a fault on the electricity distribution grid. The metering device can generate, responsive to the drop in the characteristic of electricity below the threshold, a time series of a rate of change of the characteristic of electricity for a predetermined number of cycles subsequent to the detection of the drop. The metering device can determine, based on a comparison of the time series of the rate of change with a predetermined pattern, a location of the metering device on the electricity distribution grid relative to a location of the fault on the electricity distribution grid.

Abstract: A test device and a method for testing a photovoltaic module, for testing anti-stepping performance of the photovoltaic module. The test device includes first and second test members spaced apart along a first direction. The first and second test members are configured to abut against the photovoltaic module and apply a preset load to the photovoltaic module. The first test member is at a first position when the first test member abuts against the photovoltaic module, the second test member is at a second position when the second test member abuts against the photovoltaic module, and along a movement direction of the first and second test members in a horizontal plane, the first and second positions are alternately spaced apart, to simulate force on the photovoltaic module when an operator walks on the photovoltaic module.

Abstract: A test device and a method for testing a photovoltaic module, for testing anti-stepping performance of the photovoltaic module. A test member is configured to abut against the photovoltaic module and apply a preset load to the photovoltaic module, to simulate force on the photovoltaic module when an operator walks on a surface of the photovoltaic module, so as to easily adjust and replace the material and the manufacturing process of the photovoltaic module according to test results, so that the photovoltaic module has stronger anti-stepping performance, thereby prolonging the service life of the photovoltaic module. The test member is provided with an abutment surface for abutting against the photovoltaic module, and an area S of the abutment surface satisfies: 50 cm2?S?400 cm2, which improves accuracy and reliability of the test results of the test device, thereby improving operation performance of the test device.

Abstract: The present application provides methods and systems to identify host cell protein (HCP) impurities in a sample containing high-abundance proteins. The HCP impurities can be enriched using interacting peptide ligands which have been attached to solid support. The HCP impurities can be eluted from the solid support using solution containing phase transfer surfactants. The isolated HCP impurities can be digested to generate components of the isolated HCP impurities which can subsequently be identified using a mass spectrometer.

Abstract: Genetically programmed microorganisms, such as bacteria or virus, pharmaceutical compositions thereof, and methods of modulating and treating cancers are disclosed.

Abstract: The present application describes methods for assaying activity of an enzyme by using a donor substrate, a labeling substrate, and a liquid chromatography column.

Abstract: Provided is a novel peripherally restricted multi-target cyclopeptide molecule for an opioid receptor and a neuropeptide FF (NPFF) receptor, or a pharmaceutically acceptable salt thereof. By using DN-9 as a chemical template, structural optimization is performed on opioid peptide and NPFF pharrnacophores by means of polypeptide chemical strategies such as amino acid replacement and cyclization modification to obtain a series of cyclopeptide molecules. The cyclopeptide molecules can activate both opioid receptors and NPFF receptors, and the analgesic activity and the analgesic duration thereof are greatly increased compared with parent DN-9 molecules, and opioid side effects such as analgesic tolerance, constipation, and addiction are reduced.

Abstract: Methods and apparatus for forming a conformal SiCON film on a surface are described. A SiCN film is formed on a substrate surface and exposed to a low temperature steam annealing process to form a film resistant to damage by rapid thermal processing or ashing. The film is treated by rapid thermal processing and then subjected to a high temperature anneal to form a film with a low dielectric constant.

Abstract: A firmware upgrade method of a network storage includes inquiring, by the network storage, about a latest firmware version for the network storage from a firmware upgrade platform through a network, and based on the latest firmware version being inconsistent with a current firmware version of the network storage, downloading, by the network storage, the latest firmware version from the firmware upgrade platform through the network and performing a firmware upgrade based on the latest firmware version.

Abstract: Provided herein are compositions and methods related to compositions comprising an Ig protease fusion protein. Also provided herein are compositions and methods for therapeutic treatment, such as of autoimmune diseases, allergies, or other immunological disorders, or in combination with the administration of another therapeutic, with such Ig protease fusion protein.

Abstract: The present invention generally pertains to methods of identifying sequence variants in a protein of interest. In particular, the present invention pertains to the use of heavy peptide standards with liquid chromatography-mass spectrometry analysis to specifically identify sequence variants of a protein of interest.

Abstract: Susceptor assemblies having a susceptor base with a plurality of pockets formed in a surface thereof are described. Each of the pockets has a pocket edge angle in the range of 30 to 75° and a pocket edge radius in the range of 0.40±0.05 mm to 1.20 mm±0.05 mm. The pockets have a raised central region and an outer region that is deeper than the raised central region, relative to the surface of the surface of the susceptor base.

Abstract: A composition and use thereof. The composition comprises an active component a and an active component b; the active component a is a compound as shown in general formula A; and the active component b is at least one of compounds which have insecticidal, acaricidal or bactericidal activity and are different from the compound as shown in general formula A. The composition has the advantages of synergistic effect and expanding prevention and treatment spectrum, and can be used for preventing and treating various pests, particularly mite damage, and plant diseases caused by various fungi, bacteria, nematodes and viruses.

Abstract: A hole protection system and a method for coal seam slotting and fracturing combined drainage. The system includes a hydraulic slotting subsystem, a hydraulic fracturing subsystem and a flexible hole protection system. The hydraulic slotting subsystem includes an ultra-high pressure water jet generating module, a drill pipe drilling tool module, an orifice sealer, a gas slag separator and a drilling rig. The hydraulic fracturing system includes an emulsion pump station, a water tank, a hole sealing device, a fracturing string and a casing. The flexible hole protection system includes a front end fixing device, a water injection support pipe, a first flexible support and a water injection connecting section.

Abstract: Methods for atomic layer deposition (ALD) or plasma enhanced atomic layer deposition (PEALD) of low-K films are described. A method of depositing a film comprises exposing a substrate to a silicon precursor having the general formulae (Ia), (Ib), (Ic), (Id), (IX), or (X); and exposing the substrate to an oxidant to react with the silicon-containing film to form one or more of a silicon oxycarbide (SiOC) film or a silicon oxycarbonitride (SiOCN) film on the substrate, the oxidant comprising one or more of a carboxylic acid, an aldehyde, a ketone, an ethenediol, an oxalic acid, a glyoxylic acid, a peroxide, an alcohol, and a glyoxal.

Abstract: The present disclosure pertains to compositions comprising anti-VEGF proteins and methods for producing such compositions.

Abstract: A method for constructing a large-span station by two-wing open type semi-covered excavation and semi-reverse construction, is divided into three stages of excavation. First, excavate a first-stage inner small foundation pit, then excavate a second-stage annular foundation pit within the first-stage retaining piles and outside the range of the first-stage inner small foundation pit, and finally excavate a third-stage semi-covered excavation foundation pit below the first-stage inner small foundation pit and the second-stage annular foundation pit. By setting graded retaining piles, middle upright post piles, middle top plates, local waist beams and local concrete supports in the soil-rock combination strata, so that the force transfer between the foundation pit enclosure and the station main body structures and the underlying rock layer is clear and reliable, and a stable frame structure is achieved.

Abstract: Disclosed are methods for improving compound detection and characterization. Methods for characterizing a sample are disclosed. The methods can include providing a sample to a liquid chromatography system capable of sample separation to generate sample components; analyzing sample components by multiplexed targeted selected ion monitoring (SIM) to generate an inclusion list; and performing iterative mass spectral data-dependent acquisition (DDA) from the inclusion list, to identify individual sample components thereby characterizing the sample. In one example, multiplexed targeted SIMs and iterative MS2 DDA acquisition is used to increase robust compound identification for cell culture medium analysis.