Abstract: A power generation system includes an input to receive a low-voltage alternating current and a number N of voltage-conversion modules coupled to the input, each electrically connected in series. Each voltage-conversion module includes a transformer configured to convert the low-voltage alternating current into a high-voltage alternating current. Each voltage-conversion module includes a multiplier configured to convert the high-voltage alternating current from the transformer into a high-voltage direct current. The multiplier includes a positive multiplier part and a negative multiplier part. The positive multiplier part and the negative multiplier part each includes a pair of input terminals connected in parallel with the transform and at least one multiplier stage comprising a single diode and a capacitor assembly. The number N is an even number between 4 and 24.

Abstract: Methods of identifying target binding molecules by target guided synthesis are provided. The methods include providing two or more fragments capable of reacting to form the target binding molecule and mixing the fragments with the target. The methods can be used to identify target binding molecules that bind targets such as proteins or nucleic acids, including those that bind shallow binding pockets on the surface of such targets. The methods are applied to the Bcl-XL and Mcl-1 proteins from the Bcl-2 family of proteins. Using thio acid and sulfonyl azide fragments capable of reacting through sulfo-click chemistry, new acyl sulfonamides are identified that bind one or both of the Bcl-XL and Mcl-1 proteins. Pharmaceutical formulations of these target binding molecules are also provided.

Abstract: Formulations of the HIV compounds atazanavir and cobicistat, and methods of treatment utilizing these formulations, are set forth.

Abstract: Provided is a curable resin composition which: has high levels of dielectric characteristics required in an electrically insulating material application compatible with a high frequency; provides a cured article excellent in low water absorption rate and low linear expansion rate; and is excellent in wire embedding flatness and resin fluidity. Specifically, provided is an aromatic polyester obtained by condensing (a) an aromatic oxycarboxylic acid, (b) an aromatic polyvalent carboxylic acid or an aromatic polyhydric hydroxy compound, and (c) an aromatic monohydroxy compound or an aromatic monocarboxylic acid. Also provided is a curable resin composition containing the aromatic polyester (A), an epoxy resin (D) having two or more epoxy groups per molecule, and a curing accelerator (E).

Abstract: A wireless communication device includes: a first communications unit configured to communicate with a first communication network; a second communications unit configured to communicate with a second communication network; a control unit configured to control operation of the wireless communication device; and one or more temperature sensors configured to sense operating temperatures of the first communications unit and the second communications unit and provide temperature signals to the control unit. In response to a determination that an operating temperature of the first communications unit conducting a first call exceeds a predetermined threshold temperature and an operating temperature of the second communications unit does not exceed the predetermined threshold temperature, the control unit is configured to cause the first call on the first communications unit to be switched from a first transceiver chain in the first communications unit to a second transceiver chain in the second communications unit.

Abstract: A power circuit for protecting against high pulse load current and inrush current is disclosed. The power circuit comprises a buck-boost module and a PFC controller operatively coupled with the buck-boost module. The PFC controller is configured to receive an input voltage feedback, an output voltage feedback, and a current feedback, and is configured to utilize one of an Integral Gain Compensation (IGC) and an Integral Value Compensation (IVC) to control the high pulse load current and inrush current in the power circuit.

Abstract: An apparatus is provided for extending a data model. The apparatus may include at least one memory and at least one processor configured to provide information to a queue responsive to detection of new data associated with a user or an encounter or detection of modified data associated with the user or encounter. The processor is also configured to identify a pattern(s) based on analyzing the information in the queue. The information includes content of the new data or the modified data. The patterns include instructions specifying a calculation(s) for execution based on usage of the new data or the modified data. The processor is also configured to provide results of the calculation(s) to a database to enable access of the results by an application(s) or a communication device(s) responsive to executing a pattern(s) and determining the results of the calculation. Corresponding computer program products and methods are also provided.

Abstract: A water-soluble thermally polymerizable oxetane resin composition comprises (A) a water-soluble oxetane compound and (B) at least one heteropolyacid compound selected from heteropolyacids and heteropolyacid salts. The water-soluble oxetane compound may contain one or more oxetane functional groups in the molecule and one or more alcoholic OH groups in the molecule. The heteropolyacids include phosphotungstic acid, phosphomolybdic acid, silicotungstic acid, silicomolybdic acid or mixtures thereof. The heteropolyacid salts include phosphotungstic acid salts, phosphomolybdic acid salts, silicotungstic acid salts, silicomolybdic acid salts or mixtures thereof.

Abstract: A high voltage transformer arrangement for supplying power to a high voltage tank assembly is disclosed. The high voltage transformer arrangement includes a first core arranged in the high voltage tank assembly and a secondary winding configured on the first core, a second core positioned outside of the high voltage tank assembly and at a predefined distance from the first core, and a primary winding configured on the second core. The second core and the primary winding transfers current received from an external power source to the first core and secondary winding for supplying power to the high voltage tank assembly.

Abstract: A voltage rectifier circuit for a radiation generator is provided. The voltage rectifier circuit comprises at least one ring shaped first printed circuit board and at least one ring shaped second printed circuit board coupled to each other using a plurality of connectors and wherein each of the first and second printed circuit boards comprise, a first terminal, a second terminal, and a third terminal. The first terminal and second terminal are connected via an external diode assemble, and the first and third terminal are connected by a capacitor assembly embedded between them.

Abstract: Provided are 4(1H)-quinolone derivatives effective in inhibiting or eliminating the viability of at least one of the stages in the life-cycle of the malarial parasite, and to show a reduced propensity to induce resistance to the compound by the target parasite. In particular, the compounds can be derivatives of phenoxyethoxy-quinolones, and including, but not only, 7-(2-phenoxyethoxy)quinolin derivatives. These compounds may be administered by themselves, with at least one other derivative compound, or with other antimalarial compounds, to an animal or human subject. The therapeutic compositions can be and formulated to reduce the extent of a Plasmodium infection in the recipient subject, or to reduce the likelihood of the onset or establishment of a Plasmodium infection if administered prior to the parasite contacting the subject. The therapeutic compositions can be formulated to provide an effective single dose amount of an antimalarial compound or multiple doses for administering over a period of time.

Abstract: A method of fabricating a 3D chip stack uses an interposer and an electronic circuit substrate comprising a plurality of electronic circuits. The electrical contacts of the electronic circuit substrate are bonded and electrically coupled to bumps of the interposer. A molding compound is applied over the electronic circuits to form a molded structure. The molded structure is thinned to have a second molded thickness that is less than the first molded thickness, and the interposer is thinned to a second interposer thickness that is less than a first interposer thickness.

Abstract: Methods and apparatus to correlate healthcare information are disclosed. An example method includes receiving a healthcare message from a first entity of a healthcare enterprise, wherein the healthcare message is configured according to a first identification schema of the first entity; identifying one or more subjects of the healthcare message for correlation into an electronic clinical information system; selecting one of a plurality of correlators for each identified subject to correlate each identified subject, wherein each of the correlators are customizable to handle a specific type of healthcare message subject; and correlating the identified subjects of the message to associate each of the identified subjects with an identifier internal to the electronic clinical information system.

Abstract: A voltage rectifier circuit for a radiation generator is provided. The voltage rectifier circuit comprises at least one ring shaped first printed circuit board and at least one ring shaped second printed circuit board coupled to each other using a plurality of connectors and wherein each of the first and second printed circuit boards comprise, a first terminal, a second terminal, and a third terminal. The first terminal and second terminal are connected via an external diode assemble, and the first and third terminal are connected by a capacitor assembly embedded between them.

Abstract: Provided are 4(1H)-quinolone derivatives effective in inhibiting or eliminating the viability of at least one of the stages in the life-cycle of the malarial parasite, and to show a reduced propensity to induce resistance to the compound by the target parasite. In particular, the compounds can be derivatives of phenoxyethoxy-quinolones, and including, but not only, 7-(2-phenoxyethoxy)quinolin derivatives. These compounds may be administered by themselves, with at least one other derivative compound, or with other antimalarial compounds, to an animal or human subject. The therapeutic compositions can be and formulated to reduce the extent of a Plasmodium infection in the recipient subject, or to reduce the likelihood of the onset or establishment of a Plasmodium infection if administered prior to the parasite contacting the subject. The therapeutic compositions can be formulated to provide an effective single dose amount of an antimalarial compound or multiple doses for administering over a period of time.

Abstract: Disclosed is a cationically polymerizable composition which shows improved storage stability and whose polymerization initiation temperature or curing temperature is controlled. In the case where the composition is thermosetting, it yields a cured product of three-dimensional structure excellent in mechanical properties, electrical properties, adhesive properties, heat resistance, moisture resistance, chemical resistance, and the like. The cationically polymerizable composition comprises a cationically polymerizable compound selected from vinyl compounds, lactones, cyclic ethers, and the like, a heteropolyacid selected from phosphotungstic acid, phosphomolybdic acid, silicotungstic acid, silicomolybdic acid, and the like as a cationic polymerization initiator, and a stabilizer selected from heteropolyacid salts as an inhibitor of cationic polymerization.

Abstract: Methods and apparatus to correlate healthcare information are disclosed. An example method includes receiving a healthcare message from a first entity of a healthcare enterprise, wherein the healthcare message is configured according to a first identification schema of the first entity; identifying one or more subjects of the healthcare message for correlation into an electronic clinical information system; selecting one of a plurality of correlators for each identified subject to correlate each identified subject, wherein each of the correlators are customizable to handle a specific type of healthcare message subject; and correlating the identified subjects of the message to associate each of the identified subjects with an identifier internal to the electronic clinical information system.

Abstract: Methods and apparatus for dynamic customization of clinical workflows are disclosed. An example method includes receiving a script that implements one or more actions of a clinical workflow from a first healthcare entity that utilizes an electronic clinical information system, wherein the electronic clinical information system aggregates healthcare information from a plurality of healthcare entities including the first healthcare entity; loading the script into a dynamic module core framework that interacts with a runtime environment to execute application bundles; and publishing the script of the dynamic module core framework to the runtime environment such that the clinical workflow is installed into the electronic clinical information system dynamically at runtime.

Abstract: Methods and apparatus to manage instances of an enterprise clinical information system are disclosed.

Abstract: Disclosed is a thermosetting resin composition of excellent low-temperature curability comprising an oxetane compound and also disclosed is a cured article obtained therefrom. The thermosetting resin composition comprises an oxetane compound (A) containing two or more oxetane functional groups in the molecule represented by the following general formula (1) and a heteropolyacid (B) as essential components. A cured article obtained by heat curing of this composition shows excellent mechanical properties, electrical properties, adhesive properties, resistance to heat, moisture, and chemicals, and the like. In formula (1), R1 is a hydrogen atom, alkyl group of 1 to 6 carbon atoms, fluorine atom, fluoroalkyl group of 1 to 6 carbon atoms, allyl group, aryl group, aralkyl group, furyl group, or thienyl group.