Abstract: It is an object of the present invention to provide a method for simultaneously carrying out the detection or measurement of a substance interacting with a physiologically active substance immobilized on a biosensor and the analysis of the effects of the above substance on the biological activity of the physiologically active substance. The present invention provides a measurement method using a biosensor formed by immobilizing a physiologically active substance on a substrate, wherein the detection and measurement of a substance interacting with said physiologically active substance and the measurement of the biological activity of said physiologically active substance are carried out on said single biosensor.

Abstract: The present invention provides a method of confirming the gene expression, useful in the decision of a five year survival rate of a patient with lung cancer and the use of a DNA probe kit in the method. A method useful in the decision of a survival rate of a patient with non-small cell lung cancer comprising confirming the expression strength of at least one gene selected from the group consisting of in lung cancer tissues isolated from the patient.

Abstract: In a biochemical analysis unit, a membrane is pressed into through holes formed in a substrate to form plural spot areas in each through hole, and the remaining membrane forms a thin layer on a rear face of the substrate. A probe solution is spotted on each spot area by a spot head. On the occasion of the spotting, a pin arrangement plate presses the biochemical analysis unit from the rear face. On the pin arrangement plate, pins are arranged at the same pitch as the spot areas. The pin arrangement plate is positioned such that the pins confront the corresponding spot areas. When the pressing is made, the pins push the thin layer to enter the corresponding through holes. Thus the pores in the thin layer are squashed, and it is prevented that the probe solution penetrate into the neighboring spot areas.

Abstract: A plurality of measuring units each comprising a dielectric block, a metal film layer which is formed on a surface of the dielectric block and a sample holder are supported on a support. The support is moved by a support drive means to bring in sequence the measuring units to a measuring portion comprising an optical system which projects a light beam emitted from a light source, and a photodetector which detects attenuation in total internal reflection by detecting the intensity of the light beam which is reflected in total internal reflection at the interface between the dielectric block and the metal film layer. In this measuring apparatus, lots of samples can be measured in a short time.

Abstract: A process for detecting a complementary DNA fragment is performed utilizing a DNA micro-array, a radiation image storage panel containing a stimulable phosphor, and a spacer sheet having plural openings.

Abstract: At a stage between a step for subjecting a receptor or a ligand to specific binding with ligands or receptors, each of which has been bound to one of porous adsorptive regions of a biochemical analysis unit, and a step for detecting the receptor or the ligand, which has been specifically bound to at least one of the ligands or at least one of the receptors, by the utilization of the labeling substance, at least one electrode is located such that the electrode is capable of causing an electric current to flow across each of the porous adsorptive regions of the biochemical analysis unit. A voltage is applied to the electrode in order to cause the electric current to flow across each of the porous adsorptive regions of the biochemical analysis unit.

Abstract: An image reading apparatus is adapted for irradiating an image carrier including a labeling substance contained in two-dimensionally distributed spots with a stimulating ray and photoelectrically detecting light released from the labeling substance, thereby producing image data, and the image reading apparatus includes at least one stimulating ray source for emitting a stimulating ray, a lens for shaping the stimulating ray emitted from the at least one stimulating ray source into a line beam, a sensor for photoelectrically detecting light released from the labeling substance, and a controller for performing a stimulation and detection step of irradiating the image carrier including the labeling substance contained in the two-dimensionally distributed spots with the line beam of the stimulating ray to stimulate the labeling substance, stopping irradiation with the line beam of the stimulating ray and causing the sensor to photoelectrically detect light released from the labeling substance after the completion

Abstract: An image display apparatus contains a display unit which displays information. A table displaying unit controls the display unit so as to display a measurement result table including a plurality of lists each of which is obtained from at least two corresponding measurement spots in at least two images, where the at least two corresponding measurement spots belong to the at least two images, respectively, so that the at least two images each include a plurality of measurement spots which respectively correspond to a plurality of measurement spots in every other one of the at least two images. An instruction receiving unit receives an instruction to select one of the plurality of lists in the measurement result table. An image display control unit controls the display unit so as to selectively display a portion of each of the at least two images so that the portion contains one of the plurality of measurement spots which corresponds to the one of the plurality of lists.

Abstract: A measuring apparatus includes a turntable and drive means. The turntable is used for supporting n measuring units at intervals of a predetermined angle with respect to a rotation axis thereof. The drive means is used for rotating the turntable intermittently at intervals of an angle equal to m times the predetermined angle (m is an integer). When the turntable is stopped, k kinds of processes are respectively performed on the measuring units situated at different positions on the turntable. The above-mentioned k is 2≦k≦n, and the above-mentioned m is either 1, a number that is neither the common divisor of 1 and n nor the common multiple, or a sum of 1 and the common multiple of n.

Abstract: A biochemical analysis data producing method includes the steps of exposing stimulable phosphor layer regions formed in a stimulable phosphor sheet and spaced from each other using standard light, irradiating the stimulable phosphor layer regions with a stimulating ray, detecting stimulated emission to produce correction data for the individual stimulable phosphor layer regions, superposing the stimulable phosphor sheet on a biochemical analysis unit including spot-like regions formed in the same pattern as that of the stimulable phosphor layer regions and selectively containing a radioactive labeling substance, exposing the stimulable phosphor layer regions to the radioactive labeling substance, scanning the stimulable phosphor layer regions with a stimulating ray, detecting stimulated emission to produce biochemical analysis data, and correcting the biochemical analysis data using the correction data.

Abstract: Data concerning gene expression quantities, which have been obtained for first and second samples, are indicated with points plotted on a logarithmic coordinate system, in which a horizontal axis represents logarithms of the expression quantities obtained for the first sample, and in which a vertical axis represents logarithms of the expression quantities obtained for the second sample. A coefficient is calculated from a value of an intercept of an approximate straight line, which is obtained from approximate representation of the plotted points with a straight line having a slope of 1, on the vertical axis. The data concerning the expression quantities with respect to a plurality of genes, which expression quantities have been obtained for the second sample, are divided by the coefficient and are thus normalized.

Abstract: Disclosed herein is a measuring apparatus utilizing attenuated total reflection. The measuring apparatus is equipped with a dielectric block, a thin film layer formed on one surface of the dielectric block, an optical system for making a light beam enter the dielectric block so that a condition for total internal reflection is satisfied at an interface between the dielectric block and the thin film layer, and a two-piece photodiode for detecting the light beam totally reflected at the interface. When attenuated total reflection is detected a plurality of times for a single sample, the two-piece photodiode is disposed at a predetermined position relative to a dark line when a first measurement is made. The two-piece photodiode is also disposed at the same position as the predetermined position stored in a storage unit when a second measurement and measurements thereafter are made.

Abstract: A biochemical analysis unit includes a plate-like member made of a material capable of attenuating light energy and formed with a plurality of through-holes, a plurality of absorptive regions formed by charging an absorptive membrane formed of an absorptive material at positions corresponding to those of the plurality of through-holes and light attenuating regions having a property of attenuating light energy and formed at regions in the absorptive membrane between the neighboring absorptive regions so as to be adjacent to the plate-like member in a thickness direction of the absorptive membrane. According to the biochemical analysis unit, it is possible to produce biochemical analysis data having an excellent quantitative characteristic even in the case of forming a number of the absorptive regions labeled with a labeling substance which generates chemiluminescence emission when it contacts a chemiluminescent substrate or a fluorescent substance in a biochemical analysis unit.

Abstract: A plurality of measuring units each comprising a dielectric block, a metal film layer which is formed on a surface of the dielectric block and a sample holder are supported on a support. The support is moved by a support drive means to bring in sequence the measuring units to a measuring portion comprising an optical system which projects a light beam emitted from a light source, and a photodetector which detects attenuation in total internal reflection by detecting the intensity of the light beam which is reflected in total internal reflection at the interface between the dielectric block and the metal film layer. In this measuring apparatus, lots of samples can be measured in a short time.

Abstract: A method for conducting a receptor-ligand association reaction includes the steps of dipping a biochemical analysis unit including a substrate formed with a plurality of absorptive regions which contain receptors or ligands and are formed to be spaced apart from each other in a reaction solution containing a ligand or receptor labeled with a labeling substance, simultaneously inserting a plurality of electrodes into all of the plurality of absorptive regions containing the receptors or ligands and sequentially applying a positive voltage to one of the electrodes at a time while other electrodes are grounded, thereby conducting a receptor-ligand association reaction. According to the this method, it is possible to efficiently react a ligand or receptor with receptors or ligands fixed in the plurality of absorptive regions of the biochemical analysis unit and produce biochemical analysis data having an excellent quantitative characteristic with good repeatability.

Abstract: A method for producing biochemical analysis data includes the steps of selectively binding a substance derived from a living organism and labeled with a labeling substance which generates chemiluminescence emission when it contacts a chemiluminescent substrate with specific binding substances contained in a plurality of absorptive regions formed in a biochemical analysis unit, bringing the labeling substance into contact with a chemiluminescent substrate, thereby causing it to release chemiluminescence emission, producing a first digital signal for each of the plurality of absorptive regions of the biochemical analysis unit based on an analog data obtained by detecting the chemiluminescence emission for a first exposure time using a solid state area sensor, storing the first digital signals in a memory, producing a second digital signal for each of the plurality of absorptive regions of the biochemical analysis unit based on an analog data obtained by detecting the chemiluminescence emission for a second expo

Abstract: A microarray chip manufacturing apparatus includes a plurality of picking pins which pick specific binding substances linearly or two-dimensionally arranged at first spaces and spot the specific binding substances onto a flat chip at second spaces narrower than the first spaces. The picking pins are movable so that the spaces among the picking pins can be switched between the first spaces and the second spaces, and a space switching mechanism switches the spaces among the picking means to the first spaces when the picking means pick the specific binding substances and to the second spaces when the picking means spot the specific binding substances onto the chip.

Abstract: A method for conducting a receptor-ligand association reaction includes the step of feeding a reaction solution containing a ligand or a receptor labeled with a labeling substance to a plurality of absorptive regions which are formed in a biochemical analysis unit to be spaced from each other and in which receptors or ligands are fixed so as to cut through the plurality of absorptive regions, thereby selectively associating the ligand or the receptor contained in the reaction solution with the receptors or the ligands fixed in the plurality of absorptive regions of the biochemical analysis unit. According to the present invention, it is possible to efficiently associate a ligand or a receptor with receptors or ligands fixed in a biochemical analysis unit and produce biochemical analysis data having an excellent high quantitative characteristic with excellent repeatability.

Abstract: A biochemical analysis kit includes a biochemical analysis unit including a substrate formed with a plurality of absorptive regions to be spaced apart from each other and a stimulable phosphor sheet including a support formed with a plurality of stimulable phosphor layer regions to be spaced apart from each other in substantially the same pattern as that of the plurality of absorptive regions formed in the substrate of the biochemical analysis unit.

Abstract: A method for producing biochemical analysis data by photoelectrically detecting light released from a plurality of light releasable regions two-dimensionally formed so as to be spaced apart from each other in a sample placed on a sample stage, the method for producing biochemical analysis data including the steps of intermittently moving a light guide member for leading light released from the plurality of light releasable regions to a light detector and the sample stage relative to each other in a main scanning direction and a sub-scanning direction perpendicular to the main scanning direction, leading light released from the plurality of light releasable regions two-dimensionally formed so as to be spaced apart from each other in the sample to a light detector through the light guide member, and photoelectrically detecting light by the light detector.