Patents by Inventor Nobuko Yamamoto
Nobuko Yamamoto has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 9248445Abstract: A liquid discharging device includes a plurality of liquid discharge sections. Each liquid discharge section includes a reservoir, a nozzle that discharges a solution supplied from the reservoir, and discharge energy generating means that generates energy to discharge the solution from the nozzle. The number of the liquid discharge sections corresponds to the number of probe types to be formed. The nozzles are two-dimensionally arranged. Using this liquid discharging device, probe liquids are discharged from the corresponding reservoirs onto a solid-phase substrate to form a predetermined two-dimensional probe array of high-purity probes on the substrate. This process exhibits high reproducibility and processability, and the resulting probe array has high array density.Type: GrantFiled: March 12, 2010Date of Patent: February 2, 2016Assignee: CANON KABUSHIKI KAISHAInventors: Tadashi Okamoto, Nobuko Yamamoto, Hidenori Watanabe, Tomohiro Suzuki
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Patent number: 9169480Abstract: An object of the present invention is to prepare DNA, RNA, and a protein from one cell and to provide a convenient preparation method with high reproducibility. To prepare a protein, DNA, and RNA from a cell, nuclear and cytoplasmic separation is performed, and a protein, DNA, and RNA are then extracted.Type: GrantFiled: May 26, 2010Date of Patent: October 27, 2015Assignee: CANON KABUSHIKI KAISHAInventor: Nobuko Yamamoto
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Patent number: 8535914Abstract: The present invention provides a combination of genes useful for information which can be used for the prediction of postoperative recurrence of gastric cancer and the acquisition of the information, a probe detecting these genes and a primer set for PCR, a method for detecting these genes using the primer and the primer set and a method for obtaining the information which can be used for the prediction of recurrence. Information useful for the prediction of postoperative recurrence can be obtained by determining the presence or absence of gastric cancer cells which show a possibility of postoperative recurrence in a sample such as an peritoneal wash collected from a patient by detecting a particular gene specific to gastric cancer cells or a gene product thereof.Type: GrantFiled: January 20, 2006Date of Patent: September 17, 2013Assignees: Canon Kabushiki Kaisha, President of National Cancer CenterInventors: Tomohiro Suzuki, Nobuko Yamamoto, Hiroki Sasaki, Kazuhiko Mori
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Publication number: 20120053329Abstract: An object of the present invention is to prepare DNA, RNA, and a protein from one cell and to provide a convenient preparation method with high reproducibility. To prepare a protein, DNA, and RNA from a cell, nuclear and cytoplasmic separation is performed, and a protein, DNA, and RNA are then extracted.Type: ApplicationFiled: May 26, 2010Publication date: March 1, 2012Applicant: CANON KABUSHIKI KAISHAInventor: Nobuko Yamamoto
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Patent number: 8080381Abstract: An infectious etiologic agent detection probe set which detects an infectious etiologic agent gene, includes a plurality of kinds of probes including oligonucleotide having base sequences selected from each of a plurality of groups selected from a first group including base sequences of SEQ ID Nos. 1 to 14 and complementary sequences thereof, a second group including base sequences of SEQ ID Nos. 15 to 24 and complementary sequences thereof, a third group including base sequences of SEQ ID Nos. 25 to 36 and complementary sequences thereof, a fourth group including base sequences of SEQ ID Nos. 37 to 47 and complementary sequences thereof, a fifth group including base sequences of SEQ ID Nos. 48 to 57 and complementary sequences thereof, a sixth group including base sequences of SEQ ID Nos. 58 to 68 and complementary sequences thereof, a seventh group including base sequences of SEQ ID Nos. 69 to 77 and complementary sequences thereof, an eighth group including base sequences of SEQ ID Nos.Type: GrantFiled: March 29, 2004Date of Patent: December 20, 2011Assignee: Canon Kabushiki KaishaInventors: Nobuko Yamamoto, Masaya Ogura, Masahiro Kawaguchi, Mamoru Tsukada, Hiroto Yoshii, Tomohiro Suzuki, Mie Ishii, Toshifumi Fukui
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Patent number: 7994297Abstract: Provided is a method of spotting a probe densely and efficiently on a surface of a solid support. A liquid containing a probe is attached to a solid support as droplets to form spots containing the probe on the solid support by an ink jet method.Type: GrantFiled: April 20, 2006Date of Patent: August 9, 2011Assignee: Canon Kabushiki KaishaInventors: Tadashi Okamoto, Nobuko Yamamoto, Tomohiro Suzuki
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Publication number: 20100267589Abstract: A liquid discharging device includes a plurality of liquid discharge sections. Each liquid discharge section includes a reservoir, a nozzle that discharges a solution supplied from the reservoir, and discharge energy generating means that generates energy to discharge the solution from the nozzle. The number of the liquid discharge sections corresponds to the number of probe types to be formed. The nozzles are two-dimensionally arranged. Using this liquid discharging device, probe liquids are discharged from the corresponding reservoirs onto a solid-phase substrate to form a predetermined two-dimensional probe array of high-purity probes on the substrate. This process exhibits high reproducibility and processability, and the resulting probe array has high array density.Type: ApplicationFiled: March 12, 2010Publication date: October 21, 2010Applicant: CANON KABUSHIKI KAISHAInventors: Tadashi Okamoto, Nobuko Yamamoto, Hidenori Watanabe, Tomohiro Suzuki
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Patent number: 7731904Abstract: A liquid discharging device includes a plurality of liquid discharge sections. Each liquid discharge section includes a reservoir, a nozzle that discharges a solution supplied from the reservoir, and discharge energy generating means that generates energy to discharge the solution from the nozzle. The number of the liquid discharge sections corresponds to the number of probe types to be formed. The nozzles are two-dimensionally arranged. Using this liquid discharging device, probe liquids are discharged from the corresponding reservoirs onto a solid-phase substrate to form a predetermined two-dimensional probe array of high-purity probes on the substrate. This process exhibits high reproducibility and processability, and the resulting probe array has high array density.Type: GrantFiled: September 17, 2001Date of Patent: June 8, 2010Assignee: Canon Kabushiki KaishaInventors: Tadashi Okamoto, Nobuko Yamamoto, Hidenori Watanabe, Tomohiro Suzuki
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Patent number: 7507576Abstract: A flat plate-shaped probe carrier for carrying probes such as single stranded DNAs, proteins, etc., which are reactive specifically with target substances comprises a plurality of ring bodies arranged substantially in parallel and the external space among the ring bodies is filled with a filler such that the openings of the ring bodies are oriented to the surface of the probe carrier. Each ring body has a region for fixing a probe adapted to be bonded specifically to a target substance on its inner wall. The probe carrier is produced by bundling a plurality of hollow tubular members in parallel, then filling the external space among the bundled hollow members with a filler, and cutting the bundle along a plane intersecting the axial direction of the tubular members. Probes are fixed to the fixing region before or after filling the external space.Type: GrantFiled: January 19, 2007Date of Patent: March 24, 2009Assignee: Canon Kabushiki KaishaInventors: Nobuko Yamamoto, Naoto Mihashi
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Publication number: 20090011413Abstract: Colon cancer cells in a sample are screened by analyzing the amount of expression of at least 2 or more genes or products thereof selected from the group of genes listed in Tables 1 and 30. As compared to conventional method, patients having colon cancer can be detected with higher accuracy. Colon cancer cells in stool are also screened by analyzing expression of genes selected from the group of genes listed in Table 37.Type: ApplicationFiled: June 14, 2007Publication date: January 8, 2009Applicants: CANON KABUSHIKI KAISHA, PRESIDENT OF NATIONAL CANCER CENTERInventors: Mie Ishii, Nobuko Yamamoto, Masahiro Kawaguchi, Tetsuo Okabe, Hiroki Sasaki, Satoshi Yajima, Yasuhiro Matsumura, Hisayuki Matsushita, Hiroyuki Tsunoda, Kunio Harada
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Patent number: 7445899Abstract: A method for screening presence or absence of a variation in a region of a nucleic acid which comprises the steps of (a) preparing a sample containing a test nucleic acid corresponding to the region, (b) preparing a probe having a base sequence fully complementary to a normal sequence of the region, and a plurality of probes each having at least one base not complementary to the normal sequence, (c) fixing the probes in separate regions on a surface of a substrate to prepare a DNA array substrate, (d) reacting the test nucleic acid with the probes on the DNA array substrate, (e) measuring signals in each region where the signals are originated from respective hybrids formed between the test nucleic acid and one of the probes, and (f) calling variation in the test nucleic acid using a pattern of total signals of all regions.Type: GrantFiled: May 3, 2005Date of Patent: November 4, 2008Assignee: Canon Kabushiki KaishaInventors: Nobuko Yamamoto, Tadashi Okamoto, Shinya Tanaka, Tomohiro Suzuki
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Patent number: 7402384Abstract: A probe array comprises a plurality of probes immobilized at a plurality of matrix sites on a substrate for capturing a target substance, wherein the probes are sequentially synthesized at the matrix sites on the substrate until a desired length, the probes are different from each other, and a labeling compound is coupled to each terminus of the probes in a final step of the synthesis. The probe array of the invention allows sensitive and reliable detection of the target substance. A method of evaluating the amount of the fully synthesized probes at respective matrix sites is also provided.Type: GrantFiled: August 4, 2003Date of Patent: July 22, 2008Assignee: Canon Kabushiki KaishaInventors: Tadashi Okamoto, Nobuko Yamamoto, Tomohiro Suzuki
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Publication number: 20080051293Abstract: A method for identifying an unknown base sequence present in a target single-stranded nucleic acid utilizing a probe array in which single-stranded nucleic acid probes are arranged as isolated spots on a substrate, where each probe has a base sequence complementary to one of the plural base sequences expected to be the unknown base sequence, and a fluorescence pattern of a sample on the probe array is compared with template patterns to identify the base sequence of the sample.Type: ApplicationFiled: August 30, 2007Publication date: February 28, 2008Applicant: CANON KABUSHIKI KAISHAInventors: Nobuko Yamamoto, Tadashi Okamoto, Tomohiro Suzuki
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Publication number: 20070264635Abstract: The present invention provides a combination of genes useful for information which can be used for the prediction of postoperative recurrence of gastric cancer and the acquisition of the information, a probe detecting these genes and a primer set for PCR, a method for detecting these genes using the primer and the primer set and a method for obtaining the information which can be used for the prediction of recurrence. Information useful for the prediction of postoperative recurrence can be obtained by determining the presence or absence of gastric cancer cells which show a possibility of postoperative recurrence in a sample such as an peritoneal wash collected from a patient by detecting a particular gene specific to gastric cancer cells or a gene product thereof.Type: ApplicationFiled: January 20, 2006Publication date: November 15, 2007Applicants: Canon Kabushiki Kaisha, President of National Cancer CenterInventors: Tomohiro Suzuki, Nobuko Yamamoto, Hiroki Sasaki, Kazuhiko Mori
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Patent number: 7273697Abstract: A method for identifying an unknown base sequence present in a target single-stranded nucleic acid utilizing a probe array in which single-stranded nucleic acid probes are arranged as isolated spots on a substrate, where each probe has a base sequence complementary to one of the plural base sequences expected to be the unknown base sequence, and a fluorescence pattern of a sample on the probe array is compared with template patterns to identify the base sequence of the sample.Type: GrantFiled: August 31, 2001Date of Patent: September 25, 2007Assignee: Canon Kabushiki KaishaInventors: Nobuko Yamamoto, Tadashi Okamoto, Tomohiro Suzuki
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Publication number: 20070148679Abstract: Colon cancer cells in a sample are screened by analyzing the amount of expression of at least 2 or more genes or products thereof selected from the group of genes listed in Tables 1 and 30. As compared to conventional method, patients having colon cancer can be detected with higher accuracy.Type: ApplicationFiled: December 12, 2006Publication date: June 28, 2007Applicants: CANON KABUSHIKI KAISHA, PRESIDENT OF NATIONAL CANCER CENTERInventors: Mie Ishii, Nobuko Yamamoto, Masahiro Kawaguchi, Tetsuo Okabe, Hiroki Sasaki, Satoshi Yajima, Yasuhiro Matsumura, Hisayuki Matsushita, Hiroyuki Tsunoda, Kunio Harada
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Publication number: 20070117139Abstract: A flat plate-shaped probe carrier for carrying probes such as single stranded DNAs, proteins, etc., which are reactive specifically with target substances comprises a plurality of ring bodies arranged substantially in parallel and the external space among the ring bodies is filled with a filler such that the openings of the ring bodies are oriented to the surface of the probe carrier. Each ring body has a region for fixing a probe adapted to be bonded specifically to a target substance on its inner wall. The probe carrier is produced by bundling a plurality of hollow tubular members in parallel, then filling the external space among the bundled hollow members with a filler, and cutting the bundle along a plane intersecting the axial direction of the tubular members. Probes are fixed to the fixing region before or after filling the external space.Type: ApplicationFiled: January 19, 2007Publication date: May 24, 2007Applicant: CANON KABUSHIKI KAISHAInventors: NOBUKO YAMAMOTO, NAOTO MIHASHI
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Publication number: 20070105100Abstract: A process for rapid and simple assay of nucleic acid on the basis of competitive hybridization using a DNA microarray that comprises a step of hybridizing a labeled nucleic acid other than the target nucleic acid with one of the immobilized probes on the substrate, where the labeled nucleic acid has a known sequence complementary to the probe and can bind thereto specifically.Type: ApplicationFiled: April 28, 2004Publication date: May 10, 2007Applicant: CANON KABUSHIKI KAISHAInventors: Hiroto Yoshii, Nobuko Yamamoto, Keiko Yonezawa
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Publication number: 20060228711Abstract: A probe carrier is provided on which probes capable of specifically binding to a target substance are immobilized as a plurality of spots in known locations on the carrier, characterized in that the probe carrier has two or more separated areas, wherein in each area probes of the same kind are immobilized as one or more spots and probes of different kinds are not immobilized and in at least one area probes of the same kind are immobilized as two or more spots. This probe carrier allows simple and convenient measurement of the content of a target substance even when inexpensive line sensor, area sensor and the like are used.Type: ApplicationFiled: August 27, 2004Publication date: October 12, 2006Inventor: Nobuko Yamamoto
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Publication number: 20060177868Abstract: Provided is a method of spotting a probe densely and efficiently on a surface of a solid support. A liquid containing a probe is attached to a solid support as droplets to form spots containing the probe on the solid support by an ink jet method.Type: ApplicationFiled: April 20, 2006Publication date: August 10, 2006Applicant: Canon Kabushiki KaishaInventors: Tadashi Okamoto, Nobuko Yamamoto, Tomohiro Suzuki