Abstract: A multi-stage adjusting damping valve as well as a shock absorber and suspension system using the damping valve are provided. The multi-stage adjusting damping valve comprises a throttle valve, an overflow valve and a multi-stage pilot valve. The multi-stage pilot valve comprises a mechanical regulating valve and a plurality of high-speed switch electromagnetic valves having different throttle hole diameters. The damping valve is connected between a rod cavity and an oil storage cavity of the shock absorber by means of a middle cavity, and the multi-stage damping rapid regulation of the shock absorber is achieved through high-frequency opening and closing of a high-speed switching electromagnetic valve, and in comparison, the machining precision, the manufacturing cost and the control and calibration difficulty of the present disclosure are greatly reduced.

Abstract: An aromatic vinyl compound and preparation method therefor, and intermediate, pharmaceutical composition, and application thereof. The aromatic vinyl compound is represented by formula I-0. The aromatic vinyl compound has a significant inhibitory effect on PD-1/PD-L1, has a higher drug peak concentration, a larger area under the drug concentration time curve, better oral bioavailability, is a type of extremely effective small molecule inhibitor for PD-1/PD-L1, and can effectively alleviate or treat cancer and a related disease.

Abstract: A self-adaptive heavy-duty gear transmission walking device includes a guide track. A carrying seat is slidably installed on the guide track. A loading platform is arranged on the carrying seat, and matching frames are arranged at the bottom of the carrying seat and positioned opposite from each other. A first driving mechanism, a walking mechanism, a first support bracket, a stop mechanism, and a second support bracket are arranged on the carrying seat. A vertical support mechanism and a horizontal support mechanism are arranged in the matching frame. The first driving mechanism is connected to one end of the walking mechanism. The walking mechanism penetrates through the carrying seat and is magnetically connected to the guide track. The other end of the walking mechanism is connected to a first transmission shaft. The first transmission shaft penetrates through the first support bracket and is fixedly installed with a brake disc.

Abstract: Disclosed are a thienopyrimidine derivative and a preparation method therefor. Provided is a method for preparing a compound as shown in formula B, which method is characterized by comprising the following steps: subjecting a compound as shown in formula C with a compound as shown in formula K to a coupling reaction as shown below under a protective gas atmosphere, in a solvent and in the presence of a catalyst and a base, wherein the catalyst comprises a palladium compound and a phosphine ligand. The preparation method of the present invention can improve the yield of products, and reduce the production cost; in addition, the preparation method has simple reaction conditions and a strong process operability, which is beneficial to industrial production and the reduction of the generation of three wastes.

Abstract: Disclosed in the present invention are a crystal form of aromatic vinyl derivatives, and a preparation method therefor and the use thereof. Specifically disclosed in the present invention are crystal form A, crystal form B and crystal form C of a compound as shown in formula I. The crystal forms of the present invention have a good stability, are less hygroscopic and are easy to prepare, and have an important value in terms of the optimization and development of drugs.

Abstract: The invention provides methods for treating a cancer, comprising administering to a subject in need thereof a therapeutically effective amount of a small molecule inhibitor of the PD-1/PD-L1 interaction or a pharmaceutically acceptable salt or prodrug thereof in combination with a therapeutically effective amount of an anti-PD-1 antibody, wherein the small molecule inhibitor of the PD-1/PD-L1 interaction is not a protein.

Abstract: Provided herein are methods for treating a cancer in a subject having a tumor with interstitial fluid pressure (IFP) of at least 10 mmHg, comprising administering to the subject a therapeutically effective amount of a compound or a pharmaceutically acceptable salt or prodrug thereof, which is an inhibitor of the interaction between the PD-1 receptor and its ligand PD-L1 and which is not a protein, alone, or in combination with other agents, e.g., in combination with the use of anti-PD-1/PD-L1 antibodies, in combination with an inhibitor of the CTLA-4/B7 interaction, or in combination with an inhibitor binding to VEFG.

Abstract: Disclosed in the present invention are an aromatic vinyl or aromatic ethyl derivative, a preparation method therefor, an intermediate, a pharmaceutical composition, and an application. The aromatic vinyl or aromatic ethyl derivative in the present invention is as represented by general formula (I). The aromatic vinyl or aromatic ethyl derivative in the present invention has an obvious inhibitory effect on PD-1/PD-L1, is a very effective small-molecule PD-1/PD-L1 inhibitor, and can effectively alleviate or treat relevant diseases such as cancer.

Abstract: Disclosed in the present invention are an aromatic vinyl or aromatic ethyl derivative, a preparation method therefor, an intermediate, a pharmaceutical composition, and an application. The aromatic vinyl or aromatic ethyl derivative in the present invention is as represented by general formula (I). The aromatic vinyl or aromatic ethyl derivative in the present invention has an obvious inhibitory effect on PD-1/PD-L1, is a very effective small-molecule PD-1/PD-L1 inhibitor, and can effectively alleviate or treat relevant diseases such as cancer.

Abstract: An apparatus for controllably unfolding a flexible mesh for a continuous miner includes a mesh roll storage rack, a height adjustment post, a mesh rolling shaft and a flexible mesh. The flexible mesh includes a mesh roll and an unfolded mesh. The mesh roll and the unfolded mesh are an integrated structure. The mesh roll is located on the mesh roll storage rack. The unfolded mesh is clamped on the mesh rolling shaft, and is pressed on a cut un-supported tunnel roof via a roof bolt. The mesh rolling shaft is rotatably connected to a top portion of the height adjustment post. The mesh roll storage rack and the height adjustment post are both mounted on the continuous miner. The mesh rolling shaft is located at a back end of the mesh roll storage rack. A limit mechanism and a damping mechanism are disposed on the mesh rolling shaft.

Abstract: Disclosed are a salt of a fused ring pyrimidine compound, a crystal form thereof and a preparation method therefor and the use thereof. The fused ring pyrimidine compound is N-[7-(4-fluoro-2-methoxyphenyl)-6-methylthieno[3,2-d]pyrimidin-2-yl]-1-(piperidin-4-yl)-1H-pyrazol-4-amine, having a structure as shown in formula 1. The preparation methods in the invention for the salt of the fused ring pyrimidine compound and the crystal form thereof are simple; and the salt of the fused ring pyrimidine compound and the crystal form thereof at least have the characteristics of having a better stability, not easily absorbing moisture, being of a polycrystalline type, having a chemical stability and pharmacokinetics, and having an improved solubility.

Abstract: A small molecule inhibitor of PD-1/PD-L1, a pharmaceutical composition thereof with a PD-L1 antibody, and an application of the same. The small molecule inhibitor of PD-1/PD-L1 is aromatic ethylene or aromatic ethylene derivative represented by general formula (I) and can be used to treat cancer.

Abstract: A single-anchor centrally grouted full-length anchored steel wire bundle and a supporting method thereof are described herein. The steel wire bundle consists of parallel steel wires and a central pipe, wherein multiple strands of parallel steel wires are arranged around the central pipe, the central pipe is provided with a slurry output bracket which divides the parallel steel wires into a front part and a rear part, the front part is provided with large stirring jackets, and the rear part is provided with a threaded casing on its tail end. After the coal is cut by a tunneling machine and a roadway is formed, the steel wire bundle is anchored at the ends, and the roadway tunneling speed is increased; central grouting is carried out for the steel wire bundle so as to anchor the steel wire bundle in full length and ensure long-time stability of the roadway.

Abstract: A synergistic mining method for underground mining, separation and filling for a close distance coal seam group is applicable to the mining engineering field. Full-mechanized caving mining is carried out for a close distance coal seam group, an underground coal gangue separation system and a filling face are designed according to the yield of gangue in the production process; the gangue produced in the mining process is transported centrally into an underground coal gangue separation chamber, and the separated gangue is transported to the filling face for filling and mining; the gangue produced at the filling face is transported back to the filling face for backfilling after underground washing separation. The method separates nearby and filling at selected locations, reduces the damage and disturbance to the underground rock mass that may be caused by a conventional mining method, and solves problems in treatment of strong dynamic pressure in advance.

Abstract: The present invention provides a diphenyl-like compound, and intermediate thereof, a preparation method therefor, a pharmaceutical composition thereof and the uses thereof. According to the invention, the diphenyl-like compound has a significant inhibitory effect on PD-1 and/or PD-L1, and can effectively alleviate or treat related diseases such as cancer.

Abstract: A device and method for testing the working performance of an anchor rod cable by simulating stratum fracture and separation on the basis of electromagnetic action, applicable to the technical field of testing working performance of anchor rod cables by simulating a tunnel field. The device comprises a top base (1) and a bottom base (2); a plurality of hydraulic vertical columns (3) are provided between the top base (1) and the bottom base (2); the plurality of hydraulic vertical columns (3) are provided thereon with clamping devices, and an electromagnetic block (9) is disposed between two groups of drawing block-shaped clamp holders (4).

Abstract: The present invention provides a single-anchor centrally grouted full-length anchored steel wire bundle and a supporting method thereof, which are suitable for use in supporting engineering for the deep dynamic pressure roadway or soft rock roadway. The steel wire bundle consists of parallel steel wires and a central pipe, wherein multiple strands of parallel steel wires are arranged around the central pipe, the central pipe is provided with a slurry output bracket which divides the parallel steel wires into a front part and a rear part, the front part is provided with large stirring jackets, and the rear part is provided with a threaded casing on its tail end.

Abstract: Disclosed are an integral clamping steel strand drawing test apparatus, and a method for using same, wherein same are suitable for use in a steel strand mechanical property test. The apparatus comprises a rectangular lower base (13) and a rectangular upper base (14), with a hydraulic telescopic mechanism being provided between the lower base (13) and the upper base (14), the hydraulic telescopic mechanism being provided with an integral clamping mechanism, a steel strand test piece (4) to be tested being provided in the integral clamping mechanism, the steel strand test piece (4) to be tested being provided with a plurality of binding protective devices (2), and a safety protection door (16) being provided outside the hydraulic telescopic mechanism.

Abstract: The present invention discloses a zero-gangue-discharge short-wall face pillar-free mining method, which is applicable to zero-gangue-discharge disposal in the mining operation in a mine shaft. A short-wall face is arranged in a selected area near a mine shaft according to the actual conditions of the mine shaft, the short-wall face is mined in a fully mining and fully back-filling mode, the gangues produced at other mining faces of the mine shaft are filled into the short-wall face, the short-wall face is supported with anchor rods along the edge of the filling face and the solid coal side to form an entry, and the entry is utilized to mine an adjacent working face. The method in the present invention mainly displaces the coal mass with gangues and thereby maximizes the utilization of the resources; in addition, the method can fully control the roof and realize mining without damage to the rock formation. Therefore, the method is of great value for wide application.

Abstract: A device and method for testing the working performance of an anchor rod cable by simulating stratum fracture and separation on the basis of electromagnetic action, applicable to the technical field of testing working performance of anchor rod cables by simulating a tunnel field. The device comprises a top base (1) and a bottom base (2); a plurality of hydraulic vertical columns (3) are provided between the top base (1) and the bottom base (2); the plurality of hydraulic vertical columns (3) are provided thereon with clamping devices, and an electromagnetic block (9) is disposed between two groups of drawing block-shaped clamp holders (4).