Patents by Inventor Nong Zhang

Nong Zhang has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20190177332
    Abstract: Disclosed are a condensed-ring pyrimidylamino derivative, a preparation method therefor, and an intermediate, a pharmaceutical composition and applications thereof. The method for preparing the condensed-ring pyrimidylamino derivative comprises: in a solvent, in the presence of a palladium-containing catalyst, allowing a compound represented by formula I-a and a compound represented by formula I-b? to have a coupling reaction, and then preparing a compound represented by formula I by means of a deprotection reaction. Also disclosed applications of the condensed-ring pyrimidylamino derivative in the preparation of drugs for preventing, relieving and/or treating tumors or diseases caused by an anaplastic lymphoma kinase. The condensed-ring pyrimidylamino derivative of the present invention has an obvious restraint effect on the anaplastic lymphoma kinase.
    Type: Application
    Filed: February 19, 2019
    Publication date: June 13, 2019
    Applicant: GUANGZHOU MAXINOVEL PHARMACEUTICALS CO., LTD.
    Inventors: Nong ZHANG, Zusheng XU, Tinghan WANG, Yuguang WANG
  • Publication number: 20190169987
    Abstract: The present invention provides a self-drilling and self-anchoring extendable anchor rod applicable to soft and weak coal rocks and an anchoring method thereof, which are suitable for supporting soft and weak coal rock mass in roadways.
    Type: Application
    Filed: June 7, 2017
    Publication date: June 6, 2019
    Applicant: CHINA UNIVERSITY OF MINING AND TECHNOLOGY
    Inventors: Nong ZHANG, Changliang HAN, Ke YANG, Zhengzheng XIE
  • Patent number: 10280750
    Abstract: The present invention provides a full-roadway full-process full-cross-section deformation monitoring device and a monitoring method thereof, which are applicable to the field of roadway surface deformation monitoring. A monitoring station is deployed utilizing an anchor rope, a supporting frame and a rotary laser measuring device are connected via a threaded sleeve at the tail end of the anchor rope, the rotary laser measuring device can rotate and drive a laser range finder to rotate, the data of a plurality of cross sections can be measured at the same time with one monitoring station, the data is processed by computer programming, so that the measurement data is converted into coordinates in a three-dimensional coordinate system, and thereby full-roadway full-process full-cross-section digital imaging is realized.
    Type: Grant
    Filed: June 7, 2017
    Date of Patent: May 7, 2019
    Assignee: CHINA UNIVERSITY OF MINING AND TECHNOLOGY
    Inventors: Nong Zhang, Zhengzheng Xie, Changliang Han, Dongjiang Pan
  • Patent number: 10259816
    Abstract: Disclosed are a condensed-ring pyrimidylamino derivative, a preparation method therefor, and an intermediate, a pharmaceutical composition and applications thereof. The method for preparing the condensed-ring pyrimidylamino derivative comprises: in a solvent, in the presence of a palladium-containing catalyst, allowing a compound represented by formula I-a and a compound represented by formula I-b? to have a coupling reaction, and then preparing a compound represented by formula I by means of a deprotection reaction. Also disclosed applications of the condensed-ring pyrimidylamino derivative in the preparation of drugs for preventing, relieving and/or treating tumors or diseases caused by an anaplastic lymphoma kinase. The condensed-ring pyrimidylamino derivative of the present invention has an obvious restraint effect on the anaplastic lymphoma kinase.
    Type: Grant
    Filed: April 22, 2016
    Date of Patent: April 16, 2019
    Assignee: GUANGZHOU MAXINOVEL PHARMACEUTICALS CO., LTD.
    Inventors: Nong Zhang, Zusheng Xu, Tinghan Wang, Yuguang Wang
  • Publication number: 20180371907
    Abstract: The present invention provides a full-roadway full-process full-cross-section deformation monitoring device and a monitoring method thereof, which are applicable to the field of roadway surface deformation monitoring. A monitoring station is deployed utilizing an anchor rope, a supporting frame and a rotary laser measuring device are connected via a threaded sleeve at the tail end of the anchor rope, the rotary laser measuring device can rotate and drive a laser range finder to rotate, the data of a plurality of cross sections can be measured at the same time with one monitoring station, the data is processed by computer programming, so that the measurement data is converted into coordinates in a three-dimensional coordinate system, and thereby full-roadway full-process full-cross-section digital imaging is realized.
    Type: Application
    Filed: June 7, 2017
    Publication date: December 27, 2018
    Inventors: Nong ZHANG, Zhengzheng XIE, Changliang HAN, Dongjiang PAN
  • Patent number: 10100016
    Abstract: Disclosed are a condensed ring derivative, and a preparation method, an intermediate, a pharmaceutical composition and a use thereof. The condensed ring derivative of the present invention has a significant inhibitive effect on URAT1, which can effectively alleviate or treat hyperuricemia and other related diseases.
    Type: Grant
    Filed: May 22, 2018
    Date of Patent: October 16, 2018
    Assignee: SHANGHAI YINGLI PHARMACEUTICAL CO., LTD.
    Inventors: Zusheng Xu, Nong Zhang, Qingrui Sun, Tianzhi Wu
  • Patent number: 10100015
    Abstract: Disclosed are a condensed ring derivative, and a preparation method, an intermediate, a pharmaceutical composition and a use thereof. The condensed ring derivative of the present invention has a significant inhibitive effect on URAT1, which can effectively alleviate or treat hyperuricemia and other related diseases.
    Type: Grant
    Filed: February 1, 2016
    Date of Patent: October 16, 2018
    Assignee: SHANGHAI YINGLI PHARMACEUTICAL CO., LTD.
    Inventors: Zusheng Xu, Nong Zhang, Qingrui Sun, Tianzhi Wu
  • Publication number: 20180265476
    Abstract: Disclosed are a condensed ring derivative, and a preparation method, an intermediate, a pharmaceutical composition and a use thereof. The condensed ring derivative of the present invention has a significant inhibitive effect on URAT1, which can effectively alleviate or treat hyperuricemia and other related diseases.
    Type: Application
    Filed: May 22, 2018
    Publication date: September 20, 2018
    Inventors: Zusheng XU, Nong ZHANG, Qingrui SUN, Tianzhi WU
  • Publication number: 20180208604
    Abstract: Disclosed area fused ring pyrimidine compound, and an intermediate, a preparation method, a composition and a use thereof. The fused ring pyrimidine compound is a compound as shown in formula I, a tautomer, an enantiomer, a diastereoisomer, a pharmaceutically acceptable salt, a metabolite, a metabolic precursor or a prodrug thereof, wherein the above-mentioned compound is used for the preparation of a medicine for preventing, remitting or treating one or more of immune system diseases, autoimmune diseases, cell proliferative diseases, allergic disorders and cardiovascular diseases, and the compound has a strong inhibitory effect on the Janues kinase, FGFR kinase, FLT3 kinase and Src family kinase.
    Type: Application
    Filed: July 21, 2016
    Publication date: July 26, 2018
    Inventors: Zusheng XU, Nong ZHANG, Tinghan WANG, Qingrui SUN, Yuguang WANG
  • Publication number: 20180127420
    Abstract: Disclosed area condensed-ring pyrimidylamino derivative, a preparation method therefor, and an intermediate, a pharmaceutical composition and applications thereof. The method for preparing the condensed-ring pyrimidylamino derivative comprises: in a solvent, in the presence of a palladium-containing catalyst, allowing a compound represented by formula I-a and a compound represented by formula I-b? to have a coupling reaction, and then preparing a compound represented by formula I by means of a deprotection reaction. Also disclosed applications of the condensed-ring pyrimidylamino derivative in the preparation of drugs for preventing, relieving and/or treating tumors or diseases caused by an anaplastic lymphoma kinase. The condensed-ring pyrimidylamino derivative of the present invention has an obvious restraint effect on the anaplastic lymphoma kinase.
    Type: Application
    Filed: April 22, 2016
    Publication date: May 10, 2018
    Applicant: GUANGZHOU MAXINOVEL PHARMACEUTICALS CO., LTD.
    Inventors: Nong ZHANG, Zusheng XU, Tinghan WANG, Yuguang WANG
  • Publication number: 20180072678
    Abstract: Disclosed are a condensed ring derivative, and a preparation method, an intermediate, a pharmaceutical composition and a use thereof. The condensed ring derivative of the present invention has a significant inhibitive effect on URAT1, which can effectively alleviate or treat hyperuricemia and other related diseases.
    Type: Application
    Filed: February 1, 2016
    Publication date: March 15, 2018
    Inventors: Zusheng XU, Nong ZHANG, Qingrui SUN, Tianzhi WU
  • Patent number: 9745320
    Abstract: A five-and-six-membered heterocyclic compound as represented by general formula I, pharmaceutically acceptable salt, metabolite, metabolic precursors or drug precursors thereof, preparation method, pharmaceutical composition, and use thereof; the five-and-six-membered heterocyclic compound has activity as a Janus kinase (JAK) inhibitor, and can be used to prepare drugs for treating diseases caused by the abnormal activity of kinase, such as cell proliferation diseases like cancer.
    Type: Grant
    Filed: January 17, 2014
    Date of Patent: August 29, 2017
    Assignee: GUANGZHOU MAXINOVEL PHARMACEUTICALS CO., LTD.
    Inventors: Zusheng Xu, Nong Zhang, Qingrui Sun, Tinghan Wang
  • Publication number: 20150336982
    Abstract: A five-and-six-membered heterocyclic compound as represented by general formula I, pharmaceutically acceptable salt, metabolite, metabolic precursors or drug precursors thereof, preparation method, pharmaceutical composition, and use thereof; the five-and-six-membered heterocyclic compound has activity as a Janus kinase (JAK) inhibitor, and can be used to prepare drugs for treating diseases caused by the abnormal activity of kinase, such as cell proliferation diseases like cancer.
    Type: Application
    Filed: January 17, 2014
    Publication date: November 26, 2015
    Applicant: SHANGHAI CHEMEXPLORER CO., LTD.
    Inventors: Zusheng XU, Nong ZHANG, Qingrui SUN, Tinghan WANG
  • Patent number: 8691822
    Abstract: Dihydroperidinone derivatives, preparation process and pharmaceutical use thereof are disclosed. Specially, new dihydroperidinone derivatives represented by general formula (I), wherein each substituent of the general formula (I) is defined as in the description, their preparation process, pharmaceutical compositions comprising said derivatives and their use as therapeutical agents, especially as Plk kinase inhibitors are disclosed.
    Type: Grant
    Filed: September 14, 2010
    Date of Patent: April 8, 2014
    Assignees: Jiangsu Hengrui Medicine Co., Ltd., Shanghai Hengrui Pharmaceutical Co., Ltd.
    Inventors: Peng Cho Tang, Nong Zhang, Baolei Zhang, Weimin Wang, Hao Zheng, Lin Wu
  • Publication number: 20120184543
    Abstract: Dihydroperidinone derivatives, preparation process and pharmaceutical use thereof are disclosed. Specially, new dihydroperidinone derivatives represented by general formula (I), wherein each substituent of the general formula (I) is defined as in the description, their preparation process, pharmaceutical compositions comprising said derivatives and their use as therapeutical agents, especially as Plk kinase inhibitors are disclosed.
    Type: Application
    Filed: September 14, 2010
    Publication date: July 19, 2012
    Applicants: SHANGHAI HENGRUI PHARMACEUTICAL CO., LTD., JIANGSU HENGRUI MEDICINE CO., LTD.
    Inventors: Peng Cho Tang, Nong Zhang, Baolei Zhang, Weimin Wang, Hao Zheng, Lin Wu