Abstract: A modifier for paving asphalt, which comprises Trinidad Epure having a maximum size of less than 25 mm and a pulverulent solid having a maximum size of less than 2.5 mm, the powder comprising essentially a substance having a higher softening point than Trinidad Epure and compatibility with paving petroleum asphalt, wherein the volume of the powdery solid is 0.8 to 2.8 times the void volume of the granulated Trinidad Epure when in the stored state.

Abstract: Novel isoquinoline derivatives of the general formula ##STR1## wherein R represents a lower alkyl group, a lower cycloalkyl group, or a group of the formula ##STR2##in which R.sup.2 represents a hydrogen atom, a halogen atom, a methyl group, a trifluoromethyl group, a methoxy group, a methylamino group or a dimethylami no group;R.sup.1 represents a hydrogen atom or a lower alkyl group; andY represents a carboxyl group, a cyano group, a carbamoyl group, a lower alkoxycarbonyl group or a lower alkylaminocarbonyl group;or a salt thereof; a process for the production thereof.The above compound is useful as an anti-inflammatory and analgesic agent.