Abstract: Provided are a biomarker composition for the diagnosis of moyamoya disease, including caveolin-1, a kit for the diagnosis of moyamoya disease, a method of providing information for moyamoya disease diagnosis, and a method of screening a moyamoya disease therapeutic agent. According to the present disclosure, specific treatment for moyamoya disease is possible by distinguishing the disease from atherosclerosis, which is a similar cerebrovascular stenosis disease, and thus unnecessary factors or risk factors that may be accompanied by side effects may be avoided and, therefore, may be applied to effective MMD therapies.

Abstract: The present invention relates to a composition including stem cell-derived microvesicles as an active ingredient for promoting neurogenesis. The stem cell-derived microvesicles according to the present invention can promote neurogenesis and migration of nerves and also promote angiogenesis in vascular endothelial cells, and thus can be usefully used in treatment of neurological damage.

Abstract: Disclosed herein is an injectable anticancer composition for local administration, which contains a suspension of quinine hydrochloride. The anticancer composition for local administration according to the present invention shows an IC50 value against MKN-45 cells, which is about 10 times lower than Paclitaxel, as determined by an MTT assay in vitro, suggesting that the anticancer composition has an excellent cytotoxic effect. The anticancer composition can be administered as a safe anticancer agent in clinical applications, and also shows an anticancer effect by inducing the necrosis and detachment of solid cancer cells. Particularly, the anticancer composition has an anticancer mechanism by which the composition acts locally in a tumor tissue administered with the composition and shows a rapid antitumor effect (1-2 weeks after administration).

Abstract: The present invention relates to a composition for topically delivering SDF-1 into the brain, in which the composition comprises a dual ionic pH-sensitive copolymer and a nerve regeneration and protective factor. In the present invention, when a dual ionic pH-sensitive copolymer containing SDF-1 as a nerve regeneration and protective factor is applied to a patient suffering from ischemic stroke as a drug carrier, it induces the effective delivery of the treatment factor to a topical lesion site, and moreover, the risk factors for adverse effects may be cancelled out, so that it can be effectively used as a novel therapeutic agent for ischemic brain diseases.

Abstract: Disclosed are a UV hardening composition having improved light resistance, a three dimensional film, and a method for manufacturing the three dimensional film. Particularly, the UV hardening composition having improved light resistance may be used in interior materials and the like for a vehicle which generally are substantially exposed to UV rays. In addition, the UV hardening composition may also be used for indoor electronic products. The UV hardening composition according to the present invention includes a urethane acrylate resin, a polyester acrylate resin, a UV absorber, a hindered amine light stabilizer (HALS), an antioxidant and the like. Further, the three dimensional film including the UV hardening composition may be advantageous due to the improvement in the carbon pattern three dimensional effect formed in the three dimensional film.

Abstract: An exhaust manifold-integrated cylinder head with a water jacket includes intake ports through which outside air is supplied and exhaust ports through which exhaust gas is discharged. Intake valve holes and exhaust valve holes open the intake ports and the exhaust ports. Spark plug holes are formed on a top side of the cylinder head. A head water jacket is formed within the cylinder head to allow a coolant to flow from one end to another end. The head water jacket includes exhaust port bridge coolant passages formed between the exhaust ports. Lower coolant guides protrude inside the cylinder head so that the coolant flows upward from a bottom side of the cylinder head through the exhaust port bridge coolant passages.

Abstract: The present invention relates to a novel magnetic resonance image technique for imaging collateral circulation in a human body. In the present invention, source data of a dynamic susceptibility contrast enhancement perfusion-weighted image (DSC-PWI) is subjected to an image-post-processing and an image obtained through the image-post-processing is then compared with an image obtained by digital subtraction angiography (DSA), thereby imaging the collateral circulation. The method according to the present invention can non-invasively, rapidly and easily visualize and evaluate the collateral circulation. Therefore, the method can provide information, which is important for understanding, treatment strategy determination and outcome prediction of a disease generated due to angiostenosis or occlusion.

Abstract: The present invention relates to a carbazole-based phosphine oxide compound, and an organic electroluminescent device including the same. According to the present invention, provided are a compound for an organic electroluminescent device which can improve the thermal stability and efficiency characteristics which are unstable and low, respectively, corresponding to problems of known compounds for organic electroluminescent devices, and particularly, can implement excellent efficiency characteristics in a pure blue phosphorescent device, by using the carbazole-based phosphine oxide compound of the compound for the organic electroluminescent device, and the organic electroluminescent device. According to one aspect of the present invention, the carbazole-based phosphine oxide compound of the compound for the organic electroluminescent device is provided, and the organic electroluminescent device containing the same which can implement thermal stability and high efficiency characteristics is also provided.

Abstract: Disclosed are a separator for a battery, which comprises a gel polymer layer formed on a substrate, the gel polymer layer including a plurality of three-dimensional open pores interconnected with each other, and an electrochemical device comprising the same separator. Also, disclosed is a method for preparing the gel polymer layer including a plurality of three-dimensional open pores interconnected with each other on a substrate.

Abstract: Provided is a lighting device. The lighting device includes a light emitting diode (LED) mounted on a substrate, a light transmitting member disposed above an illumination surface with a minimal gap from the LED, and a housing in which the substrate, the light transmitting member, and a battery assembly are assembled, wherein the light transmitting member is formed of a transparent material to transmit light from a light source onto the illumination surface, the light transmitting member has a generally thin rectangular shape formed by two mutually-facing lateral surfaces, two mutually-facing end surfaces, an upper major surface, and a lower major surface, one or more of the end surfaces being coated with a reflective material, and one or more of the upper and lower major surfaces having negative curvatures.

Abstract: The present invention relates to a composition comprising an ischemic serum for promoting the activation of a stem cell, to a method for promoting the activation of a stem cell and to a stem cell, the activation of which is promoted by the composition or the method. The ischemic serum according to the present invention may stimulate the stem cell to facilitate the secretion of a growth factor, improve survival rate, improve mobility to an injured part, improve proliferation rate and maintain characteristics of the stem cell, thus promoting an activation of the stem cell such that the stem cell becomes suitable for transplantation of the stem cell to a patient having a brain injury.