Abstract: The present application relates to a novel tetrahydroquinoline derivative, to a process for its preparation, to its use on its own or in combination for treating and/or preventing diseases and to its use for preparing medicaments, in particular as an inhibitor of the cholesterol ester transfer protein (CETP) for the treatment and/or prevention of cardiovascular disorders, in particular hypolipoproteinaemias, dyslipidaemias, hypertriglyceridaemias, hyperlipidaemias, hypercholesterolaemias and arteriosclerosis.

Abstract: The present invention relates to pharmaceutical compositions for treating virus infections and/or diseases caused by virus infections comprising at least a diaryl urea compound optionally combined with at least one additional therapeutic agent. Useful combinations include e.g. BAY 43-9006 as a diaryl urea compound.

Abstract: A method of diagnosing a cooling subsystem of an engine system in response a parameter extracted from dynamic hydraulic pressure sensed in the cooling subsystem, and products and systems using same.

Abstract: A method and system for estimating engine parameters in a combustion engine gas exchange system based on dynamic pressure readings taken by one or more pressure sensors. According to an exemplary embodiment, the method and system may use an artificial neural network (ANN) to process the dynamic pressure readings and any additional engine conditions that may have been provided.

Abstract: A valve assembly for use in an air management assembly having an engine, an exhaust side, and an intake side, where the valve assembly provides a housing, a plurality of openings in the housing, a valve in the housing, and an actuator operably connected to the valve. The housing is in fluid communication with the exhaust side and the intake side. The plurality of openings in the housing form at least one inlet and at least one outlet in the housing. The valve moves with respect to the plurality of openings.

Abstract: The invention relates to a method for the production of a pharmaceutical composition for treating cancer by combining Parapoxvirus ovis with at least one anticancer agent. The invention furthermore relates to a method for treating a patient afflicted with cancer comprising the administration of Parapoxvirus ovis in combination with at least one anticancer agent.

Abstract: Another embodiment of the invention includes a method of controlling a turbocharger to achieve at least one of: produce air in excess of that required to operate a combustion engine at a specific power demand; control the flow of gas through the turbine; or control the turbine speed independent of boost pressure required to avoid specific speeds.

Abstract: The present invention relates to the use of Parapoxviruses in combination with other agents for the treatment of viral diseases, and in particular HIV infections and AIDS. The invention also relates to methods for producing medicaments based on combinations of Parapoxviruses and other antiviral agents, and to such medicaments. In particular, the invention relates to the use of Parapoxviruses in combination with agents of the kind used for antiretroviral therapy and highly active antiretroviral therapy (HAART).

Abstract: Disclosed are compounds and derivatives thereof, their synthesis, and their use as Rho-kinase inhibitors. These compounds of the present invention are useful for inhibiting tumor growth, treating erectile dysfunction, and treating other indications mediated by Rho-kinase, e.g., coronary heart disease.

Abstract: An engine assembly (10) comprising an engine, a plurality of coolers, a plurality of bypasses, and at least one actuator (32). The engine has an exhaust manifold and an intake manifold. The gaseous fluid exiting the exhaust manifold is recirculated to the intake manifold. The exhaust gas passes through either an air cooler or a bypass. At least one actuator is operably connected to the plurality of bypasses. The bypasses have a valve (28, 30) which is actuated to control the flow of the gaseous fluid through the bypass as both the bypass and the cooler. Therefore, when a single actuator is used to control the valves in both bypasses, the valves in the bypasses have the same relationship with the inlets so that a single actuator movement will control both valves in the same manner.

Abstract: The present invention relates to the use of antibodies against the CD52 antigen, specifically monoclonal antibodies, for the production of medicaments for the treatment of diseases of the central nervous system, in particular transmissible spongiform encephalopathies, diseases that are also called prion diseases.

Abstract: Disclosed are compounds and derivatives thereof, their synthesis, and their use as Rho-kinase inhibitors. These compounds of the present invention are useful for inhibiting tumor growth, treating erectile dysfunction, and treating other indications mediated by Rho-kinase, e.g., coronary heart disease.

Abstract: The present invention relates to pharmaceutical compositions for treating virus infections and/or diseases caused thereby comprising 4{4-[3-(4-chloro-3-trifluoromethylphenyl)-ureido]-3-fluorophenoxy}-pyridine-2-carboxylic acid methylamide optionally combined with at least one additional therapeutic agent.

Abstract: The present invention relates to benzofuran and benzothiophene derivatives and compositions containing such compounds for the production of medicaments for the treatment of cancers of the central nervous system as monotherapy or combination with other agents.

Abstract: A process for the preparation of various quinazoline compounds which are useful as Rho-Kinase inhibitors, and thus having utility in the treatment of hypertension and other indications.

Abstract: An adsorption element for adsorbing gases and vapors from the gaseous atmosphere in the intake tract of an internal combustion engine. The adsorption element is disposed within a wall of a flow cross section carrying the intake air, has a planar adsorption medium along which the intake air flows, and is pleated to create folds in longitudinal direction of the intake stream.

Abstract: The present invention relates to a compressor-cooler module, having a housing, a compressor contained in the housing and an air cooler disposed within the housing and positioned in the flow path of the compressor. The present invention also includes an intake in fluid communication with the housing, a cooler bypass valve operably associated with the air cooler and the compressor, and a low-pressure exhaust gas recirculation passage operably associated with the cooler bypass valve, and the cooler by pass valve selectively directs exhaust gas to bypass the air cooler.

Abstract: A method for monitoring and diagnosing an air charger system for use in an engine assembly having pre-existing sensors, having the steps of providing an air charger having a turbine and a compressor operatively coupled to one another. Providing a control unit for monitoring a plurality of operating conditions of the engine assembly. The control unit calculates an expected value of a selected operating condition based upon at least another of the plurality of operating conditions. Comparing the expected value and at least another of the plurality of operating conditions. Diagnosing a fault condition, if present, based upon the expected value and said at least another of said plurality of operating conditions being outside a predetermined tolerance.

Abstract: Disclosed are compounds and derivatives thereof their synthesis, and their use as Rho-kinase inhibitors. These compounds of the present invention are useful for inhibiting tumor growth, treating erectile dysfunction, and treating other indications mediated by Rho-kinase, e.g., coronary heart disease.

Abstract: A process for the preparation of various quinazoline compounds which are useful as Rho-Kinase inhibitors, and thus having utility in the treatment of hypertension and other indications.