Abstract: Novel dihydropyrimidines and combinations thereof with other antiviral agents, suitable for combating HBV infections.

Abstract: Disclosed are compounds and derivatives thereof, their synthesis, and their use as Rho-kinase inhibitors. These compounds of the present invention are useful for inhibiting tumor growth, treating erectile dysfunction, and treating other indications mediated by Rho-kinase, e.g., coronary heart disease.

Abstract: An air filter system with an air filter element having an inflow and an outflow face and comprising alternating flat and pleated layers, which are configured to form channels. The channels are alternately sealed in inflow and outflow direction, such that the medium to be filtered must pass through one of the layers as it flows from the inflow face through the filter to the outflow face. An adsorber element made of an activated carbon coated honeycomb structure is disposed adjacent the air filter element.

Abstract: The present invention relates to the preparation and use of organ-specific, tissue-specific and/or cell-specific recombinant parapoxvirus ovis as a pathogen-specific and organ-specific, targeted immunotherapeutic agent for chronic viral infections and inflammatory, degenerative and proliferative diseases, in particular of the liver, and cancer.

Abstract: The present invention relates to pyrrolo[2.1-a]dihydroisoquinolines which are inhibitors of phosphodiesterase 10a and can be used for combating cancer.

Abstract: The invention relates to the novel compounds of formula (I), to a method for producing the same and to their use as drugs, especially as antiviral drugs.

Abstract: The invention relates to polynucleotides coding for the PPVO viral genome, to fragments of the polynucleotides coding for the PPVO genome and to polynucleotides coding for individual open reading frames (ORFs) of the PPVO viral genome. The invention also relates to recombinant proteins expressed from the above mentioned polynucleotides and to fragments of said recombinant proteins, and to the use of said recombinant proteins or fragments for the preparation of pharmaceutical compositions.

Abstract: The invention relates to compounds of the general formulae (I) and (Ia) 1

Abstract: The present invention relates to pyrrolo[2.1-a]dihydroisoquinolines which are inhibitors of phosphodiesterase 10a and can be used for combating cancer.

Abstract: The invention relates to compounds of the general formulae (I) and (Ia) The invention furthermore relates to processes for preparing the compounds of the formulae (I) and (Ia) and to their use as medicaments, in particular for the treatment and prophylaxis of hepatitis B.

Abstract: The present invention relates to the use of strains of Parapoxvirus ovis as immunotherapeutic agents for immunodeficiencies of an infectious or non-infectious nature, and to the use of strains of Parapoxvirus ovis for treating tumor diseases and viral infections, and diseases which accompany them, and the use of strains of Parapoxvirus ovis for producing medicaments for use in humans and animals.

Abstract: Disclosed are compounds and derivatives thereof, their synthesis, and their use as Rho-kinase inhibitors. These compounds of the present invention are useful for inhibiting tumor growth, treating erectile dysfunction, and treating other indications mediated by Rho-kinase, e.g., coronary heart disease.

Abstract: The present invention relates to novel compounds, to a process for their preparation and to their use as medicaments, in particular as antiviral medicaments.

Abstract: The present invention relates to pyrrolo[2.1-a]isoquinolines which are inhibitors of phosphodiesterase 10a, a process for preparing these compounds and a method of treating cancer in humans and animals by administering these compounds.

Abstract: Novel dihydropyrimidines and combinations thereof with other antiviral agents, suitable for combating HBV infections.

Abstract: A process for the preparation of various quinazoline compounds which are useful as Rho-Kinase inhibitors, and thus having utility in the treatment of hypertension and other indications.

Abstract: An intake system (13) for an internal combustion engine (12) which includes a housing (15a) with a filter insert (16) and a membrane (22) for separating nitrogen and enriching the combustion air with oxygen. The membrane is integrated into the filter housing so as to save construction space and provide a lower cost system. The membrane (22) can alternatively be arranged on the clean air side of the air filter insert (16) to prevent the membrane from being soiled and to improve the functional reliability of the oxygen enrichment. Alternatively, instead of arranging the membrane (22) on the clean side of the filter insert (16), the membrane can be protected from being soiled by using a cover (23).

Abstract: The present invention relates to the use, in humans, of inactivated parapoxviruses for the prophylaxis and treatment of diseases which are accompanied by an increased deposition of collagen, with it being possible for both internal organs, such as the liver, and the skin and its appended structures, to be affected. The invention relates, in particular, to liver fibrosis and/or liver cirrhosis consequent upon virus hepatitis, or to ethanol-induced liver diseases and to cystic fibrosis.

Abstract: Isoxazoles are highly effective anti-viral agents. Combinations of isoxazoles, dihydropyrimidines and/or lamivudine and, optionally, interferon inhibit the proliferation of HBV viruses better than conventional agents.

Abstract: Disclosed are compounds and derivatives thereof, their synthesis, and their use as Rho-kinase inhibitors. These compounds of the present invention are useful for inhibiting tumor growth, treating erectile dysfunction, and treating other indications mediated by Rho-kinase, e.g., coronary heart disease.