Abstract: A turbomachine including a gas generator endowed with a first shaft, a gear box, at least one reversible electric machine coupled to the gear box, and a free turbine endowed with a second shaft and rotationally driven by a gas stream of the gas generator and at least one accessory coupled to the accessory gear box, wherein the turbomachine includes a first mechanical coupling means configured to mechanically couple said first mechanical shaft to the accessory gear box in a first configuration and to mechanically uncouple said first mechanical shaft from the accessory gear box in a second configuration, and a second mechanical coupling means configured to mechanically couple said second mechanical shaft to the accessory gear box in a first configuration and to mechanically uncouple said second mechanical shaft from the accessory gear box in a second configuration.

Abstract: An aircraft turbine engine includes a turbine shaft having a first axis of rotation, a propulsion propeller having a second axis of rotation parallel to and spaced from the first axis, and a mechanical reduction gear coupled to the turbine shaft and rotating the propeller. The reduction gear has a sun gear connected to the turbine shaft, a ring gear, and at least two planet gears, each including a first external toothing that is meshed with an external toothing of the sun gear. A second external toothing is located within the ring gear and is meshed with an internal toothing of the ring gear.

Abstract: A holder for an inhaler article. The holder comprises a housing comprising a housing cavity. The holder further comprises an engagement member located at least partially within the housing cavity. The engagement member is movable relative to the housing between an upstream position and a downstream position. The engagement member comprised a first follower member. The housing comprises a first guide and a first latch, the first follower member is arranged to follow the first guide between a first position, a second position, and a third position. The first latch is arranged such that the first follower member may pass from the first position to the second position, but may not return to the first position without first passing the third position. An inhaler system comprises a holder and an inhaler article.

Abstract: The present invention provides SOCE inhibitors that are useful as therapeutic agents in a variety of applications. The present invention also relates to pharmaceutical compositions, products and kits comprising such SOCE inhibitors, and methods of using the SOCE inhibitors in the treatment of a variety of diseases.

Abstract: The invention relates to multispecific antibody constructs comprising Fab fragments having mutations at the interface of the CH1 and CL domains, said mutations preventing heavy chain/light chain mispairing.

Abstract: Motor vehicle comprising a drive system arranged in a compartment at the front of a vehicle, a cradle (2) comprising a platform (4) fastened in this compartment in the region of a floor of the vehicle, an anti-roll bar (10) fastened in the vertical direction above the platform (4), and an impact device (30) fastened to a front edge (20) of the platform (4), behind an impact block fastened to a powertrain of this vehicle, in order, in the event of a recoil of this powertrain, to allow the impact block to bear on the impact device (30), which deforms, the impact device (30) comprising an upper part projecting above the platform (4), which, in the event of a large deformation, bears on the anti-roll bar (10).

Abstract: A process for shaping, by compaction, a fibrous structure obtained by three-dimensional or multilayer weaving between a plurality of layers of warp yarns and a plurality of layers of weft yarns. The yarns of each plurality of layers of warp yarns and layers of weft yarns are coated with a sizing composition. The shaping includes a pre-compaction stage followed by a stage of final compaction of the fibrous structure. During pre-compaction and final compaction, the fibrous structure is at a temperature greater than or equal to the softening temperature of the sizing composition. The process further includes the cooling of the fibrous preform obtained after final compaction of the fibrous structure.

Abstract: A device and a method for mixing a fluid in a specimen bag is provided herein. In one embodiment, the device includes a mechanism for creating a first vortex and a second vortex. The first vortex is on a first side of a bag containing the fluid, and the second vortex is on a second side of the bag. The mechanism includes a first inflatable airbag and a second inflatable airbag. The first inflatable airbag is configured to create the first vortex when inflated and the second inflatable airbag is deflated. The second inflatable airbag is configured to create the second vortex when inflated and the first inflatable airbag is deflated.

Abstract: An OSS animated display system for an interventional device (40) including an integration of one or more optical shape sensors and one or more interventional tools. The OSS animated display system employs a monitor (121) and a display controller (110) for controlling a real-time display on the monitor (121) of an animation of a spatial positional relationship between the OSS interventional device (40) and an object (50). The display controller (110) derives the animation of the spatial positional relationship between the OSS interventional device (40) and the object (50) from a shape of the optical shape sensor(s).

Abstract: According to some implementations, a n medical interventional imaging device for monitoring an interventional procedure is described. The medical interventional imaging device includes a temporary data buffer configured to temporarily store medical interventional fluoroscopic image data, a signal processor configured to detect if an abnormal state occurs during an intervention and to record an instant at which the abnormal state has occurred, and a permanent data storage configured to permanently store at least a part of the medical interventional fluoroscopic image data stored temporarily before and/or at the recorded instant if the abnormal state is detected.

Abstract: The present invention relates to image processing for enhancing ultrasound images. In order to provide image data showing the current situation, for example in a region of interest of a patient, an image processing device (10) for enhancing ultrasound images is provided that comprises an image data input unit (12), a central processing unit (14), and a display unit (16). The image data input unit is configured to provide an ultrasound image of a region of interest of an object, and to provide an X-ray image of the region of interest of the object. The central processing unit is configured to select a predetermined image area in the X-ray image, to register the ultrasound image and the X-ray image, to detect the predetermined area in the ultrasound image based on the registered selected predetermined image area, and to highlight at least a part of the detected area in the ultrasound image to generate a boosted ultrasound image.

Abstract: A toothed coupling mechanism for an assembly of rotating elements of an aircraft gas turbine engine includes a pair of coupling halves having an axial toothed coupling interface therebetween. Each coupling half has a plurality of splined teeth inter-engaged about an axis for transmitting torque therebetween. A protrusion is located on one of the splined teeth of one of the coupling halves. A splined tooth of the other coupling half comes into contact with the protrusion in a situation of uncoupling of said coupling halves.

Abstract: The present invention relates to displaying spatial information of an interventional device in a live 2D X-ray image. In order to provide a facilitated visualization technique to provide 3D information of a subject, a device (10) for providing spatial information of an interventional device in a live 2D X-ray image is provided. The device comprises an input unit (12), and a processing unit (16). The input unit is configured to provide an actual 2D X-ray image (18) of a region of interest related to a portion of a patient's body. A target location (22) lies within the region of interest. At least a portion (20) of an interventional device is arranged in the region of interest. The input unit is configured to provide actual 3D ultrasound data of at least a part of the region of interest and at least a portion of an interventional device (19). The target location (22) lies within the region of interest. The processing unit is configured to register the actual 3D ultrasound data to the actual 2D X-ray image.

Abstract: A method for ultrasound image acquisition for tracking an object of interest in ultrasound image information includes receiving X-ray image information and ultrasound image information, determining, before the tracking, a spatial relationship between the X-ray image information and the ultrasound image information, detecting an object of interest in the X-ray image information and steering two-dimensional ultrasound image acquisition such that the object of interest is within an ultrasound image plane.

Abstract: In cardiac roadmapping, a “roadmap”, which is typically a representation of the vasculature of a patient obtained via previously acquired data from a CT scan, is overlaid on live intervention data, showing the position of an intervention device obtained using fluoroscopy. In this way, the intervention device may be tracked inside a realistic representation of the patient. The accurate registration of the fluoroscopic image to the roadmap data is an important step, otherwise the reported live position of the intervention device would not be shown at an accurate position inside the roadmap. Registration can be performed by the injection of contrast medium. In the case of cardiac roadmapping, the small vessel diameters mean that it is possible to register intervention devices directly. However, the behavior of intervention devices in larger vessels is difficult to predict, and so device-based registration is harder to achieve in such a context.

Abstract: According to some implementations, a n medical interventional imaging device for monitoring an interventional procedure is described. The medical interventional imaging device includes a temporary data buffer configured to temporarily store medical interventional fluoroscopic image data, a signal processor configured to detect if an abnormal state occurs during an intervention and to record an instant at which the abnormal state has occurred, and a permanent data storage configured to permanently store at least a part of the medical interventional fluoroscopic image data stored temporarily before and/or at the recorded instant if the abnormal state is detected.

Abstract: The present invention relates to an medical interventional imaging device (1) for monitoring an interventional procedure, the medical interventional imaging device (1) comprising: a temporary data buffer (10) configured to temporarily store medical interventional fluoroscopic image data; a signal processor (20) configured to detect if an abnormal state occurs during an intervention and to record an instant at which the abnormal state has occurred; and a permanent data storage (30) configured to permanently store at least a part of the medical interventional fluoroscopic image data stored temporarily before and/or at the recorded instant if the abnormal state is detected.

Abstract: An OSS animated display system for an interventional device (40) including an integration of one or more optical shape sensors and one or more interventional tools. The OSS animated display system employs a monitor (121) and a display controller (110) for controlling a real-time display on the monitor (121) of an animation of a spatial positional relationship between the OSS interventional device (40) and an object (50). The display controller (110) derives the animation of the spatial positional relationship between the OSS interventional device (40) and the object (50) from a shape of the optical shape sensor(s).

Abstract: A method and device is proposed for automatic detection of an event in which a device is leaving a stable position relative to and within an anatomy. The method comprises the steps of receiving a sequence of fluoroscopic images, detecting a device in at least two of the fluoroscopic images, determining a motion field of the detected device in the sequence of fluoroscopic images, generating a sequence of integrated images by integrating the sequence of fluoroscopic images taking into consideration the motion field, determining a saliency metric based on the integrated images, identifying a landmark in the integrated images based on the saliency metric, and determining as to whether the landmark is moving relative to the device, based on a variation of the saliency metric.

Abstract: A system (1) and a corresponding method enable an enhanced roadmapping visualization without unnecessary device-footprints. The system (1) includes an x-ray imaging device (3) for acquiring x-ray images and a calculation unit (5). The x-ray imaging device (3) is adapted for acquiring a first x-ray image (21) with an interventional device (17) present in the vessels (19) while no contrast agent is present in the vessels (19) and a second x-ray image (23) with the interventional device (17) present in the vessels (19) while contrast agent is present in the vessels (19). The calculation unit is adapted for creating a roadmap image (27) by subtracting the first x-ray image (21) from the second x-ray image (23) and automatically minimizing the visibility of the interventional device (17) in the roadmap image (27). A display unit (7) is adapted to display the roadmap image (27) or an overlay of a current fluoroscopy image (31) with the roadmap image (27).