Abstract: A medical device and method for facilitating selection of a shape and/or size of an annuloplasty implant for a patient comprises a catheter with a proximal end and a distal end, and an extension member at least partly arranged inside the catheter with an operator end and a measurement end. The measurement end is extendable relative from the distal end of the catheter for apposition with at least one commissure of a cardiac valve. The measurement end of the extension member comprises means for guiding the annuloplasty implant at at least one commissure.

Abstract: A medical arrangement for introducing an implant into an anatomical target position comprises a first introducer and a guide wire. The guide wire is configured to be introduced before the implant into or towards the anatomical target position. The implant is configured to be delivered along the guide wire into the anatomical target position. The guide wire is configured to be retracted after the implant has been introduced into said anatomical target position so that said object essentially maintains the shape taken when introduced into said anatomical target position.

Abstract: A medical arrangement for introducing an object, such as an implant into an anatomical target position comprises a first introducer, a guide wire and a guiding catheter). The guide wire is configured to be introduced before the guiding catheter and object into or towards the anatomical target position. The guiding catheter is configured to be delivered into the position along the guide wire, after which the guide wire is configured to be retracted. The object is configured to be delivered inside the guiding catheter after the guide wire is retracted.

Abstract: An annuloplasty device is disclosed comprising first and second support rings having a coiled configuration, an elongate element to apply a force onto retention units and being movable between a first state and a second state, at least part of the first and second support rings comprises an interior channel to contain the elongate element, wherein, in the first state of the elongate element, the retention units have a retracted position, in which the retention units are arranged radially within an outer surface of the first and/or second support rings, wherein, in the second state of the elongate element, the retention units have an expanded position, in which the retention units protrude from the outer surface of the first and/or second support rings.

Abstract: A medical arrangement is configured to introduce an object, such as an implant or medicament, from a distal end of the arrangement into an anatomical target position. The medical arrangement comprises a first and second introducer, both having distal and proximal ends. The first introducer is an outer introducer and the second introducer is configured to be operated inside and guided by the first introducer. In addition, at least a portion of the first introducer is configured to take a first curved shape, and at least a portion of the second introducer is configured to take a second curved shape so that the first and second curved shapes are concentric curved shapes so all curves are in the same hand direction and thereby form a helical loop structure.

Abstract: An annuloplasty system is disclosed comprising an annuloplasty implant and a delivery device, the annuloplasty implant comprising first and second supports being adapted to be arranged on opposite sides of native heart valve leaflets. The delivery device comprising a locking structure to interlock with a correspondingly mating first locking structure of a delivery device connector of the annuloplasty implant, the locking structure comprising a first locking side to lock rotational movement of the annuloplasty implant, when interlocked with the delivery device, around an axial direction of the annuloplasty implant, and a second locking side to lock movement of the annuloplasty implant along said axial direction, when interlocked with the delivery device. A method of repairing a defective heart valve is also disclosed.

Abstract: A medical device is disclosed that reinforces weakened or degenerated areas of at least a portion of a leaflet (24) Of the heart valve. Function of a heart valve is thus improved. The medical device comprises at least a first partly flexible leaflet reinforcement patch (30) having an extension between an inner section (34) and an outer section (32), wherein said outer section (32) is configured to be oriented towards said annulus, and said inner section (34) is configured to be oriented towards said inner section of said valve tissue, and at least a portion of said inner section (34) of said flexible leaflet reinforcement patch (32) having at least one of said plurality of leaflets (24) in juxtaposition to said portion of said inner section (34), and said portion of said inner section (34) being positioned to provide reinforcement to said plurality of leaflets (24).

Abstract: A device for improving the function of a heart valve comprises a first loop-shaped support, which is configured to abut a first side of the heart valve. A first flange unit is may be configured as a fabric sleeve covering the loop-shaped support. A portion of the fabric sleeve forms a flange that is attached to the annulus when said first loop-shaped support is abutting said heart valve. The flange is provideable by folding at least a portion of said sleeve over itself for forming a double layer of opposing fabrics thereof, such that said sleeve comprises a flange portion extending from said first loop-shaped support configured to overlap a surface of and form a collar around, at least a portion of said annulus.

Abstract: A method for repairing a defective heart valve includes directing a delivery catheter to form a first curve around the heart valve at a first side of the heart valve leaflets and forming a second curve of the delivery catheter around the heart valve on a second side of the heart valve leaflets. The first and second curves are connected through a commissure of the heart valve and an annuloplasty implant is ejected from the delivery catheter while the delivery catheter is retracted such that the annuloplasty implant is arranged along the first and second curve.

Abstract: An annuloplasty device is disclosed comprising first and second support rings having a coiled configuration, and respective first and second retention units, the first support ring transitions to the second support ring over a transition section, the transition section is adapted to be arranged at a commissure of the heart valve leaflets, the first and second support rings extend in respective first and second coil planes being essentially perpendicular to the central axis, the transition section bends at least partly along the central axis so that the first coil plane is separated a distance from the second coil plane along the central axis at the transition section.

Abstract: A medical arrangement is configured to introduce an object, such as an implant, from a distal end into an anatomical target position. The medical arrangement comprises a first introducer having distal and proximal ends, and a second introducer having distal and proximal ends. The first introducer is an outer introducer and said second introducer is configured to be operated inside and guided by said first introducer. At least a portion of the first introducer is configured to take a first curved shape, and at least a portion of the second introducer is configured to take a second curved shape. The portion of the second introducer configured to take said second curved shape comprises a tubular member inside said second introducer for enabling introducing of the object or implant through said tubular member and thereby over at least said second curved shape of said second introducer.

Abstract: A kit for repairing and/or replacing a mitral valve includes a mitral valve prosthesis and a loop-shaped element with a proximal end, a distal end, and a curved body. A proximal portion of the curved body is sized for positioning on an atrial side of the mitral valve and a distal portion of the curved body is sized for positioning on a ventricular side of the mitral valve. The distal portion has a first curved region with a radius of curvature that is larger than the radius of curvature of a second curved region so that the distal portion passes between heart muscle wall and chordae and circumflex the chordae of the mitral valve when the distal portion is rotated into place at the ventricular side of the native mitral valve.

Abstract: A device for improving the function of a heart valve comprises: a support member formed from a shape memory material, and a restraining member providing a restraining action on a course of the support member. The support member may abut one side of the valve conforming to the shape of the valve annulus upon said shape memory material assuming an activated shape while the restraining member restrains the course of the support member. The restraining action is removable for allowing the support member to assume a desired, altered course. The restraining member may be biodegradable to be degraded within a patient or may be detachable from the support member to be withdrawn. The support member according to another embodiment presents a shape change in that an increased cross-section is associated with a shortened length of the support member. The support member according to yet another embodiment has a first and a second activated shape.

Abstract: A medical device is disclosed that reinforces weakened or degenerated areas of at least a portion of a leaflet (24) Of the heart valve. Function of a heart valve is thus improved. The medical device comprises at least a first partly flexible leaflet reinforcement patch (30) having an extension between an inner section (34) and an outer section (32), wherein said outer section (32) is configured to be oriented towards said annulus,and said inner section (34) is configured to be oriented towards said inner section of said valve tissue, and at least a portion of said inner section (34) of said flexible leaflet reinforcement patch (32) having at least one of said plurality of leaflets (24) in juxtaposition to said portion of said inner section (34), and said portion of said inner section (34) being positioned to provide reinforcement to said plurality of leaflets (24).

Abstract: An annuloplasty implant is disclosed comprising first and second supports being adapted to be arranged as a coil in a coiled configuration around an axial direction. The first and second supports are adapted to be arranged on opposite sides of native heart valve leaflets. The first support comprises first retention units fixed in relation to an outer surface of the first support and arranged along at least a first retention portion thereof. The second support comprises second retention units fixed in relation to an outer surface of the second support and arranged along at least a second retention portion thereof. First and second retention portions are curved in the coiled configuration, and the first and second retention units extend from respective first and second retention portions to produce a retention force, in use, at both of said opposite sides. A method of repairing a defective heart valve is also disclosed.

Abstract: A device for improving the function of a heart valve comprises: a support member formed from a shape memory material, and a restraining member providing a restraining action on a course of the support member. The support member may abut one side of the valve conforming to the shape of the valve annulus upon said shape memory material assuming an activated shape while the restraining member restrains the course of the support member. The restraining action is removable for allowing the support member to assume a desired, altered course. The restraining member may be biodegradable to be degraded within a patient or may be detachable from the support member to be withdrawn. The support member according to another embodiment presents a shape change in that an increased cross-section is associated with a shortened length of the support member. The support member according to yet another embodiment has a first and a second activated shape.

Abstract: An annuloplasty device is disclosed comprising first and second support rings being configured to be arranged as a coil in a first configuration around an axial direction, wherein the first and second support rings are configured to be arranged on opposite sides of native heart valve leaflets of a heart valve, a stiffening unit, wherein at least part of the first and second support rings comprises an interior channel configured to receive the stiffening unit, wherein insertion of the stiffening unit into the interior channel increases the stiffness of the first and/or second support rings. A method of repairing a defective heart valve is also disclosed.

Abstract: A delivery system and method for delivery of an annuloplasty implant for a patient are disclosed. The delivery system comprises a commissure locator device for locating a commissure, comprising; an extension member, a catheter, and wherein the extension member is extendable relative the catheter for location of at least one commissure of a cardiac valve, and a coronary sinus contractor for temporary insertion into the coronary sinus (CS) and having a displacement unit being temporarily transferable to an activated state in Which the shape of the annulus Of the heart valve is modified to a modified shape to be retained by said annuloplasty implant.

Abstract: A medical device for improving function of a heart valve comprises at least a first partly pliant leaflet having a distal section and a proximal section. The distal section is configured to be oriented towards said inner section of said valve tissue in use. The first leaflet comprises at least two curving segments, such as bending lines extending from the proximal section towards said distal section thereby dividing said first leaflet to at least three portions. The distance between the line ends in the distal section area is shorter than the distance between the line ends in the proximal section area, thereby allowing at least a distal part of the portion locating between said curving segments, such as bending lines and being oriented towards said inner section of said valve tissue to bend to a first direction along the curving segments, such as bending lines when in use.

Abstract: A clip for fixation of a medical implant to tissue is disclosed, having a delivery shape and a relaxed shape, comprising a proximal cylindrical portion to be arranged in a tubular lumen of a catheter, and first and second resilient legs having respective proximal ends attached to the cylindrical portion, the proximal ends being separated by a width of a bridging section of the cylindrical portion, the proximal ends being connected in an inward direction, extending from each of the proximal ends to the central longitudinal axis of the cylindrical portion, the bridging section together with the first and second legs forming an opening to receive an annuloplasty implant, each of the first and second legs having a distal portion to pierce said tissue, and wherein in said relaxed shape each of the distal portions are curved to deflect from the central longitudinal axis. A related method is disclosed.