Abstract: Disclosed herein are methods of regional gene-therapy with growth-factor transduced cells, in bone graft scenarios. In embodiments, the methods comprise use of 3D printed scaffolds.

Abstract: Described herein are fields of exercise or therapy systems in particular exercise or therapy systems that controllably generate and maintain an unweighted environment using a mechanical system or a differential air pressure (DAP) envelope about a user so as to at least partially or completely unweight the user. This application also relates to improved control systems for pressure chambers for use in differential air pressure (DAP) systems including data collection and utilization for general fitness use, athletic use, or medical use treadmills and related software, control and analytics systems, especially as related to obtaining gait data from load cells provided in the system.

Abstract: An online image search and marketplace platform and browser plug-in system is described. The system is configured to execute image-based searches of the Internet to correlate hosted images with ownership and licensing metadata, facilitating the marketing of images to users and expediting the purchase of licensing for said images. The system employs an online platform in communication with an image metadata database, providing a conduit for users to execute an image search from an image search field populated by a target image URL or direct image upload. An auto-cropping feature combined with extensive steganography integration ensures accurate image identification, ownership mapping, and usage tracking. The browser plug-in facilitates the execution of an image search within the right-click menu of any image hosted to the Internet. Image tracking enables content owners to be alerted in real-time when unlicensed use of content is detected.

Abstract: The invention relates, in certain aspects, to developable forms of certain compounds that are useful to treat and/or prevent EBV infection and related conditions in a subject. The invention further provides EBNA1 inhibitors, and/or pharmaceutical compositions comprising the same, that are useful for the treatment of diseases caused by latent Epstein-Barr Virus (EBV) infection and/or lytic EBV infection.

Abstract: A method for repairing a bone defect of a patient includes providing a ceramic scaffold configured for filling the bone defect, loading the scaffold with growth factor transduced cells incorporating a gene that encodes a growth factor essential for bone formation, placing the ceramic scaffold with the growth factor transduced cells in or across the bone defect, and stabilizing the ceramic scaffold with the growth factor transduced cells in the patient until the bone defect is healed. An assembly for repairing a bone defect includes a ceramic scaffold configured for spanning the bone defect and a culture of live growth factor transduced cells incorporating a gene that encodes a growth factor essential for bone formation loaded onto the ceramic scaffold.

Abstract: A microinjection system and apparatus comprising stationary trough chips having wells and troughs to allow for efficient organoid microinjections are described.

Abstract: The disclosure describes a distributed, pluggable architecture for an artificial reality (AR) system that enables concurrent execution and collaborative scene rendering for multiple artificial reality applications. For example, an AR system includes an image capture device configured to capture image data representative of a physical environment. The AR system also includes a head-mounted display (HMD) configured to output artificial reality content. The AR system further includes a plurality of concurrently executing artificial reality client applications. The AR system also includes a concurrent application engine configured to control rendering the artificial reality content as a common scene that include one or more objects from each of the plurality of artificial reality applications.

Abstract: Systems and methods for biometric payments are disclosed. In one embodiment, a method for conducting a biometric payment may include (1) receiving at a server and from an electronic device, transaction information comprising an identification of a good or service to purchase from a merchant and a biometric payment instruction from an individual that was captured by the electronic device; (2) at least one computer processor authenticating the individual based on the biometric payment instruction; (3) the at least one computer processor determining a payment account for the transaction from the biometric payment instruction; (4) the at least one computer processor retrieving a payment device associated with the payment account; and (5) the at least one computer processor providing the payment device to the merchant.

Abstract: Bone implants, including methods of use and assembly. The bone implants, which are optionally composite implants, generally include a distal anchoring region and a growth region that is proximal to the distal anchoring region. The distal anchoring region can have one or more distal surface features that adapt the distal anchoring region for anchoring into iliac bone. The growth region can have one or more growth features that adapt the growth region to facilitate at least one of bony on-growth, in-growth, or through-growth. The implants may be positioned along a posterior sacral alar-iliac (“SAI”) trajectory. The implants may be coupled to one or more bone stabilizing constructs, such as rod elements thereof.

Abstract: Cameras capture time-stamped images of predefined areas. Individuals and items are tracked in the images. Occluded items detected in the images are preprocessed to remove pixels associated with occluded information and the pixels remaining associated with the items are cropped. The preprocessed and cropped images are provided to a trained machine-learning algorithm or a trained neural network trained to classify and identify the items. Output received from the trained neural network provides item identifiers for the items that are present in the original images.

Abstract: An article comprising a crystalized resin material, the material having microscopic surface reliefs in a surface thereof, wherein the surface reliefs form optical structures which generate an optical image and or holographic information, the crystalized resin material is a cannabis derived resin and the microscopic surface reliefs formed in the resin form optical structures which generate an optical image or optical information.

Abstract: A dosing capsule has a shell, a seal and an inner material. The outer shell is made of a cannabis-derived resin and the inner material is made of an ingestible material. The seal may be made of a cannabis-derived resin or other sealing material. The outer shell and seal substantially protect the inner material from degradation and when the capsule is heated to a pre-determined temperature, the outer shell and seal liquefy, thereby allowing the inner material to be ingested.

Abstract: A computing system including a communication layer, including client web services managing communication with client computers, including a message parser, a message validator, and a message authenticator, and a computing engine layer, including a registrar that (i) registers purchase of a digital asset by a first consumer, (ii) generates a dated record of title to the first consumer for the digital asset, (iii) receives a resale permission message for the digital asset from the first consumer, via the client web services, whereby the permission message is parsed, validated, and authenticated by the client web services, (iv) further registers purchase of the digital asset by a second consumer, and (v) further generates an updated record of title for the digital asset to the second consumer.

Abstract: A method of generating a custom three-dimensional model of a bone is disclosed. A 2D image of the bone is obtained and an orientation and scale of the 2D image are aligned to a pre-determined coordinate system. Based on the 2D image, a representative bone is identified from a library of representative bones that are aligned to the pre-determined coordinate system. Based on the 2D image, an ideal view of a 3D model of the representative bone is selected. Modifications may be made to the 3D model by using additional representative bones from the library. A custom three-dimensional model of the bone is thereby generated.

Abstract: Devices and methods that can detect and control an individual polymer in a mixture is acted upon by another compound, for example, an enzyme, in a nanopore are provided. The devices and methods also determine (˜>50 Hz) the nucleotide base sequence of a polynucleotide under feedback control or using signals generated by the interactions between the polynucleotide and the nanopore. The invention is of particular use in the fields of molecular biology, structural biology, cell biology, molecular switches, molecular circuits, and molecular computational devices, and the manufacture thereof.

Abstract: The present invention provides EBNA1 inhibitors, and/or pharmaceutical compositions comprising the same, that are useful for the treatment of diseases caused by EBNA1 activity, such as, but not limited to, cancer, infectious mononucleosis, chronic fatigue syndrome, multiple sclerosis, systemic lupus erythematosus and/or rheumatoid arthritis. The present invention further provides EBNA1 inhibitors, and/or pharmaceutical compositions comprising the same, that are useful for the treatment of diseases caused by latent Epstein-Barr Virus (EBV) infection and/or lytic EBV infection.

Abstract: A two-bit memory device having a layer structure containing in order a bottom layer, a molecular layer containing a chiral compound having at least one polar functional group, and a top layer, which is electrically conductive and ferromagnetic. The chiral compound acts as a spin filter for electrons passing through the molecular layer. The chiral compound is of flexible conformation and has a conformation-flexible molecular dipole moment. An electrical resistance of the layer structure for an electrical current running from the bottom layer to the top layer has at least four distinct states which depend on the magnetization of the top layer and on the orientation of the conformation-flexible dipole moment of the chiral compound. Furthermore, a method for operating the two-bit memory device and an electronic component containing at least one two-bit memory device.

Abstract: Systems and methods for setting up live online conversations between people, and selecting participants for such conversations in a manner that optimizes the enjoyment of the participants. Conversations are analyzed and attributes of participants and conversations are extracted from the audio of the conversations. A quality level of the conversations is determined from the audio, and subjective quality assessments may be received from participants. Participants and conversations are divided into classes and clusters, where the classes and clusters represent groups of entities which have certain attributes in common. Based on the attributes, classes, clusters, and quality levels, compatibilities are determined between arbitrary pairs of participants and for arbitrary groups of participants. Conversations are generated, and participants are selected for the conversations based on the determined compatibilities.

Abstract: A method for repairing a bone defect of a patient includes providing a ceramic scaffold configured for filling the bone defect, loading the scaffold with growth factor transduced cells incorporating a gene that encodes a growth factor essential for bone formation, placing the ceramic scaffold with the growth factor transduced cells in or across the bone defect, and stabilizing the ceramic scaffold with the growth factor transduced cells in the patient until the bone defect is healed. An assembly for repairing a bone defect includes a ceramic scaffold configured for spanning the bone defect and a culture of live growth factor transduced cells incorporating a gene that encodes a growth factor essential for bone formation loaded onto the ceramic scaffold.