Abstract: Aspects of this disclosure relate to methods and systems for assessing multifactorial balance health and implementation of a risk alert system. The fall risk information can be used to notify the person and/or a third-party monitoring person (e.g., doctor, physical therapist, personal trainer, etc.) of the person's fall risk. This information may be used to monitor and track changes in fall risk that may be impacted by changes in health status, lifestyle behaviors, or medical treatment. Furthermore, the fall risk classification may help individuals be more careful on the days they are more at risk for falling.

Abstract: The present invention is directed to a process for preparing a compound of formula I-11 through multiple-step reactions:

Abstract: Bone implants, including methods of use and assembly. The bone implants, which are optionally composite implants, generally include a distal anchoring region and a growth region that is proximal to the distal anchoring region. The distal anchoring region can have one or more distal surface features that adapt the distal anchoring region for anchoring into iliac bone. The growth region can have one or more growth features that adapt the growth region to facilitate at least one of bony on-growth, in-growth, or through-growth. The implants may be positioned along a posterior sacral alar-iliac (“SAT”) trajectory. The implants may be coupled to one or more bone stabilizing constructs, such as rod elements thereof.

Abstract: Methods and apparatus for retracting the dura away from a cutting tool during a laminectomy procedure. The method includes inserting a memory shape surgical sponge (patty) into an initial epidural space between the dura and the tool used to decompress (e.g., drill) the lamina. As the lamina is further decompressed, the patty tends to spring back toward its nominal position, urging the dura away from the decompression and isolating the dura from the drill.

Abstract: The present invention is directed to processes for preparing beta 3 agonists of Formula (I) and Formula (II) and their intermediates. The beta 3 agonists are useful in the treatment of certain disorders, including overactive bladder, urinary incontinence, and urinary urgency.

Abstract: Myocilin-binding agents including antibodies and antigen binding fragments thereof and fusion proteins that immunospecifically bind the olfactomedin domain of myocilin Antibodies that can bind to natively folded myocilin, misfolded myocilin or both are provided herein. The disclosed antibodies and antigen binding fragments and fusion proteins are useful for the detection and extraction of natively folded and the neutralization and degradation of toxic misfolded myocilin from ex vivo samples or the eye.

Abstract: An infrastructure device includes a transceiver, programmed to communicate with a plurality of vehicles, wherein at least one of the vehicles is located within a distance defined from a location of the infrastructure device, and at least one of the vehicles is located outside the distance from the location of the infrastructure device; and a controller, programmed to measure a channel busy ratio (CBR) for communication with the plurality of vehicles, measure a package error rate (PER) for communication with one or more of the vehicles located within the distance, and responsive to the CBR being greater than a CBR threshold, or the PER being greater than a PER threshold, record an interference event into a log.

Abstract: Various embodiments herein each include at least one of systems, methods, software, and data structures for context-aided machine vision. For example, one method embodiment includes identifying a customer in a shopping area and maintaining an item bin in a computing system of data identifying items the customer has picked up for purchase. This method further includes receiving an image of the customer holding an item and performing item identification processing on the image to identify the item the customer is holding. The item identification processing may be performed based in part on a stored shopping history of the customer indicating items the customer is more likely to purchase. The identified item is then added to the item bin of the customer.

Abstract: Systems and methods for setting up live online conversations between people, and selecting participants for such conversations in a manner that optimizes the enjoyment of the participants. Conversations are analyzed and attributes of participants and conversations are extracted from the audio of the conversations. A quality level of the conversations is determined from the audio, and subjective quality assessments may be received from participants. Participants and conversations are divided into classes and clusters, where the classes and clusters represent groups of entities which have certain attributes in common. Based on the attributes, classes, clusters, and quality levels, compatibilities are determined between arbitrary pairs of participants and for arbitrary groups of participants. Conversations are generated, and participants are selected for the conversations based on the determined compatibilities.

Abstract: Bone implants, including methods of use and assembly. The bone implants, which are optionally composite implants, generally include a distal anchoring region and a growth region that is proximal to the distal anchoring region. The distal anchoring region can have one or more distal surface features that adapt the distal anchoring region for anchoring into iliac bone. The growth region can have one or more growth features that adapt the growth region to facilitate at least one of bony on-growth, in-growth, or through-growth. The implants may be positioned along a posterior sacral alar-iliac (“SAI”) trajectory. The implants may be coupled to one or more bone stabilizing constructs, such as rod elements thereof.

Abstract: Disclosed are systems and methods for mapping a virtual shopper to a physical shopper. The systems and methods may include receiving, at a backend system, unidentified customer data including information about an unidentified customer. Customer identity data including identifying information about the customer may be received from the customer. An authentication token may be generated that links the unidentified customer data to the customer identity data.

Abstract: Various embodiments herein each include at least one of systems, methods, software, and data structures for context-aided machine vision. For example, one method embodiment includes identifying a customer in a shopping area and maintaining an item bin in a computing system of data identifying items the customer has picked up for purchase. This method further includes receiving an image of the customer holding an item and performing item identification processing on the image to identify the item the customer is holding. The item identification processing may be performed based in part on a stored shopping history of the customer indicating items the customer is more likely to purchase. The identified item is then added to the item bin of the customer.

Abstract: A system comprises a computer having a processor and a memory, the memory storing instructions executable by the processor to transmit a vehicle localization signal from a first vehicle, receive vehicle localization data for the first vehicle, the vehicle localization data generated based on receipt of the vehicle localization signal by a plurality of localization receivers of a vehicle movement space, determine, based on the vehicle localization data for the first vehicle, a position of the first vehicle in the vehicle movement space, determine a position of a second vehicle in the vehicle movement space relative to the position of the first vehicle, and command a first movement by the first vehicle based on the position of the first vehicle and the position of the second vehicle relative to the position of the first vehicle.

Abstract: An orthopaedic surgical instrument system includes a first broach including a first end configured to be separately secured to a handle and a tapered body having a plurality of cutting teeth defined therein, and a second broach including a first end configured to be separately secured to the handle in place of the first broach, a first tapered body extending distally from a second end positioned opposite the first end, and a second tapered body extending distally from the first tapered body. The tapered body of the first broach and the first tapered body of the second broach have a first outer geometry and the second tapered body has a second outer geometry different from the first outer geometry.

Abstract: A computing system including a communication layer, including client web services managing communication with client computers, including a message parser, a message validator, and a message authenticator, and a computing engine layer, including a registrar that (i) registers purchase of a digital asset by a first consumer, (ii) generates a dated record of title to the first consumer for the digital asset, (iii) receives a resale permission message for the digital asset from the first consumer, via the client web services, whereby the permission message is parsed, validated, and authenticated by the client web services, (iv) further registers purchase of the digital asset by a second consumer, and (v) further generates an updated record of title for the digital asset to the second consumer.

Abstract: A vehicle includes a human-machine interface (HMI) device, configured to interact with a user; a wireless transceiver; and a controller, configured to responsive to the wireless transceiver detecting a signal strength of a wireless transmission at a predefined frequency exceeding a predefined threshold, output a message via the HMI device to ask a user to switch off a wireless device associated with the user, and responsive to continuing to detect the signal strength of the wireless transmission exceeding the threshold, output an alert, via the HMI device, to inform the user of a vehicle-to-everything (V2X) communication failure and record an identity of the wireless transmission and a location of the vehicle.

Abstract: The invention relates, in certain aspects, to developable forms of certain compounds that are useful to treat and/or prevent EBV infection and related conditions in a subject. The invention further provides EBNA1 inhibitors, and/or pharmaceutical compositions comprising the same, that are useful for the treatment of diseases caused by latent Epstein-Barr Virus (EBV) infection and/or lytic EBV infection.

Abstract: The present invention relates to a semiconducting light emitting nanoparticle comprising a polymeric layer.

Abstract: Disclosed are methods for detecting spatial proximity relationships between nucleic acid sequences in a cell. The methods include: providing a sample of one or more cells comprising nucleic acids; fragmenting the nucleic acids present in the cells, wherein the fragmented nucleic acids have ends capable of joining to other fragmented nucleic acids; joining ends of fragmented nucleic acids to other ends fragmented nucleic acid to create at least one nucleic acid concatemer having at least one junction between the joined fragmented nucleic acids, and wherein the at least one nucleic acid concatemer encodes the information about the proximity of the DNA sequences in the cell; and determining the sequence at least one junction of the at least one nucleic acid concatemer, thereby detecting spatial proximity relationships between nucleic acid sequences in a cell.

Abstract: Methods, systems, and computer programs are presented for protecting restricted actions on encryption keys that control the management of data stored by a service provider. In some implementations, a system of the service provider receives a request to generate a data encryption policy (DEP) for data stored by the system of the service provider for a customer, the request including a reference to a customer key and an availability key. The customer key and the availability key are root keys for encrypting a data encryption key. The data encryption key is used to encrypt the data stored by the service provider for the customer. Further, destructive changes to the availability key require receiving an approval from an account of the service provider. The system of the service provider validates the DEP. The system of the service provider stores the DEP based on the validation.