Abstract: The present invention relates to a compound suitable as ligand for binding to the surface of a semiconductor nanoparticle, said compound comprising an anchor group, a linker group and an organic functional group; a semiconductor nanoparticle have said ligand attached to the outermost particle surface; a composition, a formulation and a process for the preparation of said semiconductor nanoparticle; and an electronic device.

Abstract: The invention relates to a customer authentication system that comprises: identifying a customer identification based on a customer input; using the customer identification, identifying a plurality of IoT devices associated with the customer where the customer has an authentication set of IoT devices; receiving a user selection of IoT devices; determining whether the user selection matches the authentication set of IoT devices; connecting to one or more of the user selected IoT devices; transmitting a request to one or more of the user selected IoT devices for user interaction data; and verifying user activity based on the user interaction data.

Abstract: Exemplary inventive practice replicatively tests the effects of cleaning processes applied to marine hulls coated with biofouling-control substances. A sample (e.g., antifouling-coated panel) is coupled with a trolley that is linearly moveable via trolley wheels upon two parallel tracks provided along the length of an open rectangular box-shaped tank, partially filled with natural or artificial seawater. The cleaning element (e.g., brush bristles) points vertically upward in a stationary position atop a motorized cleaning unit installed proximate the bottom of the tank. In accordance with the trolley's horizontal movement, and while the sample and cleaning element are immersed in seawater, the sample traverses the cleaning element in a contactual manner that mimics underwater cleaning dynamics for a hull surface.

Abstract: An apparatus in one embodiment comprises at least one processing platform including a plurality of processing devices. The processing platform is configured to receive a request to execute an application in a function-as-a-service (“FaaS”) environment, to initiate execution of the application responsive to the request, and to invoke a plurality of application functions with each such application function interacting with one or more backend services in executing the application. The processing platform is further configured to automatically generate an application manifest characterizing relationships between the application functions and the backend services utilized in executing the application, to capture state of the application for a particular point in time based at least in part on the application manifest, and to perform operational recovery of the application for the particular point in time utilizing the captured state.

Abstract: A positioning unit mountable on a moving object includes at least one light source measuring unit and a processor. The light source measuring units have high directional sensitivity along a first axis and low directional sensitivity along a second axis orthogonal to the first axis to capture relative angular information of the moving object with respect to a plurality of simultaneously active stationary light sources located at multiple locations in a space. The processor determines positioning information of the moving object at least from the output of the at least one light source measuring unit. Each light source measuring unit includes an optical arrangement and a linearly configured imaging sensor to receive light from the stationary light sources through the optical arrangement.

Abstract: Systems and methods are disclosed for determining the appropriateness of medical interventions. In one embodiment, a machine learning system for determining the appropriateness of a selected medical intervention includes health-related data sources, the health-related data sources providing at least one data file of a first type, and a second data file of a second type. A machine learning module is configured to receive the first and second data files, perform a normalization procedure on at least one of the first and second data files, and apply at least one previously trained machine learning model to the normalized data files to produce a prediction output. The prediction output may include a confidence level associated with an appropriateness of the selected medical intervention.

Abstract: Pharmaceutical formulations with a tropomyosin-related kinase inhibitor (“Trk inhibitor”) are disclosed. The pharmaceutical formulations comprise 3-(3-methoxy-4-((4-methoxybenzyl)oxy)benzyl)-6-(1-methyl-1H-pyrazol-4-yl)-3H-imidazo[4,5-b]pyridin-2-amine in microcrystalline suspension formulations in its monohydrate form, which shows improved characteristics over the anhydrate form, and in extended release formulations. The extended release pharmaceutical formulations comprise 3-(3-methoxy-4-((4-methoxybenzyl)oxy)benzyl)-6-(1-methyl-1H-pyrazol-4-yl)-3H-imidazo[4,5-b]pyridin-2-amine-loaded microspheres.

Abstract: The present disclosure provides a system for modulating jaw pain and bruxism. The system includes a tube having a composition formulated as a topical balm comprising a botanical formulation and a topically acceptable carrier and a dispensing tube having an applicator tip.

Abstract: According to some embodiments of the invention, an intervertebral disc replacement includes a first layer having a lower surface for contacting a first vertebral bone, a second layer coupled to the first layer, the second layer comprising a plurality of compressible column springs, and a third layer coupled to the second layer, the third layer having an upper surface for contacting a second vertebral bone. Each of the plurality of compressible column springs comprises a plurality of stacked coils, and each of the plurality of stacked coils has a spring constant (K). At least one of the plurality of compressible column springs includes a first coil having a first spring constant and a second coil comprising a second spring constant, wherein the first spring constant is different from the second spring constant.

Abstract: An online image search and marketplace platform and browser plug-in system is described. The system is configured to execute image-based searches of the Internet to correlate hosted images with ownership and licensing metadata, facilitating the marketing of images to users and expediting the purchase of licensing for said images. The system employs an online platform in communication with an image metadata database, providing a conduit for users to execute an image search from an image search field populated by a target image URL or direct image upload. An auto-cropping feature combined with extensive steganography integration ensures accurate image identification, ownership mapping, and usage tracking. The browser plug-in facilitates the execution of an image search within the right-click menu of any image hosted to the Internet. Image tracking enables content owners to be alerted in real-time when unlicensed use of content is detected.

Abstract: Disclosed is a method for detecting spatial proximity relationships between RNA and DNA molecules in a cell. The method includes: providing a sample of RNA and DNA wherein the RNA and DNA have ends capable ofjoining to other DNA and RNA, respectively; joining at least one end of the fragmented RNA to the end of at least one fragmented DNA, to create at least one joined RNA-DNA hybrid molecule, wherein the join encodes the information about the proximity of the RNA and DNA in the cell; reverse transcribing the at least one joined rRNA-DNA hybrid molecule to create least one target join DNA molecule that retains the information of the join, and determining the sequence of the target join thereby detecting spatial proximity relationships between RNA and DNA molecules in a cell.

Abstract: Chromatin 3D structure modulating agents in the context of the present invention are intended to interfere or manipulate the function of loop anchor motifs, such as CTCF motifs. In certain example embodiments, the present invention may block formation of an loop anchor or chromatin domain or induce formation of a loop anchor or chromatin domain at a targeted genomic location. For instance, a loop anchor motif can be altered, such as by mutating (including inverting) a binding motif so as to remove such a motif, or by adding new binding motifs in new locations within a loop domain, so as to reduce the size of an existing loop, so as to modify the size of an existing loop, or combinations thereof. Alternatively, the chromatin 3D structure modulating agent may bind a target region and mask a loop anchor motif, thereby preventing a loop anchor or chromatin domain from forming. The chromatin 3D structure modulating agent may bind a target region and cause a loop anchor of chromatin domain to form.

Abstract: Disclosed is an in situ method for detecting spatial proximity relationships between nucleic acid sequences, such as DNA, in a cell. The method includes: providing a sample of one or more cells comprising nucleic acids; fragmenting the nucleic acids present in the cells that leaves 5? overhanging ends; filling in the overhanging ends with at least one labeled nucleotide; joining the filled in end of the fragmented nucleic acids that are in close physical proximity to create one or more end joined nucleic acid fragments having a junction; isolating the one or more end joined nucleic acid fragments using the labeled nucleotide; and determining the sequence at the junction of the one or more end joined nucleic acid fragments.

Abstract: Movement of vehicles through an intersection relative to one another is actively coordinated. The coordination includes sharing data among the vehicles using Vehicle-to-Everything messaging technology. The shared data is used to sequence the movement of the vehicles through the intersection.

Abstract: A vehicle includes a human-machine interface (HMI) device, configured to interact with a user; a wireless transceiver; and a controller, configured to responsive to the wireless transceiver detecting a signal strength of a wireless transmission at a predefined frequency exceeding a predefined threshold, output a message via the HMI device to ask a user to switch off a wireless device associated with the user, and responsive to continuing to detect the signal strength of the wireless transmission exceeding the threshold, output an alert, via the HMI device, to inform the user of a vehicle-to-everything (V2X) communication failure and record an identity of the wireless transmission and a location of the vehicle.

Abstract: The data reported herein describe the production and evaluation of a recombinant subunit filovirus vaccine using insect cell expressed surface glycoprotein (GP) and a highly effective adjuvant. The vaccine provides protection in humans against filovirus infection, including Ebola virus and Marburg virus.

Abstract: The present invention is directed to a process for preparing a compound of formula I-11 through multiple-step reactions:

Abstract: The present invention relates to a composition comprising a nanoparticle and a process for preparation thereof.

Abstract: The present invention provides EBNA1 inhibitors, and/or pharmaceutical compositions comprising the same, that are useful for the treatment of diseases caused by EBNA1 activity, such as, but not limited to, cancer, infectious mononucleosis, chronic fatigue syndrome, multiple sclerosis, systemic lupus erythematosus and/or rheumatoid arthritis. The present invention further provides EBNA1 inhibitors, and/or pharmaceutical compositions comprising the same, that are useful for the treatment of diseases caused by latent Epstein-Barr Virus (EBV) infection and/or lytic EBV infection.

Abstract: Systems and methods for biometric payments are disclosed. In one embodiment, a method for biometric payments may include (1) receiving transaction information from a merchant terminal, the transaction information comprising an identification of a good or service to purchase and a biometric payment instruction; (2) at least one computer processor authenticating the individual based on the biometric payment instruction; (3) the at least one computer processor determining a payment account from the biometric payment instruction; (4) the at least one computer processor retrieving a payment device associated with the payment account; and (5) the at least one computer processor providing the payment device to the merchant terminal.