Abstract: A method of generating a custom three-dimensional model of a bone is disclosed. A 2D image of the bone is obtained and an orientation and scale of the 2D image are aligned to a pre-determined coordinate system. Based on the 2D image, a representative bone is identified from a library of representative bones that are aligned to the pre-determined coordinate system. Based on the 2D image, an ideal view of a 3D model of the representative bone is selected. Modifications may be made to the 3D model by using additional representative bones from the library. A custom three-dimensional model of the bone is thereby generated.

Abstract: Methods, computing devices, and systems that dynamically determine whether a service request is authorized or fraudulent are described herein. A computing device may receive a request from a user device, and a geographical location of the user device may be determined based on a signal received from the user device. A determination as to whether to activate the service or not may be made based on the determined geographical location of the user device.

Abstract: Apparatus and methods for measuring a concentration of a target molecule from a biological sample are disclosed. In one example, the apparatus includes a porous pad, which is impregnated with a solution containing at least one agent and which contains an unfilled capillary matrix, a housing for the porous pad, and a membrane that covers the porous pad.

Abstract: Systems and methods for backing up and restoring serverless applications are provided. A serverless application is queried to identify the functions and services used. These functions and services are transformed into a manifest or graph that allows the relationships of the serverless application to be identified in an automated manner. The serverless application can be backed up and/or restored using the manifest.

Abstract: Pharmaceutical compositions of the invention comprise EBNA1 inhibitors useful for the treatment of diseases caused by EBNA1 activity such as cancer, infectious mononucleosis, chronic fatigue syndrome, multiple sclerosis, systemic lupus erythematosus and rheumatoid arthritis. Pharmaceutical compositions of the invention also comprise EBNA1 inhibitors useful for the treatment of diseases caused by latent Epstein-Barr Virus (EBV) infection. Pharmaceutical compositions of the invention also comprise EBNA1 inhibitors useful for the treatment of diseases caused by lytic Epstein-Barr Virus (EBV) infection.

Abstract: The invention relates, in certain aspects, to developable forms of certain compounds that are useful to treat and/or prevent EBV infection and related conditions in a subject. The invention further provides EBNA1 inhibitors, and/or pharmaceutical compositions comprising the same, that are useful for the treatment of diseases caused by latent Epstein-Barr Virus (EBV) infection and/or lytic EBV infection.

Abstract: The present invention provides systems and methods for identifying, isolating, and/or characterizing microRNAs, their targets, and microRNA response elements, and for predicting their biological function.

Abstract: Bone implants, including methods of use and assembly. The bone implants, which are optionally composite implants, generally include a distal anchoring region and a growth region that is proximal to the distal anchoring region. The distal anchoring region can have one or more distal surface features that adapt the distal anchoring region for anchoring into iliac bone. The growth region can have one or more growth features that adapt the growth region to facilitate at least one of bony on-growth, in-growth, or through-growth. The implants may be positioned along a posterior sacral alar-iliac (“SAI”) trajectory. The implants may be coupled to one or more bone stabilizing constructs, such as rod elements thereof.

Abstract: Dynamic honeypots for computer program execution environments are described. A determination is made whether a time period has expired since a computer program execution environment, of multiple computer program execution environments, began executing a computer program that provides a user service. The computer program execution environment is changed into a computer security mechanism that counteracts an attempt of unauthorized use of a system that comprises the computer program execution environment, in response to a determination that the time period has expired since the computer program execution environment began executing the computer program that provides the user service.

Abstract: Myocilin-binding agents including antibodies and antigen binding fragments thereof and fusion proteins that immunospecifically bind the coiled-coil domain of myocilin but do not bind to misfolded myocilin are provided herein. The disclosed antibodies and antigen binding fragments and fusion proteins are useful for the detection and extraction of natively folded myocilin from a sample.

Abstract: The disclosure describes a distributed, pluggable architecture for an artificial reality (AR) system that enables concurrent execution and collaborative scene rendering for multiple artificial reality applications. For example, an AR system includes an image capture device configured to capture image data representative of a physical environment. The AR system also includes a head-mounted display (HMD) configured to output artificial reality content. The AR system further includes a plurality of concurrently executing artificial reality client applications. The AR system also includes a concurrent application engine configured to control rendering the artificial reality content as a common scene that include one or more objects from each of the plurality of artificial reality applications.

Abstract: Chromatin 3D structure modulating agents in the context of the present invention are intended to interfere or manipulate the function of loop anchor motifs, such as CTCF motifs. In certain example embodiments, the present invention may block formation of an loop anchor or chromatin domain or induce formation of a loop anchor or chromatin domain at a targeted genomic location. For instance, a loop anchor motif can be altered, such as by mutating (including inverting) a binding motif so as to remove such a motif, or by adding new binding motifs in new locations within a loop domain, so as to reduce the size of an existing loop, so as to modify the size of an existing loop, or combinations thereof. Alternatively, the chromatin 3D structure modulating agent may bind a target region and mask a loop anchor motif, thereby preventing a loop anchor or chromatin domain from forming. The chromatin 3D structure modulating agent may bind a target region and cause a loop anchor of chromatin domain to form.

Abstract: A store having an automated checkout can automatically associate multiple shoppers with a single purchase. For example, a mother and her children can walk independently through the store and select items. Upon checkout, the items selected by the mother and children can all be charged to the mother's credit card in a single purchase. The system and method discussed herein can capture images of multiple shoppers from one or more video streams of a store area, can associate the multiple shoppers with one another from the captured images when the multiple shoppers appear together in a check-in area of the store, can track the movement of the multiple shoppers within the store from the captured images, can track items selected by the multiple shoppers from the captured images, and can initiate a transaction that charges the selected items to an account associated with one of the multiple shoppers.

Abstract: Disclosed is a system which adds biochemical sensitivity to a standard biopsy needle such that the practitioner is provided immediate feedback on the metabolism and physiology of tissue in the local environment. Disclosed is a sensor integrated biopsy device for in situ and real time tissue analysis. The sensor integrated biopsy (SIB) needle system will enable biopsy teams to measure local tissue biochemistry in real time during biopsy procedures, adding a valuable new set of parameters to augment and extend conventional image-guided procedures.

Abstract: Systems and methods are disclosed for determining the appropriateness of medical interventions. In one embodiment, a machine learning system for determining the appropriateness of a selected medical intervention includes health-related data sources, the health-related data sources providing at least one data file of a first type, and a second data file of a second type. A machine learning module is configured to receive the first and second data files, perform a normalization procedure on at least one of the first and second data files, and apply at least one previously trained machine learning model to the normalized data files to produce a prediction output. The prediction output may include a confidence level associated with an appropriateness of the selected medical intervention.

Abstract: A secure cloud-based privileged access management (CBPAM) service manages on-premise resources. While enrolling an on-premise authentication domain admin group, a secured cloud-based shadow administrating group (SCBSAG) is created; a SCBSAG security identification includes at least part of the enrollee's security identification. The SCBSAG belongs to a clean CBPAM authentication domain which may be secured by defense in depth controls such as time limits on authentication or authorization, password avoidance, least privilege, one-way syncing, and one-way trust. Management via the configured SCBSAG may be fostered by emptying the on-premise admin group, although a break glass account may be kept. CBPAM services direct administrative actions toward on-premise resources through SCBSAGs for cloud tenants, providing secure management control as a service, with broader geographic scope and lower maintenance burdens and costs than privileged access management approaches that are not cloud-based.

Abstract: The present invention relates to a nanoparticle and a composition comprising a nanoparticle.

Abstract: Described herein are methods and compositions relating to the treatment of cancer, e.g., breast cancer, using, e.g., aptamer-siRNA chimera molecules.

Abstract: A store having an automated checkout can automatically associate multiple shoppers with a single purchase. For example, a mother and her children can walk independently through the store and select items. Upon checkout, the items selected by the mother and children can all be charged to the mother's credit card in a single purchase. The system and method discussed herein can capture images of multiple shoppers from one or more video streams of a store area, can associate the multiple shoppers with one another from the captured images when the multiple shoppers appear together in a check-in area of the store, can track the movement of the multiple shoppers within the store from the captured images, can track items selected by the multiple shoppers from the captured images, and can initiate a transaction that charges the selected items to an account associated with one of the multiple shoppers.

Abstract: The present invention relates to methods to treat or prevent cancers in a subject, in particular the present invention relates to a method of treating and/or preventing cancer comprising targeting cancer stem cells by administering miRNAs which have reduced expression or are lacking in the cancer stem cells. in some embodiments, the miRNAs that are reduced or lacking in cancer stem cells are let-7 miRNAs. In alternative embodiments, the present invention relates to a method of treating and/or preventing cancer comprising targeting cancer stem cells by administering miRNAs which have increased expression levels in the cancer stem cells. Another aspect of the present invention relates to methods to enrich for a cancer stem cell population. Another aspect of the present invention relates to methods to identify miRNAs which contribute to the self-renewal capacity of cancer stem cells.