Patents by Inventor Ove Ohman
Ove Ohman has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
-
Patent number: 9279768Abstract: A fluorescence reader for an optical assay arrangement that includes a polymeric sample substrate having a reaction site-surface and a substrate surface. The fluorescence reader includes a light source arranged to illuminate the reaction site-surface through the substrate surface, and a detector device arranged to detect fluorescent light emitted from the reaction site-surface and transmitted through the substrate surface, the substrate surface being configured to increase transmission of emitted fluorescent light by suppression of total internal reflection.Type: GrantFiled: March 31, 2014Date of Patent: March 8, 2016Assignee: JOHNSON & JOHNSON ABInventors: Tomas Lindstrom, Ib Mendel-Hartvig, Ove Öhman, Johan Backlund, Kennet Vilhelmsson
-
Publication number: 20150031586Abstract: There is provided an assay device comprising a lid and a base, said base comprising, a sample addition zone, a reaction zone and an absorbing zone, said components being in fluid connection and being part of a fluid passage leading from the sample addition zone to the absorbing zone, wherein: (a) a sample addition well is integrated in the lid, (b) the absorbing zone consists of an area on an non-porous substrate, having substantially perpendicular projections, said projections defining a volume, which together with the volume of the fluid passage defines the sample volume subjected to the assay, and (c) at least one filter is between the sample addition well and the sample addition zone. There is further provided methods for handling samples.Type: ApplicationFiled: October 6, 2014Publication date: January 29, 2015Inventors: Per Ove Öhman, Ib Mendel-Hartvig
-
Patent number: 8877142Abstract: There is provided an assay device comprising a lid and a base, said base comprising, a sample addition zone, a reaction zone and an absorbing zone, said components being in fluid connection and being part of a fluid passage leading from the sample addition zone to the absorbing zone, wherein: (a) a sample addition well is integrated in the lid, (b) the absorbing zone consists of an area on an non-porous substrate, having substantially perpendicular projections, said projections defining a volume, which together with the volume of the fluid passage defines the sample volume subjected to the assay, and (c) at least one filter is between the sample addition well and the sample addition zone. There is further provided methods for handling samples.Type: GrantFiled: June 20, 2007Date of Patent: November 4, 2014Assignee: Johnson & Johnson ABInventors: Per Ove Öhman, Ib Mendel-Hartvig
-
Patent number: 8821812Abstract: An absorbing zone for establishing and/or maintaining fluid transport through or along at least one fluid passage is manufactured on the basis of a non-porous substrate having a surface, the non-porous substrate having projections substantially perpendicular to the surface, and the projections having a height, diameter and a distance or distances between the projections such, that lateral capillary flow of the fluid in the zone is achieved.Type: GrantFiled: June 19, 2006Date of Patent: September 2, 2014Assignee: Johnson & Johnson ABInventors: Per Ove Öhman, Ib Mendel-Hartvig
-
Publication number: 20140212984Abstract: A fluorescence reader for an optical assay arrangement that includes a polymeric sample substrate having a reaction site-surface and a substrate surface. The fluorescence reader includes a light source arranged to illuminate the reaction site-surface through the substrate surface, and a detector device arranged to detect fluorescent light emitted from the reaction site-surface and transmitted through the substrate surface, the substrate surface being configured to increase transmission of emitted fluorescent light by suppression of total internal reflection.Type: ApplicationFiled: March 31, 2014Publication date: July 31, 2014Applicant: Johnson & Johnson ABInventors: Tomas Lindstrom, Ib Mendel-Hartvig, Ove Öhman, Johan Backlund, Kennet Vilhelmsson
-
Patent number: 8759115Abstract: An assay device for performing an assay on a liquid sample using a detection conjugate capable of binding to an antigen and containing a label. The device includes a substrate surface having a sample addition zone, a reaction zone and an absorbing zone, the zones being connected by at least one fluid passage, wherein the device has a first functionality verifying feature located between the sample addition zone and the reaction zone, and a second functionality verifying feature located within the absorbing zone. Both functionality verifying features are capable of undergoing a detectable change when contacted by the sample, in which the assay device further includes at least one alignment verification zone. There is further provided a kit of parts and a method of conducting an assay.Type: GrantFiled: December 12, 2012Date of Patent: June 24, 2014Assignee: Johnson & Johnson ABInventors: Per Ove Ohman, Ib Mendel-Hartvig, Tomas Lindstrom
-
Patent number: 8753585Abstract: A device for handling liquid samples, comprising a flow path with at least one zone for receiving the sample, and a transport or incubation zone, said zones connected by or comprising an area having projections substantially vertical to its surface, said device provided with a sink with a capacity of receiving said liquid sample, said sink comprising an area having projections substantially vertical to its surface, and said sink being adapted to respond to an external influence regulating its capacity to receive said liquid sample.Type: GrantFiled: June 8, 2010Date of Patent: June 17, 2014Assignee: Johnson & Johnson ABInventors: Per Ove Ohman, Ib Mendel-Hartvig
-
Patent number: 8691153Abstract: A fluorescence reader for an optical assay arrangement includes a polymeric sample substrate having a reaction site-surface and a substrate surface. A light source is arranged to illuminate the reaction site-surface through the substrate surface, and a detector device is arranged to detect fluorescent light emitted from the reaction site-surface and transmitted through the substrate surface, the substrate surface provided, for example, as a light-collecting body to allow fluorescent light rays exceeding a critical emission angle for total internal reflection to escape the substrate and enter the body.Type: GrantFiled: March 22, 2007Date of Patent: April 8, 2014Assignee: Johnson & Johnson ABInventors: Tomas Lindstrom, Ib Mendel-Hartvig, Ove Öhman, Johan Backlund, Kennet Vilhelmsson
-
Publication number: 20130236982Abstract: A sensor comprising a substrate (100) having a first surface (105) and a second surface (110) is described. The first surface has at least one sensor site (115) provided thereon. The substrate is configured such that on excitation of a sample provided at the sensor site, luminescence originating from the sensor site propagates into the substrate, the second surface of the substrate being configured to selectively transmit the luminescence propagating within the substrates at angles greater than the critical angle out of the substrate where it may be detected by a detector (160) provided below the substrate.Type: ApplicationFiled: May 11, 2011Publication date: September 12, 2013Applicants: AMIC AB, DUBLIN CITY UNIVERSITYInventors: Jim Writser Peter Bakker, Ove Ohman, Dirk Kurzbuch, Thomas Ruckstuhl, Brian MacCraith, Stephen O'Driscoll
-
Patent number: 8409523Abstract: An analysis device having at least one sample addition zone, at least one sink, and at least one flow path connecting the at least one sample addition zone and the at least one sink. The at least one flow path includes projections substantially vertical to the surface of the substrate and having a height (H), diameter (D) and reciprocal spacing (t1, t2) such that lateral capillary flow of a liquid sample is achieved. The device includes at least two reaction zones in series, wherein each reaction zone is adapted to facilitating measurement of a response originating from one and the same analyte, and wherein the reaction zones are positioned to allow calculation of the concentration of at least one analyte. Advantages include that a more accurate value can be calculated, variations are reduced, and an estimation of the uncertainty of the response can be calculated.Type: GrantFiled: July 1, 2010Date of Patent: April 2, 2013Assignee: Amic ABInventors: Ib Mendel-Hartvig, Gerd Rundström, Per Ove Öhman
-
Patent number: 8343439Abstract: The present invention provides an assay device for performing an assay on a liquid sample using a detection conjugate capable of binding to an antigen and containing a label, said device comprising a substrate having a substrate surface, wherein the surface comprises projections substantially perpendicular to said surface, said projections having a height, diameter and distance capable of generating lateral capillary flow of a fluid in said passage, said surface comprising a sample addition zone, a reaction zone and an absorbing zone, said zones being connected by at least one fluid passage, wherein said device has a first functionality verifying feature located between the sample addition zone and the reaction zone, and a second functionality verifying feature located within the absorbing zone, and both functionality verifying features being features capable of undergoing a detectable change when contacted by the sample, said assay device further comprising at least one alignment verification zone.Type: GrantFiled: June 20, 2007Date of Patent: January 1, 2013Assignee: AMIC ABInventors: Per Ove Öhman, Ib Mendel-Hartvig, Tomas Lindström
-
Publication number: 20120107851Abstract: The present invention is directed to a lateral flow assay device for the monitoring and measuring of coagulation and method thereof. Ideally, the invention is directed to a lateral capillary flow device for the monitoring and/or measurement of coagulation in a liquid sample wherein the device comprises a non-porous substrate with a zone for receiving a sample and a defined flow path zone wherein a clotting agent is deposited on at least part of the defined flow path zone to accelerate the coagulation of the liquid sample, enable the formation of an evenly distributed clot along the defined flow path zone and to result in the change in flow rate or cessation of flow of the liquid sample along the defined flow path zone.Type: ApplicationFiled: April 23, 2010Publication date: May 3, 2012Inventors: Anthony Joseph Killard, Magdalena Maria Dudek, Brian MacCraith, Ib Mendel-Hartvig, Ove Öhman
-
Publication number: 20110306519Abstract: In combination, a polymeric microarray support for an optical assay arrangement, that includes an optical detection instrument having a known depth of focus for detecting light emitted from said microarray support. The polymeric microarray support has a support surface made from a polymeric support material having a thickness varying over the area of the support surface by a thickness variation value. The said support includes formed microfeatures made up of grooves arranged to have a predetermined depth at the time of forming, the groove depth being selected based on the depth of focus of the optical detection instrument and the thickness of the support. The sum of the depth for the grooves and the thickness variation value of the polymeric support surface substantially corresponds to the depth of focus of the optical detection instrument in order to reduce noise, the polymeric support surface having attached thereto probe molecules to form binding sites.Type: ApplicationFiled: July 8, 2011Publication date: December 15, 2011Applicant: Amic ABInventors: Tomas Lindstrom, Ove Ohman
-
Patent number: 8025854Abstract: The invention relates to a micro fluidic system comprising a substrate, and, provided on said substrate, at least one flow path interconnecting with functional means in which liquid samples can be treated by desired procedures. The flow paths are laid out to form a pattern for the transport of liquid samples to and from said functional means. These flow paths comprise a plurality of micro posts protruding upwards from said substrate, the spacing between the micro posts being small enough to induce a capillary action in a liquid sample applied anywhere within any of said flow paths, so as to force said liquid to move from where said liquid sample was applied.Type: GrantFiled: June 4, 2003Date of Patent: September 27, 2011Assignee: AMIC ABInventors: Ove Ohman, Ib Mendel-Hartvig
-
Patent number: 8000001Abstract: The invention comprises a polymeric microarray support (1) for an optical assay arrangement (2) comprising optical means (3, 4, 6) for detection of light emitted from the support. The microarray support is provided with microfeatures comprising a surface enlarging pattern (5), i.e. grooves having a selected depth (8). The depth is selected such that the sum of the depth and of the variations in the thickness (7) of the support substantially corresponds to the depth of focus of the optical means.Type: GrantFiled: May 18, 2004Date of Patent: August 16, 2011Assignee: Amic ABInventors: Tomas Lindström, Ove Öhman
-
Publication number: 20110146387Abstract: The present invention relates to a measurement system which comprises a reader and a chip and concerns a method to determining and detecting biological and chemical agents or materials in biological samples.Type: ApplicationFiled: December 16, 2010Publication date: June 23, 2011Inventors: Ove Öhman, Lieven Jozef Stuyver
-
Publication number: 20110003398Abstract: An analysis device having at least one sample addition zone, at least one sink, and at least one flow path connecting the at least one sample addition zone and the at least one sink. The at least one flow path includes projections substantially vertical to the surface of the substrate and having a height (H), diameter (D) and reciprocal spacing (t1, t2) such that lateral capillary flow of a liquid sample is achieved. The device includes at least two reaction zones in series, wherein each reaction zone is adapted to facilitating measurement of a response originating from one and the same analyte, and wherein the reaction zones are positioned to allow calculation of the concentration of at least one analyte. Advantages include that a more accurate value can be calculated, variations are reduced, and an estimation of the uncertainty of the response can be calculated.Type: ApplicationFiled: July 1, 2010Publication date: January 6, 2011Applicant: AMIC ABInventors: Ib Mendel-Hartvig, Gerd Rundström, Per Ove Öhman
-
Patent number: 7829799Abstract: Manufacturing of miniaturised three-dimensional electric components are presented, as well as components manufactured by the methods. The manufacturing methods comprise micro-replication of at least one master structure, e.g. via a mould structure, in at least one polymer layer onto which layer at least one conductive path is provided.Type: GrantFiled: July 31, 2007Date of Patent: November 9, 2010Assignee: Nokia CorporationInventors: Tapani Ryhänen, Hans Otto Scheck, Ove Öhman, Olle Larsson, Michael Read, Tomas Lindström
-
Publication number: 20100248394Abstract: A device for handling liquid samples, comprising a flow path with at least one zone for receiving the sample, and a transport or incubation zone, said zones connected by or comprising an area having projections substantially vertical to its surface, said device provided with a sink with a capacity of receiving said liquid sample, said sink comprising an area having projections substantially vertical to its surface, and said sink being adapted to respond to an external influence regulating its capacity to receive said liquid sample.Type: ApplicationFiled: June 8, 2010Publication date: September 30, 2010Applicant: AMIC ABInventors: Per Ove Ohman, Ib Mendel-Hartvig
-
Publication number: 20100041154Abstract: The present invention provides an assay device for performing an assay on a liquid sample using a detection conjugate capable of binding to an antigen and containing a label, said device comprising a substrate having a substrate surface, wherein the surface comprises projections substantially perpendicular to said surface, said projections having a height, diameter and distance capable of generating lateral capillary flow of a fluid in said passage, said surface comprising a sample addition zone, a reaction zone and an absorbing zone, said zones being connected by at least one fluid passage, wherein said device has a first functionality verifying feature located between the sample addition zone and the reaction zone, and a second functionality verifying feature located within the absorbing zone, and both functionality verifying features being features capable of undergoing a detectable change when contacted by the sample, said assay device further comprising at least one alignment verification zone.Type: ApplicationFiled: June 20, 2007Publication date: February 18, 2010Applicant: AMIC ABInventors: Per Ove Öhman, Ib Mendel-Hartvig, Tomas Lindström