Abstract: A pressure sensor device comprises a casing (2a, 3 a) defining a chamber (20) and an inlet passage (14a, 14b) of the chamber. Accommodated in the chamber (20) is a pressure sensor (17) having a sensor body with a cavity and a membrane capable of deformation under pressure action of a fluid present in the inlet passage (14a, 14b). The device further comprises a circuit arrangement (26, 27, 30) to which the pressure sensor (17) is electrically connected, the circuit arrangement including a circuit support at least partially accommodated in the chamber (20). The sensor body is not rigidly associated to the casing (2a, 3 a) and/or to other parts of the device (26, 27, 30, 35), i.e. it is mounted elastically or in a moveable manner with respect to the casing (2a, 3 a) and/or to said other parts (26, 27, 30, 35) inside the chamber (20).

Abstract: Powder particles comprising a pharmaceutically acceptable salt of 8-hydroxy-5-[(1R)-1-hydroxy-2-[[(1R)-2-(4-methoxyphenyl)-1-methylethyl]amino]ethyl]-2(1H)-quinolinone (carmoterol) having a specific properties exhibit improved adhesion properties for dry powder formulations for inhalation. Such particles are useful for formulations in the form of powders for inhalation and the treatment of certain conditions and diseases.

Abstract: A semiconductor pressure sensor for a pressure sensor device has a pressure detection element which includes a membrane made of semiconductor material, particularly silicon. The sensor includes a support having a three-dimensional body passed through by a detection passage. The detection element is made integral with a first end face of the three-dimensional body, substantially at a respective end of the detection passage. The support is configured to serve the function of a mechanical and/or hydraulic adaptor or interface, with the aim of mounting the sensor into a pressure sensor device, particularly to allow mounting the pressure sensor into a pressure sensor device configured for mounting a sensor of the type referred to as monolithic or ceramic.

Abstract: The present invention falls within the field of molecular biology, and in particular it refers to peptides, polypeptides, protein molecules, uses, methods, processes, systems and compositions for minimizing the presence of molecules in a material and/or interfering with effects associated to such molecules. In particular, the present invention can appear in the form of anti-septic shock pharmacological composition and systems of purification from bacterial endotoxins.

Abstract: An antifraud device for a vehicle has a tank with a filler provided with a removable cap. The device comprises a first sensor, for detecting a movement of the cap with respect to the filler, and second sensor, configured for detecting at least one of the level and a qualitative characteristic of the contents of the tank. A control unit generates first information being indicative of detections made by the first sensor, and second information being indicative of detections made by the second sensor, and stores the information in a correlated form. The device is further arranged for making explicit the first information and the second information in a correlated form, in order to identify one or more of the following conditions: removal of at least part of the contents of the tank; dilution or alteration of the contents of the tank; replacement of at least part of the contents of the tank; effective removal of the cap following upon a movement thereof in the filler.

Abstract: The described agglomeration of drug microparticles blended with excipient microparticles is a technique for the size enlargement of micronized products that could be damaged by granulation or compaction techniques. These agglomerates can be used as oral prompt or delayed-release dosage forms administered as they are or dispersed in a liquid. The composition and quantity of the excipient microparticles resulted to be the crucial factors for the agglomerate quality. Therefore, adjusting the content of surface-active agent between 8-20%, of the excipient microparticles it is possible to agglomerate microparticles of drugs that could not be agglomerated per se. Increasing the surfactant concentration in the spray-dried excipient microparticles or increasing the fraction of these excipient microparticles in the blend, the agglomeration was improved. The spray drying technique concentrates the surface-active agent on the microparticle surface.

Abstract: In accordance with the invention there are devices and processes for making ceramic nanofiber mats and ceramic filters for use in high temperature and in corrosive environments. The process for forming a ceramic filter can include electrospinning a preceramic polymer solution into a preceramic polymer fiber having a diameter from about 10 nm to about 1 micron and forming a preceramic polymer fiber web from the preceramic polymer fiber onto a collector. The process can also include pyrolyzing the preceramic polymer fiber web to form a ceramic nanofiber mat having a diameter less than the diameter of the preceramic polymer fiber, the ceramic nanofiber mat comprising one or more of an oxide ceramic and a non-oxide ceramic such that the ceramic fiber mat can withstand temperature greater than about 1000° C.

Abstract: A removable cap for fuel tanks of vehicles includes a gripping portion and a locking portion, operatively set between which is a key-operated locking device. In the closing condition of the device, a rotation movement imparted manually upon the gripping portion is not transferred to the locking portion, while in the opening condition of the device a rotation movement imparted manually upon the first part is transferred to the clamping portion. In the closing condition at least one component of the locking device is rotatable together with the gripping portion, and switching with the key of the locking device between the conditions of closing and opening causes an angular movement of the component with respect to the gripping portion, between a first pre-defined angular position and a second pre-defined angular position.

Abstract: A module which is destroyed in the presence of water solution, composed of a compressed powdery mixture, the said powdery mixture comprising a matrix building component, suitable to release an optionally included active substance into a surrounding aqueous liquid, and one or more tabletting aids chosen from the group consisting of lubricants, glidants, and anti-adherent agents, the said module being provided with particular male topological features allowing its connection to a corresponding female module, giving raise to an assembly that can be safely handled on industrial scale, wherein, in the composition of the male module, the percentage ratio between the tabletting aid and the matrix building component is comprised between 1:2.5 and 1:999. The module can be employed to convey pharmaceuticals, nutraceuticals, agrochemicals or other active principles to the intended site of action.

Abstract: A pressure-sensor device (1) comprises:—a pressure-sensitive component (9) having a body, defined in which is a blind cavity, and having a membrane portion (9a), operatively associated to which is a detection element (R); and—a connection structure (2), which has a duct in communication with the cavity of the pressure-sensitive component (9) and is to receive a fluid, a pressure of which is to be detected. The connection structure (2) comprises a supporting body (2a) of the pressure-sensitive component (9), which defines a respective passage (2b), and a compressible element (12, 18) that is designed to be in contact with the fluid and is configured for compensating possible variations of volume thereof. The compressible element (12, 18) is positioned at least in part within the cavity (11) of the pressure-sensitive component (9) and/or in a stretch of the passage (2b) of the supporting body (2a) that is close to the cavity (11) of the pressure-sensitive component (9).

Abstract: Single-layer film for active ingredients dermal and transdermal administration containing at least an active ingredient, a film-forming agent, and a hydrophilic adhesive polymer.

Abstract: A semiconductor pressure sensor for a pressure sensor device has a pressure detection element which includes a membrane made of semiconductor material, particularly silicon. The sensor includes a support having a three-dimensional body passed through by a detection passage. The detection element is made integral with a first end face of the three-dimensional body, substantially at a respective end of the detection passage. The support is configured to serve the function of a mechanical and/or hydraulic adaptor or interface, with the aim of mounting the sensor into a pressure sensor device, particularly to allow mounting the pressure sensor into a pressure sensor device configured for mounting a sensor of the type referred to as monolithic or ceramic.

Abstract: The invention describes novel dried powders of peptide therapeutic agent useful for producing highly respirable aerosols and the methods for their manufacture. Insulin is the peptide therapeutic agent in the preferred embodiment. The powders of insulin prepared for pulmonary administration are characterized by the peculiar structure and shape of the microparticles that allow the powder to flow and to be easy aerosolized. Typical dry powder of insulin described in this patent show corrugated, nonagglomerated microparticles with a low tapped density. The mean geometric diameter (particle size) ranges between 1.0 and 10.0 micron and the mass median aerodynamic diameter (MMAD) ranges between 1.0 and 4.0 micron. These insulin pulmonary powders exhibit in vitro a very high respirable fraction (>75%).

Abstract: A device for the delivery of active principles for dermal and, in particular, transdermal application having the form of a two-layered patch consisting of a first layer having a homogeneous composition and comprising at least one active principle, a water-soluble film-forming agent and a hydrophilic adhesive polymer, and of a second layer joined in a permanent manner to the first and having a water vapour permeability of less than 500 g/m2 in 24 hours.

Abstract: An antifraud device for a vehicle has a tank with a filler provided with a removable cap. The device comprises a first sensor, for detecting a movement of the cap with respect to the filler, and second sensor, configured for detecting at least one of the level and a qualitative characteristic of the contents of the tank. A control unit generates first information being indicative of detections made by the first sensor, and second information being indicative of detections made by the second sensor, and stores said information in a correlated form. The device is further arranged for making explicit the first information and the second information in a correlated form, in order to identify one or more of the following conditions: removal of at least part of the contents of the tank; dilution or alteration of the contents of the tank; replacement of at least part of the contents of the tank; effective removal of the cap following upon a movement thereof in the filler.

Abstract: A removable cap for fuel tanks of vehicles includes a gripping portion and a locking portion, operatively set between which is a key-operated locking device. In the closing condition of the device, a rotation movement imparted manually upon the gripping portion is not transferred to the locking portion, while in the opening condition of the device a rotation movement imparted manually upon the first part is transferred to the clamping portion. In the closing condition at least one component of the locking device is rotatable together with the gripping portion, and switching with the key of the locking device between the conditions of closing and opening causes an angular movement of the component with respect to the gripping portion, between a first pre-defined angular position and a second pre-defined angular position.

Abstract: Carrier particles, for use in the preparation of powdery mixtures for administration by inhalation, and having a median diameter of greater than 90 microns and a surface rugosity expressed as the fractal dimension of less than or equal to 1.1, may be prepared by subjecting particles having a median diameter of greater than 90 microns to repeated stages of wetting with a solvent and drying.

Abstract: A method for producing ceramic micromanufactured items comprises the following stages: a starting material constituting at least a micromanufactured item (1) is prepared and used to from the micromanufactured item (1); said starting material includes at least a pre-ceramic polymer, and the method further comprises a stage in which the inner structure of the starting material is modified, said structure being turned from a polymeric structure to a ceramic structure after the forming stage of said micromanufactured item (1).

Abstract: The invention describes novel dried powders of peptide therapeutic agent useful for producing highly respirable aerosols and the methods for their manufacture. Insulin is the peptide therapeutic agent in the preferred embodiment. The powders of insulin prepared for pulmonary administration are characterized by the peculiar structure and shape of the microparticles that allow the powder to flow and to be easy aerosolized. Typical dry powder of insulin described in this patent show corrugated, nonagglomerated microparticles with a low tapped density. The mean geometric diameter (particle size) ranges between 1.0 and 10.0 micron and the mass median aerodynamic diameter (MMAD) ranges between 1.0 and 4.0 micron. These insulin pulmonary powders exhibit in vitro a very high respirable fraction (>75%).

Abstract: The invention provides a process for the preparation of fludarabine phosphate from 2-fluoroadenine and 9-?-D-arabinofuranosyl-uracil using Enterobacter aerogenes (EBA). 2-Fluoroadenine is reacted with 9-?-D-arabinosyl-uracile in a water solution at pH=7 in the presence of EBA cell paste, to yield fludarabine. Fludarabine is then treated with acetic anhydride and the resulting acetylderivative is crystallised and hydrolysed to fludarabine. Phosphorylation and purification with organic amines or with ammonium hydroxide afford fludarabine phosphate.