Patents by Inventor Paramjit S. Arora

Paramjit S. Arora has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11891422
    Abstract: This invention relates to macrostructures (and pharmaceutical formulations containing them) that include a parallel coiled-coil structure, wherein the parallel coiled-coil comprises a first coil of Formula I and a second coil of Formula II: T1-f0-g0-a1-b1-c1-d1-e1-f1-g1-a2-b2-c2-d2-e2-f2-g2-a3-b3-c3-d3-e3-T2??(I) T3-g?0-a?1-b?1-c?1-d?1-e?1-f?1-g?1-a?2-b?2-c?2-d?2-e?2-f?2-g?2-a?3-b?3-c?3-d?3-e?3-f?3-T4??(II), as described in the present application. Methods of using these macrostructures are also disclosed.
    Type: Grant
    Filed: November 14, 2019
    Date of Patent: February 6, 2024
    Assignee: NEW YORK UNIVERSITY
    Inventors: Paramjit S. Arora, Michael G. Wuo
  • Patent number: 11560359
    Abstract: The present invention relates to oxopiperazines that mimic helix ?B of the C-terminal transactivation domain of HIF1?. Also disclosed are pharmaceutical compositions containing these oxopiperazines and methods of using these oxopiperazines (e.g., to reduce gene transcription, treat or prevent disorders mediated by interaction of HIF1? with CREB-binding protein and/or p300, reduce or prevent angiogenesis in a tissue, induce apoptosis, and decrease cell survival and/or proliferation).
    Type: Grant
    Filed: August 3, 2020
    Date of Patent: January 24, 2023
    Assignee: NEW YORK UNIVERSITY
    Inventors: Paramjit S. Arora, Brooke Bullock Lao, Richard Bonneau, Kevin Drew
  • Publication number: 20220289802
    Abstract: This invention relates to macrostructures (and pharmaceutical formulations containing them) that include a parallel coiled-coil structure, wherein the parallel coiled-coil comprises a first coil of Formula I and a second coil of Formula II: T1-f0-g0-a1-b1-c1-d1-e1-f1-g1-a2-b2-c2-d2-e2-f2-g2-a3-b3-c3-d3-e3-T2??(I) T3-g?0-a?1-b?1-c?1-d?1-e?1-f?1-g?1-a?2-b?2-c?2-d?2-e?2-f?2-g?2-a?3-b?3-c?3-d?3-e?3-f?3-T4??(II), as described in the present application. Methods of using these macrostructures are also disclosed.
    Type: Application
    Filed: April 19, 2022
    Publication date: September 15, 2022
    Inventors: Paramjit S. ARORA, Ethel CESARMAN, Michael G. WUO, Jouliana SADEK
  • Patent number: 11440938
    Abstract: This invention relates to a macrostructure that includes an antiparallel coiled-coil structure or a parallel coiled-coil structure.
    Type: Grant
    Filed: August 26, 2020
    Date of Patent: September 13, 2022
    Assignee: NEW YORK UNIVERSITY
    Inventors: Paramjit S. Arora, Michael G. Wuo
  • Patent number: 11180481
    Abstract: The present invention relates to oligooxopiperazines for modulating the p53-Mdm2 interaction. Exemplary oligooxopiperazines include those of Formula IA, Formula IB, and Formula IC below (wherein the various substituents are as defined herein). Methods of using the oligooxopiperazines are also disclosed.
    Type: Grant
    Filed: April 15, 2015
    Date of Patent: November 23, 2021
    Assignee: NEW YORK UNIVERSITY
    Inventors: Paramjit S. Arora, Brooke Bullock Lao, Danielle Guarracino, Richard Bonneau, Kevin Drew
  • Publication number: 20210277059
    Abstract: This invention relates to a macrostructure that includes an antiparallel coiled-coil structure shown below or a parallel coiled-coil structure shown below and described in the present application.
    Type: Application
    Filed: August 26, 2020
    Publication date: September 9, 2021
    Inventors: Paramjit S. ARORA, Michael G. WUO
  • Publication number: 20210171473
    Abstract: The present invention relates to oxopiperazines that mimic helix ?B of the C-terminal transactivation domain of HIF1?. Also disclosed are pharmaceutical compositions containing these oxopiperazines and methods of using these oxopiperazines (e.g., to reduce gene transcription, treat or prevent disorders mediated by interaction of HIF1? with CREB-binding protein and/or p300, reduce or prevent angiogenesis in a tissue, induce apoptosis, and decrease cell survival and/or proliferation).
    Type: Application
    Filed: August 3, 2020
    Publication date: June 10, 2021
    Inventors: Paramjit S. ARORA, Brooke Bullock LAO, Richard BONNEAU, Kevin DREW
  • Patent number: 10851133
    Abstract: This invention relates to a macrostructure that includes an antiparallel coiled-coil structure shown below or a parallel coiled-coil structure shown below and described in the present application.
    Type: Grant
    Filed: June 8, 2016
    Date of Patent: December 1, 2020
    Assignee: New York University
    Inventors: Paramjit S. Arora, Michael G. Wuo
  • Patent number: 10787424
    Abstract: The present invention relates to oxopiperazines that mimic helix ?B of the C-terminal transactivation domain of HIF1?. Also disclosed are pharmaceutical compositions containing these oxopiperazines and methods of using these oxopiperazines (e.g., to reduce gene transcription, treat or prevent disorders mediated by interaction of HIF1a with CREB-binding protein and/or p300, reduce or prevent angiogenesis in a tissue, induce apoptosis, and decrease cell survival and/or proliferation).
    Type: Grant
    Filed: May 20, 2015
    Date of Patent: September 29, 2020
    Assignee: NEW YORK UNIVERSITY
    Inventors: Paramjit S. Arora, Brooke Bullock Lao, Richard Bonneau, Kevin Drew
  • Publication number: 20200190155
    Abstract: This invention relates to macrostructures (and pharmaceutical formulations containing them) that include a parallel coiled-coil structure, wherein the parallel coiled-coil comprises a first coil of Formula I and a second coil of Formula II: T1-f0-g0-a1-b1-c1-d1-e1-f1-g1-a2-b2-c2-d2-e2-f2-g2-a3-b3-c3-d3-e3-T2 ??(I) T3-g?0-a?1-b?1-c?1-d?1-e?1-f?1-g?1-a?2-b?2-c?2-d?2-e?2-f?2-g?2-a?3-b?3-c?3-d?3-e?3-f?3-T4 ??(II), as described in the present application. Methods of using these macrostructures are also disclosed.
    Type: Application
    Filed: November 14, 2019
    Publication date: June 18, 2020
    Inventors: Paramjit S. ARORA, Ethel CESARMAN, Michael G. WUO, Jouliana SADEK
  • Patent number: 10221215
    Abstract: The present invention relates to peptides having one or more stable, internally-constrained HBS ?-helices, where the peptide is capable of interacting with Ras and related proteins.
    Type: Grant
    Filed: March 6, 2015
    Date of Patent: March 5, 2019
    Assignee: New York University
    Inventors: Paramjit S. Arora, Dafna Bar-Sagi, Anupam Patgiri, Kamlesh Yadav
  • Publication number: 20180162907
    Abstract: This invention relates to a macrostructure that includes an antiparallel coiled-coil structure shown below or a parallel coiled-coil structure shown below and described in the present application.
    Type: Application
    Filed: June 8, 2016
    Publication date: June 14, 2018
    Inventors: Paramjit S. ARORA, Michael G. WUO
  • Patent number: 9783526
    Abstract: The present invention relates to oligooxopiperazines that mimic helix ?B of the C-terminal transactivation domain of HIF-1?. Also disclosed are pharmaceutical compositions containing these oligooxopiperazines and methods of using these oligooxopiperazines (e.g., to reduce gene transcription, treat or prevent disorders mediated by interaction of HIF-1? with CREB-binding protein and/or p300, reduce or prevent angiogenesis in a tissue, induce apoptosis, and decrease cell survival and/or proliferation).
    Type: Grant
    Filed: February 8, 2016
    Date of Patent: October 10, 2017
    Assignee: New York University
    Inventors: Paramjit S. Arora, Brooke Bullock Lao
  • Publication number: 20170247324
    Abstract: The present invention relates to ligation agents and their use in making an amide ligation product. Methods of making the ligation agents are also disclosed.
    Type: Application
    Filed: March 13, 2017
    Publication date: August 31, 2017
    Inventors: Paramjit S. Arora, Monika Raj, Huabin Wu
  • Publication number: 20170190673
    Abstract: The present invention relates to oxopiperazines that mimic helix ?B of the C-terminal transactivation domain of HIF1?. Also disclosed are pharmaceutical compositions containing these oxopiperazines and methods of using these oxopiperazines (e.g., to reduce gene transcription, treat or prevent disorders mediated by interaction of HIF1a with CREB-binding protein and/or p300, reduce or prevent angiogenesis in a tissue, induce apoptosis, and decrease cell survival and/or proliferation).
    Type: Application
    Filed: May 20, 2015
    Publication date: July 6, 2017
    Inventors: Paramjit S. ARORA, Brooke Bullock LAO, Richard BONNEAU, Kevin DREW
  • Patent number: 9695153
    Abstract: The present invention relates to oligooxopiperazines for reactivating p53. The oligooxopiperazines comprise two or three oxopiperazine rings and substantially mimic helix ?B of the C-terminal transactivation domain of Hypoxia-Inducible Factor 1?. Methods of using the oligooxopiperazines are also disclosed. Exemplary oligooxopiperazines include those of Formula I below (wherein A, R1, R2, R3, R4, and B are as defined herein).
    Type: Grant
    Filed: January 21, 2014
    Date of Patent: July 4, 2017
    Assignees: New York University, The Ohio State University Research Foundation, The Regents of the University of Michigan
    Inventors: Paramjit S. Arora, Quintin Pan, Anna Mapp
  • Patent number: 9624203
    Abstract: The present invention relates to oligooxopiperazines and their use. Methods for preparing oligooxopiperazines are also disclosed.
    Type: Grant
    Filed: April 11, 2016
    Date of Patent: April 18, 2017
    Assignee: New York University
    Inventors: Paramjit S. Arora, Petra To{hacek over (s)}ovská, Danielle Guarracino, Brooke Bullock Lao
  • Patent number: 9605026
    Abstract: The present invention relates to peptidomimetics for reactivating p53. Methods of using the peptidomimetics are also disclosed.
    Type: Grant
    Filed: January 21, 2014
    Date of Patent: March 28, 2017
    Assignees: NEW YORK UNIVERSITY, THE OHIO STATE UNIVERSITY RESEARCH FOUNDATION, THE REGENTS OF THE UNIVERSITY OF MICHIGAN
    Inventors: Paramjit S. Arora, Quintin Pan, Anna Mapp
  • Patent number: 9593142
    Abstract: The present invention relates to ligation agents and their use in making an amide ligation product. Methods of making the ligation agents are also disclosed.
    Type: Grant
    Filed: December 26, 2014
    Date of Patent: March 14, 2017
    Assignee: New York University
    Inventors: Paramjit S. Arora, Monika Raj, Huabin Wu
  • Publication number: 20170066801
    Abstract: The present invention relates to peptides having a stable, internally-constrained HBS ?-helix, where the peptide mimics at least a portion of the ?-H helix of the Sos protein and contains a mixture of alpha and beta amino acid residues in the pattern ?3/?1. Methods using the peptides of the present invention for inhibiting Ras signaling in a cell, promoting cell death, and treating, preventing, and/or diagnosing a cellular proliferative disorder, differentiative disorder, and/or neoplastic condition in a subject in need thereof are also disclosed.
    Type: Application
    Filed: February 23, 2015
    Publication date: March 9, 2017
    Applicant: NEW YORK UNIVERSITY
    Inventors: Paramjit S. ARORA, Dafna BAR-SAGI, Stephen Taro JOY, Seth NICKERSON