Patents by Inventor Paramjit S. Arora

Paramjit S. Arora has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • ALPHA3BETA HYDROGEN BOND SURROGATE MACROCYCLES AS MODULATORS OF RAS
    Publication number: 20170066801
    Abstract: The present invention relates to peptides having a stable, internally-constrained HBS ?-helix, where the peptide mimics at least a portion of the ?-H helix of the Sos protein and contains a mixture of alpha and beta amino acid residues in the pattern ?3/?1. Methods using the peptides of the present invention for inhibiting Ras signaling in a cell, promoting cell death, and treating, preventing, and/or diagnosing a cellular proliferative disorder, differentiative disorder, and/or neoplastic condition in a subject in need thereof are also disclosed.
    Type: Application
    Filed: February 23, 2015
    Publication date: March 9, 2017
    Applicant: NEW YORK UNIVERSITY
    Inventors: Paramjit S. ARORA, Dafna BAR-SAGI, Stephen Taro JOY, Seth NICKERSON
  • OXOPIPERAZINE HELIX MIMETICS AS INHIBITORS OF THE p53-MDM2 INTERACTION
    Publication number: 20170037033
    Abstract: The present invention relates to oligooxopiperzines for modulating the p53-Mdm2 interaction. Methods of using the oligooxopiperazines are also disclosed.
    Type: Application
    Filed: April 15, 2015
    Publication date: February 9, 2017
    Applicant: NEW YORK UNIVERSITY
    Inventors: Paramjit S. ARORA, Brooke Bullock LAO, Danielle GUARRACINO, Richard BONNEAU, Kevin DREW
  • CONTROL OF HYPOXIA-INDUCIBLE GENE EXPRESSION WITH OLIGOOXOPIPERAZINE NONPEPTIDIC HELIX MIMETICS
    Publication number: 20160297802
    Abstract: The present invention relates to oligooxopiperazines that mimic helix ?B of the C-terminal transactivation domain of HIF-1?. Also disclosed are pharmaceutical compositions containing these oligooxopiperazines and methods of using these oligooxopiperazines (e.g., to reduce gene transcription, treat or prevent disorders mediated by interaction of HIF-1? with CREB-binding protein and/or p300, reduce or prevent angiogenesis in a tissue, induce apoptosis, and decrease cell survival and/or proliferation).
    Type: Application
    Filed: February 8, 2016
    Publication date: October 13, 2016
    Applicants: New York University, University of Southern California
    Inventors: Paramjit S. ARORA, Bogdan Z. Olenyuk, Brooke Bullock Lao, Ivan Grishagin
  • OLIGOOXOPIPERAZINES AND METHODS OF MAKING AND USING THEM
    Publication number: 20160214965
    Abstract: The present invention relates to oligooxopiperazines and their use. Methods for preparing oligooxopiperazines are also disclosed.
    Type: Application
    Filed: April 11, 2016
    Publication date: July 28, 2016
    Inventors: Paramjit S. ARORA, Petra TOSOVSKÁ, Danielle GUARRACINO, Brooke Bullock LAO
  • Inhibiting interaction between the HIF-1ALPHA and p300/CBP with hydrogen bond surrogate-based helices
    Patent number: 9399666
    Abstract: The present invention relates to peptides having one or more stable, internally constrained ?-helices, and that include a sequence that mimics at least a portion of the C-terminal transactivation domain of HIF-1?. Also disclosed are pharmaceutical compositions containing these peptides and methods of using these peptides, for example to reduce gene transcription, treat or prevent disorders mediated by interaction of HIF-1? with CREB-binding protein and/or p300, reduce or prevent angiogenesis in a tissue, induce apoptosis, decrease cell survival and/or proliferation, and identify potential ligands of CREB-binding protein and/or p300.
    Type: Grant
    Filed: September 18, 2009
    Date of Patent: July 26, 2016
    Assignees: New York University, The Arizona Board of Regents on Behalf of the University of Arizona
    Inventors: Paramjit S. Arora, Bogdan Olenyuk, Ross N. Chapman, Laura Henchey, Katherine M. Block
  • Proteolytically resistant hydrogen bond surrogate helices
    Patent number: 9376469
    Abstract: The present invention relates to peptidomimetics having a stable, internally constrained protein secondary structure, where the peptidomimetics contain a hydrogen bond surrogate in the internal constraint, and at least one beta amino acid. Methods for promoting cell death using peptidomimetics that inhibit p53/hDM2 are also disclosed.
    Type: Grant
    Filed: December 21, 2012
    Date of Patent: June 28, 2016
    Assignee: New York University
    Inventors: Paramjit S. Arora, Anupam Patgiri, Stephen Joy
  • Oligooxopiperazines and methods of making and using them
    Patent number: 9309230
    Abstract: The present invention relates to oligooxopiperazines and their use. Methods for preparing oligooxopiperazines are also disclosed.
    Type: Grant
    Filed: June 13, 2014
    Date of Patent: April 12, 2016
    Assignee: New York University
    Inventors: Paramjit S. Arora, Petra To{hacek over (s)}ovská, Danielle Guarracino, Brooke Bullock Lao
  • Control of hypoxia-inducible gene expression with oligooxopiperazine nonpeptidic helix mimetics
    Patent number: 9255086
    Abstract: The present invention relates to oligooxopiperazines that mimic helix ?B of the C-terminal transactivation domain of HIF-1?. Also disclosed are pharmaceutical compositions containing these oligooxopiperazines and methods of using these oligooxopiperazines (e.g., to reduce gene transcription, treat or prevent disorders mediated by interaction of HIF-1? with CREB-binding protein and/or p300, reduce or prevent angiogenesis in a tissue, induce apoptosis, and decrease cell survival and/or proliferation).
    Type: Grant
    Filed: February 19, 2013
    Date of Patent: February 9, 2016
    Assignees: New York University, University of Southern California
    Inventors: Paramjit S. Arora, Bogdan Olenyuk, Brooke Bullock Lau, Ivan Grishagin
  • HYDROGEN BOND SURROGATE MACROCYCLES AS MODULATORS OF RAS
    Publication number: 20150239935
    Abstract: The present invention relates to peptides having one or more stable, internally-constrained HBS ?-helices, where the peptide is capable of interacting with Ras and related proteins.
    Type: Application
    Filed: March 6, 2015
    Publication date: August 27, 2015
    Applicant: New York University
    Inventors: Paramjit S. ARORA, Dafna BAR-SAGI, Anupam PATGIRI, Kamlesh YADAV
  • ALDEHYDE CAPTURE LIGATION TECHNOLOGY FOR SYNTHESIS OF AMIDE BONDS
    Publication number: 20150232504
    Abstract: The present invention relates to ligation agents and their use in making an amide ligation product. Methods of making the ligation agents are also disclosed.
    Type: Application
    Filed: December 26, 2014
    Publication date: August 20, 2015
    Applicant: NEW YORK UNIVERSITY
    Inventors: Paramjit S. Arora, Monika Raj, Huabin Wu
  • OLIGOOXOPIPERAZINES AND METHODS OF MAKING AND USING THEM
    Publication number: 20150072991
    Abstract: The present invention relates to oligooxopiperazines and their use. Methods for preparing oligooxopiperazines are also disclosed.
    Type: Application
    Filed: June 13, 2014
    Publication date: March 12, 2015
    Applicant: NEW YORK UNIVERSITY
    Inventors: Paramjit S. ARORA, Petra TOSOVSKÁ, Danielle GUARRACINO, Brooke Bullock LAO
  • INHIBITING INTERACTION BETWEEN HIF-1ALPHA AND p300/CBP WITH HYDROGEN BOND SURROGATE-BASED HELICES
    Publication number: 20150065436
    Abstract: The present invention relates to peptidomimetics that mimic helix ?B of the C-terminal transactivation domain of HIF-1?. Methods of using the peptidomimetics to, e.g., inhibit the HIF-1?-p300/CBP interaction, are also disclosed.
    Type: Application
    Filed: September 3, 2014
    Publication date: March 5, 2015
    Applicants: UNIVERSITY OF SOUTHERN CALIFORNIA, NEW YORK UNIVERSITY
    Inventors: Paramjit S. ARORA, Brooke Bullock LAO, Laura K. HENCHEY, Nathaniel J. TRAASETH, Paul THOMSON, Swati KUSHAL, Bogdan Z. OLENYUK
  • CONTROL OF HYPOXIA-INDUCIBLE GENE EXPRESSION WITH OLIGOOXOPIPERAZINE NONPEPTIDIC HELIX MIMETICS
    Publication number: 20150018364
    Abstract: The present invention relates to oligooxopiperazines that mimic helix ?B of the C-terminal transactivation domain of HIF-1?. Also disclosed are pharmaceutical compositions containing these oligooxopiperazines and methods of using these oligooxopiperazines (e.g., to reduce gene transcription, treat or prevent disorders mediated by interaction of HIF-1? with CREB-binding protein and/or p300, reduce or prevent angiogenesis in a tissue, induce apoptosis, and decrease cell survival and/or proliferation).
    Type: Application
    Filed: February 19, 2013
    Publication date: January 15, 2015
    Applicants: NEW YORK UNIVERSITY, UNIVERSITY OF SOUTHERN CALIFORNIA
    Inventors: Paramjit S. Arora, Bogdan Olenyuk, Brooke Bullock Lau, Ivan Grishagin
  • REVERSIBLY CROSSLINKED HELICAL HYDROGEN BOND SURROGATE MACROCYCLES
    Publication number: 20150011728
    Abstract: The present invention relates to peptides having one or more stable, reversibly and internally-constrained HBS ?-helices.
    Type: Application
    Filed: February 22, 2013
    Publication date: January 8, 2015
    Applicant: NEW YORK UNIVERSITY
    Inventors: Paramjit S. Arora, Stephen E. Miller
  • HYDROGEN-BOND SURROGATE PEPTIDES AND PEPTIDOMIMETICS FOR p53 REACTIVATION
    Publication number: 20140220159
    Abstract: The present invention relates to peptidomimetics for reactivating p53. Methods of using the peptidomimetics are also disclosed.
    Type: Application
    Filed: January 21, 2014
    Publication date: August 7, 2014
    Inventors: Paramjit S. ARORA, Quintin PAN, Anna MAPP
  • Oligooxopiperazines and methods of making and using them
    Patent number: 8791121
    Abstract: The present invention relates to oligooxopiperazines and their use. Methods for preparing oligooxopiperazines are also disclosed.
    Type: Grant
    Filed: November 1, 2010
    Date of Patent: July 29, 2014
    Assignee: New York University
    Inventors: Paramjit S. Arora, Petra Tosovska, Danielle Guarracino, Brooke Bullock
  • HYDROGEN-BOND SURROGATE PEPTIDES AND PEPTIDOMIMETICS FOR p53 REACTIVATION
    Publication number: 20140205681
    Abstract: The present invention relates to peptidomimetics for reactivating p53. Methods of using the peptidomimetics are also disclosed.
    Type: Application
    Filed: January 21, 2014
    Publication date: July 24, 2014
    Inventors: Paramjit S. ARORA, Quintin PAN, Anna MAPP
  • OLIGOOXOPIPERAZINES FOR p53 REACTIVATION
    Publication number: 20140205655
    Abstract: The present invention relates to oligooxopiperazines for reactivating p53. Methods of using the oligooxopiperazines are also disclosed.
    Type: Application
    Filed: January 21, 2014
    Publication date: July 24, 2014
    Inventors: Paramjit S. ARORA, Quintin PAN, Anna MAPP
  • THIOETHER-, ETHER-, AND ALKYLAMINE-LINKED HYDROGEN BOND SURROGATE PEPTIDOMIMETICS
    Publication number: 20130123196
    Abstract: Provided herein are peptidomimetics and their salts having a stable, internally constrained protein secondary structure containing a thioether-, ether-, or alkylamine-linked hydrogen bond surrogate; compositions containing at least one of these, and methods of making and using these.
    Type: Application
    Filed: August 31, 2012
    Publication date: May 16, 2013
    Applicant: NEW YORK UNIVERSITY
    Inventors: Paramjit S. Arora, Andrew Mahon
  • OLIGOOXOPIPERAZINES AND METHODS OF MAKING AND USING THEM
    Publication number: 20120040992
    Abstract: The present invention relates to oligooxopiperazines and their use. Methods for preparing oligooxopiperazines are also disclosed.
    Type: Application
    Filed: November 1, 2010
    Publication date: February 16, 2012
    Applicant: NEW YORK UNIVERSITY
    Inventors: Paramjit S. Arora, Petra Tosovska, Danielle Guarracino, Brooke Bullock