Abstract: Methods, compositions, and devices for transdermally administering an active agent such as memantine are provided.

Abstract: Applicators for a microprojection array and methods of using the applicators are described.

Abstract: Methods, compositions, and devices for transdermally administering an active agent such as donepezil are provided. In one aspect, the method comprises contacting skin with a transdermal device designed to create a depot of the active agent in the subject, removing the transdermal device and continuing to administer the active agent for a period after the device is removed.

Abstract: Verifying architectural compliance of a processor core using processor-sparing functions. A simulation of a model for a register-transfer level design of the processor core is performed. A first state of the model is dumped, when no error exists. An error is injected in the model. A second state of the model is dumped, after the injected error is detected in the simulation. Upon dumping the second state, the model is reset and initialized with the first state. State information of the second state is loaded in the reset and initialized model.

Abstract: A transdermal delivery system for systemic delivery of donepezil is described, where the system comprises an adhesive matrix drug reservoir layer comprised of a copolymer of acrylic acid/vinyl acetate, triethyl citrate, and donepezil base generated in situ by reaction of donepezil HCl and an alkaline salt. The system is provided for treatment of Alzheimer's disease, and achieves transdermal delivery of the therapeutic agent at steady state that is bioequivalent to administration of the therapeutic agent orally.

Abstract: The present disclosure relates to method and device for determining performance of an intermittently used refrigerator. Performance measuring device receives time stamped temperature data from temperature sensor configured in the intermittently used refrigerator. The received time stamped temperature data is used to determine values for each of one or more predefined parameters associated with the intermittently used refrigerator. The performance measuring device determines temperature variation of the intermittently used refrigerator at predefined time intervals. Based on the determined temperature variation, additional service windows in a site comprising the intermittently used refrigerator are identified i.e. the intensity of sales in the site are identified. The determined values of each of the one or more predefined parameters and the determined temperature variation, helps in determining the performance of intermittently used refrigerator.

Abstract: A transdermal delivery system for systemic delivery of donepezil is described, where the system comprises an adhesive matrix drug reservoir layer comprised of a copolymer of acrylic acid/vinyl acetate, triethyl citrate, and donepezil base generated in situ by reaction of donepezil HCl and an alkaline salt. The system is provided for treatment of Alzheimer's disease, and achieves transdermal delivery of the therapeutic agent at steady state that is bioequivalent to administration of the therapeutic agent orally.

Abstract: Methods and apparatus are described for stitching independently encoded content streams together such that they appear to be part of a single streaming session.

Abstract: Applicators for a microprojection array and methods of using the applicators are described.

Abstract: In an aspect of the invention, a composition for making a patch for the transdermal delivery of tamsulosin is provided. The composition comprises (a) at least about 1 wt % tamsulosin or a pharmaceutically acceptable salt of tamsulosin, (b) at least about 40 wt % polyisobutylene adhesive or hydrophobic synthetic rubber adhesive, (c) about 1-20 wt % of an aprotic solvent in which tamsulosin dissolves readily, (d) about 1-20 wt % of an unsaturated fatty acid or an alpha-hydroxy acid or a mixture of unsaturated fatty acids or alpha-hydroxy acids or of both unsaturated fatty acids and alpha-hydroxy acids, (e) a lipophilic permeation enhancer, and (f) a matrix modifier.

Abstract: In an aspect of the invention, an array of microprotrusions is formed by providing a mold with cavities corresponding to the negative of the microprotrusions, casting atop the mold a first solution comprising a biocompatible material and a solvent, removing the solvent, casting a second solution atop the first cast solution, removing the solvent from the second solution, and demolding the resulting array from the mold. The first solution preferably contains an active ingredient.

Abstract: The disclosed principles describe systems and methods for assessing the security posture of a target device, wherein the assessment is performed by a scanning computer in communication with the target device via a communication network. By employing a system or method in accordance with the disclosed principles, distinct advantages are achieved. Specifically, conducting such a remote scan allows for the scanner computer to perform a remote scan of the remote device without installing client software to the remote device. Thus, the disclosed principles reduce the need for internal IT resources to manage the deployment and updates of client software on the target device. Also, conducting a remote scan according to the disclosed principles allows for the remote scan to be performed even if the scanner computer and remote device run different operating systems.

Abstract: Embodiments include a method for verifying a counter design within a tolerance window within which a race condition occurs between a context event and a design event. The method includes receiving a plurality of events within the counter design, the plurality of events including the context event and the design event. The method also includes dynamically determining the tolerance window around the context event by setting a first portion of the tolerance window to precede an occurrence of the context event and by setting a second portion of the tolerance window to follow the context event. Additionally, the method includes performing a verification of whether the design event is within the first portion of the tolerance window or the second portion of the tolerance window.

Abstract: Applicators for a microprojection array capable of multiple impacts and methods of using the applicators are described.

Abstract: A transdermal delivery system is described, where the system comprises a drug reservoir layer comprising an active agent and a skin contact adhesive layer. A microporous membrane that has been pretreated with a membrane treatment composition before the membrane is incorporated into the system is disposed between the drug reservoir layer and the skin contact adhesive layer.

Abstract: A composition is provided, wherein the composition comprises a water-swellable, water insoluble polymer, a blend of a hydrophilic polymer and a complementary oligomer capable of hydrogen bonding to the hydrophilic polymer, and a whitening agent, preferably a peroxide. The composition finds utility as a tooth whitening composition and is applied to the teeth in need of whitening, and then removed when the degree of whitening has been achieved. In certain embodiments, the composition is translucent. Methods for preparing and using the compositions are also disclosed.

Abstract: In one example, a strut for mounting a jet engine to a wing of an aircraft includes a plurality of engine mounts and a space frame truss supported from the wing and including front and aft portions, the front portion being coupled to and supporting the engine mounts, the aft portion extending upwardly and rearwardly from an aft end of the front portion. By removing the aft end of the strut from the core exhaust zone of the engine, substantial reductions in the weight and drag of the strut, and a corresponding increase in the specific fuel consumption of the associated aircraft may be achieved.

Abstract: An information management cell health monitoring system is provided herein that can monitor one or more information management systems, identify any performance issues that are occurring within an information management system, and automatically, or in response to a user input, transmit an instruction to the information management system to execute a workflow to resolve the performance issue(s). For example, the information management cell health monitoring system receives operational data, secondary copy policies, and/or similar data from an information management cells via a network. The information management cell health monitoring system analyzes the received information to identify any issues. If an issue is detected, the information management cell health monitoring system retrieves workflows and determines whether any of the workflows can be used to resolve the detected issue.

Abstract: Verifying architectural compliance of a processor core using processor-sparing functions. A simulation of a model for a register-transfer level design of the processor core is performed. A first state of the model is dumped, when no error exists. An error is injected in the model. A second state of the model is dumped, after the injected error is detected in the simulation. Upon dumping the second state, the model is reset and initialized with the first state. State information of the second state is loaded in the reset and initialized model.

Abstract: A transdermal delivery system for systemic delivery of donepezil is described, where the system comprises an adhesive matrix drug reservoir layer comprised of a copolymer of acrylic acid/vinyl acetate, triethyl citrate, and donepezil base generated in situ by reaction of donepezil HCl and an alkaline salt. The system is provided for treatment of Alzheimer's disease, and achieves transdermal delivery of the therapeutic agent at steady state that is bioequivalent to administration of the therapeutic agent orally.