Abstract: The present invention relates to amino acid sequences that are directed against vascular endothelial growth factor (VEGF), as well as to compounds or constructs, and in particular proteins and polypeptides, that comprise or essentially consist of one or more such amino acid sequences. The amino acid sequences, compounds and constructs can be used for prophylactic, therapeutic or diagnostic purposes, such as for the treatment of conditions and diseases characterized by excessive and/or pathological angiogenesis or neovascularization.

Abstract: A method for identifying compounds that inhibit amyloid-beta precursor protein processing in cells, comprising contacting a test compound with a GPCR polypeptide, or fragment thereof, and measuring a compound-GPCR property related to the production of amyloid-beta peptide. Cellular assays of the method measure indicators including second messenger and/or amyloid beta peptide levels. Therapeutic methods, and pharmaceutical compositions including effective amyloid-beta precursor processing-inhibiting amounts of GPCR expression inhibitors, are useful for treating conditions involving cognitive impairment such as Alzheimers Disease.

Abstract: A method for identifying compounds that inhibit amyloidal-beta precursor protein processing in cells, comprising contacting a test compound with a GPCR polypeptide, or fragment thereof, and measuring a compound-GPCR property related to the production of amyloidal-beta peptide. Cellular assays of the method measure indicators including second messenger and/or amyloid beta peptide levels. Therapeutic methods,and pharmaceutical compositions including effective amyloidal-beta precursor processing-inhibiting amounts of GPCR expression inhibitors, are useful for treating conditions involving cognitive impairment such as Alzheimers Disease.

Abstract: This object is achieved by the bleed-off means comprising means for tapping air from the primary duct which are arranged upstream of the intermediate casing and means for evacuating the air tapped into the secondary duct downstream of the support arms, these means comprising conduits arranged around the intermediate casing under the platforms.

Abstract: Process for the production of sodium chloride crystals from a sodium chloride brine contaminated by potassium chloride and sulphate ions, according to which a calcium compound (32) is added to the brine (48) to crystallize glauberite (35), which is isolated, the resulting aqueous solution (36) is subjected to evaporation to crystallize sodium chloride (40), which is collected, and the aqueous mother liquor (41) from the crystallization of the sodium chloride is subjected to cooling (42) to crystallize glaserite (45).

Abstract: A backup locking system for a thrust reverser door comprises a catch pivotally mounted by a pivot pin to a fixed structure of the thrust reverser. A hook with a self-locking profile is provided at the free end of said catch for cooperation with a locking interface on the door in the event of failure of the normal locking systems. At its other end remote from said hook, the catch has a heel ending in a part-cylindrical surface which is concentric with said pivot pin. The catch is urged against the locking interface by a piston rod which presses against a front face of said heel under the force of a spring acting on a piston to which said piston rod is attached. When the rod is retracted, a double lever positively moves the catch toward a minimum opening angle, at which point the door can be opened. An unlocking spring causes the full opening of the catch to maximum open position when an opening lever is released.

Abstract: In a turbojet thrust reverser comprising, in an annular section of an outer cowling of the turbojet, a number of movable doors which, in an inactive position during operation in a forward thrust configuration, close off passages separating rigid spars of a fixed structure, there is provided, between two adjacent doors, a locking system which allows substantially simultaneous opening of the two doors. The locking system comprises, for each door, at least one hook mounted on the fixed structure so that it can be pivoted by an olive secured to the door between a door locking position and an unlocked position during opening or closing movement of the door. The two hooks of the locking system are rotationally interlinked by a mechanical linkage device, for example link rods, so as to prevent the unlocking of one door if the other door is closed.

Abstract: The invention relates to a bypass turbojet comprising a primary duct, a secondary duct, a low-pressure compressor, a high-pressure compressor, and a structural intermediate casing arranged axially between said low-pressure compressor and said high-pressure compressor, said intermediate casing being equipped at its periphery with a plurality of support arms having platforms which internally delimit the secondary duct, in which bleed-off means are provided, allowing some of the gaseous stream delivered by the low-pressure compressor to be tapped off and led to the secondary duct. Said bleed-off means comprise means for tapping air from said primary duct which are arranged upstream of said intermediate casing and means for removing the air tapped from said secondary duct downstream of said support arms, these means comprising conduits arranged around said intermediate casing under said platforms.

Abstract: A backup locking system for a thrust reverser door comprises a catch pivotally mounted by a pivot pin to a fixed structure of the thrust reverser. A hook with a self-locking profile is provided at the free end of said catch for cooperation with a locking interface on the door in the event of failure of the normal locking systems. At its other end remote from said hook, the catch has a heel ending in a part-cylindrical surface which is concentric with said pivot pin. The catch is urged against the locking interface by a piston rod which presses against a front face of said heel under the force of a spring acting on a piston to which said piston rod is attached. When the rod is retracted, a double lever positively moves the catch toward a minimum opening angle, at which point the door can be opened. An unlocking spring causes the full opening of the catch to maximum open position when an opening lever is released.

Abstract: In a turbojet thrust reverser comprising, in an annular section of an outer cowling of the turbojet, a number of movable doors which, in an inactive position during operation in a forward thrust configuration, close off passages separating rigid spars of a fixed structure, there is provided, between two adjacent doors, a locking system which allows substantially simultaneous opening of said two doors. The locking system comprises, for each door, at least one hook mounted on said fixed structure so that it can be pivoted by an olive secured to said door between a door locking position and an unlocked position during opening or closing movement of the door. The two hooks of the locking system are rotationally interlinked by a mechanical linkage device, for example link rods, so as to prevent the unlocking of one door if the other door is closed.

Abstract: A stator suitable for high-pressure compressors in gas turbine engines includes two points of ventilation at different temperatures. It is recommended that the upstream section of the stator be constructed with a casing and a shroud, both of which are unbroken around a circumference and made of a material with a low degree of thermal expansion. Downstream the shroud is, however, constructed using angular sectors in a material with a higher degree of thermal expansion.

Abstract: A thrust reverser for aircraft gas-turbine engines includes latch devices that display a tell-tale visible indication when thrust reverser shutters (doors, etc.) are ajar. A latch of the lock at least partly projects from a wall (13, 14) radially bounding the annular structure (12) of the thrust reverser (10) when the latch (37) is in the open mode.

Abstract: A turbojet-engine thrust reverser includes bypass flow deflectors (3) which in a forward thrust mode are retracted into a wall of the primary cowling (4) of the engine and which are driven by linear actuator (6) mounted inside the primary cowling (4) to form an annular flow-deflecting assembly aft of the outlet of the bypass flow duct for producing thrust reversal. Each deflector (3) is independently driven by an actuator (6) and a linkage element (9) into rotation about one or more displaceable pivots (12) which in turn is or are translated by at least one linear actuator along one or more longitudinal guide elements (10). Each actuator (6) is connected to a deflector at the downstream end of the deflector and drives the associated deflector downstream end in an upstream or forward direction, the guide elements extending in a fore and aft direction.

Abstract: A gas flow guide is disclosed for an aircraft jet engine thrust reverser having a thrust reverser door movably connected to an engine cowling so as to move between forward and reverse thrust positions, the cowling having a reverse thrust opening bounded by a forward edge having a deflector, an opposite lateral side edges, an inner surface of the cowling forming an outer boundary of a gas flow duct, a forward inner surface of the thrust reverser door tapering toward an outer surface so as to form a cavity opening into the gas flow duct when the thrust reverser door is in the forward thrust position, wherein the gas flow guide has at least one guide vane connected to the cowling so as to be located within the cavity when the thrust reverser door is in the forward thrust position and located rearwardly of the deflector extending from the forward edge so as to guide the gas passing through the reverse thrust opening when the thrust reverser door is in the reverse thrust position.

Abstract: A thrust reverser is disclosed for a high bypass ratio turbofan jet engine having a cowling with an inner surface forming an outer boundary of a gas flow duct, the cowling having a plurality of lateral openings and a plurality of thrust reverser doors connected to the cowling so as to be movable between forward thrust positions and reverse thrust positions. The thrust reverser also includes a plurality of linear actuators, one linear actuator connected to the cowling and to each thrust reverser door so as to move the thrust reverser doors between their forward and reverse thrust positions.

Abstract: A ducted fan aircraft turbojet engine having an inner engine core cowling, an outer fan shroud, an outer fan outlet cowling including a thrust reverser, a fan exhaust duct between the inner engine core cowling and the outer fan outlet cowling, at least one fan shroud brace connecting the engine and the outer fan shroud, and at least one fairing element extending into and along the fan exhaust duct and located directly adjacent and rearwardly of the at least one fan shroud brace. The at least one fairing may be connected directly to the at least one fan shroud brace, the inner engine core cowling or the outer fan outlet cowling. The invention has utility where the fan outlet cowling and thrust reverser are mounted independently of the inner engine core cowling over their respective inner areas.

Abstract: An aircraft gas turbine-engine thrust-reverser specifically designed to withstand impacts possibly caused by objects propelled from the engines around which they are mounted, for instance disk or blade fragments. These impacts have the energy to distort the annular thrust-reverser structure or to break its bracing components. An emergency locking system for such thrust reverser (35) each comprises a hinging latch (38) of which one end is in the form of a hook (40) partly enclosing the lock-interfacing mechanism (43) with the latch (38) being automatically biased into closing by an elastic arrangement (47). Such a configuration allows setting up additional mechanical connections which are able to compensate for any distortion of the thrust-reverser's annular structure or for any ruptured bracing component in the event of impact by an engine piece.

Abstract: A locking system is disclosed for an aircraft jet engine thrust reverser door that is movably connected to an engine cowling so as to be movable between a forward thrust position and a reverse thrust position, the cowling having a reverse thrust opening that is covered by the thrust reverser door when in the forward thrust position and uncovered when the thrust reverser door is in the reverse thrust position. The locking system has a plurality of locking devices attached to the cowling at the forward side of the reverse thrust opening with at least one locking device located on opposite sides of a longitudinal line equidistantly spaced from opposite lateral sides of the thrust reverser door such that the locking devices simultaneously lock the thrust reverser door in the forward thrust position.

Abstract: A linkage system is disclosed for releasably latching a thrust reverser to an engine casing having a longitudinal axis, the linkage system having a seat on the thrust reverser and a movable latching member on the engine casing movable between an open position in which the latching member is displaced away from the seat, and a closed position in which the latching member is located adjacent to the seat so as to prevent displacement of the thrust reverser away from the engine casing.

Abstract: A gas flow guide is disclosed for an aircraft jet engine thrust reverser having a thrust reverser door movably connected to a cowling so as to move between forward and reverse thrust positions, the cowling having a reverse thrust opening bounded by a forward edge having a deflector, an opposite lateral side edges, an inner surface of the cowling forming an outer boundary of a gas flow duct, a forward inner surface of the thrust reverser door tapering toward an outer surface so as to form a cavity opening into the gas flow duct when the thrust reverser door is in the forward thrust position, wherein the gas flow guide has at least one guide vane connected to the cowling so as to be located within the cavity when the thrust reverser door is in the forward thrust position and located rearwardly of the deflector extending from the forward edge so as to guide the gas passing through the reverse thrust opening when the thrust reverser door is in the reverse thrust position.