Patents by Inventor Patrice Caillat
Patrice Caillat has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20230095227Abstract: A device is for estimating a blood pressure of a user by a combination of an acoustic mode employing acoustic emitters and acoustic detectors and an optical mode using light sources and photodetectors forming source—detector pairs. The device includes an acoustic selection unit to determine the pertinent acoustic emitter—acoustic detector pair as well as an optical selection unit to determine the pertinent light source—photodetector pairs.Type: ApplicationFiled: September 30, 2022Publication date: March 30, 2023Applicant: Commissariat à l'Energie Atomique et aux Energies AlternativesInventors: Rémi GERBELOT BARILLON, Pierre BLANDIN, Stéphane BONNET, Patrice CAILLAT
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Patent number: 11325126Abstract: A device for preparing a blood sample, including a microfluidic card including: a first chamber for separating and/or extracting proteins to be analyzed that are present in the blood sample; a second chamber used for an operation involving digestion of proteins of different species that are present in the sample, to obtain a second sample containing digested peptides and nondigested proteins; and a third chamber connected to the second chamber to receive the second sample containing the digested peptides and the non-digested proteins, the third chamber being used for an operation involving purification and stabilization of the digested peptides.Type: GrantFiled: March 14, 2017Date of Patent: May 10, 2022Assignee: COMMISSARIAT A L'ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVESInventors: Patrice Caillat, Anne-Gaelle Bourdat, Virginie Brun, Benoit Gilquin
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Publication number: 20210178175Abstract: An optically stimulating module to be integrated into a probe is implantable into a living being with a view to locally illuminating a region of said living being. The module includes a casing that is at least partially transparent, and a hermetic electronic unit placed in the casing. The hermetic electronic unit includes an internal volume housing two light sources, a control and processing unit, and a first photodetector. The module also includes a connecting device for connecting the module to a central control and power unit.Type: ApplicationFiled: December 10, 2020Publication date: June 17, 2021Applicant: Commissariat A L'Energie Atomique et aux Energies AlternativesInventors: Claude CHABROL, Patrice CAILLAT
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Publication number: 20200197939Abstract: A device for preparing a blood sample, including a microfluidic card including: a first chamber for separating and/or extracting proteins to be analyzed that are present in the blood sample; a second chamber used for an operation involving digestion of proteins of different species that are present in the sample, to obtain a second sample containing digested peptides and nondigested proteins; and a third chamber connected to the second chamber to receive the second sample containing the digested peptides and the non-digested proteins, the third chamber being used for an operation involving purification and stabilization of the digested peptides.Type: ApplicationFiled: March 14, 2017Publication date: June 25, 2020Applicant: COMMISSARIAT A L'ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVESInventors: Patrice CAILLAT, Anne-Gaelle BOURDAT, Virginie BRUN, Benoit GILQUIN
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Patent number: 9901934Abstract: A detection method of detecting analytes of interest which are present in a liquid. The detection method including the steps of forming drops of liquid on a first surface by capillary breaking of a finger of liquid, which is initially formed by liquid dielectrophoresis. The thus formed drops each come into contact with a different detection surface, which is arranged facing the first surface. Analytes of interest which are present in each of the drops are detected at the corresponding detection surface.Type: GrantFiled: February 11, 2011Date of Patent: February 27, 2018Assignee: Commissariat à l'énergie atomique et aux énergies alternativesInventors: Vincent Agache, Patrice Caillat, Pierre Puget
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Patent number: 9642602Abstract: The invention relates to a device for transiently contacting at least one unit for capturing biological targets with a body fluid containing them, a method for recovering the captured targets for analysis, and a system for contacting and recovering a capture substrate included in said unit. The invention relates to samples obtained in particular in vivo from body fluids of the human body, e.g. circulating body fluids, said fluids possibly containing, as targets, proteins, oligonucleotides such as RNA or DNA, antibodies, enzymes or cells.Type: GrantFiled: January 10, 2011Date of Patent: May 9, 2017Assignees: Commissariat a l'Energie Atomique et aux Energies Alternatives, Institut National de la Sante Et de la Recherche Medicale (INSERM), Centre Hospitalier Universitaire De Grenoble, Universite Jospeh FourierInventors: Patrice Caillat, François Berger, Raymond Campagnolo, Marie-Line Cosnier, Affif Zaccaria
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Patent number: 8699777Abstract: A method of counting thrombocytes contained in a sample of blood, the method having the steps: mixing said sample with: fluorescent markers suitable for bonding specifically with the thrombocytes; and an agent for inhibiting activation of said thrombocytes; introducing the sample (E) into a fluidic chamber (CF) having at least one transparent face; acquiring at least one digital image (IN) of said sample by fluorescence microscopy under stationary illumination; and counting the thrombocytes (T) present in said or each image by image processing computer means (O). Apparatus for implementing the method.Type: GrantFiled: April 28, 2010Date of Patent: April 15, 2014Assignee: Commissariat a l'energie Atomique et aux Energies AlternativesInventors: Magalie Faivre, Patrice Caillat, Myriam-Laure Cubizolles, Christine Peponnet, Claude Vauchier
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Publication number: 20140008224Abstract: A detection method of detecting analytes of interest which are present in a liquid. The detection method including the steps of forming drops of liquid on a first surface by capillary breaking of a finger of liquid, which is initially formed by liquid dielectrophoresis. The thus formed drops each come into contact with a different detection surface, which is arranged facing the first surface. Analytes of interest which are present in each of the drops are detected at the corresponding detection surface.Type: ApplicationFiled: February 11, 2011Publication date: January 9, 2014Applicant: Commissariat a l'energie atomique et aux ene altInventors: Vincent Agache, Patrice Caillat, Pierre Puget
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Publication number: 20130079663Abstract: The invention relates to a device for transiently contacting at least one unit for capturing biological targets with a body fluid containing them, a method for recovering the captured targets for analysis, and a system for contacting and recovering a capture substrate included in said unit. The invention relates to samples obtained in particular in vivo from body fluids of the human body, e.g. circulating body fluids, said fluids possibly containing, as targets, proteins, oligonucleotides such as RNA or DNA, antibodies, enzymes or cells.Type: ApplicationFiled: January 10, 2011Publication date: March 28, 2013Applicants: CENTRE HOSPITALIER UNIVERSITAIRE DE GRENOBLE, Institut National De La Sante Et De La Recherche Medicale (INSERM), Commissariat A L'Energies Atomique Et Aux Energies Alternatives, UNIVERSITE JOSEPH FOURIERInventors: Patrice Caillat, Francois Berger, Raymond Campagnolo, Marie-Line Cosnier, Affif Zaccaria
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Patent number: 8152736Abstract: A device (6) to sample molecules of biological interest is described. The device (6) includes capture zones (10) whose developed surface area is much greater than the surface so that sampling by contact allows a sufficient quantity of molecules to be obtained to achieve reliable analysis, whilst being sized so that the device (6) is neither invasive nor aggressive. In particular, the device comprises tiered capture zones (10) located on a support (12) fabricated using microtechnology techniques; the capture zones (10) may advantageously be functionalised.Type: GrantFiled: February 2, 2006Date of Patent: April 10, 2012Assignee: Commisariat a l'Energie AtomiqueInventors: Patrice Caillat, Franck Martin, Marie-Line Cosnier
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Publication number: 20110264166Abstract: A lead for deep electrical neurostimulation, the lead comprising: a rod of biocompatible material; and a blade, also of biocompatible material, secured to one end of said rod and in alignment therewith; in which said blade presents two main faces and a plurality of electrodes disposed on at least one of said two main faces in a two-dimensional configuration, said electrodes being connected to conductor elements disposed inside or on a surface of said rod. A deep electrical neurostimulation system comprising: an electrical pulse generator for deep electrical neurostimulation; and at least one lead of the above-described type, having its electrodes electrically connected to said electrical pulse generator.Type: ApplicationFiled: July 5, 2011Publication date: October 27, 2011Applicant: COMMISSARIAT A L'ENERGIE ATOMIQUEInventors: Alim Louis Benabid, Fabien Sauter-Starace, Patrice Caillat
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Patent number: 7991481Abstract: A lead for deep electrical neurostimulation comprising a rod of biocompatible material and a blade, also of biocompatible material, secured to one end of the rod and in alignment therewith. The blade presents two main faces and a plurality of electrodes disposed on at least one of the two main faces in a two-dimensional configuration. The electrodes are connected to conductor elements disposed inside or on a surface of said rod. A deep electrical neurostimulation system comprising an electrical pulse generator connected to at least one lead of the above-described type is also disclosed.Type: GrantFiled: July 2, 2008Date of Patent: August 2, 2011Assignee: Commissariat A L'Energie AtomiqueInventors: Alim Louis Benabid, Fabien Sauter-Starace, Patrice Caillat
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Patent number: 7945336Abstract: Probe (1) for deep electrical neurostimulation, and more specifically for deep brain electrostimulation, comprising: a tubular body (10) of biocompatible material with a lateral wall (11) defining a lumen (12) and a closed anterior end (13), said tubular body (11) can be introduced for at least a part of its length inside a patient's body for reaching a region to be stimulated; wherein it also comprises: a plurality of electrically insulating arms (32) each bearing at least one electrode (40) and being able to pass from a first position in which they are housed inside of said tubular body (11) to a second position in which they project radially from this latter and inversely; and means (20 and 50) for making said arms (32) pass from said first position to said second position and inversely.Type: GrantFiled: December 18, 2007Date of Patent: May 17, 2011Assignee: Commissariat a l'Energie AtomiqueInventors: Fabien Sauter-Starace, Alim Louis Benabid, Patrice Caillat
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Patent number: 7894912Abstract: A lead for deep brain electrical stimulation, to be inserted into liquid cavities, such as ventricles, or cysternae or subarachnoidal spaces, the lead comprising: a tubular body of biocompatible material having a side wall defining a lumen, said tubular body being suitable for being inserted over at least a fraction of its length into the inside of a patient's body in order to reach a region for stimulation; electrodes disposed close to a distal end of the tubular body; and a rigid stylet for inserting removably into the lumen of said tubular body; the lead being wherein said tubular body has an equilibrium shape that is not rectilinear, being different from the shape of the stylet and presenting one and only one bend, and that is sufficiently flexible and elastic to follow the shape of said stylet by deforming reversibly when the stylet is inserted into the lumen.Type: GrantFiled: February 25, 2008Date of Patent: February 22, 2011Assignee: Commissariat a l'Energie AtomiqueInventors: Alim-Louis Benabid, Fabien Sauter-Starace, Patrice Caillat, Stephan Chabardes
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Publication number: 20110002526Abstract: A method of counting thrombocytes contained in a sample of blood, the method having the steps: mixing said sample with: fluorescent markers suitable for bonding specifically with the thrombocytes; and an agent for inhibiting activation of said thrombocytes; introducing the sample (E) into a fluidic chamber (CF) having at least one transparent face; acquiring at least one digital image (IN) of said sample by fluorescence microscopy under stationary illumination; and counting the thrombocytes (T) present in said or each image by image processing computer means (O). Apparatus for implementing the method.Type: ApplicationFiled: April 28, 2010Publication date: January 6, 2011Inventors: Magalie Faivre, Patrice Caillat, Myriam-Laure Cubizolles, Christine Peponnet, Claude Vauchier
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Publication number: 20100049083Abstract: A device (6) to sample molecules of biological interest is described. The device (6) includes capture zones (10) whose developed surface area is much greater than the surface so that sampling by contact allows a sufficient quantity of molecules to be obtained to achieve reliable analysis, whilst being sized so that the device (6) is neither invasive nor aggressive. In particular, the device comprises tiered capture zones (10) located on a support (12) fabricated using microtechnology techniques; the capture zones (10) may advantageously be functionalised.Type: ApplicationFiled: February 2, 2006Publication date: February 25, 2010Applicant: COMMISSARIAT A L'ENERGIE ATOMIQUEInventors: Patrice Caillat, Franck Martin, Marie-Line Cosnier
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Publication number: 20090317835Abstract: A microtechnological device (6) for sampling cells on or in a tissue or other element of the body. It comprises a support (12) having at least one surface of interest (14) on which is present at least one recovery zone (10) comprised of a bottom wall (22) equipped with a plurality of protuberances (24). Preferably, the microtechnological device comprises at least one recovery zone covered with a coating that has the power to attract the cells to be sampled.Type: ApplicationFiled: July 12, 2007Publication date: December 24, 2009Applicant: COMMISSARIAT A L'ENERGIE ATOMIQUEInventors: Marie-Line Cosnier, Patrice Caillat, Franck Martin, François Berger
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Patent number: 7569398Abstract: The present invention relates to a method of transporting an analyte present in a sample, to a method of concentrating an analyte present in a sample, and to a device for implementing these methods. In the method of transporting an analyte present in a sample of the present invention, a solution A in which the analyte is attached to magnetic particles is prepared from the sample; the solution A is introduced into a first container connected via a bottleneck to a second container; and the analyte attached to the magnetic particles is moved, by means of a magnetic system, from the first container to the second container via the bottleneck, the second container being filled with all or part of the solution A and/or with another solution.Type: GrantFiled: November 27, 2001Date of Patent: August 4, 2009Assignee: Commissariat a l'Energie AtomiqueInventors: Pierre Puget, Patrick Pouteau, Frédéric Ginot, Patrice Caillat
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Patent number: 7494622Abstract: A device for measuring electrical activity of biological elements, including a substrate that has lower and upper faces and at least one through opening, the opening being delimited by a set of walls. Two plates are placed on either side of the lower and upper faces of the substrate and delimit, with the set of walls, a chamber. Each of the plates is provided, on its face lying opposite the substrate, with at least one electrode facing the opening in the substrate. Each of the plates further has at least one channel that starts inside the chamber and connects the chamber to the outside of the device, and the chamber communicates with the outside of the device only through the channels.Type: GrantFiled: August 28, 2003Date of Patent: February 24, 2009Assignee: Commissariat a l'Energie AtomiqueInventors: Nathalie Picollet-Dahan, Patrice Caillat, Frederic Revol-Cavalier, Francois Chatelain, Fabien Sauter
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Publication number: 20090012593Abstract: A lead for deep electrical neurostimulation, the lead comprising: a rod of biocompatible material; and a blade, also of biocompatible material, secured to one end of said rod and in alignment therewith; in which said blade presents two main faces and a plurality of electrodes disposed on at least one of said two main faces in a two-dimensional configuration, said electrodes being connected to conductor elements disposed inside or on a surface of said rod. A deep electrical neurostimulation system comprising: an electrical pulse generator for deep electrical neurostimulation; and at least one lead of the above-described type, having its electrodes electrically connected to said electrical pulse generator.Type: ApplicationFiled: July 2, 2008Publication date: January 8, 2009Inventors: Alim Louis Benabid, Fabien Sauter-Starace, Patrice Caillat