Patents by Inventor Patrice Caillat

Patrice Caillat has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 9901934
    Abstract: A detection method of detecting analytes of interest which are present in a liquid. The detection method including the steps of forming drops of liquid on a first surface by capillary breaking of a finger of liquid, which is initially formed by liquid dielectrophoresis. The thus formed drops each come into contact with a different detection surface, which is arranged facing the first surface. Analytes of interest which are present in each of the drops are detected at the corresponding detection surface.
    Type: Grant
    Filed: February 11, 2011
    Date of Patent: February 27, 2018
    Assignee: Commissariat à l'énergie atomique et aux énergies alternatives
    Inventors: Vincent Agache, Patrice Caillat, Pierre Puget
  • Patent number: 9642602
    Abstract: The invention relates to a device for transiently contacting at least one unit for capturing biological targets with a body fluid containing them, a method for recovering the captured targets for analysis, and a system for contacting and recovering a capture substrate included in said unit. The invention relates to samples obtained in particular in vivo from body fluids of the human body, e.g. circulating body fluids, said fluids possibly containing, as targets, proteins, oligonucleotides such as RNA or DNA, antibodies, enzymes or cells.
    Type: Grant
    Filed: January 10, 2011
    Date of Patent: May 9, 2017
    Assignees: Commissariat a l'Energie Atomique et aux Energies Alternatives, Institut National de la Sante Et de la Recherche Medicale (INSERM), Centre Hospitalier Universitaire De Grenoble, Universite Jospeh Fourier
    Inventors: Patrice Caillat, François Berger, Raymond Campagnolo, Marie-Line Cosnier, Affif Zaccaria
  • Patent number: 8699777
    Abstract: A method of counting thrombocytes contained in a sample of blood, the method having the steps: mixing said sample with: fluorescent markers suitable for bonding specifically with the thrombocytes; and an agent for inhibiting activation of said thrombocytes; introducing the sample (E) into a fluidic chamber (CF) having at least one transparent face; acquiring at least one digital image (IN) of said sample by fluorescence microscopy under stationary illumination; and counting the thrombocytes (T) present in said or each image by image processing computer means (O). Apparatus for implementing the method.
    Type: Grant
    Filed: April 28, 2010
    Date of Patent: April 15, 2014
    Assignee: Commissariat a l'energie Atomique et aux Energies Alternatives
    Inventors: Magalie Faivre, Patrice Caillat, Myriam-Laure Cubizolles, Christine Peponnet, Claude Vauchier
  • Publication number: 20140008224
    Abstract: A detection method of detecting analytes of interest which are present in a liquid. The detection method including the steps of forming drops of liquid on a first surface by capillary breaking of a finger of liquid, which is initially formed by liquid dielectrophoresis. The thus formed drops each come into contact with a different detection surface, which is arranged facing the first surface. Analytes of interest which are present in each of the drops are detected at the corresponding detection surface.
    Type: Application
    Filed: February 11, 2011
    Publication date: January 9, 2014
    Applicant: Commissariat a l'energie atomique et aux ene alt
    Inventors: Vincent Agache, Patrice Caillat, Pierre Puget
  • Publication number: 20130079663
    Abstract: The invention relates to a device for transiently contacting at least one unit for capturing biological targets with a body fluid containing them, a method for recovering the captured targets for analysis, and a system for contacting and recovering a capture substrate included in said unit. The invention relates to samples obtained in particular in vivo from body fluids of the human body, e.g. circulating body fluids, said fluids possibly containing, as targets, proteins, oligonucleotides such as RNA or DNA, antibodies, enzymes or cells.
    Type: Application
    Filed: January 10, 2011
    Publication date: March 28, 2013
    Applicants: CENTRE HOSPITALIER UNIVERSITAIRE DE GRENOBLE, Institut National De La Sante Et De La Recherche Medicale (INSERM), Commissariat A L'Energies Atomique Et Aux Energies Alternatives, UNIVERSITE JOSEPH FOURIER
    Inventors: Patrice Caillat, Francois Berger, Raymond Campagnolo, Marie-Line Cosnier, Affif Zaccaria
  • Patent number: 8152736
    Abstract: A device (6) to sample molecules of biological interest is described. The device (6) includes capture zones (10) whose developed surface area is much greater than the surface so that sampling by contact allows a sufficient quantity of molecules to be obtained to achieve reliable analysis, whilst being sized so that the device (6) is neither invasive nor aggressive. In particular, the device comprises tiered capture zones (10) located on a support (12) fabricated using microtechnology techniques; the capture zones (10) may advantageously be functionalised.
    Type: Grant
    Filed: February 2, 2006
    Date of Patent: April 10, 2012
    Assignee: Commisariat a l'Energie Atomique
    Inventors: Patrice Caillat, Franck Martin, Marie-Line Cosnier
  • Publication number: 20110264166
    Abstract: A lead for deep electrical neurostimulation, the lead comprising: a rod of biocompatible material; and a blade, also of biocompatible material, secured to one end of said rod and in alignment therewith; in which said blade presents two main faces and a plurality of electrodes disposed on at least one of said two main faces in a two-dimensional configuration, said electrodes being connected to conductor elements disposed inside or on a surface of said rod. A deep electrical neurostimulation system comprising: an electrical pulse generator for deep electrical neurostimulation; and at least one lead of the above-described type, having its electrodes electrically connected to said electrical pulse generator.
    Type: Application
    Filed: July 5, 2011
    Publication date: October 27, 2011
    Applicant: COMMISSARIAT A L'ENERGIE ATOMIQUE
    Inventors: Alim Louis Benabid, Fabien Sauter-Starace, Patrice Caillat
  • Patent number: 7991481
    Abstract: A lead for deep electrical neurostimulation comprising a rod of biocompatible material and a blade, also of biocompatible material, secured to one end of the rod and in alignment therewith. The blade presents two main faces and a plurality of electrodes disposed on at least one of the two main faces in a two-dimensional configuration. The electrodes are connected to conductor elements disposed inside or on a surface of said rod. A deep electrical neurostimulation system comprising an electrical pulse generator connected to at least one lead of the above-described type is also disclosed.
    Type: Grant
    Filed: July 2, 2008
    Date of Patent: August 2, 2011
    Assignee: Commissariat A L'Energie Atomique
    Inventors: Alim Louis Benabid, Fabien Sauter-Starace, Patrice Caillat
  • Patent number: 7945336
    Abstract: Probe (1) for deep electrical neurostimulation, and more specifically for deep brain electrostimulation, comprising: a tubular body (10) of biocompatible material with a lateral wall (11) defining a lumen (12) and a closed anterior end (13), said tubular body (11) can be introduced for at least a part of its length inside a patient's body for reaching a region to be stimulated; wherein it also comprises: a plurality of electrically insulating arms (32) each bearing at least one electrode (40) and being able to pass from a first position in which they are housed inside of said tubular body (11) to a second position in which they project radially from this latter and inversely; and means (20 and 50) for making said arms (32) pass from said first position to said second position and inversely.
    Type: Grant
    Filed: December 18, 2007
    Date of Patent: May 17, 2011
    Assignee: Commissariat a l'Energie Atomique
    Inventors: Fabien Sauter-Starace, Alim Louis Benabid, Patrice Caillat
  • Patent number: 7894912
    Abstract: A lead for deep brain electrical stimulation, to be inserted into liquid cavities, such as ventricles, or cysternae or subarachnoidal spaces, the lead comprising: a tubular body of biocompatible material having a side wall defining a lumen, said tubular body being suitable for being inserted over at least a fraction of its length into the inside of a patient's body in order to reach a region for stimulation; electrodes disposed close to a distal end of the tubular body; and a rigid stylet for inserting removably into the lumen of said tubular body; the lead being wherein said tubular body has an equilibrium shape that is not rectilinear, being different from the shape of the stylet and presenting one and only one bend, and that is sufficiently flexible and elastic to follow the shape of said stylet by deforming reversibly when the stylet is inserted into the lumen.
    Type: Grant
    Filed: February 25, 2008
    Date of Patent: February 22, 2011
    Assignee: Commissariat a l'Energie Atomique
    Inventors: Alim-Louis Benabid, Fabien Sauter-Starace, Patrice Caillat, Stephan Chabardes
  • Publication number: 20110002526
    Abstract: A method of counting thrombocytes contained in a sample of blood, the method having the steps: mixing said sample with: fluorescent markers suitable for bonding specifically with the thrombocytes; and an agent for inhibiting activation of said thrombocytes; introducing the sample (E) into a fluidic chamber (CF) having at least one transparent face; acquiring at least one digital image (IN) of said sample by fluorescence microscopy under stationary illumination; and counting the thrombocytes (T) present in said or each image by image processing computer means (O). Apparatus for implementing the method.
    Type: Application
    Filed: April 28, 2010
    Publication date: January 6, 2011
    Inventors: Magalie Faivre, Patrice Caillat, Myriam-Laure Cubizolles, Christine Peponnet, Claude Vauchier
  • Publication number: 20100049083
    Abstract: A device (6) to sample molecules of biological interest is described. The device (6) includes capture zones (10) whose developed surface area is much greater than the surface so that sampling by contact allows a sufficient quantity of molecules to be obtained to achieve reliable analysis, whilst being sized so that the device (6) is neither invasive nor aggressive. In particular, the device comprises tiered capture zones (10) located on a support (12) fabricated using microtechnology techniques; the capture zones (10) may advantageously be functionalised.
    Type: Application
    Filed: February 2, 2006
    Publication date: February 25, 2010
    Applicant: COMMISSARIAT A L'ENERGIE ATOMIQUE
    Inventors: Patrice Caillat, Franck Martin, Marie-Line Cosnier
  • Publication number: 20090317835
    Abstract: A microtechnological device (6) for sampling cells on or in a tissue or other element of the body. It comprises a support (12) having at least one surface of interest (14) on which is present at least one recovery zone (10) comprised of a bottom wall (22) equipped with a plurality of protuberances (24). Preferably, the microtechnological device comprises at least one recovery zone covered with a coating that has the power to attract the cells to be sampled.
    Type: Application
    Filed: July 12, 2007
    Publication date: December 24, 2009
    Applicant: COMMISSARIAT A L'ENERGIE ATOMIQUE
    Inventors: Marie-Line Cosnier, Patrice Caillat, Franck Martin, François Berger
  • Patent number: 7569398
    Abstract: The present invention relates to a method of transporting an analyte present in a sample, to a method of concentrating an analyte present in a sample, and to a device for implementing these methods. In the method of transporting an analyte present in a sample of the present invention, a solution A in which the analyte is attached to magnetic particles is prepared from the sample; the solution A is introduced into a first container connected via a bottleneck to a second container; and the analyte attached to the magnetic particles is moved, by means of a magnetic system, from the first container to the second container via the bottleneck, the second container being filled with all or part of the solution A and/or with another solution.
    Type: Grant
    Filed: November 27, 2001
    Date of Patent: August 4, 2009
    Assignee: Commissariat a l'Energie Atomique
    Inventors: Pierre Puget, Patrick Pouteau, Frédéric Ginot, Patrice Caillat
  • Patent number: 7494622
    Abstract: A device for measuring electrical activity of biological elements, including a substrate that has lower and upper faces and at least one through opening, the opening being delimited by a set of walls. Two plates are placed on either side of the lower and upper faces of the substrate and delimit, with the set of walls, a chamber. Each of the plates is provided, on its face lying opposite the substrate, with at least one electrode facing the opening in the substrate. Each of the plates further has at least one channel that starts inside the chamber and connects the chamber to the outside of the device, and the chamber communicates with the outside of the device only through the channels.
    Type: Grant
    Filed: August 28, 2003
    Date of Patent: February 24, 2009
    Assignee: Commissariat a l'Energie Atomique
    Inventors: Nathalie Picollet-Dahan, Patrice Caillat, Frederic Revol-Cavalier, Francois Chatelain, Fabien Sauter
  • Publication number: 20090012593
    Abstract: A lead for deep electrical neurostimulation, the lead comprising: a rod of biocompatible material; and a blade, also of biocompatible material, secured to one end of said rod and in alignment therewith; in which said blade presents two main faces and a plurality of electrodes disposed on at least one of said two main faces in a two-dimensional configuration, said electrodes being connected to conductor elements disposed inside or on a surface of said rod. A deep electrical neurostimulation system comprising: an electrical pulse generator for deep electrical neurostimulation; and at least one lead of the above-described type, having its electrodes electrically connected to said electrical pulse generator.
    Type: Application
    Filed: July 2, 2008
    Publication date: January 8, 2009
    Inventors: Alim Louis Benabid, Fabien Sauter-Starace, Patrice Caillat
  • Publication number: 20080255646
    Abstract: A lead for deep brain electrical stimulation, to be inserted into liquid cavities, such as ventricles, or cysternae or subarachnoidal spaces, the lead comprising: a tubular body of biocompatible material having a side wall defining a lumen, said tubular body being suitable for being inserted over at least a fraction of its length into the inside of a patient's body in order to reach a region for stimulation; electrodes disposed close to a distal end of the tubular body; and a rigid stylet for inserting removably into the lumen of said tubular body; the lead being wherein said tubular body has an equilibrium shape that is not rectilinear, being different from the shape of the stylet and presenting one and only one bend, and that is sufficiently flexible and elastic to follow the shape of said stylet by deforming reversibly when the stylet is inserted into the lumen.
    Type: Application
    Filed: February 25, 2008
    Publication date: October 16, 2008
    Inventors: Alim-Louis Benabid, Fabien Sauter-Starace, Patrice Caillat, Stephan Chabardes
  • Publication number: 20080161896
    Abstract: Probe (1) for deep electrical neurostimulation, and more specifically for deep brain electrostimulation, comprising: a tubular body (10) of biocompatible material with a lateral wall (11) defining a lumen (12) and a closed anterior end (13), said tubular body (11) can be introduced for at least a part of its length inside a patient's body for reaching a region to be stimulated; wherein it also comprises: a plurality of electrically insulating arms (32) each bearing at least one electrode (40) and being able to pass from a first position in which they are housed inside of said tubular body (11) to a second position in which they project radially from this latter and inversely; and means (20 and 50) for making said arms (32) pass from said first position to said second position and inversely.
    Type: Application
    Filed: December 18, 2007
    Publication date: July 3, 2008
    Inventors: Fabien Sauter-Starace, Alim Louis Benabid, Patrice Caillat
  • Publication number: 20070276193
    Abstract: The invention relates to an in vivo diagnostic or therapy micro-device comprising a substantially longitudinal body provided with preferably parallel faces comprising, in the direction of its length, at least one main canal (24), one input (18) of which is located at a first end (14) of the body.
    Type: Application
    Filed: November 19, 2004
    Publication date: November 29, 2007
    Inventors: Florence Rivera, Patrice Caillat, Martine Cochet, Jean Berthier
  • Publication number: 20070207055
    Abstract: The present invention relates to an operating device characterized in that it comprises an active surface that is substantially non-wetting with respect to a liquid of interest; at least one zone for the localized capture of a drop of said liquid formed on said active surface; at least one operating zone arranged with a capture zone in such a way that the operating zone is at least partially covered by the drop of the liquid when said drop is captured by said capture zone; and means for leaving a drop of said liquid on said capture zone. This device makes it possible in particular to form high-density arrays of drops of said liquid on a surface, with the aim in particular of carrying out chemical and/or biochemical reactions and/or of analysing the liquid of interest in each drop. It finds, for example, an application in biological chips.
    Type: Application
    Filed: October 21, 2003
    Publication date: September 6, 2007
    Applicant: Commissariat A L'Energie Atomique
    Inventors: Gilles Marchand, Cyril Delattre, Patrick Pouteau, Patrice Caillat