Abstract: A lead for deep brain electrical stimulation, to be inserted into liquid cavities, such as ventricles, or cysternae or subarachnoidal spaces, the lead comprising: a tubular body of biocompatible material having a side wall defining a lumen, said tubular body being suitable for being inserted over at least a fraction of its length into the inside of a patient's body in order to reach a region for stimulation; electrodes disposed close to a distal end of the tubular body; and a rigid stylet for inserting removably into the lumen of said tubular body; the lead being wherein said tubular body has an equilibrium shape that is not rectilinear, being different from the shape of the stylet and presenting one and only one bend, and that is sufficiently flexible and elastic to follow the shape of said stylet by deforming reversibly when the stylet is inserted into the lumen.

Abstract: Probe (1) for deep electrical neurostimulation, and more specifically for deep brain electrostimulation, comprising: a tubular body (10) of biocompatible material with a lateral wall (11) defining a lumen (12) and a closed anterior end (13), said tubular body (11) can be introduced for at least a part of its length inside a patient's body for reaching a region to be stimulated; wherein it also comprises: a plurality of electrically insulating arms (32) each bearing at least one electrode (40) and being able to pass from a first position in which they are housed inside of said tubular body (11) to a second position in which they project radially from this latter and inversely; and means (20 and 50) for making said arms (32) pass from said first position to said second position and inversely.

Abstract: The invention relates to an in vivo diagnostic or therapy micro-device comprising a substantially longitudinal body provided with preferably parallel faces comprising, in the direction of its length, at least one main canal (24), one input (18) of which is located at a first end (14) of the body.

Abstract: The present invention relates to an operating device characterized in that it comprises an active surface that is substantially non-wetting with respect to a liquid of interest; at least one zone for the localized capture of a drop of said liquid formed on said active surface; at least one operating zone arranged with a capture zone in such a way that the operating zone is at least partially covered by the drop of the liquid when said drop is captured by said capture zone; and means for leaving a drop of said liquid on said capture zone. This device makes it possible in particular to form high-density arrays of drops of said liquid on a surface, with the aim in particular of carrying out chemical and/or biochemical reactions and/or of analysing the liquid of interest in each drop. It finds, for example, an application in biological chips.

Abstract: This invention relates to a cerebral electrostimulation device containing a commutation device (300) comprising at least one input and several outputs each connected to at least one biocompatible electrode or at least one active area (202) of a biocompatible electrode (200), the commutation device (300) being used to selectively connect at least one input to one or more outputs. This electrostimulation device may be used for methods of diagnostic or therapy for the treatment of some pathologies, for example such as epilepsy or Parkinson's disease.

Abstract: A device for measuring electrical activity of biological elements, including a substrate that has lower and upper faces and at least one through opening, the opening being delimited by a set of walls. Two plates are placed on either side of the lower and upper faces of the substrate and delimit, with the set of walls, a chamber. Each of the plates is provided, on its face lying opposite the substrate, with at least one electrode facing the opening in the substrate. Each of the plates further has at least one channel that starts inside the chamber and connects the chamber to the outside of the device, and the chamber communicates with the outside of the device only through the channels.

Abstract: The invention relates to a micro-system intended to receive beads and to obtain a precise positioning of the beads at preset locations in the micro-system. This micro-system comprises a tank that has a cavity, the cavity being fitted with blocking elements allowing the beads to be ordered and stacked in the interstices between the blocking elements, the interstices constituting the preset locations. It also comprises a cap anchored hermetically to the tank and input means and output means allowing a fluid to flow in the cavity. The invention also relates to the implementation and use of the bead-filled micro-system.

Abstract: The subject of the invention is a device for chemical or biological analysis comprising a carrier (21) containing a plurality of analysis sites able to fix a chemical or biological reagent, in which the analysis sites are formed of microdishes (23) hollowed out of the carrier, the side walls and the bottom of the microdishes and the areas of the carrier surface surrounding each microdish, called microdish edges, being made in at least one hydrophilic material (24), and the planar areas of the carrier arranged between the areas surrounding the microdishes being made in a hydrophobic material (27). Drops (29) of reagent are therefore guided into the microdishes (23) on account of the hydrophobic areas (27). It is therefore possible to increase the density of analysis sites on the carrier.

Abstract: The present invention relates to a method to produce a biochip and to a biochip, said biochip being composed particularly of biological probes grafted onto a conductive polymer. The method according to the invention comprises the following steps: a) structuring of a substrate so as to obtain on said substrate microtroughs comprising in their base a layer of a material capable of initiating and promoting the adhesion onto said layer of a film of a pyrrole and functionalised pyrrole copolymer by electropolymerisation, b) collective electropolymerisation, so as to form an electropolymerised film of a pyrrole and functionalised pyrrole copolymer on the base of said microtroughs, c) direct or indirect fixation of functionalised oligonucleotides by microdeposition or a liquid jet printing technique.

Abstract: The invention concerns the use of a miniature device for separating and isolating biological objects for various applications in the field of molecular biology, methods for making DNA or protein chips in particular, and the DNA or protein chips obtained by using said methods.

Abstract: The invention concerns a miniature device for separating and isolating biological objects, the use of said device for isolating, separating, culturing and/or analysing biological objects and a method for separating and isolating biological objects using said device.

Abstract: The present invention relates to a method of transporting an analyte present in a sample, to a method of concentrating an analyte present in a sample, and to a device for implementing these methods.

Abstract: A chemical or biological analysis multi-point micro-system including a structure equipped with micro-wells, each micro-well being intended to receive a reagent coupled with a conductive polymer. Each micro-well includes a reception electrode on which the reagent is fixed by the conductive polymer with which it is coupled. Each micro-well also includes a counter-electrode arranged so as to be able to apply, in a volume of the micro-well, an electric field between its counter-electrode and its reception electrode. The structure further enables the simultaneous connection of all the reception electrodes to a first electric potential and enables the simultaneous connection of all the counter-electrodes to a second electric potential to be able to set up the electric field.

Abstract: A method and device for testing an electronic chip (10) having on the surface a plurality of addressable electrically conductive sensitive elements (12) in which the sensitive elements on the chip are put in contact with a conductive solution (52), one or more sensitive elements (12) are addressed selectively in order to apply to each sensitive element addressed an electrical test signal referred to as an input signal, and a signal, referred to as the output signal, on an electrode (60, 60a) also in contact with the conductive solution, is measured.

Abstract: Device comprising a carrier (100) and at least one cover (104) able to be bonded to the carrier to form with the carrier at least one cavity (114) having a controlled atmosphere around at least one component (102). In accordance with the invention, at least one of either the cover or the carrier is provided with at least one wedge (110) in fusible material and a strip of insulation (112) formed around said component, and before bonding, the wedge of fusible material is of sufficient thickness to prevent the strip of insulation (112) from coming into contact both with the cover and with the carrier when they are assembled together. Particular application to the encapsulation of electronic, mechanical or electromagnetic components.

Abstract: A process for manufacturing an anisotropic conducting film including an insulating film in which holes are formed. Conducting inserts are located in the holes. First ends of the inserts project from one side of the insulating film, from a substrate in which compartments are formed on one surface, corresponding to the distribution of inserts on the insulating film, the shape of the compartments being complementary to the shape of the first ends of the inserts. The manufacturing process includes the steps of using a substrate with compartments with a tipped finish, producing an insulating film above the substrate with holes facing the compartments, producing conducting inserts in the holes and the compartments, and separating the insulating film in which the conducting inserts are formed.

Abstract: Assembly allowing for connection of optical fibres with optical or optoelectronic components and process for manufacturing this assembly. According to the invention, at least one fibre support (4, 6) is formed including, for each fibre (2), a V-shaped housing. The support and the component (32) are attached to a substrate (12) with meltable elements (16, 38) and the fibre is positioned in the housing so as to vertically align the fibre with the component, horizontal alignment being obtained by the melted elements. Application is to microelectronics.

Abstract: The invention concerns an analysis device including at least one chip (110) equipped with a plurality of analysis electrodes (112). In accordance with the invention, the device also includes means of individual heating (150) of the analysis electrodes. The invention can be used for the analysis of chemical or biological products, for example in an antigen/antibody recognition or DNA/DNA analysis.

Abstract: Process for the production of a sealing and mechanical strength ring between a substrate and a chip hybridized by bumps on the substrate. The invention provides a process for producing an encapsulating ring (13) ensuring the sealing and mechanical strength of a chip (1) hybridized by bumps on a substrate (5). More particularly, contemporaneously with the production of the hybridization bumps (9) on the lower face (1a) of the chip or the substrate by a first meltable material, a sealing and mechanical strength ring is formed by depositing on the substrate or lower face of the electronic component a ring (13) of a second meltable material.

Abstract: An analysis micro-system with integrated cuvette comprising:a chip support (250) having at least one cuvette (252),at least one chip (210) arranged in each cuvette, the chip comprising analysis electrodes (212) and addressing electrodes (214), andconnection means (258, 260, 262) to connect the addressing electrodes to at least one electrical apparatus external to the micro-system.Conforming to the invention, the connection means comprise connection terminals (258) arranged on the support, outside the cuvette (252), and electrical links (260, 262) connecting the connection terminals (258) to the addressing electrodes.Application to the analysis of chemical and biological products.