Abstract: The present invention provides methods of making engineered viral proteins and protein complexes that are useful as vaccine immunogens, engineered viral proteins and protein complexes made using such methods, and pharmaceutical compositions comprising such engineered viral proteins and protein complexes. Such engineered viral proteins and protein complexes may comprise one or more cross-links that stabilize the conformation of an antibody epitope, such as a quaternary neutralizing antibody, and may exhibit an enhanced ability to elicit a protective immune response when administered to a subject as a component of a vaccine.

Abstract: The present invention provides methods of making engineered viral proteins and protein complexes that are useful as vaccine immunogens, engineered viral proteins and protein complexes made using such methods, and pharmaceutical compositions comprising such engineered viral proteins and protein complexes. Such engineered viral proteins and protein complexes may comprise one or more cross-links that stabilize the conformation of an antibody epitope, such as a quaternary neutralizing antibody, and may exhibit an enhanced ability to elicit a protective immune response when administered to a subject as a component of a vaccine.

Abstract: In some embodiments, the present invention provides respiratory syncytial virus (RSV) F proteins, polypeptides and protein complexes that comprise one or more cross-links to stabilize the protein, polypeptide or protein complex in its pre-fusion conformation. In some embodiments the present invention provides RSV F proteins, polypeptides and protein complexes comprising one or more mutations to facilitate such cross-linking. In some embodiments the present invention provides compositions comprising such proteins, polypeptides or protein complexes, including vaccine compositions, and methods of making and using the same.

Abstract: In some embodiments the present invention provides influenza hemagglutinin (“HA”) polypeptides, proteins, and protein complexes that comprise a stalk domain that is engineered to facilitate maintenance of its native trimeric conformation, even if the head domain of the HA protein is removed or disrupted. In some embodiments, the present invention provides compositions comprising such polypeptides, proteins, and protein complexes, and methods of use of such proteins and compositions, for example as vaccine immunogens.

Abstract: A novel tank cryogenic-compatible composite pressure vessel that beneficially utilizes Vapor Cooled Shielding (VCS) is introduced to minimize thermal gradients along support structures and reduces heat loads on cryogenic systems. In particular, the configurations and mechanisms to be utilized herein include: providing for a desired number of passageways and a given thickness of the VCS, reducing the thermal conductivity of the VCS material, and increasing the cooling capacitance of the hydrogen vapors.

Abstract: A novel tank cryogenic-compatible composite pressure vessel that beneficially utilizes Vapor Cooled Shielding (VCS) is introduced to minimize thermal gradients along support structures and reduces heat loads on cryogenic systems. In particular, the configurations and mechanisms to be utilized herein include: providing for a desired number of passageways and a given thickness of the VCS, reducing the thermal conductivity of the VCS material, and increasing the cooling capacitance of the hydrogen vapors.

Abstract: In some embodiments the present invention provides influenza hemagglutinin (“HA”) polypeptides, proteins, and protein complexes that comprise a stalk domain that is engineered to facilitate maintenance of its native trimeric conformation, even if the head domain of the HA protein is removed or disrupted. In some embodiments, the present invention provides compositions comprising such polypeptides, proteins, and protein complexes, and methods of use of such proteins and compositions, for example as vaccine immunogens.

Abstract: In some embodiments the present invention provides influenza hemagglutinin (“HA”) polypeptides, proteins, and protein complexes that comprise a stalk domain that is engineered to facilitate maintenance of its native trimeric conformation, even if the head domain of the HA protein is removed or disrupted. In some embodiments, the present invention provides compositions comprising such polypeptides, proteins, and protein complexes, and methods of use of such proteins and compositions, for example as vaccine immunogens.

Abstract: A novel tank cryogenic-compatible composite pressure vessel that beneficially utilizes Vapor Cooled Shielding (VCS) is introduced to minimize thermal gradients along support structures and reduces heat loads on cryogenic systems. In particular, the configurations and mechanisms to be utilized herein include: providing for a desired number of passageways and a given thickness of the VCS, reducing the thermal conductivity of the VCS material, and increasing the cooling capacitance of the hydrogen vapors.

Abstract: In some embodiments the present invention provides influenza hemagglutinin (“HA”) polypeptides, proteins, and protein complexes that comprise a stalk domain that is engineered to facilitate maintenance of its native trimeric conformation, even if the head domain of the HA protein is removed or disrupted. In some embodiments, the present invention provides compositions comprising such polypeptides, proteins, and protein complexes, and methods of use of such proteins and compositions, for example as vaccine immunogens.

Abstract: In some embodiments, the present invention provides respiratory syncytial virus (RSV) F proteins, polypeptides and protein complexes that comprise one or more cross-links to stabilize the protein, polypeptide or protein complex in its pre-fusion conformation. In some embodiments the present invention provides RSV F proteins, polypeptides and protein complexes comprising one or more mutations to facilitate such cross-linking. In some embodiments the present invention provides compositions comprising such proteins, polypeptides or protein complexes, including vaccine compositions, and methods of making and using the same.

Abstract: A multi-sensor system can be attached to a high voltage power line, draw power from the power line inductively, and convert the power to lower voltages and direct currents for operating cameras, sensors, a processor, and communications equipment that provide persistent intelligence, surveillance, and reconnaissance capabilities. The multi-sensor system can detect and track targets in detection regions and transmit such detection data and other data from the camera and sensors to a remote operator who can initiate response actions and send control instructions to the multi-sensor system from the remote location.

Abstract: Improvements in a leveling table top are disclosed. The adjustable leveling table top comprises a lower platform having a bottom portion and a top portion and an upper platform with a locking adjustable swivel mechanism centrally affixed there between. The upper and lower platforms are further coupled through sliding arms affixed to the left and right sides, wherein both sides have two sliding arms. The lower platform has a plurality of legs extending therefrom, and the upper platform has a bubble level. To create a level surface, the leveling table top is placed so that the legs engage a desired surface the upper platform is manipulated around the swivel mechanism while the lower platform remains stationary, upon reaching a sufficiently level position for the upper platform as determined by the bubble level, the swivel mechanism and the sliding arms are locked.

Abstract: An apparatus and method provide rotation of avian enclosures. In a first mode of operation, the apparatus automatically rotates the avian enclosure at a slow speed when a bird is detected, and automatically rotates the avian enclosure at a faster speed when a larger animal, such as a squirrel, is detected. In a second mode of operation, the apparatus may be controlled using a wireless remote control to perform a desired action. In a third mode of operation, the apparatus sends one or more signals via wireless transmission to a wireless notification device, which notifies a user of the presence of a bird or a larger animal. The user then has the option of using a wireless remote control to perform a desired action, which may include rotating the avian enclosure at a desired speed, stopping rotation of the avian enclosure, activating a beeper or vibrator, etc.

Abstract: A bird feeder that includes a container having top and bottom ends spaced apart in a first direction, and a cylindrical wall surrounding a central region between the top and bottom ends to hold bird feed. The container also includes a plurality of feeding openings in the wall to provide access to the bird feed in the container. The plurality of feeding openings are spaced at a respective distance from the top end toward the bottom end. The bird feeder also includes a generally helical member having a first end portion and a second end portion. The helical member is wound around the container in a spiral manner along a generally helical path between the top and bottom ends. Top and bottom caps are also provided to close the top and bottom ends of the bird feed container. Both the top and bottom caps can be removed from the container.

Abstract: An apparatus and method provide rotation of avian enclosures. In a first mode of operation, the apparatus automatically rotates the avian enclosure at a slow speed when a bird is detected, and automatically rotates the avian enclosure at a faster speed when a larger animal, such as a squirrel, is detected. In a second mode of operation, the apparatus may be controlled using a wireless remote control to perform a desired action. In a third mode of operation, the apparatus sends one or more signals via wireless transmission to a wireless notification device, which notifies a user of the presence of a bird or a larger animal. The user then has the option of using a wireless remote control to perform a desired action, which may include rotating the avian enclosure at a desired speed, stopping rotation of the avian enclosure, activating a beeper or vibrator, etc.

Abstract: An artificial campfire device is disclosed and is fueled by a pressurized fuel source. The device includes a base receptacle which defines an open top, the base receptacle being adapted for placement on a ground surface. A burner member is positioned within the receptacle and is adapted to provide a flame of variable height. A fuel control mechanism is adapted for coupling a pressurized fuel source with the burner member for controlling the flow of fuel to the burner member and the size of flame emitted by the burner member. Finally, a plurality of artificial refractory log members are adapted for assembly in crisscross fashion to form a log cluster in the base receptacle.

Abstract: An artificial campfire device is disclosed. The device is fueled by a pressurized fuel source and is adapted for permanent mounting to a fixed ground member. The device includes a base receptacle having a peripheral edge defining an open top and an interior bottom surface. The base receptacle is mountable to the fixed ground member. A burner member is mounted to and positioned above the interior bottom surface and is adapted to provide a flame of variable height. A fuel control mechanism is adapted for coupling a pressurized fuel source exterior to the receptacle base with the burner member to control the flow of fuel to the burner member and the size of flame emitted thereby. Finally, a plurality of artificial refractory log members are secured to each other in crisscross fashion to form a log cluster, and the log cluster is permanently secured to the base receptacle bottom surface.

Abstract: A tracheotomy tube water blocking system including a strap adapted for securement around a neck of a wearer. The strap has an aperture through a front portion thereof. The aperture has a cylindrical collar secured therein. The cylindrical collar has an open inner end and an open outer end. The open inner end is dimensioned for coupling with an existing tracheotomy tube of the wearer. An air flow tube is provided having a generally inverted L-shaped configuration. The air flow tube has an upper horizontal portion with an open inner end coupling with the open outer end of the cylindrical collar. The air flow tube includes a lower vertical portion extending downwardly from the upper horizontal portion. The lower vertical portion having an open lower end.

Abstract: A portable artificial campfire device is disclosed. The device includes a receptacle having upper and lower portions, an open top defined by a peripheral edge of the upper portion, and an interior bottom surface. A burner is positioned above the interior bottom surface and is adapted to provide a flame of variable height. A pressurized fuel source is positioned exterior to the receptacle, and a control member couples the fuel source with the burner for controlling the flow of fuel to the burner and the size of flame emitted by the burner. A plurality of artificial refractory log members are secured to each other in crisscross fashion to form a log cluster. A structure is provided for supporting the log cluster within the receptacle. Finally, a mechanism is provided for selectively adjusting the vertical position of the log cluster in the receptacle to vary the vertical position of the log cluster relative to the plane the open top.