Abstract: A radiation source assembly comprises a source base, a UV transparent sleeve, and a UV lamp. The source base comprises a sealed electrical connection interface and an opposing sealed sleeve interface. The sealed electrical connection interface comprises a electrical contacts and the sealed sleeve interface comprise a radial sealing element, an outer collar, and a compression ring. The UV transparent sleeve is engaged with the sleeve interface such that the radial sealing element of the sealed sleeve interface is disposed between the UV transparent sleeve and the outer collar of the source base, and the compression ring is positioned over the UV transparent sleeve and engaged with the source base to compress the radial sealing element onto the UV transparent sleeve and the outer collar. The UV lamp is disposed within the UV transparent sleeve and electrically coupled to the electrical contacts of the electrical connection interface.

Abstract: A radiation source assembly comprises a source base, a UV transparent sleeve, and a UV lamp. The source base comprises a sealed electrical connection interface and an opposing sealed sleeve interface. The sealed electrical connection interface comprises a electrical contacts and the sealed sleeve interface comprise a radial sealing element, an outer collar, and a compression ring. The UV transparent sleeve is engaged with the sleeve interface such that the radial sealing element of the sealed sleeve interface is disposed between the UV transparent sleeve and the outer collar of the source base, and the compression ring is positioned over the UV transparent sleeve and engaged with the source base to compress the radial sealing element onto the UV transparent sleeve and the outer collar. The UV lamp is disposed within the UV transparent sleeve and electrically coupled to the electrical contacts of the electrical connection interface.

Abstract: Provided herein are recombinant nucleic acids encoding T cell receptor (TCR) fusion proteins (TFPs), modified ?? T cells expressing the encoded molecules, and methods of use thereof for the treatment of diseases, including cancer.

Abstract: The invention relates to bispecific antibodies comprising a first antigen binding domain that specifically binds to PD1 and a second antigen binding domain that specifically binds to LAG3. The invention further relates to methods of producing these molecules and to methods of using the same.

Abstract: Provided herein are recombinant nucleic acids encoding T cell receptor (TCR) fusion proteins (TFPs), modified human immune cells expressing the encoded molecules, and methods of use thereof for the treatment of diseases, including cancer.

Abstract: A cabinet heater system and devices comprising an air plenum thermostat controller are discussed herein. Embodiments of the present invention include a cabinet heater system comprising a housing, and a thermostat mounted within an air plenum formed within a cavity of the housing, configured to sense air plenum temperature and maintain a set temperature. A mounting unit secure positioning of at least one of a heating unit, an air moving device, and the thermostat. A control compartment, separate from the air plenum cavity can further house controls configured to adjust the thermostat and one or more components of the cabinet heater system and devices.

Abstract: An electrical fuse includes a housing, first and second terminal assemblies coupled to the housing, and at least one fuse element assembly extending internally in the housing and coupled between the first and second terminal assemblies. A filler surrounds the at least one fuse element assembly, and the filler includes sodium silicate sand and at least one reinforcing structure suspended within the filler.

Abstract: The embodiments disclosed herein are related to a computing system for generating a mask-augmented inverted index. The mask-augmented inverted index is structured to allow phrase query searching while minimizing the amount of computing system processing and memory resources needed to generate the mask-augmented inverted index. In one embodiment, a first token is mapped to a first listing of documents that include the first token. A first mask is included that comprises a probabilistic representation of a set of integers corresponding to one or more locations of the first token in each of the individual documents of the first listing. A second mask is included that comprises a probabilistic representation of a set of integers that indicate a positional relationship between the first token and one or more other tokens in each of the individual documents of the first listing.

Abstract: The invention relates to bispecific antibodies comprising a first antigen binding domain that specifically binds to PD1 and a second antigen binding domain that specifically binds to LAG3. The invention further relates to methods of producing these molecules and to methods of using the same.

Abstract: Aspects of the invention are directed to characteristics and parameters of color coatings on keratin fibers. The color coatings are produced from compositions of several kinds of polymers that enable the color coatings to exhibit adherence, remanence, wear fastness and resistance to environmental attack.

Abstract: A film coating for keratin fibers is described. The film coating is produced by applying to the keratin fibers a pretreatment composition and a film forming composition and curing the compositions to produce the film coating. The coating may be clear and function as a styling, conditioning and holding. The coating alternatively may contain pigment particles and provide a color coating.

Abstract: Provided herein are recombinant nucleic acids encoding T cell receptor (TCR) fusion proteins (TFPs) and a TCR constant domain, modified T cells expressing the encoded molecules, and methods of use thereof for the treatment of diseases, including cancer.

Abstract: Provided herein are T cell receptor (TCR) fusion proteins (TFPs), T cells engineered to express one or more MUC16 or IL 13R?2 or MSLN TFPs, and methods of use thereof for the treatment of diseases, including cancer.

Abstract: A doubly curved reflector for compact storage in a folded state includes a plurality of gores, each gore having on either long side a gore side curve. At least one hinge is mechanically coupled between each adjacent gore, the at least one hinge including a fold roll hinge or a living hinge. In a stowed doubly curved reflector state each gore folds about the at least one hinge when folded closed such that a face surface of each gore folds against an adjacent face surface of another gore into a substantially cylindrical structure. In a deployed doubly curved reflector state, each hinge. A doubly curved reflector for compact storage in a folded state and a locked open state, a method of manufacture, and a method for designing a substantially wrinkle free doubly curved foldable reflector having gores of a composite material are also described.

Abstract: The present disclosure discloses trehalose for use in treatment of neurological disorders, wherein the trehalose is for a single daily administration with the daily dose between about 0.25 to about 12.5 g/kg/day. The daily dose may be about 2.67 g/kg/day. A method for treating a neurological disorders is disclosed which involves administering trehalose to a subject as a single daily administration with a daily dose between about 0.25 to about 12.5 g/kg/day and in an embodiment of this method the daily dose is about 2.67 g/kg/day. Also disclosed herein is the use of trehalose in the manufacture of a medicament for treatment of neurological disorders, wherein the trehalose is formulated as a single daily dose with the trehalose present in the medicament in an amount of between about 0.25 to about 12.5 g/kg/day. In an embodiment the daily dose is about 2.67 g/kg/day.

Abstract: Provided herein are T cell receptor (TCR) fusion proteins (TFPs) having specificity for more than one tumor cell associated antigen, T cells engineered to express one or more TFP, and methods of use thereof for the treatment of diseases, including cancer.

Abstract: A high-performance distributed ledger and transaction computing network fabric over which large numbers of transactions (involving the transformation, conversion or transfer of information or value) are processed concurrently in a scalable, reliable, secure and efficient manner. In one embodiment, the computing network fabric or “core” is configured to support a distributed blockchain network that organizes data in a manner that allows communication, processing and storage of blocks of the chain to be performed concurrently, with little synchronization, at very high performance and low latency, even when the transactions themselves originate from distant sources. This data organization relies on segmenting a transaction space within autonomous but cooperating computing nodes that are configured as a processing mesh. Each computing node typically is functionally-equivalent to all other nodes in the core.

Abstract: An embodiment of an arc flash reduction maintenance system includes a pyrotechnic disconnect module and an overcurrent protection device connected to the pyrotechnic disconnect module. A control line is connected to the at least one pyrotechnic disconnect module and in parallel with one of the pyrotechnic disconnect module and the overcurrent protection device. The control line provides a self-generating control signal to cause the pyrotechnic disconnect module to electrically isolate the overcurrent protection device. A switch is located in the control line to selectively enable or disable at least one arc flash reduction maintenance system mode in the control line.