Abstract: Various embodiments of the present disclosure provide computer forecasting techniques for forecasting holistic, causal risk-based scores. The techniques may include generating a predictive risk-based opportunity score for an evaluation entity based on (i) a plurality of engagement scores and (ii) a plurality of predictive risk scores respectively corresponding to a plurality of predictive entities within an entity cohort associated with the evaluation entity. Using action-specific causal inference models, a predictive impact score of a prediction-based action on the evaluation entity is generated and used to generate a causal gap closure score for the evaluation entity based on a gap closure rate associated with the evaluation entity. The techniques include generating a causal risk-based impact score for the prediction-based action and the evaluation entity based on the predictive risk-based opportunity score, the predictive impact score, and a predictive improvement measure.

Abstract: Various embodiments of the present disclosure provide computer forecasting techniques for forecasting holistic, categorical improvement predictions. The techniques may include generating a predictive quality performance measure based on (i) an evaluation entity of a plurality of evaluation entities within an entity group and (ii) a quality metric of a plurality of quality metrics corresponding to a categorical ranking scheme for the entity group. The techniques include using an action-specific causal inference model to generate a metric-specific predictive impact measure. The techniques include generating a metric-level categorical improvement prediction and a categorical improvement prediction for the entity group with respect to the categorical ranking scheme based on a weighted aggregation of the metric-level categorical improvement prediction and a plurality of metric-level categorical improvement predictions respectively corresponding the plurality of quality metrics.

Abstract: Various embodiments of the present disclosure provide computer forecasting techniques for initiating presentation of an interactive user interface. The techniques may include receiving one or more candidate prediction-based actions and generating a plurality of causal risk-based impact scores with respect to a candidate prediction-based action. The techniques include generating a plurality of causal quality-based impact scores and an action sequence for a plurality of evaluation entities and generating a causal net impact score based on (i) an aggregation of the plurality of causal risk-based impact scores and the plurality of causal quality-based impact scores and (ii) a sequence impact metric corresponding to the action sequence. The techniques include generating a sequence ranking for the action sequence and initiating a presentation of an interactive user interface reflective of the action sequence and the sequence ranking.

Abstract: Vascular access devices and methods of their use are provided. In one embodiment, a vascular access device includes a catheter and at least one deployable wire. The catheter includes a primary lumen extending from a proximal end to a distal end of the catheter. The at least one deployable wire is secured to the catheter and configured to move relative to the catheter between a delivery configuration and a deployed configuration.

Abstract: The present invention is directed to a mild bar composition with enhanced antimicrobial activity. The bar composition of the present invention is mild and unexpectedly yields superior antimicrobial activity when used in cleansing applications. The bar composition comprises an anionic surfactant and an acid, and is formulated, when lathered, to generate a wash slurry having a pH from 2.9 to 5.2.

Abstract: The invention is directed to a mild liquid composition with enhanced antimicrobial activity. The liquid composition of the present invention is mild and unexpectedly yields superior antimicrobial activity when used in cleansing applications. The liquid composition comprises an anionic surfactant and an acid, and is formulated to yield a wash solution having a pH from 2.9 to 5.2.

Abstract: Search management systems and methods that cryptographically-secure search indices, search queries, and associated document records while in-use by cloud-based search software without requiring modification to the cloud-based search core software. The search proxy resides between a cloud-based vendor application and the cloud-based search software. The search proxy uses key-based deterministic cryptographic tokenization to irreversibly cryptographically-secure plaintext words from document records for indexing and plaintext keywords from search queries for search and retrieval. The search proxy separately uses key-based encryption on the document record's pre-tokenized plaintext words, adding the encrypted data as a separate field to the document record. This encrypted field is stored as part of the document by the search service.

Abstract: The present invention provides for a panel for receiving neurocognitive data having a collapsible and portable user interface touch screen display bounded by a frame, the touch screen display having a width that extends into a user's peripheral vision by having the touch screen display extending from 60 to 120 degrees from a center of the user's gaze. The invention provides the touch screen display mounted on a support stand at the user's eye level and a computer electronically connected to the touch screen display via a control unit, the touch screen display comprising a tactile area having touch sensing capacity. The touch screen display for receiving at least one stimulus via the electronic connection to the control unit.

Abstract: Molecules compounds are provided having the structure in Formula I, or a salt thereof, wherein n1 is independently 0, 1, 2, or 3; n2 is 0, 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, or 20; n3 is from 0, 1, 2, or 3; n4 is 0 or 1; and n5 is 0, 1, 2, or 3; and wherein X is O, N, or S; Y, Z, XX, and YY are the same or different and are independently O or S; ZZ comprises nitrogen, oxygen, sulfur, or selenium; and wherein R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R11, R12 are as described herein. Methods are also provided for the synthesis of and use of the provided molecules in applications for diagnostic testing.

Abstract: A system and method for analyzing bodily fluid include a sample holder holding a bodily fluid sample, an image capture device generating an image of the bodily fluid sample comprising a plurality of fields of view. An image processor is programmed to determine a biofilm in the bodily fluid sample from the image, determine a biofilm area or volume within each of the plurality of fields of view to form a plurality of biofilm areas, determine a total biofilm area or total biofilm volume by adding the plurality of biofilm areas, determine a first value corresponding to a comparison of the total biofilm area or the total biofilm volume and a total volume of the bodily fluid sample, and classify the first value into a classification. An analyzer, using the classification, displays an indicator on a display for indicating the classification of the biofilm within the bodily fluid sample.

Abstract: The invention relates to bar composition comprising minimum floor levels of C10 soap while minimizing ratio of unsaturated C18 soap to caprate. Such bars provide enhanced rapid, antibacterial activity. Disclosed is a soap bar composition comprising: a) 25 to 85%, preferably 35 to 75% by weight of C8 to C24 fatty acid soap comprising: (i) C10 soap at 8% or 15% or greater, more preferably 16 to 32% by weight of total bar composition; and, (ii) unsaturated C18 soap, wherein weight ratio of said unsaturated C18 soap to C10 (caprate) soap is 1.2 to 0.1. b) 1 to 45% organic and inorganic adjuvant materials by weight of the composition; and, c) 5 to 30%, preferably 13 to 28% water by weight of the composition, wherein excess of C10 soap to unsaturated C18 soap is at least 6%.

Abstract: Described herein are methods for enhancing the nuclear reprogramming of somatic cells to become induced pluripotent stem cells. In particular, the methods disclosed herein involve the use of damage-associated molecular pattern molecules (DAMP). In certain embodiments the DAMPs are aluminum compositions such as aluminum hydroxide. Such DAMPs have unexpectedly and surprisingly been found to enhance the nuclear reprogramming efficiency of the reprogramming factors commonly used to induce somatic cells to become induced pluripotent stem cells. Accordingly, this disclosure describes methods of nuclear reprogramming as well as cells obtained from such methods along with therapeutic methods for using such cells for the treatment of disease amendable to treatment by stem cell therapy; as well as kits for such uses.

Abstract: The present invention provides for a panel for receiving neurocognitive data having a collapsible and portable user interface touch screen display bounded by a frame, the touch screen display having a width that extends into a user's peripheral vision by having the touch screen display extending from 60 to 120 degrees from a center of the user's gaze. The invention provides the touch screen display mounted on a support stand at the user's eye level and a computer electronically connected to the touch screen display via a control unit, the touch screen display comprising a tactile area having touch sensing capacity. The touch screen display for receiving at least one stimulus via the electronic connection to the control unit.

Abstract: The present invention provides a method of making an enantiomerically enriched tertiary or quaternary ammonium salt, and the use of a non-racemic chiral compound in the synthesis of an enantiomerically enriched tertiary or quaternary ammonium salt. The control of nitrogen-based chirality, achieved via the method of the invention, is useful where a specific tertiary or quaternary ammonium enantiomer is preferred over the other enantiomer, for example where a specific tertiary or quaternary ammonium enantiomer is more effective than the other enantiomer in treating a specific medical condition.

Abstract: Search management systems and methods that cryptographically-secure search indices, search queries, and associated document records while in-use by cloud-based search software without requiring modification to the cloud-based search core software. The search proxy resides between a cloud-based vendor application and the cloud-based search software. The search proxy uses key-based deterministic cryptographic tokenization to irreversibly cryptographically-secure plaintext words from document records for indexing and plaintext keywords from search queries for search and retrieval. The search proxy separately uses key-based encryption on the document record's pre-tokenized plaintext words, adding the encrypted data as a separate field to the document record. This encrypted field is stored as part of the document by the search service.

Abstract: A system and method for analyzing bodily fluid include a sample holder holding a bodily fluid sample, an image capture device generating an image of the bodily fluid sample comprising a plurality of fields of view. An image processor is programmed to determine a biofilm in the bodily fluid sample from the image, determine a biofilm area or volume within each of the plurality of fields of view to form a plurality of biofilm areas, determine a total biofilm area or total biofilm volume by adding the plurality of biofilm areas, determine a first value corresponding to a comparison of the total biofilm area or the total biofilm volume and a total volume of the bodily fluid sample, and classify the first value into a classification. An analyzer, using the classification, displays an indicator on a display for indicating the classification of the biofilm within the bodily fluid sample.

Abstract: Described embodiments provide a flat conductive fluid sensor cable capable of manufacture in long lengths comprising a flexible substrate, two or more flat conductors, and a fluid-permeable cover material arranged to allow a conductive fluid to form an electrically conductive path between the two or more conductors when conductive fluid contacts the conductive fluid sensor cable.

Abstract: Described embodiments provide a flat conductive fluid sensor cable capable of manufacture in long lengths comprising a flexible substrate, two or more flat conductors, and a fluid-permeable cover material arranged to allow a conductive fluid to form an electrically conductive path between the two or more conductors when conductive fluid contacts the conductive fluid sensor cable.

Abstract: A system and method for analyzing bodily fluid include a sample holder holding a bodily fluid sample, an image capture device generating an image of the bodily fluid sample comprising a plurality of fields of view. An image processor is programmed to determine a biofilm in the bodily fluid sample from the image, determine a biofilm area or volume within each of the plurality of fields of view to form a plurality of biofilm areas, determine a total biofilm area or total biofilm volume by adding the plurality of biofilm areas, determine a first value corresponding to a comparison of the total biofilm area or the total biofilm volume and a total volume of the bodily fluid sample, and classify the first value into a classification. An analyzer, using the classification, displays an indicator on a display for indicating the classification of the biofilm within the bodily fluid sample.