Abstract: This invention, inter alia, relates to CD19 binding agents and methods of using such CD19 binding agents for treating disease.

Abstract: The present disclosure describes systems and methods to transition a hearing prosthesis between different stimulation strategies. In accordance with one embodiment, a method is provided and includes operating a hearing prosthesis in accordance with a first parameter, receiving an instruction to operate the hearing prosthesis in accordance with a second parameter, and in response to the receiving, transitioning to operate the hearing prosthesis in accordance with the second parameter by operating the hearing prosthesis in accordance with at least one intermediate parameter.

Abstract: This invention, inter alia, relates to CD19 binding agents and methods of using such CD19 binding agents for treating disease.

Abstract: The present invention provides variant target binding agents and methods relating to the use of such binding agents for the prophylaxis or treatment of cancers and immunological disorders. The variant target binding agent is conjugated to a therapeutic agent that exerts a cytotoxic, cytostatic, or immunomodulatory effect on target cells.

Abstract: An implantable apparatus for delivering electrical stimuli to a user, the apparatus including at least a stimulator adapted to generate stimulation signals, an electrode array, said array including a plurality of electrodes for delivering said stimulation signals; and a plurality of release sites for pharmaceutical agents, said release sites being positioned at locations along said array, said release sites being controlled such that said agents can be operatively delivered at selected ones of said locations.

Abstract: A load bearing vest comprising a yoke, a core for carrying armor attached to the yoke, and a waist belt assembly for distributing weight to the waist or hips of a user attached to the yoke.

Abstract: Upper assembly including slot, hole array. Lower assembly conforming to hips. Lower assembly anchoring holes shaped/spaced as array. Lower assembly fastener hole for each slot; fastener hole having same position relative to anchoring holes as slot to array; having horizontal dimension equal to horizontal dimension of corresponding slot. Adjuster plate including anchoring points spaced as array holes. Each anchoring point dimensioned less than corresponding hole so as to fit snugly therein, and projecting a distance equal to thickness of corresponding upper and lower assembly anchoring hole. Forming an adjuster plate fastener hole for each lower assembly fastener hole. Each adjuster plate fastener hole having same position relative to anchoring points as slot to array. Releasable fastener for each lower assembly fastener hole.

Abstract: Maintaining a list of communication session servers which are currently in an active state and which are currently in a failed state, and which are currently responsible for providing communication services to which subscribers. Receiving a query in relation to a communication session involving a subscriber. In response to the list indicating that a communication session server which is currently responsible for providing communication services to the subscriber currently has an active state, responding to the query with an identifier for the communication session server. In response to the list indicating that the communication session server currently has a failed state, conducting a responsibility transfer operation to transfer responsibility for providing communication services to the subscriber from the communication session server to a different communication session server and responding to the query with an identifier for the different communication session server.

Abstract: The claimed invention is a mounting device for an object. The preferred embodiment is as a jewelry device or display device. The mounting device comprises supports and restraints whose surfaces correspond precisely to selected surfaces on the object. Mounting surfaces allow tolerance with regard to interfit with the object. In the jewelry industry, the result is that the interior surfaces of seats in a mounting are the mirror image of facets on a gemstone. This use of reflected geometry in a mounting provides benefits in manufacturing, setting, and usage of a finished article. The mounting may be constructed of one or more than one piece, and those pieces may be permanently or temporarily joined to form the mounting. The mounting may be manufactured by any of several methods subject to a skilled designer's preference, including but not limited to fabrication by manual process, computer-aided design and manufacturing, metal-powder.

Abstract: A stimulating medical device comprising a stimulating assembly implantable proximate to nerve cells of a recipient having at least one agent delivery port and a plurality of electrical contacts; an electrical stimulation controller configured to generate electrical stimulation signals for application to a first population of the nerve cells via one or more of the plurality of electrical contacts; a pharmaceutical agent source configured to provide a pharmaceutical agent to the at least one delivery port for application to a second population of the nerve cells; and a pharmaceutical agent controller configured to control one or more of the pharmaceutical agent source and the at least one delivery port to cause selective application of the pharmaceutical agent to the second population of nerve cells.

Abstract: A method and apparatus for neural stimulation are disclosed. The principle is that a conventional current path is used to deliver the stimulus to neural structures, but an alternative current path is provided to bypass the neural structures during the opposite polarity part of the current flow. As a consequence, charge balance can be provided at the tissue/electrode interface, whilst delivering stimuli which are not charge balanced to the neural structures.

Abstract: The present disclosure describes systems and methods to transition a hearing prosthesis between different stimulation strategies. In accordance with one embodiment, a method is provided and includes operating a hearing prosthesis in accordance with a first parameter, receiving an instruction to operate the hearing prosthesis in accordance with a second parameter, and in response to the receiving, transitioning to operate the hearing prosthesis in accordance with the second parameter by operating the hearing prosthesis in accordance with at least one intermediate parameter.

Abstract: The system and method for quick release can include a remote release enclosure having a connection side and a trigger side. at least one cable assembly traversing through the release enclosure from the connection side to the trigger side, a trigger assembly coupled the at least one cable assembly, and a plurality of attachment, assemblies coupled the other end of the at least, one cable assembly. The trigger assembly can be operatively coupled to each of the plurality of attachment assemblies via the cable assemblies. The attachment assemblies can have a male portion having an inner guide post between at least two outer guide posts and a female portion. The cable assemblies can couple the male portions of the attachment assemblies to the trigger assembly such that movement of the trigger assembly can release or disengage the male portion of the attachment assembly from the female portion.

Abstract: Disclosed are CD70 binding agents, such as humanized anti-CD70 antibodies and fragments and derivatives, that exert a cytotoxic, cytostatic or immunomodulatory on CD70 expressing cells, as well as pharmaceutical compositions and kits comprising the antibody, fragment or derivative. Also disclosed are methods for the treatment of CD70-expressing cancers and immunological disorders, comprising administering to a subject the CD70 binding agents or pharmaceutical compositions.

Abstract: The system and method for quick release can include a remote release enclosure having a connection side and a trigger side, at least one cable assembly traversing through the release enclosure from the connection side to the trigger side, a trigger assembly coupled the at least one cable assembly, and a plurality of attachment assemblies coupled the other end of the at least one cable assembly. The trigger assembly can be operatively coupled to each of the plurality of attachment assemblies via the cable assemblies. The attachment assemblies can have a male portion having an inner guide post between at least two outer guide posts and a female portion. The cable assemblies can couple the male portions of the attachment assemblies to the trigger assembly such that movement of the trigger assembly can release or disengage the male portion of the attachment assembly from the female portion.

Abstract: A stimulating medical device comprising a stimulating assembly implantable proximate to nerve cells of a recipient having at least one agent delivery port and a plurality of electrical contacts; an electrical stimulation controller configured to generate electrical stimulation signals for application to a first population of the nerve cells via one or more of the plurality of electrical contacts; a pharmaceutical agent source configured to provide a pharmaceutical agent to the at least one delivery port for application to a second population of the nerve cells; and a pharmaceutical agent controller configured to control one or more of the pharmaceutical agent source and the at least one delivery port to cause selective application of the pharmaceutical agent to the second population of nerve cells.

Abstract: An implantable stimulation device is disclosed which provides for reduced power consumption when compared with bipolar stimulation and better stimulation performance when compared with monopolar stimulation. Implantable stimulator devices use less power in monopolar stimulation mode than that of bipolar stimulation but stimulation performance is greater when using bipolar stimulation. The device comprises circuitry capable of simultaneous stimulation between a reference electrode and an electrode of a stimulation array and between electrodes of the stimulation array, the ratio of current to the reference electrode and array electrodes being selectable.

Abstract: Medical device implants for stimulating the nervous system of a recipient are disclosed. Embodiments include a cochlear implant with electrodes for delivering charge to the cochlea of the recipient and stimulation circuitry for delivering the charge to the electrodes. The medical devices include a transfer line which carries power and/or communication signals, the transfer line being in contact with tissue of the recipient when the medical device implant is implanted. A leakage capture conductor and/or sensing electrode is located or locatable proximate the insulated conductor.

Abstract: A body stimulating device operatively adapted to provide electrical stimuli within a body, the device including stimulating electrodes, stimulus generator, and electrode voltage sensors, said electrode voltage sensors operatively measuring the DC/LF voltage of the electrodes, wherein if the sensors determine that the electrode voltage for an electrode is outside a predetermined range, then a compensating current is applied to that electrode, so as to reduce the voltage.