Abstract: Disclosed are CD70 binding agents, such as humanized anti-CD70 antibodies and fragments and derivatives, that exert a cytotoxic, cytostatic or immunomodulatory on CD70 expressing cells, as well as pharmaceutical compositions and kits comprising the antibody, fragment or derivative. Also disclosed are methods for the treatment of CD70-expressing cancers and immunological disorders, comprising administering to a subject the CD70 binding agents or pharmaceutical compositions.

Abstract: Upper assembly including slot, hole array. Lower assembly conforming to hips. Lower assembly anchoring holes shaped/spaced as array. Lower assembly fastener hole for each slot; fastener hole having same position relative to anchoring holes as slot to array; having horizontal dimension equal to horizontal dimension of corresponding slot. Adjuster plate including anchoring points spaced as array holes. Each anchoring point dimensioned less than corresponding hole so as to fit snugly therein, and projecting a distance equal to thickness of corresponding upper and lower assembly anchoring hole. Forming an adjuster plate fastener hole for each lower assembly fastener hole. Each adjuster plate fastener hole having same position relative to anchoring points as slot to array. Releasable fastener for each lower assembly fastener hole.

Abstract: Arrangement with one or more buckles, wherein each buckle has at least two buckle parts that are detachably connectable with each other, at least one release mechanism, actuatable by means of pressure for detaching the buckle parts from each other, and at least one pressure accumulator connected via at least one pressure line with the buckle(s) for actuating the release mechanism of the buckle, and with at least one release valve for opening a pressure connection guided via the pressure line between the pressure accumulator and the buckle or the buckles, and with at least one trigger for actuating the release valve, wherein the arrangement has a pump for the build-up of pressure in the pressure accumulator.

Abstract: The present invention provides variant target binding agents and methods relating to the use of such binding agents for the prophylaxis or treatment of cancers and immunological disorders. The variant target binding agent is conjugated to a therapeutic agent that exerts a cytotoxic, cytostatic, or immunomodulatory effect on target cells.

Abstract: A method and apparatus for neural stimulation are disclosed. The principle is that a conventional current path is used to deliver the stimulus to neural structures, but an alternative current path is provided to bypass the neural structures during the opposite polarity part of the current flow. As a consequence, charge balance can be provided at the tissue/electrode interface, whilst delivering stimuli which are not charge balanced to the neural structures.

Abstract: Medical device implants for stimulating the nervous system of a recipient are disclosed. Embodiments include a cochlear implant with electrodes for delivering charge to the cochlea of the recipient and stimulation circuitry for delivering the charge to the electrodes. The medical devices include a transfer line which carries power and/or communication signals, the transfer line being in contact with tissue of the recipient when the medical device implant is implanted. A leakage capture conductor and/or sensing electrode is located or locatable proximate the insulated conductor.

Abstract: Aspects of the present invention are generally directed to impedance spectroscopy in an active implantable medical device (AIMD) comprising a component with one or more electrodes. In an embodiment, the AIMD applies a signal at a plurality of frequencies using one or more of the electrodes. Measurements are then obtained for the applied signal to determine impedance(s) at the applied frequencies of the tissue in which the electrodes are located.

Abstract: An implantable hearing prosthesis, comprising an integrated integrity system. The integrity system is configured to measure one or more electrical characteristics of at least one component of the prosthesis, to evaluate the integrity of the prosthesis based on the measurements, and to perform at least one diagnostic operation based on the evaluation.

Abstract: This invention, inter alia, relates to CD19 binding agents and methods of using such CD19 binding agents for treating disease.

Abstract: A method and apparatus for neural stimulation are disclosed. The principle is that a conventional current path is used to deliver the stimulus to neural structures, but an alternative current path is provided to bypass the neural structures during the opposite polarity part of the current flow. As a consequence, charge balance can be provided at the tissue/electrode interface, while delivering stimuli which are not charge balanced to the neural structures.

Abstract: This invention relates to CD30 binding agents and methods of using such binding agents for treating disease characterized by expression of CD30 antigen.

Abstract: This invention relates to CD 19 binding agents and methods of using such CD 19 binding agents for treating disease.

Abstract: Release assembly for a personal equipment carrier. Release assembly includes securing component, a plurality of first cable assemblies, a plurality of attachment assembly first portions, trigger termination, and trigger activator. Securing component is attachable to a personal equipment carrier. The first cable assemblies, include an outer member and an inner member. A first end of each first cable assembly outer member is anchored to the securing component. Each attachment assembly first portion includes a detachment portion. The detachment portion is attached to a second end of each first cable assembly inner member. The detachment portion is operable, upon tensioning of the attached first cable assembly inner member, for detaching the attachment assembly first portion from an attached attachment assembly second portion. The trigger termination is connected to the first end of each first cable assembly inner member at the securing component. The trigger activator is connected to the trigger termination.

Abstract: An implantable stimulation device is disclosed which provides for reduced power consumption when compared with bipolar stimulation and better stimulation performance when compared with monopolar stimulation. Implantable stimulator devices use less power in monopolar stimulation mode than that of bipolar stimulation but stimulation performance is greater when using bipolar stimulation. The device comprises circuitry capable of simultaneous stimulation between a reference electrode and an electrode of a stimulation array and between electrodes of the stimulation array, the ratio of current to the reference electrode and array electrodes being selectable.

Abstract: Release assembly for a personal equipment carrier. Release assembly includes securing component, a plurality of first cable assemblies, a plurality of attachment assembly first portions, trigger termination, and trigger activator. Securing component is attachable to a personal equipment carrier. The first cable assemblies, include an outer member and an inner member. A first end of each first cable assembly outer member is anchored to the securing component. Each attachment assembly first portion includes a detachment portion. The detachment portion is attached to a second end of each first cable assembly inner member. The detachment portion is operable, upon tensioning of the attached first cable assembly inner member, for detaching the attachment assembly first portion from an attached attachment assembly second portion. The trigger termination is connected to the first end of each first cable assembly inner member at the securing component. The trigger activator is connected to the trigger termination.

Abstract: Disclosed are CD70 binding agents, such as humanized anti-CD70 antibodies and fragments and derivatives, that exert a cytotoxic, cytostatic or immunomodulatory on CD70 expressing cells, as well as pharmaceutical compositions and kits comprising the antibody, fragment or derivative. Also disclosed are methods for the treatment of CD70-expressing cancers and immunological disorders, comprising administering to a subject the CD70 binding agents or pharmaceutical compositions.

Abstract: This invention, inter alia, relates to CD19 binding agents and methods of using such CD19 binding agents for treating disease.

Abstract: Disclosed are CD70 binding agents, such as humanized anti-CD70 antibodies and fragments and derivatives, that exert a cytotoxic, cytostatic or immunomodulatory on CD70 expressing cells, as well as pharmaceutical compositions and kits comprising the antibody, fragment or derivative. Also disclosed are methods for the treatment of CD70-expressing cancers and immunological disorders, comprising administering to a subject the CD70 binding agents or pharmaceutical compositions.

Abstract: The system and method for quick release can include a remote release enclosure having a connection side and a trigger side, at least one cable assembly traversing through the release enclosure from the connection side to the trigger side, a trigger assembly coupled the at least one cable assembly, and a plurality of attachment assemblies coupled the other end of the at least one cable assembly. The trigger assembly can be operatively coupled to each of the plurality of attachment assemblies via the cable assemblies. The attachment assemblies can have a male portion having an inner guide post between at least two outer guide posts and a female portion. The cable assemblies can couple the male portions of the attachment assemblies to the trigger assembly such that movement of the trigger assembly can release or disengage the male portion of the attachment assembly from the female portion.

Abstract: A body stimulating device operatively adapted to provide electrical stimuli within a body, the device including stimulating electrodes, stimulus generator, and electrode voltage sensors, said electrode voltage sensors operatively measuring the DC/LF voltage of the electrodes, wherein if the sensors determine that the electrode voltage for an electrode is outside a predetermined range, then a compensating current is applied to that electrode, so as to reduce the voltage.