Abstract: The present invention relates to L genes and gene products that are differentially expressed in cancer tissues and cell lines. In a particular aspect of the invention, L genes and gene products are differentially expressed in lung cancer tissues and cell lines. In accordance with the present invention, L nucleic acid sequences, amino acid sequences and antibodies thereto, and methods of use thereof are presented. The L molecules and methods of the invention may be used to monitor expression levels of L genes, wherein the detection of aberrant levels of L molecules provides a positive diagnostic indicator of lung cancer and/or other L gene associated cancers and a useful prognostic indice of the state of such diseases. Also provided are compounds capable of modulating an L molecule mediated activity, which are identified using the L molecules and methods of the invention. Such L molecule modulating compounds may be used efficaciously to treat patients with lung cancer, or other L antigen positive cancers.

Abstract: Methods for the high yield production of antibody Fv-containing polypeptides, especially Fab? and F(ab?)2 antibody fragments are provided. Expression of heavy and light chain Fv in a microbial secretory system is followed by recovery of Fv from the periplasm under conditions that maintain a cysteine residue as a free thiol. The free thiol is reacted with free thiol of an antibody fragment of the same or differing specificity, or with agents such as diagnostic labels or therapeutic moieties. The products offer advantages of homogeneity and purity not available through the use of known methods for preparing such derivatives.

Abstract: Various forms of c-mpl agonist antibodies are shown to influence the replication, differentiation or maturation of blood cells, especially megakaryocytes and megakaryocyte progenitor cells. Accordingly, these compounds may be used for treatment of thrombocytopenia.

Abstract: The present invention relates to antibodies that bind to the IL-4 receptor, fragments, muteins, and derivatives of such antibodies, nucleic acids encoding such antibodies, fragments, muteins and derivatives, and methods of making and using such antibodies, fragments, muteins, derivatives and nucleic acids. Methods for treating medical conditions induced by interleukin-4 involve administering an IL-4 receptor binding antibody, or an IL-4 receptor binding fragment, mutein, or derivative of an IL-4 receptor binding antibody, to a patient afflicted with such a condition. Particular antibodies provided herein include human monoclonal antibodies. Certain of the antibodies inhibit both IL-4-induced and IL-13-induced biological activities.

Abstract: The WSX receptor and antibodies which bind thereto (including agonist and neutralizing antibodies) are disclosed, including various uses therefor. Uses for WSX ligands (e.g., anti-WSX receptor agonist antibodies or OB protein) in hematopoiesis are also disclosed.

Abstract: A process for the preparation of white and brown sugar from raw diffuser beet juice. The juice is purified by membrane filtration at 70-95° C. on a filter having a molecular weight cut-off between 2,000 and 500,000 Dalton and evaporated to a dry matter content of between 60 and 80% by weight under vacuum to a thick juice. A conventional multi-step evaporative crystallisation of the thick juice gives crops of white and brown sugar crystals. The brown sugar obtained have valuable organoleptic properties.

Abstract: The invention provides methods and compositions for treating septic shock, endotoxemia, and related diseases and conditions, involving the use of an antiendotoxin drug and an activated Protein C.

Abstract: Benzhydryl derivatives of the formula I, where the index and the variables are as defined below: X is oxygen or sulfur; R1, R3 are halogen, cyano, nitro, hydroxyl, mercapto, amino, alkyl, alkenyl, alkynyl, alkoxy, alkenyloxy, alkynyloxy, alkylcarbonyloxy, formyloxy, alkylthio, alkenylthio, alkynylthio, alkylamino, dialkylamino, alkylcarbonyl or formyl, where the carbon atoms in the radicals mentioned may be partially or fully halogenated; R2 is halogen, cyano, nitro, hydroxyl, mercapto, amino, alkyl, alkoxy, haloalkyl or haloalkoxy, where the groups R2 may be different if n=2; R4 is alkyl, alkenyl or alkynyl, where the carbon atoms in these radicals may be unsubstituted or partially or fully halogenated; R5, R6 are hydroxyl, alkyl, alkenyl, haloalkyl, haloalkenyl, alkoxy, alkenyloxy, haloalkoxy, haloalkenyloxy, cycloalkyl, cycloalkylalkyl, cycloalkoxy or cycloalkylalkoxy; n is 0, 1 or 2; processes for preparing the compounds I, compositions comprising them and their use for con

Abstract: Benzhydryl derivatives of the formula I, 1

Abstract: A webcasting system and method for presenting multimedia content to viewers over the internet. The user (creator) of the webcast presentation is able to create and send the webcast to viewers using a simple, web-based process. The webcast includes a video presentation and slide presentation. Video and slide presentation files are automatically encoded and uploaded to a media server, without the user needing to understand file formats of the webcast content or how the files are to be compressed for efficient storage and transmission. The synchronization and editing of the video and slide presentations is made efficient by separately storing or buffering the slide file at the viewer's system before the video is streamed to the viewer's system. Slide files prepared in a structured storage format (PowerPoint) are automatically converted to JPG format in order to more efficiently transmit the presentation to the viewer.

Abstract: The invention provides a method of treating or inhibiting the growth of cancerous tumour cells and associated diseases in a mammal in need thereof which comprises administering to said mammal an effective amount of a substituted triazolopyrimidine derivative or a pharmaceutically acceptable salt thereof and further provides a method of treating or inhibiting the growth of cancerous tumour cells and associated diseases in a mammal in need thereof by interacting with tubulin and microtubules and promoting microtubule polymerization which comprises administering to said mammal an effective amount of a substituted triazolopyrimidine derivative or a pharmaceutically acceptable salt thereof.

Abstract: The novel optically active compounds of formula I: (R1, Hal and L1 through L5 are defined in the specification) wherein the enantiomeric excess of the (S)-enantiomer is at least 70%., show enhanced selective fungicidal activity. The new compounds are processed with carriers, and optionally with adjuvants, to form fungicidal compositions.

Abstract: An improved process for the preparation of (S)-1,1,1-trifluoroalkyl-2-amines of formula IIIA, ##STR1## where R.sup.1 is a C.sub.1-6 alkyl group, from the corresponding racemic mixture, which process includes treating 1 part by mole of the racemic mixture with approximately 0.3 to 0.7 part by mole of D-(-)-tartaric acid in the presence of an inert solvent.

Abstract: An implanted device such as cochlear implant having electrodes is provided with a pulse generator for generating stimulating pulses. The pulses are adjusted to insure that during the idle periods between the pulses, the voltage on the electrodes is at zero or at a preselected level. In one embodiment, the pulse durations or amplitudes adjusted, In another embodiment the voltage on the electrodes is measured before and during each pulse to determine IR drops from the electrodes to a reference point, and to compensate for the same.

Abstract: A low-cost solid state replacement circuit for an inertial platform with the resulting consequence of increased resolution, significantly reduced cost, and improved reliability and accuracy. The invention comprises no moving parts and permits the use of a strap-down angular rate sensor system which has a fixed orientation relative to an AGV on which the circuit is used. The invention creatively emulates encoder signals previously emanating from the inertial table through the use of a voltage controlled oscillator, a direction of turn determining circuit and an encoder emulator. Cabling which exists in current inertial tables does not need to be changed and information format previously used remains unchanged.

Abstract: A low-cost solid state replacement circuit for an inertial platform with the resulting consequence of increased resolution, significantly reduced cost, and improved reliability and accuracy. The invention comprises no moving parts and permits the use of a strap-down angular rate sensor system which has a fixed orientation relative to an AGV on which the circuit is used. The invention creatively emulates encoder signals previously emanating from the inertial table through the use of a voltage controlled oscillator, a direction of turn determining circuit and an encoder emulator. Cabling which exists in current inertial tables does not need to be changed and information format previously used remains unchanged.

Abstract: The invention provides a fungicidal composition comprising a carrier and, as active ingredient, certain tetrahydropyrimidine derivatives of the general formula ##STR1## or an acid-addition salt or metal salt complex thereof, in which n is 0, 1, 2 or 3; R represents an optionally substituted alkyl, aryl or aralkyl group; R.sup.1 represents a hydrogen atom or an optionally substituted alkyl or aralkyl group; R.sup.2 represents an optionally substituted aryl group; p is 0 or 1; X represents a group --NR.sup.3 -- or --NR.sup.3 --NR.sup.3 -- where each R.sup.3 independently represents a hydrogen atom or an optionally substituted alkyl, aryl or aralkyl group or R.sup.1 and (X).sub.p --A--R.sup.2 together represent a group --(CR.sup.4 R.sup.5).sub.q --N(A--R.sup.2)-- where q is 2 or 3 and each of R.sup.4 and R.sup.5 is independently selected from a group consisting of hydrogen atoms and optionally substituted alkyl groups; and A represents a group --(CR.sup.6 R.sup.7).sub.

Abstract: A powered toilet seat used in association with a toilet bowl or throw-away waste receptacle and which may be used to assist a person in being raised and lowered relative to the toilet bowl. The present invention provides separate sets of mechanical linkages in order to provide the optimum motion for raising and lowering of the seat and for raising and lowering of the armrest. While the seat is constrained to both lift and move forward slightly while it is being rotated forwardly, the armrests follow a circular arc in which the armrests initially move predominately in the upward direction and complete the motion by moving predominately in a forward direction. In addition, the armrests are maintained in a horizontal orientation at all time.

Abstract: The invention provides piperidine derivatives of the general formula ##STR1## or an acid-addition salt or metal salt complex thereof, in which R represents a hydrogen atom or an optionally substituted alkyl, alkenyl, alkynyl, alkoxy, cycloalkyl, aryl, arylcarbonyl, heterocyclyl or heterocyclyloxy group; R.sup.1 represents an optionally substituted alkyl, phenyl, benzyl or cycloalkyl group; R.sup.2 represents a hydrogen atom or an optionally substituted alkyl group; one of W and X represents --CH.sub.2 --, --CH.sub.2 CH.sub.2 -- or --O--, the other of W and X being --CH.sub.2 -- or --CH.sub.2 CH.sub.2 or X represents a single chemical bond; m is 0 or 1 and n represents an integer from 0 to 3; processes for their preparation; compositions containing such compounds and their use as fungicides.