Abstract: Examples of enterprise management using managed virtual machines (VMs) are described. In one example, a virtual machine base image is validated to comply with a plurality of managed virtual machine packaging rules of a management service. Managed virtual machine configuration parameters are written to a managed virtual machine configuration file of a managed virtual machine. The managed virtual machine includes a management component that implements instructions from a management service. A managed virtual machine package file is generated to include the managed virtual machine configuration file and enterprise-specific enterprise resources identified from the management service based on the enterprise identifier.

Abstract: An adjustable stent graft system. A first branch extension includes a first main body and a first renal branch. The first main body includes first proximal and distal end regions. The first renal branch is configured to extend into a first renal artery. The first proximal end region is configured to anchor to a connecting platform. The first distal end region is configured to extend into a first common iliac artery (CIA). A second branch extension includes a second main body and a second renal branch. The second main body includes second proximal and distal end regions. The second renal branch is configured to extend into a second renal artery. The second proximal end region is configured to anchor to the connecting platform. The second distal end region is configured to extend into a second CIA. The first and second branch extensions are independently adjustable relative to the connecting platform.

Abstract: A device and system for and methods of using an ultrasound probe housing containing ultrasound probes configured to produce images inside the body of a patient for procedures requiring needle or probe insertion. The ultrasound probe housing can be configured with a guide channel cut-out or aperture between the ambient side and body side of a patient. A needle guide assembly may be pivotally connected internal to the guide channel cut-out or aperture of the ultrasound probe housing at a pivot point such that during use the needle enters the patient through the needle guide assembly within the ultrasonic probe housing so that the needle can be visualized by the ultrasonic probes in real time. The ultrasound probe housing may also provide an adhesion or suction quality to the body side of the device to facilitate aspects of the invention.

Abstract: A device and system for and methods of using an ultrasound probe housing containing ultrasound probes configured to produce images inside the body of a patient for procedures requiring needle or probe insertion. The ultrasound probe housing can be configured with a guide channel cut-out or aperture between the ambient side and body side of a patient. A needle guide assembly may be pivotally connected internal to the guide channel cut-out or aperture of the ultrasound probe housing at a pivot point such that during use the needle enters the patient through the needle guide assembly within the ultrasonic probe housing so that the needle can be visualized by the ultrasonic probes in real time. The ultrasound probe housing may also provide an adhesion or suction quality to the body side of the device to facilitate aspects of the invention.

Abstract: Vehicles and related systems and methods are provided for controlling a vehicle in an autonomous operating mode. One method involves determining a current value for a range of view associated with a sensing device onboard the vehicle, determining a target value for the range of view based at least in part on a speed of the vehicle, and in response to determining the current value is less than the target value, determining a dropback adjustment distance based at least in part on a difference between target value for the range of view and an estimated distance to a closest in path (CIP) vehicle ahead of the vehicle within a current lane of travel, determining a longitudinal trajectory for the vehicle based at least in part on the dropback adjustment distance, and autonomously operating one or more actuators onboard the vehicle in accordance with the longitudinal trajectory.

Abstract: The present invention relates to a method for identification of common patient-spanning tumor-specific T cell receptors (TCRs) and their corresponding antigens. The invention also relates to these TCR sequences, a nucleic acid encoding the TCR, and a T cell comprising the TCR and/or the encoding nucleic acid.

Abstract: The present invention relates to a binding molecule which is at least bispecific comprising a first and a second binding domain, wherein the first binding domain is capable of binding to epitope cluster 3 of BCMA, and the second binding domain is capable of binding to the T cell CD3 receptor complex. Moreover, the invention provides a nucleic acid sequence encoding the binding molecule, a vector comprising said nucleic acid sequence and a host cell transformed or transfected with said vector. Furthermore, the invention provides a process for the production of the binding molecule of the invention, a medical use of said binding molecule and a kit comprising said binding molecule.

Abstract: The present invention relates to a binding molecule which is at least bispecific comprising a first and a second binding domain, wherein the first binding domain is capable of binding to epitope cluster 3 of BCMA, and the second binding domain is capable of binding to the T cell CD3 receptor complex. Moreover, the invention provides a nucleic acid sequence encoding the binding molecule, a vector comprising said nucleic acid sequence and a host cell transformed or transfected with said vector. Furthermore, the invention provides a process for the production of the binding molecule of the invention, a medical use of said binding molecule and a kit comprising said binding molecule.

Abstract: The present invention relates to novel tri-specific binding molecules. The invention also relates to nucleic acids encoding such binding molecules; to methods for preparing such binding molecules; to host cells expressing or capable of expressing such binding molecules; to compositions comprising such binding molecules; and to uses of such binding molecules or such compositions, in particular for therapeutic purposes in the field of cancer diseases.

Abstract: Methods and systems are provided for controlling a vehicle. In one embodiment, a method includes: determining, by a processor, that a lane centering feature is active in the vehicle; identifying, by the processor, a pattern of steering wheel torque; determining, by the processor, a driver requested offset based on a location of the vehicle and a location of a center of the lane; applying, by the processor, the driver requested offset to a planned trajectory of the vehicle; evaluating, by the processor, one or more duration conditions; and in response to the evaluating, selectively generating, by the processor, a control signal based on the planned trajectory with the driver requested offset.

Abstract: A method of automated vehicle braking control includes detecting a first object threat in a reverse travel path of a vehicle, monitoring a distance of the vehicle from the first object threat with respect to a time to collision threshold, and in response to a determination that the vehicle is crossing the time to collision threshold, initiating a first rear virtual bumper event by automatically applying brakes of the vehicle. The method includes storing a location of the first object threat, defining a boundary region surrounding the location of the first object threat, detecting a second object threat in the reverse travel path, comparing a location of the second object threat with the boundary region, and inhibiting automatic application of the brakes in response to a determination that the location of the second object threat is within the boundary region, to avoid a second rear virtual bumper event.

Abstract: Methods and systems of controlling a vehicle. The methods and systems include switching to a second processor executed mode in response to determining that a range of perception information extends to a range end point that is closer to the vehicle than a first Look Ahead (LA) point. In the second processor executed mode: a motion planner requests a lateral controller to provide a closer LA point relative to the vehicle. The lateral controller determines the closer LA point and sends the closer LA point to the motion planner. The lateral controller generates control commands for an EPS system based on an error between a desired trajectory and an actual trajectory at the closer LA point. The motion planner generates the desired trajectory based on perception data and the closer LA point.

Abstract: A vehicle control system for evasive steering maneuvers includes a forward object detector configured to detect objects in a driving path of a vehicle, a steering wheel configured to control a steering direction of the vehicle, a vehicle user interface configured to display a visual indication to a driver and generate audio for the driver, and a vehicle control module configured to identify, via the forward object detector, an object in the driving path of the vehicle, determine an estimated time to collision with the object, and in response to the estimated time to collision being less than a specified time threshold, execute at least one of providing a visual indication of a recommended evasive steering maneuver to the driver via the vehicle user interface, generating an audio alert of the recommended evasive steering maneuver, applying steering torque to the steering wheel to indicate the recommended evasive steering maneuver.

Abstract: Methods and systems for providing driving assistance in a vehicle. In one embodiment, a method includes: determining, by a processor, a trajectory of the vehicle along a roadway; determining, by the processor, a confidence score based on a predicted lateral acceleration and an actual lateral acceleration at a point along the trajectory; determining, by the processor, longitudinal velocity data based on the confidence score; and generating, by the processor, control signals to vehicle actuators to control the vehicle based on the longitudinal velocity data.

Abstract: A system for controlling lateral positioning in a host vehicle includes a controller having a processor and tangible, non-transitory memory. The host vehicle is located on a host lane defined by a host lane center. The controller is adapted to determine if a first and second enabling condition are met. The first enabling condition is met when the host vehicle is travelling on a non-divided road having no physical barrier separating respective traffic lanes travelling in opposing directions. The second enabling condition is met when the host lane is an inner most lane adjacent to an opposing traffic lane. When the first and second enabling conditions are both met, the controller is adapted to determine a non-divided road offset relative to the host lane center in real-time. Operation of the vehicle is controlled based in part on a magnitude, and a direction of the non-divided road offset.

Abstract: A rotor blade configured to be installed on a rotary-wing aircraft includes a main blade body including an inboard end configured to be coupled to a rotor blade hub and an outboard end. The rotor blade includes a blade tip removably coupled to the outboard end of the main blade body, the blade tip including an inner cavity. The rotor blade further includes a tip block including an inboard portion coupled to the outboard end of the main blade body and a cantilevered portion extending beyond the outboard end of the rotor blade and into the inner cavity of the blade tip.

Abstract: The present disclosure provides solid forms of resiquimod useful, e.g., as an immunomodulatory payload component of certain biomaterials (e.g., hydrogels) and/or formulations for administration to subjects.

Abstract: A rotor blade includes a spar with forward end, an aft end, and a substantially oval cross-section. The cross-section includes an upper portion tapering from a first thickness to a smaller, second thickness beginning between about 55% and about 65% of the distance to the aft end from the forward end and ending between about 65% and about 75% of the distance to the aft end measured from the forward end, and a lower portion tapering from a third thickness to a smaller, fourth thickness beginning between about 55% and about 65% of the distance to the aft end from the forward end and ending between about 65% and about 75% of the distance to the aft end measured from the forward end. The rotor blade further includes an upper blade skin, a lower blade skin, and a leading edge sheath.

Abstract: The present invention relates to novel DLL3/CD3 binding proteins. The invention also relates to nucleic acids encoding such proteins; to methods for preparing such proteins; to host cells expressing or capable of expressing such proteins; to compositions comprising such proteins; and to uses of such proteins or such compositions, in particular for therapeutic purposes in the field of cancer diseases.

Abstract: Systems and methods are provided for detecting unclassified hazards for a driver assistance system of a vehicle. The systems include a data storage device comprising map data, one or more sensors configured to generate sensor data indicative of one or more sensed objects in proximity to the vehicle, and a controller configured to, by one or more processors thereof, receive the map data and the sensor data, filter the sensor data to omit at least one of the sensed objects located outside of a bounding area that includes a portion of an adjacent lane next to a current lane in which the vehicle is operating, determine whether an unclassified hazard is present in the adjacent lane, and maintain operation of the vehicle in the current lane in response to a determination that the unclassified hazard is present in the adjacent lane.