Abstract: The disclosure relates to nanoparticle drug conjugates (NDC) that comprise ultrasmall nanoparticles, folate receptor (FR) targeting ligands, and linker-drug conjugates, and methods of making and using them to treat cancer.

Abstract: The present invention relates to novel B7H6/CD3 binding proteins. The invention also relates to nucleic acids encoding such proteins; to methods for preparing such proteins; to host cells expressing or capable of expressing such proteins; to compositions comprising such proteins; and to uses of such proteins or such compositions, in particular for therapeutic purposes in the field of cancer diseases.

Abstract: Disclosed are various embodiments for provisioning client devices. A configuration file previously installed on the computing device can be read. The configuration file can contain a provisioning address. Then, a user account is automatically created using a predefined username and credential stored in the configuration file. Next, an enrollment request can be sent to the provisioning address to enroll the computing device with a provisioning service using the user account. In response, an enrollment response can be received from the provisioning service. The computing device can then be configured based upon the enrollment response.

Abstract: The disclosure relates to carrier particle-drug conjugates, including nanoparticle drug conjugates (NDC), that can be used in the delivery of a drug to a biological target (e.g., for targeted delivery of a cytotoxic drug to a cancer cell or tumor). Also disclosed are self-immolative linkers and linker-payload conjugates suitable for use in a carrier particle drug conjugate, and methods of making the same, and methods for treating cancer.

Abstract: A device and system for and methods of using an ultrasound probe housing containing ultrasound probes configured to produce images inside the body of a patient for procedures requiring needle or probe insertion. The ultrasound probe housing can be configured with a guide channel cut-out or aperture between the ambient side and body side of a patient. A needle guide assembly may be pivotally connect internal to the guide channel cut-out or aperture of the ultrasound probe housing at a pivot point such that during use the needle enters the patient through the needle guide assembly within the ultrasonic probe housing so that the needle can be visualized by the ultrasonic probes in real time. The ultrasound probe housing may also provide an adhesion or suction quality to the body side of the device to facilitate aspects of the invention.

Abstract: A device and system for and methods of using an ultrasound probe housing containing ultrasound probes configured to produce images inside the body of a patient for procedures requiring needle or probe insertion. The ultrasound probe housing can be configured with a guide channel cut-out or aperture between the ambient side and body side of a patient. A needle guide assembly may be pivotally connect internal to the guide channel cut-out or aperture of the ultrasound probe housing at a pivot point such that during use the needle enters the patient through the needle guide assembly within the ultrasonic probe housing so that the needle can be visualized by the ultrasonic probes in real time. The ultrasound probe housing may also provide an adhesion or suction quality to the body side of the device to facilitate aspects of the invention.

Abstract: A device and system for and methods of using an ultrasound probe housing containing ultrasound probes configured to produce images inside the body of a patient for procedures requiring needle or probe insertion. The ultrasound probe housing can be configured with a guide channel cut-out or aperture between the ambient side and body side of a patient. A needle guide assembly may be pivotally connect internal to the guide channel cut-out or aperture of the ultrasound probe housing at a pivot point such that during use the needle enters the patient through the needle guide assembly within the ultrasonic probe housing so that the needle can be visualized by the ultrasonic probes in real time. The ultrasound probe housing may also provide an adhesion or suction quality to the body side of the device to facilitate aspects of the invention.

Abstract: A device comprises an ultrasound probe housing containing ultrasound probes configured to produce images inside the body of a patient for procedures requiring needle or probe insertion. Each of a first subset of the ultrasound probes is positioned such that a direction of ultrasound waves generated thereby is through a body side of the ultrasound probe housing and perpendicular thereto. Each of a second subset of the ultrasound probes is positioned non-perpendicular to the body side of the ultrasound probe housing such that a direction of ultrasound waves generated thereby is toward a site of needle penetration directly beneath a guide channel cut-out or aperture of the ultrasound probe housing. A first ultrasound probe in the first subset of ultrasound probes may be located further from the body side of the ultrasound probe housing that a second ultrasound probe in the first subset of ultrasound probes.

Abstract: A device and system for and methods of using an ultrasound probe housing containing ultrasound probes configured to produce images inside the body of a patient for procedures requiring needle or probe insertion. The ultrasound probe housing can be configured with a guide channel cut-out or aperture between the ambient side and body side of a patient. A needle guide assembly may be pivotally connect internal to the guide channel cut-out or aperture of the ultrasound probe housing at a pivot point such that during use the needle enters the patient through the needle guide assembly within the ultrasonic probe housing so that the needle can be visualized by the ultrasonic probes in real time. The ultrasound probe housing may also provide an adhesion or suction quality to the body side of the device to facilitate aspects of the invention.

Abstract: A device and system for and methods of using an ultrasound probe housing containing ultrasound probes configured to produce images inside the body of a patient for procedures requiring needle or probe insertion. The ultrasound probe housing can be configured with a guide channel cut-out or aperture between the ambient side and body side of a patient. A needle guide assembly may be pivotally connect internal to the guide channel cut-out or aperture of the ultrasound probe housing at a pivot point such that during use the needle enters the patient through the needle guide assembly within the ultrasonic probe housing so that the needle can be visualized by the ultrasonic probes in real time. The ultrasound probe housing may also provide an adhesion or suction quality to the body side of the device to facilitate aspects of the invention.

Abstract: Disclosed is a plant growing system (100), comprising: a plurality of plant growing zones (122); a control apparatus (120) configured to control one or more environmental conditions in each of the plurality of plant growing zones (122); and a receiver (142) configured to receive input data indicating plant type characteristics of a plurality of plant characteristics types to be grown in a plant growing apparatus (120). Also disclosed is a plant growing apparatus (120) configured to grow a plurality of plant types, a method to control a plant growing apparatus (120) configured to grow a plurality of plant types, and a computer program including computer-readable instructions executable to perform a method to control a plant growing apparatus (120) configured to grow a plurality of plant types.

Abstract: An autonomous vehicle and a system and method of operating the autonomous vehicle. The system includes a sensor and a processor. The processor determines an effective observation area of the sensor, the effective observation area being affected by an extrinsic condition. The processor determines an available time for performing a lane change based on the effective observation area and performs the lane change based on the available time.

Abstract: A device and system for and methods of using an ultrasound probe housing containing ultrasound probes configured to produce images inside the body of a patient for procedures requiring needle or probe insertion. The ultrasound probe housing can be configured with a guide channel cut-out or aperture between the ambient side and body side of a patient. A needle guide assembly may be pivotally connect internal to the guide channel cut-out or aperture of the ultrasound probe housing at a pivot point such that during use the needle enters the patient through the needle guide assembly within the ultrasound probe housing so that the needle can be visualized by the ultrasonic probes in real time. The ultrasound probe housing may also provide an adhesion or suction quality to the body side of the device to facilitate aspects of the invention.

Abstract: A device and system for and methods of using an ultrasound probe housing containing ultrasound probes configured to produce images inside the body of a patient for procedures requiring needle or probe insertion. The ultrasound probe housing can be configured with a guide channel cut-out or aperture between the ambient side and body side of a patient. A needle guide assembly may be pivotally connect internal to the guide channel cut-out or aperture of the ultrasound probe housing at a pivot point such that during use the needle enters the patient through the needle guide assembly within the ultrasound probe housing so that the needle can be visualized by the ultrasonic probes in real time. The ultrasound probe housing may also provide an adhesion or suction quality to the body side of the device to facilitate aspects of the invention.

Abstract: Various examples for discovering policy bindings between group policy rules in a legacy management framework and unified endpoint management rules that are utilized in a modern mobile device management (MDM) device management framework. A configuration state view can allow an administrator to understand inconsistencies or conflicts between group policy rules and UEM rules.

Abstract: In an exemplary embodiment, a vehicle system is provided that includes a sensor array and a processor. The sensor array is configured to generate vehicle sensor data pertaining to a target vehicle in proximity to the vehicle. The processor is coupled to the sensor array, and is configured to at least facilitate: beginning an overtake maneuver for the vehicle, via instructions provided to the drive system, when conditions for an overtake of the target vehicle by the vehicle are initially determined by the processor to be valid; subsequent to the beginning of the overtake maneuver, determining via the processor whether the conditions for the overtake of the target vehicle are still valid, based on updated sensor data reflecting variant traffic conditions; and further controlling the overtake maneuver based on the determining as to whether the conditions for the overtake of the target vehicle are still valid.

Abstract: A method is provided for autonomously operating a vehicle. The method includes receiving vehicle state and vehicle environment data; determining that a vehicle position is not in a position for autonomous mode based on vehicle state and vehicle environment data, wherein the position is associated with a center of one lane of a roadway; enabling a steering assistance torque for a lane-centering operation concurrently within a pre-determined period of time of engagement of the autonomous mode for a vehicular operation; blending the steering assistance torque for assisting in vehicle guidance with a torque applied by the operator for the lane-centering operation with the autonomous mode of vehicular operation engaged; and executing enablement of the autonomous vehicular operation mode with the vehicle positioned within the center of one lane of the roadway as the operator is transitioned from a hands-on to a hands-off control of the vehicle.

Abstract: Examples of enterprise management using managed virtual machines for virtualized applications are described. In some examples, a managed virtual machine is executed on a host device and enrolled with a management service. A virtualized application drive is stored in the managed virtual machine. A launch agent executed within the managed virtual machine detects an application access request corresponding to user interaction with a host operating system of the host device. The application volumes launch agent accesses the virtualized application drive and launches the virtualized application corresponding to the application access request.

Abstract: A method for controlling operation of a motor vehicle includes an electronic controller receiving, e.g., from a vehicle-mounted sensor array, sensor data with dynamics information for a target vehicle and, using the received sensor data, predicting a lane assignment for the target vehicle on a road segment proximate the host vehicle. The electronic controller also receives map data with roadway information for the road segment; the controller fuses the sensor and map data to construct a polynomial overlay for a host lane of the road segment across which travels the host vehicle. A piecewise linearized road map of the host lane is constructed and combined with the predicted lane assignment and polynomial overlay to calculate a lane assignment for the target vehicle. The controller then transmits one or more command signals to a resident vehicle system to execute one or more control operations using the target vehicle's calculated lane assignment.