Abstract: Disclosed are compounds of the formula (I) and pharmaceutically acceptable salts thereof: (I) wherein R1, R2, R3, R4, R5, R6, R8, R9, X, X1, X2, X3, L1 and n are as defined herein. The compounds are inhibitors of adrenomedullin receptor subtype 2 (AM2). Also disclosed are the compounds for use in the treatment of diseases modulated AM2, including proliferative diseases such as cancer; pharmaceutical compositions comprising the compounds; methods for preparing the compounds; and intermediates useful in the preparation of the compounds.

Abstract: The disclosure relates to antibodies specific to FcRn, formulations comprising the same, use of each in therapy, processes for expressing and optionally formulating said antibody, DNA encoding the antibodies and hosts comprising said DNA.

Abstract: An energy harvesting apparatus may include a thermoelectric device, a heat exchanger coupled to the thermoelectric device, a thermal capacitor container, and a thermal capacitor generation device. The thermal capacitor generation device may be configured to generate a thermal capacitor fluid, to be contained in the thermal capacitor container. An electrical energy storage device may be electrically connected to the thermoelectric device, to store electricity generated by the thermoelectric device.

Abstract: The disclosure relates to antibodies specific to FcRn, formulations comprising the same, use of each in therapy, processes for expressing and optionally formulating said antibody, DNA encoding the antibodies and hosts comprising said DNA.

Abstract: Presented herein are compositions comprising L-serine, or a precursor, derivative or conjugate thereof, and a non-toxic metal, such as zinc. Compositions disclosed herein can be used for the prevention and treatment of neurodegenerative diseases, or related symptoms thereof.

Abstract: A computer implemented method for controlling operational states of a hardware matching processor includes monitoring, by a circuit breaker, incoming electronic data transaction request messages to the hardware matching processor; dynamically defining a range of values as a function of values included with electronic data transaction request messages received during a rolling lookback window; detecting that an incoming electronic data transaction request message contains a value outside the range of values; transitioning the electronic data transaction processing system into a pre-open state for a predetermined period, thereby preventing the hardware matching processor from matching incoming electronic data transaction request messages; calculating a pre-open value at an end of the pre-open state; and re-opening the electronic data transaction processing system at the calculated pre-open value, thereby allowing the hardware matching processor to match incoming electronic data transaction request messages.

Abstract: The present invention generally relates to the treatment of psoriasis with an antibody that binds to the p19 subunit of human IL-23, in particular dosage regimens for the treatment of the disease.

Abstract: Disclosed are compounds of the formula (I) and pharmaceutically acceptable salts thereof: wherein HET, R1, R2, R3, R4, R5, L, L1, X1, X2, X3 and q are as defined herein. The compounds are inhibitors of adrenomedullin receptor subtype 2 (AM2). Also disclosed are the compounds for use in the treatment of diseases modulated AM2, including proliferative diseases such as cancer; pharmaceutical compositions comprising the compounds; methods for preparing the compounds; and intermediates useful in the preparation of the compounds.

Abstract: A headliner system includes a plurality of segments connected together and outlining a central opening and a central section received in the central opening. The central section is selected from a group of central sections consisting of a multisection panel incorporating an overhead airbag grid system, a panel incorporating a fold down display panel and a panel incorporating a pull down divider.

Abstract: The disclosure relates to antibodies specific to FcRn, formulations comprising the same, use of each in therapy, processes for expressing and optionally formulating said antibody, DNA encoding the antibodies and hosts comprising said DNA.

Abstract: L-serine, L-serine precursors, L-serine derivatives and L-serine conjugates for treatment, amelioration and/or prevention of protein aggregation/tangles/plaques and diseases associated with protein aggregation/tangles/plaques. In particular, treatments and uses for L-serine, L-serine precursors, L-serine derivatives and L-serine conjugates include Alzheimer's disease (AD), Parkinson's disease, Amyotrophic Lateral Sclerosis (ALS), and Huntington disease (HD).

Abstract: An inlet or primary particle size fractionator for a direct-reading PM2.5 mass sensor described herein may remove atmospheric particles of a given size, such as particles greater than the inlet cut point (e.g., having a 10 ?m AD cut point) and may transport particles less than the cut point to a mass sensing element or a secondary particle size fractionator (e.g., having a 2.5 ?m AD cut point). The inlet may have a flow rate range of between 1 mL/min and 50 mL/min (or higher flow rates depending on the application). The inlet may include a virtual impactor (VI), real impactor, cyclone, or virtual cyclone (VC). A sensing element may measure particle mass below the primary particle size fractionator (e.g., 2.5 ?m AD particles with a 10 ?m AD cut point inlet) and/or between the size range of the primary and secondary particle size fractionators (e.g., between 2.5 ?m and 10 ?m AD, or coarse particles).

Abstract: A vehicle control system for moving a vehicle to a target location is disclosed. According to examples of the disclosure, a camera captures one or more images of a known object corresponding to the target location. An on-board computer having stored thereon information about the known object can process the one or more images to determine vehicle location with respect to the known object. The system can use the vehicle's determined location and a feedback controller to move the vehicle to the target location.

Abstract: A computer implemented method for controlling operational states of a hardware matching processor includes monitoring, by a circuit breaker, incoming electronic data transaction request messages to the hardware matching processor; dynamically defining a range of values as a function of values included with electronic data transaction request messages received during a rolling lookback window; detecting that an incoming electronic data transaction request message contains a value outside the range of values; transitioning the electronic data transaction processing system into a pre-open state for a predetermined period, thereby preventing the hardware matching processor from matching incoming electronic data transaction request messages; calculating a pre-open value at an end of the pre-open state; and re-opening the electronic data transaction processing system at the calculated pre-open value, thereby allowing the hardware matching processor to match incoming electronic data transaction request messages.

Abstract: An electronics package is disclosed herein that includes a glass substrate having an exterior portion surrounding an interior portion thereof, wherein the interior portion has a first thickness and the exterior portion has a second thickness larger than the first thickness. An adhesive layer is formed on a lower surface of the interior portion of the glass substrate. A semiconductor device having an upper surface is coupled to the adhesive layer, the semiconductor device having at least one contact pad disposed on the upper surface thereof. A first metallization layer is coupled to an upper surface of the glass substrate and extends through a first via formed through the first thickness of the glass substrate to couple with the at least one contact pad of the semiconductor device.

Abstract: A grab handle assembly for a vehicle includes first and second anchoring features coupled to a vehicle surface. A rail extends between the first and second anchoring features in a spaced relationship with the vehicle surface. A slot is defined by the rail and configured to receive a key feature for attachment of the key feature to the rail.

Abstract: Embodiments of the present invention are directed to methods, systems, and circuitry for reduced error in power consumption estimation for distinct circuitries. A non-limiting example includes distinct circuitry having an optimized power consumption definition. The distinct circuitry includes a substrate. The distinct circuitry includes an arrangement of interoperable hardware components disposed on the substrate having input pins defined according to a model described by a hardware description language operable to emulate toggle events of the interoperable hardware components defined by the model having a toggle event count based on combinations of the toggle events that correspond to predetermined power quantities. The toggle events define an aggregate toggle power consumption closer to an actual power consumption than an aggregate pin power consumption based on the input pins.

Abstract: A vehicle control system for moving a vehicle to a target location is disclosed. According to examples of the disclosure, a camera captures one or more images of a known object corresponding to the target location. An on-board computer having stored thereon information about the known object can process the one or more images to determine vehicle location with respect to the known object. The system can use the vehicle's determined location and a feedback controller to move the vehicle to the target location.

Abstract: A computer-implemented method is provided for simultaneous simulation of one-dimensional flow and multi-dimensional flow in a fluid flow network. Processes define meshes of nodes for both one-dimensional and multi-dimensional flow components in a fluid flow network. Another process defines a relational data structure for each adjacent node pair in each multi-dimensional flow component. A flow analysis code is executed to model fluid flow throughout the fluid flow network using the one-dimensional and multi-dimensional meshes of nodes, and each relational data structure.

Abstract: The technology is directed to a web browser and associated systems and methods for providing tailored experiences based on a user's use of the web browser. One or more processors may receive a requested URL and classify the requested URL into an activity type. The one or more processors may retrieve additional information associated with the requested URL based on the classified activity type and determine one or more driving actions based on the activity type and the retrieve additional information, each of the one or more driving actions configured to cause a web browser to perform an action. The one or more processors may provide the one or more driving actions, the classified activity type, and the additional information to the web browser.