Abstract: Apparatus and methods for manufacturing compostable, biodegradable drink straws from polyhydroxyalkanoate (PHA) material are disclosed herein. Such apparatus may include a hopper that contains raw PHA material, an extruder that receives the raw PHA material from the hopper and produces extruded PHA material, one or more waters baths that cool the extruded PHA material, a puller that pulls a tubular stream of PHA material through the system, and a cutter that is configured to cut the stream of PHA material into finished straws. The finished straws may be soil- and marine-biodegradable, as well as home- and industrial-compostable.

Abstract: The present disclosure provides DNA-guided CRISPR systems; polynucleotides comprising DNA, RNA and mixtures thereof for use with CRISPR systems; and methods of use involving such polynucleotides and DNA-guided CRISPR systems.

Abstract: A hands-free diatonic harmonica configured to be held by the mouth only, permitting harmonica to be easily played and manipulated solely by player's mouth, jaw, teeth, lips, and tongue and attachable elongated ergonomic and acoustical bullet shaped harmonica microphone housing with mirror image top and bottom access ports and through rod(s) accommodating multiple microphones digital processing and adhesive pads providing or modifying mouth alone attributes.

Abstract: An applicator for an analyte monitoring device may include an actuatable housing having a body defining a cavity therein and having a distal opening and a side opening. A cuff and a shuttle are received within the cavity and are separately translatable relative to the housing body. A base may removable engage the housing body at the distal opening. The housing body, the cuff, the shuttle, and/or the base may be engaged with one another with one or more releasable coupling features. The base may be removed from an engagement with the housing body, causing the cuff and the shuttle to be aligned and positioned in a configuration in which the analyte monitoring device, held by the shuttle, is ready for insertion into the skin.

Abstract: A self-supporting inorganic and radiation-hard neutron shielding panel for use in absorbing thermal neutrons. The panel is constructed substantially of concrete and includes a high level of boron by weight to enhance the absorption of thermal neutrons. A layer of radiation-resistant fiber reinforcement within the panel enables production of a thin, strong panel that is self-supporting and easily transportable. Mounting means are included on the panel to facilitate easy mounting on a wall or similar surface. The panels are constructed entirely of inorganic materials and include at least 58% boron by weight to maximize their effectiveness in shielding against thermal neutrons. Further disclosed are methods for forming the neutron-shielding panels.

Abstract: A telecommunications system is disclosed that coordinates and executes complex communication tasks using structured messaging and off-line synchronization.

Abstract: An applicator for an analyte monitoring device may include an actuatable housing having a body defining a cavity therein and having a distal opening and a side opening. A cuff and a shuttle are received within the cavity and are separately translatable relative to the housing body. A base may removable engage the housing body at the distal opening. The housing body, the cuff, the shuttle, and/or the base may be engaged with one another with one or more releasable coupling features. The base may be removed from an engagement with the housing body, causing the cuff and the shuttle to be aligned and positioned in a configuration in which the analyte monitoring device, held by the shuttle, is ready for insertion into the skin.

Abstract: A solar module mounting bracket system including a plurality of solar modules including mounting slots formed in a sidewall of the solar module, a torque tube configured to support the solar modules such that they can be rotated, a plurality of mounting brackets configured for integration with the torque tube and to which the plurality of solar modules are mounted, at least one first retainer assembly connected to one of the plurality of mounting brackets, the first retainer assembly including a through bolt, a spring, a mounting tab, and nut. When a solar module is placed on the mounting bracket and supported by the torque tube the mounting tab retainer assembly is received in the mounting slot of the solar module.

Abstract: A controller for removing deposits in a vehicle is disclosed. The controller includes at least one processor and a memory storing instructions therein that, when executed by the at least one processor, cause the at least one processor to: determine an amount of deposits accumulated in the vehicle based on an amount of time; determine a combustion target for the vehicle in response to determining that the amount of deposits exceeds a deposit threshold; and modulate a fluid flow of the vehicle based on the determined combustion target.

Abstract: A method includes: determining that at least one cylinder of a first cylinder bank of an engine is active; determining that at least one cylinder of a second cylinder bank of the engine is inactive; receiving an inlet temperature of a selective catalytic reduction system; comparing the inlet temperature to a temperature setpoint; and adjusting at least one of a first exhaust manifold pressure setpoint for the first cylinder bank or a second exhaust manifold pressure setpoint for the second cylinder bank based on the comparison.

Abstract: A stringed musical instrument saddle containing a plurality of electrically independent transducers and associated electrical conditioning components where each transducer is located within the saddle such that it is sensitive to the vibratory energy of a corresponding string or course and senses the vibratory energy in both vertical and horizontal modes. The saddle contains at least one multi-conductor connector which connects to a removable multi-conductor cable to convey the transducer signals out of the saddle to external receiving electronics. The saddle is constructed of workable materials such that its top and bottom can be fit to a particular instrument by a technician.

Abstract: A door closer, including: an anchor assembly, including: a frame mounting plate which is fixable relative to a door frame; and an adjustor plate; and an actuator assembly for mounting within the thickness of a door leaf to move the door leaf between open and closed configurations relative to the door frame, the actuator assembly including an operating member coupled by a link to the adjustor plate and mounted for a range of movements between a fully retracted position, in which the anchor assembly is held adjacent the actuator assembly when the door leaf is in the closed configuration, and an extended position, in which the anchor assembly is in spaced relation to the actuator assembly when the door leaf is in the open configuration, the link being configured to extend from the adjustor plate along a first axis, wherein the frame mounting plate is provided with one or more slot(s), the or each slot being elongated along a second axis, the second axis being generally orthogonal to the first axis.

Abstract: Methods, systems, and devices for automatically customizing operation of a robotic vehicle are described. The method may include identifying an operator, retrieving an operator profile and associated metadata for the operator from a database, where the metadata includes operator habit information, and configuring the robotic vehicle based on existing preference-based and performance-based settings, where the existing preference-based and performance-based settings are based on the metadata. The methods may include identifying operator habit information during operation of the robotic vehicle, deriving updated preference-based and performance-based settings for the operator based on the identified operator habit information, and providing, to the database, modifications to the metadata associated with the operator profile of the operator.

Abstract: Example electrosurgical devices and systems are disclosed. An example electrosurgical device includes a body, an electrosurgical electrode secured to the body, the electrosurgical electrode including a distal tip. The electrosurgical device also includes a shroud translatable relative to the electrosurgical electrode between a first position and a second position, a first magnetic component which is operably connected to the body, and a second magnetic component which is operably connected to the shroud, wherein the first and second magnetic components magnetically interact to releasably maintain the shroud in the first position.

Abstract: The present disclosure provides engineered polynucleotide sequences that form scaffolds and nucleoprotein complexes comprising such engineered polynucleotide sequences that form scaffolds and nucleic acid binding proteins. Nucleic acid sequences encoding the engineered polynucleotide sequences that form scaffolds, as well as expression cassettes, vectors and cells comprising such polynucleotide sequences, are described. A variety of methods for making and using the engineered polynucleotide sequences that form scaffolds are also disclosed.

Abstract: A drug delivery device includes a housing, a container disposed in the housing, an activation mechanism, a needle insertion mechanism, a fluid flow connection, and a valve in fluid communication with the fluid flow connection and the needle insertion mechanism. The container has an inner volume to contain a medicament which is urged out of the container by the activation mechanism. The needle insertion mechanism is adapted to insert a needle and/or a cannula to deliver the medicament from the container via the fluid flow connection. The valve is in fluid communication with the fluid flow connection and needle insertion mechanism, and is movable between first and second positions. Upon insertion of the needle and/or the cannula, the valve remains in the first position whereby fluid flow is restricted. At a later time, the valve is urged to the second position whereby fluid may flow through the needle or cannula.

Abstract: A method includes receiving an execute packet that includes a first instruction and a second instruction and executing the first instruction and the second instruction using a pipeline. Executing the first and second instructions includes storing a result of the first instruction in a holding register; determining whether an event that interrupts execution of the execute packet occurs prior to completion of the executing of the second instruction; and based on the event not occurring, committing the result of the first instruction after completion of the executing of the second instruction.

Abstract: A solar module mounting bracket system including a plurality of solar modules including mounting slots formed in a sidewall of the solar module, a torque tube configured to support the solar modules such that they can be rotated, a plurality of mounting brackets configured for integration with the torque tube and to which the plurality of solar modules are mounted, at least one first retainer assembly connected to one of the plurality of mounting brackets, the first retainer assembly including a through bolt, a spring, a mounting tab, and nut. When a solar module is placed on the mounting bracket and supported by the torque tube the mounting tab retainer assembly is received in the mounting slot of the solar module.

Abstract: A drug delivery device includes a housing, a container disposed in the housing, an activation mechanism, and a needle insertion mechanism (NIM). The container has an inner volume to contain a medicament which is urged out of the container by the activation mechanism. The needle insertion mechanism (NIM) is operably coupled with the activation mechanism and includes an actuation assembly adapted to insert a needle and a cannula to deliver the medicament from the container. The actuation assembly is movable between a storage state, a first operational state, a second operational state, and a third operational state to selectively position the needle and the cannula.

Abstract: The present disclosure provides polynucleotide guides for use in CRISPR-Cas systems wherein such polynucleotides contain at least one CRISPR abasic restricted nucleotide (CABRNT) and/or at least one CRISPR accuracy via analogs (CAVA) nucleotide. CRISPR guides that contain at least one abasic site and/or at least one base analog, as well as nucleoprotein complexes of CRISPR-Cas proteins and CABRNT, CAVA, and CABRNT-CAVA guides are also described. Also disclosed are methods for making and using the CABRNT, CAVA, and CABRNT-CAVA polynucleotides and guides and the CABRNT/Cas, CAVA/Cas, and CABRNT-CAVA/Cas nucleoprotein complexes of the present invention.