Abstract: An adaptor includes a body defining a longitudinal axis, and a transverse axis that is normal to the longitudinal axis. The body also has a leading portion defining a lock receiving recess extending transversely at least partially through the leading portion. The leading portion defines at least one linear portion in the lock receiving recess that is configured to engage the power locking device.

Abstract: Systems, methods, and apparatuses are provided for increasing exhaust gas temperature. A system includes a valve and a controller coupled to the valve. The controller is structured to determine that a plurality of cylinders of an engine are active; compare an exhaust aftertreatment temperature to an exhaust aftertreatment temperature setpoint; and in response to the comparison, adjust an effective flow area for exhaust gas from the plurality of cylinders of the engine to increase an exhaust gas temperature.

Abstract: Disclosed is a method for converting cymene generated from renewable low value terpene streams into renewable benzene, toluene, xylenes, and cymene isomers (ortho and meta) under flow disproportionation reaction conditions, which compounds are basic building blocks for fragrance materials. This technology has potential to replace high volume petrochemical-based feedstocks with plant-based building blocks that can fill the renewability gap for key fragrance ingredients.

Abstract: The present disclosure provides DNA-guided CRISPR systems; polynucleotides comprising DNA, RNA and mixtures thereof for use with CRISPR systems; and methods of use involving such polynucleotides and DNA-guided CRISPR systems.

Abstract: Methods, devices and systems enable controlling an autonomous vehicle by identifying a vehicle that is within a threshold distance of the autonomous vehicle, determining an autonomous capability metric (ACM) the identified vehicle, determining whether the ACM of the identified vehicle is greater than a first threshold, determining whether the ACM of the identified vehicle is less than a second threshold, and adjusting a driving parameter of the autonomous vehicle so that the autonomous vehicle is more or less reliant on the capabilities of the identified vehicle based on whether the ACM of the identified vehicle exceeds the thresholds.

Abstract: Various embodiments include methods and interactive traffic control devices for interactively controlling traffic, which may include receiving refined location and state information associated with individual vehicles on a roadway, and determining customized dynamic traffic control instructions for a first one or more of the individual vehicles. The determined customized dynamic traffic control instructions may be based on the received refined location and state information and offer an optional route alternative to a set limited number of the individual vehicles. The first customized dynamic traffic control instructions may be transmitted by the interactive traffic control device to the first one or more of the individual vehicles.

Abstract: A battery cell stack casing includes casing walls defining a housing interior for receiving a battery cell stack; a first end plate provided between the walls at a first end of the casing to close a first end of the housing interior. The casing also include a second end plate provided between the walls at a second end of the casing to close a second end of the housing interior. The casing walls have a multi-layer structure include: an inner layer having a first side facing into the housing interior and a second opposite side; an outer layer spaced outwardly from the second side of the inner layer; a thermally insulating volume defined between the second side of the inner layer and the outer layer, the thermally insulating material containing a low density thermally insulative material e.g., foam or other insulative material; and a layer of intumescent material provided on the first side of the inner layer.

Abstract: A battery cell stack casing includes casing walls defining a housing interior for receiving a battery cell stack, a first end plate provided between the walls at a first end of the casing to close a first end of the housing interior, and a second end plate provided between the walls at a second end of the casing to close a second end of the housing interior. The casing walls have a multi-layer structure that includes, an inner layer having a first side facing into the housing interior and a second opposite side, an outer layer spaced outwardly from the second side of the inner layer, an air or vacuum-filled thermally insulating volume defined between the second side of the inner layer and the outer layer, and a layer of intumescent material provided on the first side of the inner layer.

Abstract: A drug delivery device includes a housing releasably coupled with a patient, a pressure chamber disposed in the housing and including a vent, a container at least partially disposed in the pressure chamber for storing a drug connectable in fluid communication with a fluid conduit, an activation mechanism, and a relief mechanism. The activation mechanism releases a pressurized drive fluid into the pressure chamber for expelling the drug from the container into the fluid conduit. The relief mechanism is operably coupled to the fluid conduit and is adapted to open the vent to release the drive fluid from the pressure chamber in response to a predetermined condition.

Abstract: This disclosure provides for compositions and methods for the use of nucleic acid-targeting nucleic acids and complexes thereof. Genome engineering can refer to altering the genome by deleting, inserting, mutating, or substituting specific nucleic acid sequences. The altering can be gene or location specific. Genome engineering can use nucleases to cut a nucleic acid thereby generating a site for the alteration. Engineering of non-genomic nucleic acid is also contemplated.

Abstract: A drug delivery device includes a housing releasably coupled with a patient, a container disposed in the housing, a plunger disposed in the container, an activation mechanism, and a seal member. The container includes a wall with an interior surface. The plunger includes an interior surface and is moveably disposed in the container. The interior surfaces of the wall and the plunger define a reservoir adapted to contain a drug. The activation mechanism is adapted to release a drive fluid for moving the plunger through the container to expel the drug therefrom. The seal member is moveably disposed in the container and is adapted to inhibit ingress of the drive fluid into the reservoir.

Abstract: A method includes receiving an execute packet that includes a first instruction and a second instruction and executing the first instruction and the second instruction using a pipeline. Executing the first and second instructions includes storing a result of the first instruction in a holding register; determining whether an event that interrupts execution of the execute packet occurs prior to completion of the executing of the second instruction; and based on the event not occurring, committing the result of the first instruction after completion of the executing of the second instruction.

Abstract: An adaptor includes a body defining a longitudinal axis, and a transverse axis that is normal to the longitudinal axis. The body also has a leading portion defining a lock receiving recess extending transversely at least partially through the leading portion. The leading portion defines at least one linear portion in the lock receiving recess that is configured to engage the power locking device.

Abstract: A method and apparatus for estimating a step length of a user are disclosed. The method involves obtaining inertial data generated by an inertial sensor, extracting orthogonal motion components a plurality of directions, and estimating, based on the orthogonal motion components for each direction, a respective parameter that is indicative of energy expenditure by the user in the corresponding direction. The step length is then estimated, based on each estimated parameter indicating energy expenditure by the user, a corresponding step length.

Abstract: Various embodiments include methods and vehicles, such as an autonomous vehicle, a semi-autonomous vehicle, etc., for collaboratively directing one or more headlights among vehicles traveling in a platoon. Various aspects may include transmitting, by a first vehicle processor of a first vehicle traveling in the platoon, a collaborative lighting plan to a second vehicle traveling in the platoon, wherein the collaborative lighting plan may direct the second vehicle to direct one or more headlights of the second vehicle in a direction other than a direction of travel of the platoon. The first vehicle processor may then direct one or more the headlights of the first vehicle in accordance with the collaborative lighting plan.

Abstract: Methods, devices and systems enable controlling an autonomous vehicle by identifying vehicles that are within a threshold distance of the autonomous vehicle, determining an autonomous capability metric of each of the identified vehicles, and adjusting a driving parameter of the autonomous vehicle based on the determined autonomous capability metric of each of the identified vehicles. Adjusting a driving parameter may include adjusting one or more of a minimum separation distance, a minimum following distance, a speed parameter, or an acceleration rate parameter.

Abstract: A new CRISPR-associated (Cas) protein, termed “CasM,” is described, as well as polynucleotides encoding the same and methods of using CasM for site-specific genome engineering. CasM proteins are capable of targeting and cleaving single-stranded RNA.

Abstract: A medical device, configured for insertion into a body, may include an elongate member extending from a proximal end to a distal end, where the distal end may be configured to be positioned inside the body. The medical device may also include an imaging device positioned at the distal end. The medical device may further include a plurality of light sources positioned at the distal end, wherein a characteristic of light delivered through a first light source may be controlled independent of the characteristic of light delivered through a second light source.