Abstract: The present invention provides a novel approach to cancer diagnosis and therapy of cancer by providing compositions and methods for the identification and specific targeting of the cancer stem cell populations present in a tumour to eradicate, or slow or prevent tumour (5) growth and spread, including the potential for tumour metastasis, by modulation of the Renin-Angiotensin System including, but not limited to, Renin Receptor, Angiotensin II Receptor (2) and a secreted form of the Renin Receptor.

Abstract: A lithography tool is calibrated using a calibration substrate having a set of first marks distributed across its surface in a known pattern. The tool is operated to apply a pattern comprising a plurality of second marks at various positions on the substrate, each second mark overlying one of the first marks and being subject to an overlay error dependent on an apparatus-specific deviation. The second marks are applied by multiple exposures while the substrate remains loaded in the tool. An operating parameter of the apparatus is varied between the exposures. An overlay error is measured and used to calculate parameter-specific, apparatus-specific calibration data based on knowledge of the parameter variation used for each exposure.

Abstract: Techniques are presented herein that combine a host-based analysis of an executable file on a host computer with a network-based analysis, i.e., an analysis of domain names to detect malware generated domain names that are used by the malicious executable files to establish malicious network connections. A server receives information from a host computer about an executable file that, when executed on the host computer, initiates a network connection. The server also receives information about the network connection itself. The server analyzes the information about the executable file to determine whether the executable file has a malicious disposition. Depending on a disposition of the executable file, the server analyzes the information about the network connection and determines whether the network connection is malicious.

Abstract: A dosing cup having a longitudinal axis includes a base; an opening opposing the base, wherein the opening is circumscribed by a rim; and a sidewall extending from the base to the rim. The sidewall includes a first portion extending from the rim toward the base. The first portion has a projection with a dosing indicium. The projection is defined by a length extending axially along the sidewall and a width that is perpendicular to the length. The width of the projection is less than the length of the projection. The sidewall includes a second portion extending from the base toward the rim. The second portion has a recess. The projection of the first portion mates with the recess of the second portion. The first portion has a first translucency and the second portion has a second translucency, wherein the first translucency is different than the second translucency.

Abstract: A method for producing sterile, decellurized bioprosthetic tissue comprising: (a) contacting a human tissue with a hypotonic solution to produce a lysed tissue, (b) contacting the lysed tissue with a first surfactant to produce a surfactant-treated tissue, (c) contacting the surfactant-treated tissue with a nuclease enzyme solution to produce an enzyme-treated tissue, (d) contacting the enzyme-treated tissue with a cleaning solution comprising a second surfactant, a chaotropic agent or a mixture thereof to produce a decellurized tissue and (e) contacting the decellurized tissue with a bioburden reducing agent to produce the final bioprosthetic tissue. Kits to be used in conjunction with said method, as well as, the bioprosthetic tissue produced via said method are also provided.

Abstract: A reticle is loaded into a lithographic apparatus. The apparatus performs measurements on the reticle, so as to calculate alignment parameters for transferring the pattern accurately to substrates. Tests are performed to detect possible contamination of the reticle or its support. Either operation proceeds with a warning, or the patterning of substrates is stopped. The test uses may use parameters of the alignment model itself, or different parameters. The integrity parameters may be compared against reference values reflecting historic measurements, so that sudden changes in a parameter are indicative of contamination. Integrity parameters may be calculated from residuals of the alignment model. In an example, height residuals are used to calculate parameters of residual wedge (Rx?) and residual roll (Ryy?). From these, integrity parameters expressed as height deviations are calculated and compared against thresholds.

Abstract: Techniques are presented herein that combine a host-based analysis of an executable file on a host computer with a network-based analysis, i.e., an analysis of domain names to detect malware generated domain names that are used by the malicious executable files to establish malicious network connections. A server receives information from a host computer about an executable file that, when executed on the host computer, initiates a network connection. The server also receives information about the network connection itself. The server analyzes the information about the executable file to determine whether the executable file has a malicious disposition. Depending on a disposition of the executable file, the server analyzes the information about the network connection and determines whether the network connection is malicious.

Abstract: A method is described for distributing samples within an automated analyzer from a linear arrangement of sample vessels to a processing plate in a two-dimensional n×m arrangement wherein samples are sorted, followed by transfer with a pipetting device with a linear arrangement to a processing vessel in a two-dimensional n×m arrangement and subsequent processing of samples using a second pipetting device which has a two-dimensional n×m arrangement.

Abstract: A method is described for distributing samples within an automated analyzer from a linear arrangement of sample vessels to a processing plate in a two-dimensional n×m arrangement wherein samples are sorted, followed by transfer with a pipetting device with a linear arrangement to a processing vessel in a two-dimensional n×m arrangement and subsequent processing of samples using a second pipetting device which has a two-dimensional n×m arrangement.

Abstract: A lithography system configured to apply a pattern to a substrate, the system including a lithography apparatus configured to expose a layer of the substrate according to the pattern, and a machine learning controller configured to control the lithography system to optimize a property of the pattern, the machine learning controller configured to be trained on the basis of a property measured by a metrology unit configured to measure the property of the exposed pattern in the layer and/or a property associated with exposing the pattern onto the substrate, and to correct lithography system drift by adjusting one or more selected from: the lithography apparatus, a track unit configured to apply the layer on the substrate for lithographic exposure, and/or a control unit configured to control an automatic substrate flow among the track unit, the lithography apparatus, and the metrology unit.

Abstract: An analyzer for detecting or quantitating an analyte comprising a temporary storage unit for storing a reagent cassette and a method for presenting a reagent cassette present in a temporary storage unit to a pipetting device are described.

Abstract: A textured mask comprising a film. The film can have a first substantially continuously flat surface lying in a first plane and a second surface opposite the first surface lying in a second plane substantially parallel to the first plane. The second surface is interrupted by a plurality of cavities, each of the cavities having a first depth defined by a third surface lying in a third plane substantially parallel to the first and second planes. The depth of the cavities can be at a distance of from about 0.1 mm to about 5 mm from the second plane. The textured mask is at least partially coated with an opaque masking agent. The textured mask can make a correspondingly structured three-dimensional papermaking belt, which can make correspondingly structured three-dimensional fibrous structure.

Abstract: A method of connecting a substrate is provided, wherein the substrate may include a first main surface and a second main surface opposite the first main surface. The method may include forming at least one protrusion on the first main surface of the substrate, forming a fixing agent over the first main surface of the substrate and over the at least one protrusion; and arranging the substrate on a carrier. The at least one protrusion may contact a surface of the carrier and may be configured to keep the first main surface of the substrate at a distance to the contacted surface of the carrier corresponding to a height of the protrusion, thereby forming a space between the first main surface of the substrate and the carrier. During the arranging the substrate on the carrier, at least a part of the fixing agent formed over the at least one protrusion may be displaced into the space between the first main surface of the substrate and the carrier.

Abstract: A dosing cup having a longitudinal axis includes a base; an opening opposing the base, wherein the opening is circumscribed by a rim; and a sidewall extending from the base to the rim. The sidewall includes a first portion extending from the rim toward the base. The first portion has a projection with a dosing indicium. The projection is defined by a length extending axially along the sidewall and a width that is perpendicular to the length. The width of the projection is less than the length of the projection. The sidewall includes a second portion extending from the base toward the rim. The second portion has a recess. The projection of the first portion mates with the recess of the second portion. The first portion has a first translucency and the second portion has a second translucency, wherein the first translucency is different than the second translucency.

Abstract: An automated analyzer with an on-board fridge for long-term cooling of reagents, and a method for isolating and analyzing an analyte comprising long-term cooling of reagents.

Abstract: An automated analyzer with an on-board fridge for long-term cooling of reagents, and a method for isolating and analyzing an analyte comprising long-term cooling of reagents.

Abstract: A method includes populating an auto suggestion field with objects of the same type based upon the type of object selected in the main area of the application. The auto suggestion field is set to have N levels. The method further includes placing a recently used object in a first position of the N levels of the auto suggestion field. Succeeding objects are placed in other positions of the N levels in the auto suggestion field, wherein the succeeding objects are ordered based upon recency and frequency of use and the populating is executed by at least one processor.

Abstract: An automated analyzer with an on-board fridge for long-term cooling of reagents, and a method for isolating and analyzing an analyte comprising long-term cooling of reagents.

Abstract: Methods and systems for inspection of wafers and reticles using designer intent data are provided. One computer-implemented method includes identifying nuisance defects on a wafer based on inspection data produced by inspection of a reticle, which is used to form a pattern on the wafer prior to inspection of the wafer. Another computer-implemented method includes detecting defects on a wafer by analyzing data generated by inspection of the wafer in combination with data representative of a reticle, which includes designations identifying different types of portions of the reticle. An additional computer-implemented method includes determining a property of a manufacturing process used to process a wafer based on defects that alter a characteristic of a device formed on the wafer. Further computer-implemented methods include altering or simulating one or more characteristics of a design of an integrated circuit based on data generated by inspection of a wafer.