Abstract: A method of manufacturing a nanocomposite GRIN optical-element. The method comprises providing a volumetric gradient refractive profile and providing a plurality of nanocomposite-inks to form the GRIN optical-element. Each of the plurality of nanocomposite-inks have nanoparticles dispersed in an organic-matrix. The plurality of nanocomposite-inks comprising of a nanoparticle diffusion inhibiting nanocomposite-ink wherein nanoparticle diffusion is inhibited with respect to another of the plurality of nanocomposite-inks. The diffusion inhibiting nanocomposite-ink having a different dielectric property from at least one of the other plurality of nanocomposite-inks. The plurality of nanocomposite-inks also comprising a nanoparticle diffusion permitting nanocomposite-ink wherein nanoparticle diffusion is permitted with respect to at least another of the plurality of nanocomposite-inks.

Abstract: The present invention is directed to a pharmaceutical composition comprising the compound suvorexant, or a pharmaceutically acceptable salt thereof, a concentration-enhancing polymer, and optionally a pharmaceutically acceptable surfactant.

Abstract: A system for refinement of a voice query interpretation interprets a voice query received at a voice-enabled device to identify commands responsive to the voice query for execution at the voice-enabled device, and enables refinement of the interpretation of the voice query through a graphical user interface generated and displayed at a GUI-capable device. The graphical user interface includes a set of selectable options relating to the voice query and identifying a refinement of the interpretation of the voice query to enable control and/or adjustment of commands to be executed by the voice-enabled device. For example, if one of the selectable options is selected, then a command associated with the selected option is identified and executed by the voice-enabled device.

Abstract: A system for refinement of a voice query interpretation interprets a voice query received at a voice-enabled device to identify commands responsive to the voice query for execution at the voice-enabled device, and enables refinement of the interpretation of the voice query through a graphical user interface generated and displayed at a GUI-capable device. The graphical user interface includes a set of selectable options relating to the voice query and identifying a refinement of the interpretation of the voice query to enable control and/or adjustment of commands to be executed by the voice-enabled device. For example, if one of the selectable options is selected, then a command associated with the selected option is identified and executed by the voice-enabled device.

Abstract: An aqueous or organic solvent medium for additive manufacturing technologies comprising a nanocrystal comprising a functional group. The nanocrystal material is selected from a metal oxide, fluoride, metallic, carbon-based, semiconducting quantum dot or combinations thereof. The functional group comprises primary amine, carboxylic acid, lactam ring, polyamide polymer chain or group used to attach a similar functional group.

Abstract: A system for refinement of a voice query interpretation interprets a voice query received at a voice-enabled device to identify commands responsive to the voice query for execution at the voice-enabled device, and enables refinement of the interpretation of the voice query through a graphical user interface generated and displayed at a GUI-capable device. The graphical user interface includes a set of selectable options relating to the voice query and identifying a refinement of the interpretation of the voice query to enable control and/or adjustment of commands to be executed by the voice-enabled device. For example, if one of the selectable options is selected, then a command associated with the selected option is identified and executed by the voice-enabled device.

Abstract: The present invention is directed to a pharmaceutical composition comprising the compound suvorexant, or a pharmaceutically acceptable salt thereof, a concentration-enhancing polymer, and optionally a pharmaceutically acceptable surfactant.

Abstract: The present invention is directed to a pharmaceutical composition comprising the compound suvorexant, or a pharmaceutically acceptable salt thereof, a concentration-enhancing polymer, and optionally a pharmaceutically acceptable surfactant. The concentration-enhancing polymer is a polymer that forms an amorphous dispersion with suvorexant, that is insoluble or almost completely insoluble in water by (a) dissolving the suvorexant or (b) interacting with the suvorexant in such a way that the suvorexant does not form crystals or crystalline domains in the polymer. A concentration-enhancing polymer is water soluble or readily disperse in water, so that when the polymer is placed in water or an aqueous environment (e.g. fluids in the gastrointestinal (GI) tract or simulated GI fluids), the solubility and/or bioavailability of suvorexant is increased over the solubility or bioavailability in the absence of the polymer.

Abstract: Embodiments of the present invention recite a system for extending the lifespan of a touch screen assembly. In one embodiment, a signal is received indicating an input pressure is being applied to a touch screen assembly. It is then determined that the input pressure comprises a valid input event and the coordinates of the valid input event are received from the touch screen assembly.

Abstract: Optical inks suitable for 3D printing fabrication of gradient refractive index (GRIN) optical components are composed a monomer matrix material doped with ligand-functionalized nanoparticles, wherein the monomer has a viscosity less than 20 cPoise and is UV curable to form a solid polymer. The matrix material doped with the ligand-functionalized nanoparticles has a transmittance of at least 90% in a predetermined optical wavelength range, wherein the ligand functionalized nanoparticles have a size less than 100 nm, are loaded in the monomer matrix material at a volume percent of at least 2%, and alter an index of refraction of the monomer matrix by at least 0.02. The ligand-functionalized nanoparticles have a plurality of ligands attached to a nanoparticle core surface with an anchor functional group and terminated with a buoy functional group that are reactive, non-reactive, or combinations thereof. In some embodiments the ligands have a length less than 1.

Abstract: Methods of manufacturing a volumetric continuous gradient complex dielectric element with drop-on-demand techniques, such as inkjet printing, by calculating spatial placement of nanocomposite-ink droplets are disclosed. The methods comprise determining or having a multi-dimensional gradient profile representing a volumetric gradient complex dielectric element. Providing or having a plurality of nanocomposite-inks, at least one of the nanocomposite-inks having a curable organic-matrix and a concentration of nanoparticles dispersed within to print the volumetric continuous gradient complex dielectric device. A print mask is determined in one-, two-, or three-dimensions that reconstructs the multi-dimensional gradient profile as a discretized pattern based on the material properties of the plurality of nanocomposite-inks and properties of a printing apparatus with a plurality of printheads.

Abstract: Optical inks suitable for 3D printing fabrication of gradient refractive index (GRIN) optical components are composed a monomer matrix material doped with ligand-functionalized nanoparticles, wherein the monomer has a viscosity less than 20 cPoise and is UV curable to form a solid polymer. The matrix material doped with the ligand-functionalized nanoparticles has a transmittance of at least 90% in a predetermined optical wavelength range, wherein the ligand functionalized nanoparticles have a size less than 100 nm, are loaded in the monomer matrix material at a volume percent of at least 2%, and alter an index of refraction of the monomer matrix by at least 0.02. The ligand-functionalized nanoparticles have a plurality of ligands attached to a nanoparticle core surface with an anchor functional group and terminated with a buoy functional group that are reactive, non-reactive, or combinations thereof. In some embodiments the ligands have a length less than 1.

Abstract: Methods of manufacturing a volumetric continuous gradient complex dielectric element with drop-on-demand techniques, such as inkjet printing, by calculating spatial placement of nanocomposite-ink droplets are disclosed. The methods comprise determining or having a multi-dimensional gradient profile representing a volumetric gradient complex dielectric element. Providing or having a plurality of nanocomposite-inks, at least one of the nanocomposite-inks having a curable organic-matrix and a concentration of nanoparticles dispersed within to print the volumetric continuous gradient complex dielectric device. A print mask is determined in one-, two-, or three-dimensions that reconstructs the multi-dimensional gradient profile as a discretized pattern based on the material properties of the plurality of nanocomposite-inks and properties of a printing apparatus with a plurality of printheads.

Abstract: A method of manufacturing a nanocomposite GRIN optical-element. The method comprises providing a volumetric gradient refractive profile and providing a plurality of nanocomposite-inks to form the GRIN optical-element. Each of the plurality of nanocomposite-inks have nanoparticles dispersed in an organic-matrix. The plurality of nanocomposite-inks comprising of a nanoparticle diffusion inhibiting nanocomposite-ink wherein nanoparticle diffusion is inhibited with respect to another of the plurality of nanocomposite-inks. The diffusion inhibiting nanocomposite-ink having a different dielectric property from at least one of the other plurality of nanocomposite-inks. The plurality of nanocomposite-inks also comprising a nanoparticle diffusion permitting nanocomposite-ink wherein nanoparticle diffusion is permitted with respect to at least another of the plurality of nanocomposite-inks.

Abstract: Optical inks suitable for 3D printing fabrication of gradient refractive index (GRIN) optical components are composed a monomer matrix material doped with ligand-functionalized nanoparticles, wherein the monomer has a viscosity less than 20 cPoise and is UV curable to form a solid polymer. The matrix material doped with the ligand-functionalized nanoparticles has a transmittance of at least 90% in a predetermined optical wavelength range, wherein the ligand functionalized nanoparticles have a size less than 100 nm, are loaded in the monomer matrix material at a volume percent of at least 2%, and alter an index of refraction of the monomer matrix by at least 0.02. The ligand-functionalized nanoparticles have a plurality of ligands attached to a nanoparticle core surface with an anchor functional group and terminated with a buoy functional group that are reactive, non-reactive, or combinations thereof. In some embodiments the ligands have a length less than 1.

Abstract: Methods of manufacturing a volumetric continuous gradient complex dielectric element with drop-on-demand techniques, such as inkjet printing, by calculating spatial placement of nanocomposite-ink droplets are disclosed. The methods comprise determining or having a multi-dimensional gradient profile representing a volumetric gradient complex dielectric element. Providing or having a plurality of nanocomposite-inks, at least one of the nanocomposite-inks having a curable organic-matrix and a concentration of nanoparticles dispersed within to print the volumetric continuous gradient complex dielectric device. A print mask is determined in one-, two-, or three-dimensions that reconstructs the multi-dimensional gradient profile as a discretized pattern based on the material properties of the plurality of nanocomposite-inks and properties of a printing apparatus.

Abstract: The present invention is directed to compositions comprising the HCV NS3/4A inhibitor, (1aR,5S,8S,10R,22aR)-5-tert-butyl-N-{(1R,2S)-1-[(cyclopropylsulfonyl)carbamoyl]-2-ethenylcyclopro-pyl}-14-methoxy-3,6-dioxo-1,1a,3,4,5,6,9,10,18,19,20,21,22,22a-tetradecahydro-8H-7,10-methanocyclopropa[18,19][1,10,3,6]dioxa-diazacyclononadecino[11,12-b]quinoxaline-8-carboxamide, or a pharmaceutically acceptable salt thererof, an oral absorption enhancing polymer, and, optionally, a surfactant. The present invention is also directed to solid dispersions and pharmaceutical compositions containing or made from these compositions, and the methods for making these solid dispersions and pharmaceutical compositions.

Abstract: Embodiments of the present invention recite a data collector with expanded functionality and a method of enhancing revenue generation using a data collector with expanded functionality. In one embodiment, a central unit of a data collector is configured to receive a replaceable unit such that any one of a variety of replaceable units can be configure to be attached to said central unit.

Abstract: Optical inks suitable for 3D printing fabrication of gradient refractive index (GRIN) optical components are composed of a monomer matrix material [100] in which ligand-functionalized nanoparticles [102] are well dispersed at more than 2% loading to induce a change in the index of refraction of the matrix of at least 0.02. The ligands are less than 1.2 nm in length and are covalently bonded to both the nanoparticles and the monomer matrix. The nanoparticles are less than 100 nm in size and the doped matrix material has a transmittance of at least 90% at wavelengths of interest. The matrix material has less than 20 cPoise viscosity and is UV crosslinkable to form a cured polymer.