Abstract: An ink jet print head having a substrate with an upper surface, and an ink supply conduit passing through the substrate. An array of independently addressable ink energizing elements are attached to the upper surface of the substrate. An orifice layer has a lower surface conformally connected to the upper surface of the substrate, and has an exterior surface facing away from the substrate. The orifice layer defines a plurality of firing chambers providing communication to the ink energizing elements, and each of the orifices is positioned in registration with a respective single ink energizing element. The exterior surface defines a plurality of nozzle apertures, each providing the upper terminus of a single firing chamber. Each of the firing chambers is laterally separated from all other firing chambers by a septum portion of the orifice layer.

Abstract: Described herein is a monolithic printhead formed using integrated circuit techniques. Thin film layers, including ink ejection elements, are formed on a top surface of a silicon substrate. The various layers are etched to provide conductive leads to the ink ejection elements. At least one ink feed hole is formed through the thin film layers for each ink ejection chamber. A trench is etched in the bottom surface of the substrate so that ink can flow into the trench and into each ink ejection chamber through the ink feed holes formed in the thin film layers. The trench completely etches away portions of the substrate near the ink feed holes so that the thin film layers form a shelf in the vicinity of the ink feed holes. In one embodiment, the shelf supports the ink ejection elements. An orifice layer is formed on the top surface of the thin film layers to define the nozzles and ink ejection chambers.

Abstract: Described herein is a monolithic printhead formed using integrated circuit techniques. Thin film layers, including ink ejection elements, are formed on a top surface of a silicon substrate. The various layers are etched to provide conductive leads to the ink ejection elements. At least one ink feed hole is formed through the thin film layers for each ink ejection chamber. In one embodiment, there are more ink feed holes than ink ejection chambers, so that more than one ink feed hole provides ink to each ink ejection chamber. A trench is etched in the bottom surface of the substrate so that ink can flow into the trench and into each ink ejection chamber through the ink feed holes formed in the thin film layers. An orifice layer is formed on the top surface of the thin film layers to define the nozzles and ink ejection chambers.

Abstract: This invention provides a taxane derivative of the formula: wherein a hydrophobic organic moiety is attached to a taxane. R and R1 is each indepently H or a hydrophobic organic moiety, as long as at least one of R and R1 is not H. Attachment of a hydrophobic organic moiety to the taxane so as to obtain a taxane derivative generally stabilizes the association of the derivative with a lipid, including a liposomal lipid, carrier in the plasma of animals to which the derivative-carrier association is administered. Also provided herein is a composition containing the taxane derivative and a pharmaceutically acceptable medium; desirably, the medium also contains a lipid carrier, and the derivative is associated with the carrier. Further provided herein is a method of administering taxane derivatives to animals, for example, animals afflicted with cancers.

Abstract: This invention provides a taxane derivative of the formula: ##STR1## wherein a hydrophobic organic moiety is attached to a taxane. R and R.sup.1 is each indepently H or a hydrophobic organic moiety, as long as at least one of R and R.sup.1 is not H. Attachment of a hydrophobic organic moiety to the taxane so as to obtain a taxane derivative generally stabilizes the association of the derivative with a lipid, including a liposomal lipid, carrier in the plasma of animals to which the derivative-carrier association is administered. Also provided herein is a composition containing the taxane derivative and a pharmaceutically acceptable medium; desirably, the medium also contains a lipid carrier, and the derivative is associated with the carrier. Further provided herein is a method of administering taxane derivatives to animals, for example, animals afflicted with cancers.

Abstract: A method and apparatus for improving ink-jet print quality uses a print head having an array using a plurality of nozzles in sets in each drop generator mechanism. Where a conventional ink-jet pen fires a single droplet of ink at a pixel per firing cycle, the present invention fires a plurality of droplets at different subdivisions of pixels. The particular array design may vary from ink-to-ink or pen-to-pen. Each drop generator of a print head array includes a plurality of nozzles wherein each of the nozzles has an exit orifice with an areal dimension, and produces an ink droplet that produces a dot on adjacent print media wherein the dot has an areal dimension, less than the areal dimension of a pixel to be printed. Dots are printed in a pattern for each pixel wherein print quality is achieved that approximates a higher resolution print made by conventional ink-jet methodologies.

Abstract: Endotoxin incorporated into liposomes, lipid bilayers or lipid complexes can be detected by combining an aqueous suspension of the liposomes, lipid complexes or lipid bilayers with a suitable detergent. Preferable detergents, e.g., Lubrol-PX.TM. or a polyoxyethylene ether, solubilize the lipid bilayers, liposomes or lipid complexes at acceptable lipid concentrations, forming micelles therefrom which contain lipid bilayer, liposome or lipid complex lipid, detergent and endotoxin, should it be present. The micelles are then assayed for the presence of endotoxin.

Abstract: An ink jet print head having a substrate with an upper surface, and an ink supply conduit passing through the substrate. An array of independently addressable ink energizing elements are attached to the upper surface of the substrate. An orifice layer has a lower surface conformally connected to the upper surface of the substrate, and has an exterior surface facing away from the substrate. The orifice layer defines a plurality of firing chambers providing communication to the ink energizing elements, and each of the orifices is positioned in registration with a respective single ink energizing element. The exterior surface defines a plurality of nozzle apertures, each providing the upper terminus of a single firing chamber. Each of the firing chambers is laterally separated from all other firing chambers by a septum portion of the orifice layer.

Abstract: This invention provides a taxane derivative of the formula: ##STR1## wherein a hydrophobic organic moiety is attached to a taxane. R and R.sup.1 is each indepently H or a hydrophobic organic moiety, as long as at least one of R and R.sup.1 is not H. Attachment of a hydrophobic organic moiety to the taxane so as to obtain a taxane derivative generally stabilizes the association of the derivative with a lipid, including a liposomal lipid, carrier in the plasma of animals to which the derivative-carrier association is administered. Also provided herein is a composition containing the taxane derivative and a pharmaceutically acceptable medium; desirably, the medium also contains a lipid carrier, and the derivative is associated with the carrier. Further provided herein is a method of administering taxane derivatives to animals, for example, animals afflicted with cancers.

Abstract: An ink delivery system for an ink jet printing system having a printhead for ejecting droplets of ink, the printhead receiving ink at a controlled pressure, the controlled pressure having a specified pressure range that assures stable printhead operation which includes a replaceable ink supply removeably mounted in an ink supply station, and a controllable valve. The valve inlet is in fluid communication with the replaceable ink supply. An accumulator in fluid communication with the valve outlet and the printhead has a sensor coupled to the accumulator to sense the state of the accumulator. A controller electrically coupled to the sensor and electrically coupled to the controllable valve opens and closes the valve in response to the state of the accumulator.

Abstract: In order that ink leakage be reduced from a compressed foam storage ink container for an inkjet printer cartridge, at least one of the walls of the container is provided relief pockets having air spaces free of the compressed foam. At least one vent channel communicates between relief pockets and ambient air pressure to provide pressure equilibrium.

Abstract: This invention provides a taxane derivative of the formula: ##STR1## wherein a hydrophobic organic moiety is attached to a taxane. R and R.sup.1 is each indepently H or a hydrophobic organic moiety, as long as at least one of R and R.sup.1 is not H. Attachment of a hydrophobic organic moiety to the taxane so as to obtain a taxane derivative generally stabilizes the association of the derivative with a lipid, including a liposomal lipid, carrier in the plasma of animals to which the derivative-carrier association is administered. Also provided herein is a composition containing the taxane derivative and a pharmaceutically acceptable medium; desirably, the medium also contains a lipid carrier, and the derivative is associated with the carrier. Further provided herein is a method of administering taxane derivatives to animals, for example, animals afflicted with cancers.

Abstract: The service station provides components for wiping and capping the orifice plate of an ink-jet pen that is installed in a printer that can carry more than one pen-type. Certain service station components are dedicated for use with only one type of pen and other components are dedicated for use with another type of pen, thereby avoiding ink contamination that may occur, where, for example, a single wiper is used to wipe pens of both type.

Abstract: A printhead cartridge and carriage assembly (10) is provided comprising: a carriage (12); a snap-spring (62) for securing a printing cartridge (14) in postion on the carriage; and an interconnect strip (16) for supplying electrical signals to the cartridge, including a force loading spring pad (24) for urging a portion of the interconnect strip against a portion of the cartridge. The cartridge has top (32), bottom (34), sides (36, 38), front (40) and rear (42) surfaces and includes a printhead (44) on the bottom surface, an electrical contact strip (46) on the back surface connected to the printhead, referencing pads (56) on the side surface, and a lip (64) on the back surface for accepting the snap-spring. Referencing surface (60) are provided for receiving the referencing pads on the cartridge. The spring pad urges the interconnect strip against the electrical contact of the cartridge.

Abstract: A novel ink-jet printer (10) is provided. The print provides both paper supply tray (12) and paper collection tray (18) in the front (14) of the printer for ease of paper handling and reduced footprint. The paper collection tray is provided with a pair of opposed output rails (22) which support a sheet of paper (16c) during printing to permit ink on a sheet of paper (16b) previously printed to dry. A paper handling mechanism is provided which eliminates a sheet pickup motor and associated elements. The paper handling mechanism is configured to pick off a sheet of paper from a stack of input paper, bring it around paper drive rollers (24) onto a platen (26), where the printing operation, employing a printhead cartridge (32), occurs. The printer further includes a service station (230) for clearing clogged nozzles in the printhead (33) and removing bubbles therefrom, for covering the nozzles with a protective cap (266), and for wiping contaminants off the nozzles.

Abstract: A service station (10) for use in an ink-jet printer comprises(a) pump means (12) for priming the printhead (18) of a cartridge (20),(b) a sled (14) to actuate the service station and seal the printhead, and(c) wiping means (58) for cleaning the printhead.The service station is fixed at one end of travel of a carriage (22) supporting the cartridge. The carriage is adapted to move bidirectionally by means of a controlled motor.The service station performs a number of functions, including clearing clogged nozzles in the printhead and removing bubbles therefrom, covering the nozzles with a protective cap (50) when the printhead is not in use to prevent contamination thereof, preventing ink from drying out in the nozzles, wiping contaminants picked up during printing off the nozzles, and providing a location (60) for firing the nozzles for clearing out thereof prior to printing.

Abstract: A novel ink-jet printer (10) is provided. The printer provides both paper supply tray (12) and paper collection tray (18) in the front (14) of the printer for ease of paper handling and reduced footprint. The paper collection tray is provided with a pair of opposed output rails (22) which support a sheet of paper (16c) during printing to permit ink on a sheet of paper (16b) previously printed to dry.A paper handling mechanism is provided which eliminates a sheet pickup motor and associated elements. The paper handling mechanism is configured to pick off a sheet of paper from a stack of input paper, bring it around paper drive rollers (24) onto a platen (26), where the printing operation, employing a printhead cartridge (32) occurs.The resulting printer is easy to manufacture, has reduced complexity by eliminating components in the paper drive mechanism and is lower in cost.

Abstract: A printhead cartridge and carriage assembly (10) is provided comprising: a carriage (12); a snap-spring (62) for securing a printing cartridge (14) in postion on the carriage; and an interconnect strip (16) for supplying electrical signals to the cartridge, including a force loading spring pad (24) for urging a portion of the interconnect strip against a portion of the cartridge. The cartridge has top (32), bottom (34), sides (36, 38), front (40) and rear (42) surfaces and includes a printhead (44) on the bottom surface, an electrical contact strip (46) on the back surface connected to the printhead, referencing pads (56) on the side surface, and a lip (64) on the back surface for accepting the snap-spring. Referencing surface (60) are provided for receiving the referencing pads on the cartridge. The spring pad urges the interconnect strip against the electrical contact of the cartridge.