Abstract: A fluid ejection cartridge includes a fluid container that has both a fluid inlet and a fluid outlet. The fluid ejection cartridge has one or more fluid ejectors fluidically coupled to the fluid container outlet and a fluid valve fluidically coupled to the fluid container inlet. The fluid ejection cartridge has a filter assembly having a compliant portion with an internal volume fluidically coupled to the fluid container outlet such that the internal volume changes when fluid flows into the fluid container.

Abstract: The present invention relates to a method for the treatment of cancer in a patient in need thereof. The method comprises administering to a patient in need thereof a first amount of a histone deacetylase inhibitor in a first treatment procedure, and a second amount or dose of radiation in a second treatment procedure. The first and second treatments together comprise a therapeutically effective amount. The combination of the HDAC inhibitor and radiation therapy is therapeutically synergistic.

Abstract: The present invention provides the compound having the formula: 1

Abstract: The present invention provides a novel method for treating and/or preventing thioredoxin (TRX)-mediated diseases and conditions, by administering to a subject in need of such treatment a therapeutically effective amount of a histone deacetylase (HDAC) inhibitor or a pharmaceutically acceptable salt or hydrate thereof. The HDAC inhibitor can alter the expression of a thioredoxin-binding-protein (e.g. TBP-2), which in turn can lead to an altered TRX/thioredoxin-binding-protein cellular binding interaction, resulting in an increase or decrease in the level or activity of cellular TRX, for example the expression level or reducing activity of TRX. Thus the present invention relates to the use of HDAC inhibitors in a method of preventing and/or treating a wide variety of thioredoxin (TRX)-mediated diseases and conditions, such as inflammatory diseases, allergic diseases, autoimmune diseases, diseases associated with oxidative stress or diseases characterized by cellular hyperproliferation.

Abstract: Embodiments of the present invention provide a hot water dispenser capable of heating water to near boiling temperatures (e.g., 205° F. to 212° F.). When water at near boiling temperatures is required, a secondary heating element is activated. The secondary heating element is in thermally coupled to the dispensing tube so that the water in the tube may be further heated as it passes through the dispensing tube from the tank to the dispensing outlet. Heating the water to near boiling just prior to its being dispensed reduces energy costs because the near boiling temperature water is not stored and allowed to cool. Additionally, the need for expensive insulation or expensive thermostats is eliminated.

Abstract: Embodiments of the present invention provide a hot water dispenser capable of heating water to near boiling temperatures (e.g., 205° F. to 212° F.). When water at near boiling temperatures is required, a secondary heating element is activated. The secondary heating element is in thermally coupled to the dispensing tube so that the water in the tube may be further heated as it passes through the dispensing tube from the tank to the dispensing outlet. Heating the water to near boiling just prior to its being dispensed reduces energy costs because the near boiling temperature water is not stored and allowed to cool. Additionally, the need for expensive insulation or expensive thermostats is eliminated.

Abstract: The invention relates to a method of generating an image of an animate human or non-human animal body or part thereof. The method comprises administering to said body a physiologically tolerable contrast agent comprising a radiation absorbing component and/or a pressure inducing component, exposing said body to radiation, detecting pressure waves generated in said body by said radiation and generating an optoacoustic image therefrom of at least a part of said body containing the administered contrast agent.

Abstract: A method and apparatus for packaging items, such as meat, non-meat products and non-food products, using ultrasound or heat is disclosed herein. In a preferred embodiment, a continuous thermoplastic tubular mesh material is used to package multiple meat products. The preferred packaging method does not use metal clips as in conventional packaging, and instead uses thermal energy, ultrasonic energy, or other types of energy to create seals in the packaging material itself. The method advantageously causes one seal to be formed between each pair of adjacently packaged products. This single seal can be cut in half thereby creating two seals, one seal for each adjacently packaged product.

Abstract: An inkjet pen is disclosed having an interior chamber containing a pressure regulator. A filter within the interior chamber substantially surrounds the pressure regulator, providing a large filter surface area, and hence a low resistance to ink flow. The filter may be formed of a pleated filter material; the filter material may be retained by a rigid ink passage flange and a filter cap.

Abstract: The present invention relates to the use of particulate materials as contrast agents in in vivo light imaging.

Abstract: A fluid ejection cartridge includes a fluid container that has both a fluid inlet and a fluid outlet. The fluid ejection cartridge has one or more fluid ejectors fluidically coupled to the fluid container outlet and a fluid valve fluidically coupled to the fluid container inlet. The fluid ejection cartridge has a filter assembly having a compliant portion with an internal volume fluidically coupled to the fluid container outlet such that the internal volume changes when fluid flows into the fluid container.

Abstract: The present invention provides for a filter for an ink jet pen, comprising a filter material configured to attach to the pen, wherein a flow of ink through the filter material is substantially multidirectional. In a preferred aspect, an effective filtration surface area of the filter is substantially greater than any projection surface area of the filter. In another preferred aspect, the filter comprises a chamber at least partially bounded by the filter material, and a flow direction of ink into the chamber is substantially different than a flow direction of ink from the chamber.

Abstract: Method and apparatus for identifying broadcast digital audio signals include structure and/or function whereby the digital audio signal is provided to processing structure which is configured to (i) identify a program-identifying code in the received digital audio signal, (ii) identify a program-identifying code in a decompressed received digital audio signal, (iii) identify a feature signature in the received digital audio signal, and (iv) identify a feature signature in the decompressed received digital audio signal. Preferably, such processing structure is disposed in a dwelling or a monitoring site in an audience measurement system, such as the Nielsen TV ratings system.

Abstract: The present invention relates to the use of particulate materials as contrast agents in in vivo light imaging.

Abstract: The present invention features substantially pure HDAC9, HDAC9a, HDAC9(&Dgr;NLS), HDAC9a(&Dgr;NLS), an HDRP(&Dgr;NLS) polypeptides, and isolated nucleic acid molecules encoding those polypeptides. The present invention also features vectors containing HDAC9, HDAC9a, HDAC9(&Dgr;NLS), HDAC9a(&Dgr;NLS), and HDRP(&Dgr;NLS) nucleic acid sequences, and cells containing those vectors.

Abstract: A printhead assembly includes a carrier having a fluid manifold defined therein, and a plurality of printhead dies each mounted on the carrier and including a first nozzle set and a second nozzle set. The fluid manifold includes a first chamber and a second chamber such that the first nozzle set of each of the printhead dies communicates with the first chamber of the fluid manifold and the second nozzle set of each of the printhead dies communicates with the second chamber of the fluid manifold.

Abstract: A printhead assembly includes a substrate having a first side and a second side opposite the first side, at least one electrical component mounted on the second side of the substrate, a substructure having a fluid manifold and at least one well isolated from the fluid manifold defined therein, and a plurality of printhead dies each mounted on the first side of the substrate. The substructure is disposed on the second side of the substrate such that the at least one electrical component is confined within the at least one well.

Abstract: A fluid ejection assembly includes a carrier including a substrate and an electrical circuit with the substrate having a first side and a second side opposite the first side and the electrical circuit being disposed on the second side of the substrate, a fluid ejection device mounted on the first side of the substrate, and at least one electrical connector electrically coupled to the electrical circuit and the fluid ejection device, wherein the electrical circuit includes a printed circuit board such that the printed circuit board and the substrate both have at least one fluid passage extending therethrough with the at least one fluid passage communicating with the first side of the substrate and the fluid ejection device.

Abstract: The present invention provides the compound having the formula: wherein each of R1 and R2 is, substituted or unsubstituted, aryl, cycloalkyl, cycloalkylamino, naphtha, pyridineamino, piperidino, t-butyl, aryloxy, arylalkyloxy, or pyridine group; wherein A is an amido moiety, —O—, —S—, —NH—, or —CH2—; and wherein n is an integer from 3 to 8. The present invention also provides a method of selectively inducing growth arrest, terminal differentiation and/or apoptosis of neoplastic cells and thereby inhibiting proliferation of such cells. Moreover, the present invention provides a method of treating a patient having a tumor characterized by proliferation of neoplastic cells. Lastly, the present invention provides a pharmaceutical composition comprising a pharmaceutically acceptable carrier and a therapeutically acceptable amount of the compound above.

Abstract: The present invention provides three-dimensional structural information from the hyperthermophilic bacterium Aquifex aeolicus which is a histone deacetylase-like protein (HDLP). HDLP shares 35.2% amino acid sequence identity with human histone deacetylase (HDAC1). The present invention further provides three-dimensional structural information of HDLP bound by inhibitor molecules. The three-dimensional structural information of the present invention is useful to design, isolate and screen deacetylase inhibitor compounds capable of inhibiting HDLP, HDAC family members and HDLP-related molecules. The invention also relates to nucleic acids encoding a mutant HDLP which facilitates the determination of the three-dimensional structure of HDLP in the presence of a zinc atom.