Abstract: The present application is directed to a method of treating diseases of the central nervous system (CNS) comprising administering to a individual in need of treatment a therapeutically effective amount of an inhibitor of histone deacetylase. In particular embodiments, the CNS disease is a neurodegenerative disease. In further embodiments, the neurogenerative disease is an inherited neurodegenerative disease, such as those inherited neurodegenerative diseases which are polyglutamine expansion diseases. The individual can be a mammal such as a primate or human.

Abstract: In one embodiment an ink pen for an inkjet printer includes: an ink filter chamber; a pressure regulator chamber downstream from the ink filter chamber along a path of ink flow through the pen; a pressure regulator in the pressure regulator chamber; a filter in the ink filter chamber; an inlet to the ink filter chamber upstream from the filter along the ink flow path; and an outlet from the ink filter chamber to the pressure regulator chamber downstream from the filter along the ink flow path such that ink flowing from the inlet to the outlet passes through the filter. In another embodiment a method implemented in an ink delivery system for an inkjet ink pen includes: chambering ink in the pen; filtering the chambered ink; and then regulating the pressure of filtered ink.

Abstract: An apparatus, method and system are provided for a modular in-frame pumped refrigerant distribution system. Specifically, a micro-channel heat exchanger is positioned in an equipment cabinet close to equipment that generates heat. More specifically, the micro-channel heat exchanger may be positioned on a) a shelf above the equipment, b) the back side of the equipment, or c) a shelf below the equipment. The micro-channel heat exchanger is operable to receive a refrigerant supplied by an external heat exchanger along a primary flow path, transfer heat from air above and/or near the equipment to a coil of the micro-channel heat exchanger, circulate the refrigerant to extract the heat, and return the refrigerant with an extracted portion of generated heat to the external heat exchanger along a secondary flow path. The external heat exchanger may remove extracted heat from a building via a building chilled water system or an outdoor condenser unit.

Abstract: A method and apparatus for recording audio or video data so as to enable true raw audio or video certification includes recording on a mobile recorder an audio or video data stream taken from at least one microphone or camera respectively cooperating with the recorder, generating a digital hash and embedding the digital hash in the data stream concurrently with the recording of the data stream, enabling playback of the recording containing the digital hash by a playback device not equipped to decode the digital hash, wherein the digital hash contains attributes unique to the recording and where the digital hash is embedded in the data stream so as to minimize noise impact on a later playback of the data stream respectively by the playback device, and wherein the digital hash is embedded during the embedding continuously on a periodic basis throughout the duration of the recording.

Abstract: The embodiments of the present disclosure present systems and methods for the reversible solubilization of (aryl ether ketones) (PAEKs). A thioacetalization process is employed to modify the PAEKs into poly (aryl ether thioacetals) which, unlike PAEKs, are substantially soluble in common solvents. This modification allowing selected analysis techniques to be more easily performed on PAEKs1 such as gel permeation chromatography. The thioacetalization may be reversed through a deprotection reaction to recover the original PAEK without substantial degradation, allowing for non-destructive characterization of the PAEK. Advantageously, the thioacetalization process is generally applicable to a broad range of PAEKs, unlike presently known methods of solubilizing PAEKs. Solubilization of PAEKs further expands the utility of the PAEKs, opening up additional routes to chemical modification of PAEKs, as well as allowing for the possibility of processing PAEKs from solution.

Abstract: The present application is directed to a method of treating diseases of the central nervous system (CNS) comprising administering to a individual in need of treatment a therapeutically effective amount of an inhibitor of histone deacetylase. In particular embodiments, the CNS disease is a neurodegenerative disease. In further embodiments, the neurogenerative disease is an inherited neurodegenerative disease, such as those inherited neurodegenerative diseases which are polyglutamine expansion diseases. The individual can be a mammal such as a primate or human.

Abstract: A device and method to insure protection of a ballistic protection apparatus using a microtube indicator for alerting a user to inspect the ballistic protection apparatus for flaws, cracks and gaps. The device can include microtubes adapted to function as accelerometers. The microtubes can include a color containing component, a non-color containing component, and a frangible separating portion. The device can include a housing with a top surface, a window, a message, a bottom surface, parallel cuts, and an adhesive for securing the housing to the ballistic protection apparatus. A G-force impact that exceeds a preset limit can cause the color containing component to flow to the non-color containing component, thereby indicating that an excessive G-force event has occurred and that an inspection of the ballistic protection apparatus is required.

Abstract: An airbag assembly for a motor vehicle is disclosed having an airbag 110 that is inflated by an inflator when the airbag 110 is deployed in accordance with a control signal from an electronic controller. The airbag 110 has a main chamber 114 and at least one subsidiary chamber 116 fluidly connected to the main chamber 114 by a transfer vent 117. The main and subsidiary chambers 114 and 116 are vented to atmosphere by respective vents 115, 118 and the pressure in the subsidiary chamber 116 is arranged to be equal to or lower than the pressure in the main chamber 114. The subsidiary chamber 116 is produced in a simple manner by forming a depression in the main chamber 114 using a tether 124 and covering the depression so formed with a cover 125.

Abstract: A method, server and system for executing an application on an electronic device is provided. In one example embodiment, the method comprises: receiving an input command from an input mechanism associated with the electronic device; determining whether the input command is a command to execute an archived application, the archived application being stored in a storage memory; if the input command is a command to execute the archived application, automatically installing the archived application to application memory; and automatically executing the installed application after the application is installed to the application memory.

Abstract: In one embodiment a closure for a supply container includes: a spout affixed to the container; a plug configured to plug the spout in a partially inserted position from which the plug may be easily removed from the spout and to plug the spout in a fully inserted position from which the plug may not be easily removed from the spout; an opening in the plug through which material in the container may flow when the plug is inserted into the spout; and a breachable seal sealing the opening.

Abstract: In one embodiment a pressure regulator for an ink pen includes: a diaphragm between a lower pressure region and a higher pressure region, the diaphragm movable toward the lower pressure region in response to an increase in a pressure difference across the diaphragm; a valve operative between an open position in which ink may flow into the lower pressure region and a closed position in which ink may not flow into the lower pressure region; a first lever rotatable on a first fulcrum in response to movement of the diaphragm toward the lower pressure region; and a second lever connected to the valve, the second lever rotatable on a second fulcrum in response to rotation of the first lever to move the valve from the closed position to an open position.

Abstract: A tool for a surface treating appliance includes a main body connected to a conduit. The main body includes a first suction channel and a second suction channel in fluid communication with the first suction channel and located between the first suction channel and an outlet from the main body. In use, a relatively low vacuum is generated in the first suction channel which draws a first dirt-bearing fluid flow into the main body, and a relatively high vacuum is generated in the second suction channel, which draws a second dirt-bearing fluid flow into the main body and receives the first dirt-bearing fluid flow from the first suction channel. To maintain the pressure differences between the suction channels, the main body includes flexible surface engaging members located about the suction channels, and between the first suction channel and the second suction channel.

Abstract: A method of projecting liquid as jets or droplets from a nozzle provided on a transducer formed by a region of a material layer, the method comprising the steps of: supplying liquid to an inner end of the nozzle; exciting the nozzle to cause movement of the nozzle in a direction substantially aligned with the nozzle axis in order to project liquid as a droplet from an outer face of the nozzle; wherein the step of exciting the nozzle comprises sequentially driving the transducer with a first rising voltage change, a first falling voltage change, a second rising voltage change and a second falling voltage change; and wherein the first rising voltage change and the first falling voltage change are timed so that they enhance the movement of the material layer, and the second rising voltage change and the second falling voltage change are timed so that they substantially cancel the movement of the material layer.

Abstract: A water propulsion unit having an intake housing, a pump housing and an outlet with two spaced apart counter rotating impellers being located in the pump housing. The impeller blades on one impeller have an opposite pitch to the blades of the second impeller. The impellers are configured so that one of the impellers will impart less energy to the water as it passes the blades of the impeller than the second impeller.

Abstract: The present invention relates to a method of treating cancer in a subject in need thereof, by administering to a subject in need thereof a first amount of a histone deacetylase (HDAC) inhibitor or a pharmaceutically acceptable salt or hydrate thereof, in a first treatment procedure, and a second amount of an anti-cancer agent in a second treatment procedure. The first and second amounts together comprise a therapeutically effective amount. The effect of the HDAC inhibitor and the anti-cancer agent may be additive or synergistic.

Abstract: The present invention features, inter alia, purified antibodies that selectively bind an isolated or recombinant histone deacetylase polypeptide comprising the amino acid sequence as set forth in SEQ ID NO: 2, which comprises a histone deacetylase catalytic domain at amino acids 635 to 953 of SEQ ID NO: 2, purified antibodies that selectively bind a biologically active fragment of the polypeptide of SEQ ID NO: 2, which fragment exhibits histone deacetylase activity, transcription repression activity, and the ability to deacetylate cellular substrates, purified antibodies that selectively bind an isolated or recombinant histone deacetylase polypeptide encoded by a nucleotide sequence as set forth in SEQ ID NO: 1, purified antibodies that selectively bind an isolated or recombinant histone deacetylase polypeptide comprising the amino acid sequence as set forth in SEQ ID NO: 2 lacking a nuclear localization signal, and purified antibodies that selectively bind an isolated or recombinant histone deacetylase polyp

Abstract: A method, server and system for delivering an application are provided. In one example embodiment, the method comprises receiving application data associated with an application from a first mobile communication device; in response to receiving the application data, storing the application data in a memory; receiving a request for the application from a second mobile communication device which is associated with the first mobile communication device; and in response to receiving the request: retrieving the application associated with the request; sending the application to the second mobile communication device; retrieving the application data associated with the application; and sending the application data to the second mobile communication device.

Abstract: A method, server and system for obtaining a licensed application is provided. In one example embodiment, the method comprises: receiving an application download request from a user of the electronic device by way of an input mechanism associated with the electronic; transmitting a download request from the electronic device to an application delivery server; receiving an application from the application delivery server at the electronic device; receiving a license key from the application delivery server; and automatically injecting the license key into the application.

Abstract: The present invention relates to a novel class of hydroxamic acid derivatives having at least two aryl containing groups, at least one of which is a quinolinyl, isoquinolinyl or benzyl moiety, linked to the hydroxamic acid group through a methylene chain. The hydroxamic acid compounds can be used to treat cancer, for example, brain cancer. The hydroxamic acid compounds can also inhibit histone deacetylase and are suitable for use in selectively inducing terminal differentiation, and arresting cell growth and/or apoptosis of neoplastic cells, thereby inhibiting proliferation of such cells. Thus, the compounds of the present are useful in treating a patient having a tumor characterized by proliferation of neoplastic cells. The compounds of the invention are also useful in the prevention and treatment of TRX-mediated diseases, such as autoimmune, allergic and inflammatory diseases, and in the prevention and/or treatment of diseases of the central nervous system (CNS), such as neurodegenerative diseases.

Abstract: A slave cylinder (50) for a vibration-damped hydraulic force transmission system, particularly a hydraulic clutch actuating system for motor vehicles is disclosed, comprising a cylinder housing (52), a piston (56) received therein to be longitudinally displaceable and a pressure chamber (60) which is bounded by the cylinder housing and the piston and which can be selectably acted on by a pressure medium, by way of a pressure connection (66) provided in the cylinder housing, in order to displace the piston in the cylinder housing. An insert member (68) which is inserted in the pressure chamber and secured in the pressure connection and which is equipped with a device (70) for reducing pressure pulses, the device being constantly open to the pressure medium, is additionally provided. As a result, the vibration-damping measures or means are integrated in the slave cylinder in a particularly economic and space-saving manner.