Abstract: Estimation of a characteristic of a user's physiological signals can be improved using one or more calibration relationships that may be dependent on a characteristic of the optical sensor. For example, different calibration relationships can be used that are dependent on a spatial characteristic and/or that are dependent on a wavelength characteristic of the light emitting component(s) of the respective emitter of a channel. In some examples, a unique calibration relationship can be used for each channel. In some examples, a common calibration relationship can be used for multiple channels with shared distance and/or wavelength characteristics. Utilizing distance-dependent and/or wavelength-dependent calibration relationships can improve robustness of pulse oximetry measurements.

Abstract: A computer-implemented method and system includes a head-mounted wearable device with two current electrodes that provide input alternating currents over a range of frequencies to a subject during at least one intervention. The head-mounted wearable device includes at least two sense electrodes that collect voltage difference measurements in response to the input alternating currents. A measurement validation module applies a Hilbert transform or a Kramer-Kronig test to the voltage difference measurements to generate validated time-series impedance spectra. A cranial fluid dynamics module fits the validated time-series impedance spectra to an electrical circuit model to determine a glymphatic flow response to the at least one intervention.

Abstract: Cryotherapeutic devices for targeted lunch neuromodulation therapies and associated systems and methods are disclosed herein. A cryotherapeutic device configured in accordance with embodiments of the present technology can include, for example, an elongated shaft having a distal portion and a cooling assembly positioned at the distal portions. The shaft is configured to deliver the distal portion at a target site within a bronchus of a patient. The cooling assembly includes an expandable member, an injection lumen configured to dispel a refrigerant into the expandable member, and an exhaust lumen configured to receive expanded refrigerant. The cooling assembly is configured to impart cryogenic cooling to ablate neural fibers proximate to the target site. The device can be sized to fit within a working channel of a bronchoscope such that at least a portion of the cooling assembly can be visualized during a cryotherapeutic procedure.

Abstract: A device for measuring at least one periodic vital signal from an individual, intended to be attached to a safety apparatus of a vehicle so as to be arranged between the individual and the apparatus, the device comprising: a vibration sensor comprising: a stack of layers and including an active layer made of piezoelectric material and two contact electrodes arranged on at least one face of the active layer, a flexible support layer including a printed circuit comprising two electrical terminals, the support layer being intended to be arranged on the individual, an electrical connection layer, arranged between the stack of layers and the support layer, for connecting each contact electrode to an electrical terminal, an acoustic attenuation member intended to be arranged between the safety apparatus and the vibration sensor, the member being integral with the support layer and arranged above and spaced apart from the stack of layers.

Abstract: A controller (122) includes a memory (12220) that stores instructions and a processor (12210) that executes the instructions. When executed, the instructions cause the controller (122) to implement a process that includes obtaining (S405) pre-operative imagery of the tissue in a first modality, registering (S425) the pre-operative imagery of the tissue in the first modality with a set of sensors (195-199) adhered to the tissue, and receiving (S435), from the set of sensors (195-199), sets of electronic signals for positions of the set of sensors (195-199). The process also includes computing (S440) geometry of the positions of the set of sensors (195-199) for each set of the sets of electronic signals and computing (S450) movement of the set of sensors (195-199) based on changes in the geometry of the positions of the set of sensors (195-199) between sets of electronic signals from the set of sensors (195-199).

Abstract: Implants for the fusion or fixation of two bone segments are described. For example, the implants can be used for the fusion or fixation of the sacroiliac joint. The implants can include fenestrations, have a rectilinear overall cross-sectional area, and have a curvature. Some implants can also be used to rescue failed implants.

Abstract: An implantable prosthesis including a stem and a stem head. The stem extends along a longitudinal axis from a proximal end portion to a distal end portion of the stem. The stem head is coupled to the proximal end portion of the stem. The stem head is configured to be coupled to a joint component. The stem head includes a side surface and a side surface cleat. The side surface cleat defines a first side surface groove and a second side surface groove. The side surface cleat extends between the first side surface and the second side surface.

Abstract: A reservoir assembly for use with a liquid dispenser is provided. The reservoir assembly includes a connecting member housing having a reservoir connecting surface and a switch. The reservoir connecting surface having a first switch contact surface disposed within a first protrusion member. The assembly also includes a container housing for holding a quantity of a liquid product. The container housing configured to be removably attached to the connecting member housing. The container housing includes a main container and a connecting member housing surface. The connecting member housing surface includes a second switch contact surface configured in a first weakened region.

Abstract: A refuse collection system includes a refuse collection robot and a refuse depot. The refuse collection robot includes a chassis, a tractive element coupled to the chassis, a motor coupled to the chassis and the tractive element and configured to drive the tractive element to propel the refuse collection robot, a refuse container coupled to the chassis and defining a first storage volume, and a controller operatively coupled to the motor. The refuse depot includes a centralized storage defining a second storage volume and a refuse actuator configured to transfer refuse from the first storage volume to the second storage volume. The controller is configured to control the motor to propel the refuse collection to a pickup zone associated with a customer in response to receiving a request for refuse collection from a user device associated with the customer.

Abstract: A mandrel for forming a stent with a tapered profile and one or more anti-migration features includes a first stent shaping segment having a first diameter, a second stent shaping segment having a second diameter less than the first diameter and a tapered segment disposed therebetween. A third stent shaping segment is releasably securable to the second stent shaping segment and has a third diameter greater than the second diameter. One or more movable pins are outwardly extendable from corresponding apertures formed within the tapered segment. An actuation element is engagable with the first stent shaping segment and includes a tapered surface configured to engage the one or more movable pins and support the one or more movable pins extended from the corresponding apertures.

Abstract: Shaped, soft and textured nonwoven fabrics are provided. The nonwoven fabrics may be a topsheet and an outer cover nonwoven material of the absorbent article. A portion of a wearer-facing surface of the topsheet may have a TS7 in the range of about 1 dB V2 rms of about 1 to about 4.5 dB V2 rms and a TS750 in the range of about 6 dB V2 rms to about 30 dB V2 rms. A portion of a garment-facing surface of the outer cover nonwoven material may have a TS7 in the range of about 1 dB V2 rms of about 1 to about 4.5 dB V2 rms and a TS750 in the range of about 6 dB V2 rms to about 30 dB V2 rms. The nonwoven fabrics of the present disclosure provide soft materials with texture.

Abstract: A refuse collection drone includes a chassis, tractive elements rotatably coupled with and supporting the chassis, a propulsion system including a battery and an electric motor configured to consume electrical energy from the battery, and a bin removably coupled with the chassis and including a cover. The propulsion system is configured to drive one or more of the tractive elements to transport the refuse collection drone to a customer location. The bin defines a storage volume for refuse. The cover is configured to be driven by an actuator between an open position to allow access to the storage volume and a closed position to limit access to the storage volume. A lock is operable between a locked state to limit transition of the cover out of the closed position and an unlocked state to allow transition of the cover out of the closed position and into the open position.

Abstract: Methods of making orally available softgels includes pre-wetting a probiotic with an edible oil to produce a wetted supplement, wherein the edible oil is present in a range of 25% to 75% by weight of a total weight of the probiotic and edible oil, heating the wetted supplement to a temperature in a range of 35° C. to 40° C., blending the wetted supplement and a molten chocolate component together to produce a liquid fill material, encapsulating the liquid fill material in a softgel coating to produce an orally available softgel, and cooling the orally available softgel to have a softgel capsule shell comprising 5% to 15% by weight water. The fill material is a solid at room temperature in the cooled orally available softgel.

Abstract: The present Invention relates to a pellet comprising melatonin and methods of treating insomnia.

Abstract: A method of playing back audio content with improved immersiveness can include receiving, at a playback device, audio input including vertical content having a high-frequency portion and a low-frequency portion. The playback device can face along a first sound axis and comprise an up-firing transducer configured to direct sound along a second sound axis that is vertically angled with respect to the primary sound axis and a side-firing transducer or array configured to direct sound along a third axis that is horizontally angled with respect to the first sound axis. The low-frequency portion of the vertical content can be played back via the side-firing transducer or array, while the high-frequency portion of the vertical content can be played back via the up-firing transducer.

Abstract: Respective video streams of participants of a video conference are received. A first video stream of the respective video streams is determined to be unstitchable into a unified stream of the video conference. A request for a stitching image is transmitted to a participant of the participants corresponding to the first video stream. The stitching image is received from the participant. The first video stream is stitched into the unified stream by stitching the first video stream with at least one other video stream of the respective video streams. The unified stream is transmitted for display at a device connected to the video conference.

Abstract: An adaptor for a syringe including a shaft with a lumen and a seal. The shaft is sized and shaped to be inserted in the lumen of the syringe tip and create a seal with the opening of the syringe tip, and the seal is sized and shaped to be inserted into the needle hub and create a seal with the needle hub, such that the adaptor reduces the interior volume of the lumen of the syringe tip and the needle hub that is filled with medicament contained in the syringe. Also, an adaptor assembly comprising the adaptor and a delivery housing to which the adaptor is attached, a syringe body including the adaptor, a needle assembly including the adaptor, and a syringe including the adaptor. Further, a method of reducing the dead volume of a syringe in which the adaptor is provide in the syringe as described above.

Abstract: Antibodies that bind the tumor (T) antigen of the Merkel cell polyomavirus are disclosed. The antibodies can be use used in cell-based immunotherapies, antibody-based therapies, diagnostics, and detection assays, among other uses.

Abstract: A device (102) provides respiratory treatment for SDB (including mild OSA) and other respiratory conditions. A flow generator warms and humidifies gas at controlled flow levels. For example, the device (102) delivers breathable gas to the upper airway at flow rates of about 10-35 Liters/minute. Levels of flow rate, temperature and/or humidification of the device may be automatically adjusted in response to the detection of SDB events. The device may also automatically deliver adjustments of any of the levels in accordance with detected phases of respiratory cycles. In some embodiments, the device automatically delivers distinct levels to either of the nares based on independent control of flow to each nare. A warm-up procedure controls temperature and humidity at a desired target during a ramp-up of flow to the set therapy level. A cool-down procedure controls temperature above the dewpoint to avoid condensation internal to the device and patient interface.

Abstract: Disclosed herein are virus-like particle (VLP)-based bivalent vaccine compositions. The compositions may comprise a spherical retroviral Group-specific Antigen (“Gag”) protein core and at least two Ebola glycoproteins. The at least two Ebola glycoproteins may be located at the exterior surface of the spherical Gag protein core, such that the VLP-based vaccine presents at least two Ebola glycoprotein antigens. In one aspect, the at least two Ebola glycoproteins are a Zaire (EBOV) glycoprotein, and a Sudan (SUDV) glycoprotein.