Abstract: Illustrative methods and devices for providing stimulus to the eye to treat vision disorders. Systems and methods for testing thresholds and configuring the stimulation for a patient are provided. Various examples may include therapies for vision disorders that can progress to blindness, such as macular degeneration or other diseases and disease processes.

Abstract: A drive train for a wind-up injection device is described. The drive train includes a torsional energy storage adapted to be loaded or unloaded by a rotatable element, a rotatable user handle, a rotationally driveable expelling mechanism adapted to expel the liquid drug, and a clutch element coupled with the torsional energy storage via the rotatable element and including a ratchet for maintaining the rotatable element at one of a number of discrete angular positions against the torque of the torsional energy storage. The clutch element is adapted to transmit the torque from the user handle to the torsional energy storage, or alternatively from the torsional energy storage to the expelling mechanism. The ratchet is switchable from one position to an adjacent position by a torque transmitted from the user handle to the torsional energy storage. The drive train is adapted to dampen torque peaks visco-elastically and/or visco-frictionally.

Abstract: A solidified melt extrudate comprising an active pharmaceutical ingredient in an amorphous form and a combination of at least two polymers.

Abstract: The present disclosure provides compositions and methods for the treatment of ocular diseases associated with angiogenesis, particularly wet age-related macular degeneration.

Abstract: A regenerative filter that includes a filter housing having inlet and outlet zones; a fluid path provided between the inlet and outlet zones; a plurality of filter elements each having an outer surface filter media applied thereto and functioning to filter particulate or contaminants from the fluid path. The filter elements are disposed in an monolithic array. An inlet port arrangement is disposed at the filter housing leading to the inlet zone and is constructed and arranged to direct the fluid path into the filter housing in a manner so as to maintain a controlled turbulence at the inlet zone. The inlet port arrangement comprises a pair of inlet ports that are arranged in juxtaposition at the inlet zone and each having one end where the fluid flow enters. Embodiments that are considered as falling under the scope of the present invention include 1. Single inlet/two or more outlets; 2. Two or more inlets/single outlet, or 3. Two or more inlets and two or more outlets.

Abstract: A deployable structure includes a reconfigurable member formed from a plurality of elements defining a first end, a second end that is opposite the first end, a first side extending between the first end and the second end, and a second side, opposite the first side, extending between the first end and the second end. A first inflatable rigidizing member extends along the first side across each of the plurality of elements and a second inflatable rigidizing member extends along the second side across each of the plurality of elements.

Abstract: A reaming tool vacuum assembly comprising: a reaming tool comprising a reaming bit, the reaming bit comprising: a tip end; a base end; a plurality of flutes tapered toward the tip end; a plurality of apertures positioned between the plurality of flutes, wherein the plurality of apertures define a plurality of openings to an interior chamber of the reaming bit; a first rigid tube positioned in the interior chamber of the reaming bit, wherein the reaming bit is rotatable around a longitudinal axis of the first rigid tube and independent of the first rigid tube; and a vacuum to provide suction in the interior chamber of the reaming bit via the first rigid tube.

Abstract: A processing machine (10) for building an object (11) from powder (12) includes a build platform (26A); a powder supply assembly (18) that deposits the powder (12) onto the build platform (26A) to form a powder layer (13); and an energy system (22) that directs an energy beam (22D) at a portion of the powder (12) on the build platform (26A) to form a portion of the object (11). The powder supply assembly (18) can include (i) a powder container (640A) that retains the powder (12); (ii) a supply outlet (639) positioned over the build platform (26A); and (ii) a flow control assembly (642) that selectively controls the flow of the powder (12) from the supply outlet (639).

Abstract: A method and a system of forming a workpiece assembly including an intermediate element between first and second workpieces. A ring element is included in or on the intermediate element. The ring element is for rotating the intermediate element about the intermediate elements axis. With heating elements positioned between the intermediate element and the first and second ends of the first and second workpieces, portions of the intermediate element and the first and second workpieces are heated to a predetermined hot working temperature, in an inert (non-oxidizing) atmosphere. While the heated portions are at the predetermined hot working temperature, and while the intermediate element is rotated about its axis, one or both of the first and second workpieces are moved axially, to engage the first and second ends with the intermediate element.

Abstract: A method for manufacturing a container includes forming a top portion of a preform by injecting a first material into a mold. A bottom portion of the preform is formed by injecting a second material into the mold to form inner and outer layers of the bottom portion and injecting a third material into the mold to form an intermediate layer of the bottom portion that is positioned between the inner layer and the outer layer. The third material includes virgin polyethylene terephthalate and an additive.

Abstract: A surgical robotic system includes a surgical robotic arm having an instrument and an instrument drive unit configured to actuate the instrument. The system also includes a storage device and a controller configured to store a save point on the storage device, the save point including configuration data pertaining to at least one of the surgical robotic arm, the instrument drive unit, or the instrument. The controller is further configured to detect an error resulting in a reboot of at least one of the surgical robotic arm, the instrument drive unit, or the instrument. The controller is additionally configured to access the configuration data of the save point after the reboot of at least one of the surgical robotic arm, the instrument drive unit, or the instrument.

Abstract: Articles and devices comprising fluorinated polymers, as well as methods of preparing fluorinated polymers, are generally described. In some cases, such fluorinated elastomers can be used for sensing neural activity, e.g., by encapsulating electronic circuits, or other applications. Furthermore, according to certain embodiments, polymers can, surprisingly, be directly deposited onto layers comprising low molecular weight fluorinated polymers, e.g., without swelling in the presence of certain solvents. Some embodiments are generally directed to devices and methods for treating fluorinated polymers and subsequently depositing material onto the treated fluorinated polymers. This may allow the fabrication and patterning of multilayered articles comprising fluorinated elastomers.

Abstract: Segmented silicone polymers incorporating segments formed from medium-chain fatty acids are generally disclosed herein. Methods of using such compounds, for example, as surfactants, are also disclosed herein, as well as methods of making such compounds, for example, from medium-chain fatty acids derived from natural oils.

Abstract: An example of an apparatus to transport utility-scale lithium-ion batteries in a racked and operational state. The apparatus includes a base and an isolation platform. In addition, the apparatus includes an isolator mounted on the base to support the isolation platform. The isolator is to dampen forces exerted on the isolation platform from the base. Furthermore, the apparatus includes a rack mounted onto the isolation platform. The rack is to secure a plurality of lithium-ion batteries to store energy at a utility-scale to be provided to a power distribution network. The plurality of lithium-ion batteries is racked in an operational state during transportation.

Abstract: A sulfur-vulcanizable rubber compound comprises a silane functionalized diene elastomer, a dual silane coupling system, and a silica filler. The non-active sulfur containing silane coupling agent excludes an active sulfur moiety. The rubber compound is a reaction product of a siloxyl condensation reaction between the silane functionalized diene elastomer and the dual silane coupling system. The dual coupling system comprises a non-active sulfur containing silane coupling agent for reacting with an associated precipitated silica to produce a hydrophobic silica; and a crosslinking reagent for reacting with the non-active sulfur containing silane coupling agent and an associated polymer.

Abstract: A cooling system for an electric vehicle charge port includes a member having a base wall including an opening and a perimetrical wall extending from the base wall. The base wall and the perimetrical wall defining a volume. A heat spreader arranged in the volume. A terminal extends from the heat spreader through the opening in the base wall. An amount of phase change material (PCM) arranged in the volume, the amount of PCM is in contact with the terminal.

Abstract: Polymers derived from a metallocene comprising a group IV element and at least one cyclopentadienyl group are described. Methods for preparing refractory ceramics comprising group IV carbides and/or borides using such polymer are also disclosed. In some embodiments, the method for fabricating the refractory ceramic comprises infiltrating a fiber preform with such polymer and pyrolyzing the polymeric fiber preform.

Abstract: A bicycle storage unit is disclosed. The unit includes a rotatable bicycle storage carousel that is structured to rotate about a central axis to provide for a dense storage of bicycles, which are stored on the rotatable bicycle storage carousel in a generally vertical orientation. The unit further includes an enclosure surrounding the carousel. The rotatable bicycle storage carousel comprises an elongated central core oriented in a first direction that is orthogonal relative to a plane defined by a base structure of the rotatable bicycle storage carousel. The elongated central core is rotatable relative to the base structure. The carousel further includes multiple bicycle storage assemblies on which bicycles can be hung.

Abstract: The presently disclosed subject matter provides for antigen-recognizing receptors that specifically target uPAR and cells comprising such uPAR-targeted antigen-recognizing receptors. The presently disclosed subject matter further provides uses of the uPAR-targeted antigen-recognizing receptors for treatment.

Abstract: A propulsion assembly includes a first torque source coupled with a first shaft and a second torque source coupled with a second shaft. A coupler selectively couples the first and second torque sources. When the first and second torque sources are coupled via the coupler, in response to a command to decouple the first torque source, an unloading operation is performed to decrease the torque output provided by the first torque source to a threshold, and when reached, the first shaft is decoupled from the coupler. When the first torque source is coupled with the coupler but the second torque source is not, in response to a command to couple the second torque source, a speed matching operation is performed to increase the speed of the second shaft to match a speed of the first shaft, and when the speeds are matched, the second shaft is coupled to the coupler.