Abstract: The present patent application discloses the compounds according to Formula I shown below, or pharmaceutically acceptable salts thereof, wherein JB, n, R1, R2, R3, R4, R5, m and X as defined herein.

Abstract: Provided are methods for the isolation of phorbol from seed sources and the use of the phorbol for the generation of tigliane tiglate and derivatives thereof.

Abstract: A vision-assisted robotized depalletizer receives at a pallet station a pallet loaded with products and outputs on a conveyor unitized products aligned in a desired orientation. Such depalletizers include a vision system having one or more image acquisition sensors that are positioned relative to the pallet station so as to have a field of view covering a top portion of the pallet. The sensors send to a controller one or more image of the top portion of the pallet that the controller uses along to determine the position of each product in the top portion of the pallet. The depalletizer further includes a robot equipped with a depalletizing tool that is coupled to the vision system controller for receiving information indicative of the position of each product from the top portion and uses that information to pick and position on the output conveyor each product from the top portion.

Abstract: The embodiments provide a container of the type to hold fresh food or produce. Container has a base and a lid moveable with respect to the base between an open position and a closed position. The lid has a planar area. The base has a second planar area. In the closed position, the first planar and the second planar area include a substantially flat area suitable for receipt of an adhesive membrane, such as a self-adhesive label. The substantially flat area includes an edge of the first planar area and at least part of the second planar area.

Abstract: The present disclosure is generally directed to the use of compositions that include antibodies, e.g., monoclonal, chimeric, affinity-matured or humanized antibodies, antibody fragments, etc., that specifically bind one or more epitopes within a Sortilin protein, e.g., human Sortilin or mammalian Sortilin, and have improved and/or enhanced functional characteristics, in treating and/or delaying progression of a disease or injury in an individual in need thereof.

Abstract: The present application describes pharmaceutical formulations of bromocriptine mesylate and methods of manufacturing and using such formulations. The formulations are useful for improving glycemic control in the treatment of type 2 diabetes.

Abstract: Isolated human monoclonal antibodies which bind to human CD38, and related antibody-based compositions and molecules, are disclosed. Also disclosed are pharmaceutical compositions comprising the human antibodies, and therapeutic and diagnostic methods for using the human antibodies.

Abstract: Provides a silicon containing polyisocyanate polyaddition (PIPA) polyether polyol dispersion at readily processible viscosity for use in making flexible polyurethane foams having inherent flame retardant properties that comprises polyether polyol carrier and from 10 to 25 wt. %, based on total weight of dispersion, of particles of a silicon containing (PIPA) polyether polyol having a particle size diameter wherein 90%, by volume, of the particles in dispersion have maximum PSD of from 0.1 to 3 m and that, further, contain two or more aromatic carbamate groups. Dispersion may further comprise water or blowing agent, i) one or more catalysts, and f) one or more polyisocyanates in a foam forming mixture. In addition, provides methods for making the silicon containing PIPA polyether polyol dispersion comprising forming and mixing under shear a base polyol dispersion and delaying the addition of g) one or more polyisocyantes and h) a catalyst while mixing under shear.

Abstract: The present invention relates to compounds of formula (I), which are modulators of sortilin activity. The invention also relates to pharmaceutical compositions comprising these compounds and to the use of these compounds in the treatment or prevention of medical conditions where modulation of sortilin activity is beneficial.

Abstract: A refuse collection includes one or more memory devices storing instructions thereon, that, when executed by one or more processors, cause the one or more processors to (a) receive a request for refuse collection from a customer, the request including a desired time of the refuse collection, (b) identify, based on the request, a location of a pickup zone associated with the customer, and (c) control, based on the request, the refuse collection robot to autonomously navigate to the location of the pickup zone at the desired time and perform the refuse collection.

Abstract: A bearing unit having a roller bearing that includes an outer ring and an inner ring that is rotatable with respect to the same about an axis, The inner ring is fastened to a first component, and the outer ring is fastened to an adapter ring that is nonrotatably and axially movably supported on a second component. A method for manufacturing a structural unit and an electric motor are also provided.

Abstract: A refuse collection system includes one or more memory devices storing instructions thereon, that, when executed by one or more processors, cause the one or more processors to (a) receive a request for refuse collection from a customer, (b) identify, based on the request, a location of a pickup zone associated with the customer, (c) receive location data indicating a current location of the refuse collection robot, (d) generate a route for the refuse collection robot to travel from the current location of the refuse collection robot to the location of the pickup zone, and (e) control the refuse collection robot to follow the route and perform the refuse collection.

Abstract: Herein discussed is a method of producing hydrogen comprising: providing a tubular reactor having an open end and a closed end, wherein the reactor comprises an anode on the inside and a cathode on the outside separated by and in contact with a mixed conducting electrolyte, wherein the electrolyte comprises an electronically conducting phase and an ionically conducting phase, wherein the reactor comprises no current collector or interconnect; introducing a hydrocarbon and an oxidant into a feed tube, wherein the feed tube contains a catalyst that promotes catalytic partial oxidation (CPOX) reactions, wherein the feed tube extends into the open end of the reactor and toward the closed end of the reactor; introducing steam to the outside of the tubular reactor; and converting steam to hydrogen electrochemically without electricity input.

Abstract: A refuse collection system includes one or more memory devices storing instructions thereon, that, when executed by one or more processors, cause the one or more processors to (a) control a refuse collection robot containing a volume of refuse to navigate to a refuse depot, (b) control the refuse depot to remove the volume of refuse from the refuse collection robot, (c) receive a request from a customer for delivery of a package, (d) identify, based on the request, a location of a pickup zone associated with the customer, (e) control the refuse collection robot to receive the package, and (f) control the refuse collection robot to transport the package to the pickup zone.

Abstract: A braided carbon structure and methods of forming and processing are presented. The braided carbon structure comprises axial tows comprising carbon filaments; braid tows at a braid angle relative to the axial tows, the braid tows comprising carbon filaments; and thermoplastic material within at least one of the axial tows or the braid tows, wherein the thermoplastic material makes up less than 40 of each of the at least one of the axial tows or the braid tows.

Abstract: A method of purifying a gas composed of a product gas and one or more impurity gases including combining a feed stream with a second stream thereby forming a combined feed stream, introducing the combined feed stream into a pressure swing adsorption device, thereby producing a high purity product gas stream and an off-gas stream, and introducing the off-gas stream into a membrane separation device, thereby producing a gas stream lean in product gas and a permeate stream.

Abstract: A molding is made from a first flooring plank. A first groove is formed into the first flooring plank with a first flat bottom surface. A second groove is formed into the first flooring plank with a second flat bottom surface. The first flooring plank is folded at the first groove and second groove. A second flooring plank is disposed adjacent to the molding. A color and pattern of the first flooring plank and second flooring plank match.

Abstract: An expansion joint system for bridging a gap between spaced apart structural members and capable of self-cleaning. The expansion joint system includes first and second base members, at least one upwardly sloped base plate engaged with one of the first and second base members, and at least one substantially horizontal movable plate engaged with at least one of the first and second base members. Also disclosed is an expansion joint including a first structural member and a second structural member, first and second base members, at least one upwardly sloped base plate engaged with one of the first and second base members, and at least one substantially horizontal movable plate engaged with at least one of the first and second base members.

Abstract: A retaining assembly for coupling a fluid end component to a fluid end casing. The retaining assembly includes a pair for clamp members, each of which has a pair of rails that define a wedge-shaped groove therebetween. The groove applying an increasing amount of pre-load force or tension to a flange of the fluid end components and a flange of the fluid end casing to drive them together. The amount of pre-load tension applied can vary and can be determined by the user and amount of tightening of the clamp members.

Abstract: The invention provides compounds of formula (I): wherein the variables are defined in the specification, or a pharmaceutically-acceptable salt thereof, that are inhibitors of JAK kinases. The invention also provides pharmaceutical compositions comprising such compounds, methods of using such compounds to treat inflammatory bowel diseases, and processes and intermediates useful for preparing such compounds.