Patents by Inventor Paul Williams

Paul Williams has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20190119370
    Abstract: The present disclosure provides modified antibodies which contain an antibody or antibody fragment (AB) modified with a masking moiety (MM). Such modified antibodies can be further coupled to a cleavable moiety (CM), resulting in activatable antibodies (AAs), wherein the CM is capable of being cleaved, reduced, photolysed, or otherwise modified. AAs can exhibit an activatable conformation such that the AB is more accessible to a target after, for example, removal of the MM by cleavage, reduction, or photolysis of the CM in the presence of an agent capable of cleaving, reducing, or photolysing the CM. The disclosure further provides methods of making and using such modified antibodies and activatable antibodies.
    Type: Application
    Filed: August 23, 2018
    Publication date: April 25, 2019
    Inventors: Nancy Elizabeth Stagliano, James William West, Kathryn Kamath, Paul Henry Bessette, Fred Gluck, Jason Gary Sagert, Patrick Daugherty
  • Publication number: 20190120969
    Abstract: A communication system, includes a satellite receiver in operable communication with a central server, a cellular node configured to operate within a proximity of the satellite receiver, and at least one mobile communication device configured to communicate (i) with the cellular node, (ii) within the proximity of the satellite receiver, and (iii) using a transmission signal capable of causing interference to the satellite receiver. The satellite receiver is configured to detect a repeating portion of the transmission signal and determine a potential for interference from the at least one mobile communication device based on the detected repeating portion.
    Type: Application
    Filed: November 14, 2018
    Publication date: April 25, 2019
    Inventors: Belal Hamzeh, Peter Paul Smyth, Lin Cheng, Jim O'Connor, Eric Winkelman, Thomas H. Williams, Steve Arendt
  • Patent number: 10261389
    Abstract: An integrated optical beam steering device includes a planar dielectric lens that collimates beams from different inputs in different directions within the lens plane. It also includes an output coupler, such as a grating or photonic crystal, that guides the collimated beams in different directions out of the lens plane. A switch matrix controls which input port is illuminated and hence the in-plane propagation direction of the collimated beam. And a tunable light source changes the wavelength to control the angle at which the collimated beam leaves the plane of the substrate. The device is very efficient, in part because the input port (and thus in-plane propagation direction) can be changed by actuating only log2 N of the N switches in the switch matrix. It can also be much simpler, smaller, and cheaper because it needs fewer control lines than a conventional optical phased array with the same resolution.
    Type: Grant
    Filed: June 22, 2017
    Date of Patent: April 16, 2019
    Assignee: Massachusetts Institute of Technology
    Inventors: Scott Skirlo, Cheryl Marie Sorace-Agaskar, Marin Soljacic, Simon Verghese, Jeffrey S. Herd, Paul William Juodawlkis, Yi Yang, Dirk Robert Englund, Mihika Prabhu
  • Patent number: 10259592
    Abstract: A system and method for an aircraft refueling receptacle. The aircraft refueling receptacle comprises a pedestal, a flanged structure, a sliding valve, and a bolt. The flanged structure has a first ledge, a second ledge, and a number of flanges extending inwardly. The pedestal contacts the first ledge. The sliding valve has a first face that contacts the second ledge of the flanged structure during refueling. The bolt extends a part of a length of the pedestal and is connected to a receiver within the pedestal.
    Type: Grant
    Filed: March 2, 2015
    Date of Patent: April 16, 2019
    Assignee: The Boeing Company
    Inventors: Brian Lewis, Paul William Klenke, Dennis P. Byrne, Ky Huu Nguyen, Paul Gerard Weber
  • Patent number: 10258686
    Abstract: The subject invention pertains to isolated influenza virus that is capable of infecting canids and causing respiratory disease in the canid. The subject invention also pertains to compositions and methods for inducing an immune response against an influenza virus of the present invention. The subject invention also pertains to compositions and methods for identifying a virus of the invention and diagnosing infection of an animal with a virus of the invention.
    Type: Grant
    Filed: February 5, 2018
    Date of Patent: April 16, 2019
    Inventors: Patti Cynthia Crawford, Paul J. Gibbs, Edward J. Dubovi, Ruben Omar Donis, Jacqueline Katz, Alexander I. Klimov, Nallakannu P. Lakshmanan, Melissa Anne Lum, Daniel Ghislena Emiel Goovaerts, Mark William Mellencamp, Nancy J. Cox, William L. Castleman
  • Patent number: 10258636
    Abstract: Provided are novel prodrug salts of selective aquaporin inhibitors, their use as pharmaceuticals, and pharmaceutical compositions comprising them, and novel processes for their synthesis and novel intermediates for use in their synthesis. Also provided is use of a compound for the prophylaxis, treatment, and control of aquaporin-mediated conditions. Aquaporin inhibitors, e.g., inhibitors of AQP4 and/or AQP2, may be of utility in the treatment or control of diseases of water imbalance, for example edema (particularly edema of the brain and spinal cord), hyponatremia, and excess fluid retention, as well as diseases such as epilepsy, retinal ischemia and other diseases of the eye, myocardial ischemia, myocardial ischemia/reperfusion injury, myocardial infarction, myocardial hypoxia, congestive heart failure, sepsis, and neuromyelitis optica, as well as migraines.
    Type: Grant
    Filed: October 24, 2017
    Date of Patent: April 16, 2019
    Assignee: AEROMICS, INC.
    Inventors: Marc F. Pelletier, Paul Robert McGuirk, George William Farr, Robert Zamboni, John Colucci, Helmi Zaghdane
  • Publication number: 20190105276
    Abstract: The invention provides an oral extended release formulation for the treatment of treatment-resistant depression and treatment-resistant anxiety.
    Type: Application
    Filed: October 10, 2017
    Publication date: April 11, 2019
    Inventors: Paul William Glue, Natalie June Medlicott
  • Publication number: 20190098938
    Abstract: The present invention provides a conductive substrate useful for Joule heating, such as in an electronic smoking article. Particularly, the invention provides a resistive heating element formed of a conductive substrate. The conductive substrate comprises an electrically conductive material and a carbonaceous additive, such as a binder material. The conductive substrate is carbonized in that it is subjected to calcining conditions to effectively reduce the carbonaceous additive to its carbon skeleton. It has been found that such carbonized substrate has surprisingly improved resistance properties in relation a substrate of the same formulation that is not carbonized. The carbonized substrate can include an aerosol precursor material. The formed resistive heating element can be included in an electronic smoking article to simultaneously provide resistive heating and aerosol formation with a single, unitary component.
    Type: Application
    Filed: December 3, 2018
    Publication date: April 4, 2019
    Inventors: David William Griffith, JR., Yi-Ping Chang, Calvin W. Henderson, Ricky Lee Montgomery, Walter Charles Liebscher, II, Chandra Kumar Banerjee, Paul E. Braxton, Stephen Benson Sears, Kenneth Allen Beard, Timothy Brian Nestor, Balager Ademe, Frederic Philippe Ampolini, Dennis Lee Potter
  • Publication number: 20190099587
    Abstract: A vascular access disassembling needle assembly 20 is provided that enables rapid insertion of a guide wire into the needle and subsequent rapid removal of the access needle off the guide wire by facile disassembly of the needle. The disassembling needle assembly 20 includes a needle portion 30 wherein the needle breaks apart by splitting along at least one seam 40 that extends from the proximal to the distal end to allow removal of the guide wire. Various mechanical features are described that can facilitate the separation of the needle body along at least one seam. Once one or more seams are separated, the needle body may be removed from the guide wire without the need to withdraw the needle along the length of the guide wire, which permits preloading of expanders and other medical devices onto the guidewire.
    Type: Application
    Filed: March 20, 2017
    Publication date: April 4, 2019
    Applicant: Government of the United States as Represented by the Secretary of the Air Force
    Inventors: Timothy K Williams, Lucas Paul Neff, James B Sampson
  • Patent number: 10250670
    Abstract: A system is described to create and transmit a streamable ZIP file container. The streamable ZIP file container contains stream metadata, files, and a central directory. The stream metadata, files, and central directory can be saved in a contiguous stream without any intervening bytes. When the streamable ZIP file container is read by a client device that supports streamable ZIP file containers, the client device can exit the data stream without receiving the central directory. Interruptions during transmission of the ZIP file container can be resumed.
    Type: Grant
    Filed: August 12, 2016
    Date of Patent: April 2, 2019
    Assignee: Apple Inc.
    Inventors: Paul William Chinn, Eric Olaf Carlson, Ronnie Misra
  • Patent number: 10251164
    Abstract: A wireless communications system is described which comprises a base station, a relay device, and a terminal device. The terminal device is operable to receive from the base station an allocation of uplink resources for transmitting uplink data to the relay device, and to transmit uplink data to the relay device using the uplink resources allocated to the terminal device. The relay device is operable to receive the transmitted uplink data from the terminal device on the allocated resources, to receive an allocation of uplink resources for relaying the received uplink data to the base station, and to transmit the received uplink data to the base station using the uplink resources allocated to the relay device.
    Type: Grant
    Filed: November 15, 2016
    Date of Patent: April 2, 2019
    Inventors: Timothy James Speight, Paul William Piggin
  • Patent number: 10245407
    Abstract: A humidification system can include a heater base, a humidification chamber, and a breathing circuit. A cartridge can be removably coupled to the heater base. The cartridge can include various sensors, probes, sensor wire connectors, heater wire connectors, and/or other features. The cartridge can include features configured to mate with corresponding features on the humidification chamber and the heater base. The cartridge includes a memory, such as an EEPROM, or other suitable storage device. When the cartridge is installed on the heater base, the memory is electrically connected to a processor and/or memory of the heater base. Various models of cartridges can be produced for use with different humidification chambers, breathing circuits, and/or therapies. A connector can couple an inspiratory conduit to an outlet port of the humidification chamber. The connector can provide a pneumatic connection to the outlet port and an electrical connection to the cartridge.
    Type: Grant
    Filed: September 15, 2014
    Date of Patent: April 2, 2019
    Inventors: Hamish Adrian Osborne, Gavin Walsh Millar, Stephen David Evans, Bruce Gordon Holyoake, James William Stanton, David Leon McCauley, Gareth Thomas McDermott, Nicholas James Michael McKenna, Myfanwy Jane Antica Norton, Adrian John Elsworth, Michael John Andresen, Jonathan Andrew George Lambert, Sandeep Singh Gurm, Tessa Hazel Paris, Joseph Nathaniel Griffiths, Ping Si, Christopher Gareth Sims, Elmo Benson Stoks, Dexter Chi Lun Cheung, Peter Alan Seekup, Po-Yen Liu, Richard Edward Lang, Paul James Tonkin, Ian Lee Wai Kwan
  • Patent number: 10246025
    Abstract: A system and method for loading items onto a vehicle. The system allows a support to be easily lowered from, for example, the roof of a vehicle towards the ground. The items to be loaded are secured in the supports at a much lower height than the roof of the vehicle to reduce the possibility of injury and eliminate the need of an additional person for loading and unloading objects onto the roof of a vehicle. Once the item is loaded onto the supports, the system can raise the item onto the roof and secure it in a safe position for transportation.
    Type: Grant
    Filed: June 29, 2016
    Date of Patent: April 2, 2019
    Assignee: University of South Florida
    Inventors: Brenden Arthur Knigge, Ricardo Francisco Socci, Matthew Paul Baldwin, Ivan Wain Williams
  • Patent number: 10248609
    Abstract: A modular interconnectivity assembly for interconnecting elements of a point of sale system, the modular interconnectivity assembly including at least one interconnectivity module including an Input/Output (I/O) hub having at least one upstream facing port and at least two downstream facing ports, at least one upstream connector connected to the at least one upstream facing port of the (I/O) hub and adapted for communication in accordance with a first communication protocol, at least one downstream connector connected to at least one of the at least two downstream facing ports and adapted for communication in accordance with the first communication protocol and at least one interface connected to another of the at least two downstream facing ports and adapted for communication in accordance with a second communication protocol, different from the first communication protocol.
    Type: Grant
    Filed: January 6, 2016
    Date of Patent: April 2, 2019
    Assignee: VERIFONE, INC.
    Inventors: Scott William McKibben, Ricardo Ernesto Espinoza-Ibarra, Dennis Carr, Paul Serotta
  • Publication number: 20190096183
    Abstract: Some embodiments may include a poker indexing service. For example, a multi dimensional vector of player performance and/or other data may be determined based on gaming related activity that is input or otherwise captured. Such a vector may be used in various forms to generate a metric or to facilitate wagering and/or other gaming activity. Other methods and apparatus are described.
    Type: Application
    Filed: September 24, 2018
    Publication date: March 28, 2019
    Inventors: Lee Amaitis, Paul Williams, Nolan Glantz
  • Publication number: 20190092729
    Abstract: Compounds that modulate the oxidoreductase enzyme indoleamine 2,3-dioxygenase, and compositions containing the compounds, are described herein. The use of such compounds and compositions for the treatment and/or prevention of a diverse array of diseases, disorders and conditions, including cancer- and immune-related disorders, that are mediated by indoleamine 2,3-dioxygenase is also provided.
    Type: Application
    Filed: November 5, 2015
    Publication date: March 28, 2019
    Inventors: Hilary Plake BECK, Juan Carlos JAEN, Maksim OSIPOV, Jay Patrick POWERS, Maureen Kay REILLY, Hunter Paul SHUNATONA, James Ross WALKER, Mikhail ZIBINSKY, James Aaron BALOG, David K. WILLIAMS, Weiwei GUO
  • Patent number: 10239418
    Abstract: A linear drive transport system may include a track that includes first, second, third, and fourth track surfaces that define perimeter boundaries of the track and a magnetic drive system. The first, second, third, and fourth track surfaces include first, second, third, and fourth trajectories about the track, respectively, which are each different from one another. A mover may move along the track and include first and second leading bearings that interact with the first and second track surfaces, respectively, and first and second lagging bearings that interact with the third and fourth track surfaces, respectively, and a reaction element that interacts with the magnetic drive system to generate a propulsive force. The first and second leading bearings may be coupled to the mover at a first fixed distance from one another, and the first and second lagging bearings may be coupled to the mover at a similar distance.
    Type: Grant
    Filed: June 21, 2016
    Date of Patent: March 26, 2019
    Assignee: Rockwell Automation Technologies, Inc.
    Inventors: Michael Wayne Cromheecke, Oliver Charles Wexner Haya, Paul Jerome Grosskreuz, Jeffrey William Dujmovic
  • Patent number: 10239148
    Abstract: A welding system includes a welding torch assembly. The welding torch assembly includes a first feed roll configured to rotate about a first axis, a second feed roll disposed opposite the first feed roll about a welding wire feed region, a first helical gear coupled to the first feed roll, a second helical gear operatively coupled to the first helical gear, and a drive motor. The first helical gear is configured to rotate about the first axis, the second helical gear is configured to rotate about a second axis to rotate the first helical gear about the first axis, wherein the second axis is generally perpendicular to the first axis, and the drive motor is configured to rotate the second helical gear about the second axis. The second axis is offset from a plane defined by the welding wire feed region between the first and second feed rolls.
    Type: Grant
    Filed: June 14, 2012
    Date of Patent: March 26, 2019
    Assignee: Illinois Tool Works Inc.
    Inventor: Paul William Garvey
  • Patent number: 10238695
    Abstract: Composition containing a microorganism, preferably an Archaea, expressing a TMA methyltransferase and a TMA methyl group acceptor corrinoid protein, capable of metabolizing trimethylamine (TMA) in the presence of hydrogen in a human cavity, such as the intestine or the vagina, for use as a medicament for treating, reducing or eliminating TMA at the level of the human cavity. In addition, a composition containing a TMA methyltransferase and a TMA methyl group acceptor corrinoid protein. These compositions are of use for treating trimethylaminuria, for treating vaginal fluids in the case of bacterial vaginosis and for reducing or eliminating odours due to TMA. These compositions are also of use for reducing the level of plasma TMAO, for preventing the formation of atheroma plaques and/or for preventing cardiovascular diseases.
    Type: Grant
    Filed: September 27, 2013
    Date of Patent: March 26, 2019
    Inventors: Jean-Fran├žois Brugere, Guillaume Borrel, Paul William O'Toole, Corinne Malpuech-Brugere, Monique Alric
  • Publication number: 20190087083
    Abstract: Techniques for providing multi-user multi-touch projected capacitive touch sensors are disclosed herein. Some embodiments may include a method that includes receiving a first sense signal from a first sensing array, the first sensing array configured to provide the first sense signal indicating a first touch on a first touch surface of a touch substrate as well as receiving a second sense signal from a second sensing array, the second sensing array configured to provide the second sense signal indicating a second touch on a second touch surface of a second touch substrate occurring concurrently to the first touch. The method may further include determining whether the first touch and the second touch share at least one anti-ghost. The method may also include associating the first touch and the second touch with a common touch entity in response to determining that the first touch and the second touch share the at least one anti-ghost.
    Type: Application
    Filed: November 19, 2018
    Publication date: March 21, 2019
    Inventors: Damien BERGET, Kenneth Andrew Feehan, Paul Leonard Futter, David Samuel Hecht, Joel Christopher Kent, Robert William Kitchin, Kenneth John North, James Roney, Kyu-Tak Son, Jung Verheiden, Forrest Kim Wunderlich