Abstract: Disclosed are conjugate molecules formed from an active agent which is linked to a cannabinoid moiety through a specified linker having ester and amide end groups. The active agent can be a COX-2 inhibitor moiety, and the cannabinoid moiety can be a cannabidiol moiety. These conjugate molecules are contemplated to potentially be effective in the treatment of medical conditions.

Abstract: A welding-type power supply including a balanced plate rectifier to rectify high frequency alternating current from one or more transformers. The balanced plate rectifier includes an output terminal symmetrically connected to the plates of the plate rectifiers. The impedance between the output terminal and each plate is substantially equal.

Abstract: Thermoplastic compositions useful for sealing longitudinal joints of substrates, for example, roadways and pavement, are provided herein. Formulations including the composition and methods of using the thermoplastic composition to seal longitudinal joints are also disclosed.

Abstract: Apparatus and methods are disclosed. The apparatus comprises: an abatement chamber of an abatement apparatus which treats an effluent stream from a semiconductor processing tool to provide a combusted effluent stream having effluent particles; and a first atomiser located downstream of the abatement chamber, the first atomiser being configured to produce droplets having a droplet size based on a particle size of the effluent particles to be removed from the combusted effluent stream. In this way, the atomizer may produce droplets which combine with or adhere to the effluent particles which assists in the removal of the effluent particles from the combusted effluent stream.

Abstract: System and method for conducting enhanced oil recovery by establishing a plurality of stacked, alternating slugs of gas and liquid travelling downhole into a subterranean well. The system can include a buffer tank including a liquid inlet through which liquid is received from a liquids source into the buffer tank, a gas inlet through which gas is received from a pressured gas source into the buffer tank, a gas outlet in fluid communication with gas reservoired in the buffer tank, and a liquid outlet in fluid communication with liquid reservoired in the buffer tank. The system can further include a pressure control configured to maintain a specified pressure in gas reservoired within the buffer tank and a fluid dispensing system in fluid communication with the gas and liquid outlets of the buffer tank.

Abstract: An example buckling restrained brace (“BRB”) includes a casing exhibiting a hollow cross-sectional shape defining an interior region. The BRB also includes a core and at least a portion of the core is disposed in the interior region of the casing. For example, the casing may exhibit a first length and the core may exhibit a second length that is greater than the first length such that a portion of the core extends from the casing. The core is separated from the casing by an minimum gap distance along at least a portion of the first length of the casing and a corresponding portion of the second length of the core.

Abstract: A compressor includes a diffuser passage configured to receive refrigerant flow from an impeller of the compressor, where the diffuser passage is at least partially defined by a compressor discharge plate of the compressor. The compressor also includes a variable geometry diffuser positioned within the diffuser passage and configured to adjust a dimension of a refrigerant flow path through the diffuser passage, an actuator coupled to the variable geometry diffuser and configured to adjust a position of the variable geometry diffuser within the diffuser passage, and a controller configured to regulate operation of the actuator.

Abstract: A multi-vendor risk relationship data store may contain electronic records representing a plurality of risk relationships between multiple vendors and an enterprise and, for each risk relationship, an electronic record identifier and a set of attribute values. An information sharing portal computer server may exchange an information request with a remote vendor platform. The information request may be, for example, associated with an employee of a sponsor associated with the vendor platform. The server may process the information request via a customized vendor-specific information sharing portal interface display and execute an algorithm to adjust, based on at least one attribute value, interactions with the vendor platform via the portal interface display. The server may also aggregate information associated with a plurality of vendor platforms and transmit the aggregated information to a remote administrator device associated with the enterprise.

Abstract: Devices, systems and methods for removing heat from subcutaneously disposed lipid-rich cells are disclosed. In selected embodiments, suction and/or heat removal sources are coupled to an applicator. The applicator includes a flexible portion and a rigid portion. The rigid portion includes a thermally conductive plate and a frame coupling the thermally conductive plate and the flexible portion. An interior cavity of the applicator is in fluid communication with the suction source, and the frame maintains contiguous engagement between the heat removal source and the thermally conductive plate.

Abstract: The present invention relates to a class of N-cyanopyrrolidines with activity as inhibitors of the deubiquitylating enzyme USP30, having utility in a variety of therapeutic areas, including conditions involving mitochondrial dysfunction, cancer and fibrosis.

Abstract: The present invention pertains generally to the field of therapeutic compounds. More specifically the present invention pertains to certain 2-amino-N-(amino-oxo-aryl-?6-sulfanylidene)acetamide compounds (referred to herein as ANASIA compounds) that, inter alia, inhibit (e.g., selectively inhibit) bacterial aminoacyl-tRNA synthetase (aaRS) (e.g., bacterial leucyl-tRNA synthetase, LeuRS). The present invention also pertains to pharmaceutical compositions comprising such compounds, and the use of such compounds and compositions, both in vitro and in vivo, to inhibit (e.g., selectively inhibit) bacterial aminoacyl-tRNA synthetase; to treat disorders that are ameliorated by the inhibition (e.g., selective inhibition) of bacterial aminoacyl-tRNA synthetase; to treat bacterial infections; etc.

Abstract: A computer implemented method of data processing comprises receiving an input data stream; identifying, by a first algorithm, one or more first content features of the data stream; determining, based on at least one output of the first algorithm, one or more portions of the data stream to be stored in a first buffer; storing the determined portions in the first buffer; identifying, by a second algorithm, one or more second content features of the data stream using the stored portions of the data stream; and generating, for output to a user, an output based on the identified second content features; wherein the second algorithm is computationally more complex than the first algorithm.

Abstract: Runner assembly 10 for carrying a receptacle 12 towards and away from a structure 14. The runner assembly 10 includes: at least one pair of first bearings 16, each first bearing 16 being mountable to the structure 14 so that the first bearings 16 of the, or each, pair are spaced apart; an elongate runner 18 defining a longitudinal length and having an opposed pair of first tracks 22 spaced from each other, each first track 22 configured to cooperate with the first bearings 16 to allow the runner 18 to be carried by the first bearings 16; at least one second bearing 24 mounted to the runner 18; and an elongate track member 26 mountable to the receptacle 12, the track member 26 having a second track 28 defining at least one pair of opposed bearing surfaces 30, 31 spaced from each other and configured to cooperate with the at least one second bearing 24 to allow the track member 26 to be carried by the at least one second bearing 24.

Abstract: Exemplary embodiments of the present invention provide a virtual dispatch assist system in which various types of Intelligent Agents are deployed (e.g., as part of a new CAD system architecture or as add-ons to existing CAD systems) to analyze vast amounts of historic operational data and provide various types of dispatch assist notifications and recommendations that can be used by a dispatcher or by the CAD system itself (e.g., autonomously) to make dispatch decisions.

Abstract: Systems and methods of manufacturing a shoe outsole are provided wherein at least a portion of the resulting shoe outsole includes embedded particles. An example method includes applying adhesive to at least one region of the shoe outsole, depositing selected particles onto the adhesive to provide the shoe outsole with a first coat of particles, and at least partially curing the adhesive. The method continues by applying additional adhesive over the first coat of particles, depositing additional particles onto the adhesive to provide the shoe outsole with a second coat of particles, and at least partially curing the subsequent application of adhesive.

Abstract: A microtopography system for modulating one or more cellular processes on a surface is described. The microtopography system comprising: a repeated microtopographic pattern, said microtopographic pattern comprising: an array of repeated micropillars applied to a surface of a product, said micropillars being formed of surface structures between 1-100 ?m in height, and 1-50 ?m in width. The microtopographic pattern acts to modulate one or more cellular processes on the surface.

Abstract: Drawer assembly for mounting to a cargo area of a vehicle. The drawer assembly includes: a drawer body defining a longitudinal axis and configured to be mounted to a track system to allow moving towards and away from the cargo area along the longitudinal axis; and a utility module pivotally mounted to the drawer body about an axis arranged perpendicular to the longitudinal axis. The utility module is pivotable between a storage position, where the utility module is received within the drawer body, and an access position, where the utility module is arranged to extend away from the drawer body.

Abstract: A computing device for gaming by patrons. An identification acceptor may scan an identification document into digital form. A biological sensor such as a camera may obtain biological data describing a human patron. Input-output device(s) mounted in the computing device may present information and accept registration/login information and gaming commands from a human patron. A currency acceptor and dispenser may accept money. The computing device may ask a patron to insert an identification document into the identification acceptor and scan the document. The computing device may obtain biological data describing the patron. The computing device may verify the identity of the patron and acceptability of the patron for gaming based at least in part on the digital form of the patron's identification and the biological data. The computing device may accept currency for deposit into a wagering account.

Abstract: Provided are methods for profiling cellular analytes of a cell by barcoding the cell in a combinatorial split and pool iterative process. In some instances, a cell bead may be generated from the cell, and the analytes therein barcoded in a combinatorial split and pool iterative process while the analytes are retained in the cell bead during iterative partitioning.

Abstract: A method of compiling performance metrics for racing competitors by analyzing videos of the competitors' prior races, includes determining: (a) the GPS coordinates of race track landmarks that appear in the videos, (b) within each of the videos' images, the position and orientation of a part for each of the competitors, (c) for each of the videos' images, the camera's extrinsic and intrinsic parameters, (d) the path of each of the competitors from the race's starting line to its finish line, (e) for each of the videos' images, the GPS coordinates of the part for each of the competitors, and (f) using the camera's frame rate, the performance metrics for each of the racing competitors.