Abstract: Here we report the creation of a new positive-selection cloning vector dubbed pKILLIN, which overcomes all of the above pitfalls. The essence behind its high cloning efficiency is the extreme toxicity and small size of the toxic domain of killin, a recently discovered p53 target gene. Insertion inactivation of killin within the multiple cloning site via either blunt- or sticky-end ligation serves not only as a highly efficient cloning trap, but also may allow any cloned genes to be expressed as His-tagged fusion proteins for subsequent purification. Thus, pKILLIN is a versatile positive-selection vector ideal for cloning PCR products, making DNA libraries, as well as routine cloning and bacterial expression of genes.

Abstract: Method and systems are provided for interpreting speech data. A method and system for recognizing speech involving a filter module to generate a set of processed audio data based on raw audio data; a translation module to provide a set of translation results for the raw audio data; and a decision module to select the text data that represents the raw audio data. A method for minimizing noise in audio signals received by a microphone array is also described. A method and system of automatic entry of data into one or more data fields involving receiving a processed audio data; and operating a processing module to: search in a trigger dictionary for a field identifier that corresponds to the trigger identifier; identify a data field associated with a data field identifier corresponding to the field identifier; and providing content data associated with the trigger identifier to the identified data field.

Abstract: The present invention relates to a new tumor suppressor, designated Killin. Also described are diagnostic and therapeutic uses of the Killin protein and the killin gene, alone or in combination with traditional cancer therapies.

Abstract: An apparatus for providing a feedback force includes a calculating unit and a force feedback displacement controller. The calculating unit receives relative position information of a first object and a second object and geometric information of the first object and the second object. If the first object and the second object are not in contact, the calculating unit calculates a force feedback value based on the relative position information and the geometric information. The force feedback displacement controller outputs a displacement command, and receives the force feedback value. The displacement command allows the first object to move with respect to the second object. The force feedback displacement controller includes a displacement unit that generates the displacement command based on an operation of a user, and a force feedback unit that provides a feedback force to the displacement unit based on the force feedback value.

Abstract: A portable green power device includes an energy storage module, a manpower generating module, a control unit and an AC charging module. The energy storage module has input terminals, output terminals and a DC charging port. The output terminal is connected to an additional energy storage module in parallel and/or an external device. The energy storage module is electrically connected in parallel to expand power storage capacity, and the expansion still enable charging and discharging synchronously with voltage levels balanced dynamically. The manpower generating module utilizes relative movement between a magnetic components and an induction coil to generate energy. The control unit tracks and collects the power generated by the manpower generating module with the maximum power point tracking circuit and then transfers the power to the energy storage module. The AC charging module transforms AC power to DC power and transfers the DC power to the energy storage module.

Abstract: An embodiment of the present invention provides a TVOD song playing method, comprising: assigning coordinates of a starting point and an end point to each sentence of lyrics; determining a coordinate of a click position; determining, according to the coordinate of the click position, coordinates of the starting point and the end point of lyrics to be played; and playing the lyrics corresponding to the coordinates of the starting point and the end point. Another embodiment of the present invention further provides a TVOD song player, comprising: a lyrics editing module, a coordinate determining module, and a playing module.

Abstract: An interference preventing method applied on a machining machine includes the following steps. Firstly, a control command is provided in response to an operation event. Next, protection information corresponding to a protection target component is provided. Then basic envelop of the protection target component is obtained. Then the basic envelop is segmented into a number of sub protection blocks according to a multi-hierarchical protection parameter and sub protection blocks not linked with the protection target component are removed, so as to determine a multi-hierarchical interference protection area. Next, whether an interference event of the multi-hierarchical interference protection area and other components occurs, so as to determine whether interference event of the protection target component occurs; if so, control signal is provided to control the processing operation of the machining machine.

Abstract: A vehicle central lock antitheft method and system includes a central lock system which is connected by radio with a remote controller for identity verification using rolling codes (S101, S102), wherein the central lock system chooses a security state (S103) and transmits the security state to an engine management system according to the verification result, the ignition IG status and the door switch status signal indicating opening or closing of the door (S104). The engine management system receives the security state transmitted by the central lock system and verifies the identity of the central lock system by code matching (S106); security identification between the engine management system and the central lock system is carried out by bidirectional encryption communication (S107). The engine management system then decides whether or not to lock the engine according to the result of the security identification.

Abstract: The instant invention provides for substituted thiazoles that inhibit Akt activity. In particular, the compounds disclosed selectively inhibit one or two of the Akt isoforms. The invention also provides for compositions comprising such inhibitory compounds and methods of inhibiting Akt activity by administering the compound to a patient in need of treatment of cancer.

Abstract: Clamping tweezers include two elastic arms, two grips, and an adjustment block. The two elastic arms are connected to each other at one end to form a connected end, and start to open from the connected end. Each elastic arm defines a number of spaced grooves adjacent to the connected end. The two grips are rotatably positioned on the distal ends of the two elastic arms, and include two gripping surfaces that face to each other. The adjustment block fits over the two elastic arms from the connected end, and includes teeth and an elastic piece configured for allowing the teeth to engage with the grooves. The adjustment block is able to slide along the elastic arms to adjust an open angle of the two elastic arms.

Abstract: An interference preventing method applied on a machining machine includes the following steps. Firstly, a control command is provided in response to an operation event. Next, protection information corresponding to a protection target component is provided. Then basic envelop of the protection target component is obtained. Then the basic envelop is segmented into a number of sub protection blocks according to a multi-hierarchical protection parameter and sub protection blocks not linked with the protection target component are removed, so as to determine a multi-hierarchical interference protection area. Next, whether an interference event of the multi-hierarchical interference protection area and other components occurs, so as to determine whether interference event of the protection target component occurs; if so, control signal is provided to control the processing operation of the machining machine.

Abstract: The present invention relates to a new tumor suppressor, designated Killin. Also described are diagnostic and therapeutic uses of the Killin protein and the killin gene, alone or in combination with traditional cancer therapies.

Abstract: Clamping tweezers include two elastic arms, two grips, and an adjustment block. The two elastic arms are connected to each other at one end to form a connected end, and start to open from the connected end. Each elastic arm defines a number of spaced grooves adjacent to the connected end. The two grips are rotatably positioned on the distal ends of the two elastic arms, and include two gripping surfaces that face to each other. The adjustment block fits over the two elastic arms from the connected end, and includes teeth and an elastic piece configured for allowing the teeth to engage with the grooves. The adjustment block is able to slide along the elastic arms to adjust an open angle of the two elastic arms.

Abstract: The hard drive enclosure contains a casing member where a first rack at a first lateral side has a number of partition plates, each having a number of through holes allowing a rod to pass through. A number of covers laterally arranged in parallel on a front side of the hard drive enclosure, each capable of swiveling around a front axle and engages a rod. A number of levers are pivotally configured adjacent to a back side of the first rack, each engaged by a rod and having a pushing piece. When a cover is pulled outward, a rod is engaged to drive a lever whose pushing piece ejects the hard drive for additional distance.

Abstract: A wastewater treatment process and wastewater treatment device for generating current and desalting simultaneously are provided. The device may comprise an anode compartment, an anion exchange membrane, a middle desalting compartment, a cation exchange membrane and a cathode compartment. Wastewater flows into the anode compartment, and is oxidized under the action of an electricigenic microbe. In the desalting compartment, anions are transferred to the anode compartment through the anion exchange membrane, and cations are transferred to the cathode compartment through the cation exchange membrane, thus achieving a desalting process and forming an internal current. Electrons are transferred to the cathode through an external circuit such that a reduction reaction takes place and a current generation is achieved. The wastewater treatment, the current generation and the desalination are achieved simultaneously in the process.

Abstract: A vehicle central lock antitheft method and system includes a central lock system which is connected by radio with a remote controller for identity verification using rolling codes (S101, S102), wherein the central lock system chooses a security state (S103) and transmits the security state to an engine management system according to the verification result, the ignition IG status and the door switch status signal indicating opening or closing of the door (S104). The engine management system receives the security state transmitted by the central lock system and verifies the identity of the central lock system by code matching (S106); security identification between the engine management system and the central lock system is carried out by bidirectional encryption communication (S107). The engine management system then decides whether or not to lock the engine according to the result of the security identification.

Abstract: The present invention relates to a new tumor suppressor, designated Killin. Also described are diagnostic and therapeutic uses of the Killin protein and the killin gene, alone or in combination with traditional cancer therapies.

Abstract: This invention relates to a general methodology for efficient creation of trimeric soluble receptors for therapeutic applications. The process involves gene fusion between a soluble receptor with a ligand binding domain and a trimerization tag from the C-propeptide domain of pro-collagen, which is capable of self-assembly into a covalently linked trimer. Using both in vitro bioassays and an in vivo mouse model for collagen-induced arthritis (CIA), we show that the homotrimeric soluble TNF receptor produced with such method is a more potent blocker than dimeric TNF receptor decoys in inhibiting TNF-? mediated inflammatory diseases.

Abstract: Methods and compositions for producing secreted soluble receptors and biologically active polypeptides in trimeric forms are disclosed. The process involves fusing the DNA template encoding a soluble receptor with a ligand binding domain or biologically active polypeptide to a DNA sequence encoding a C-propeptide of collagen, which is capable of self-assembly into a covalently linked trimer. The resulting fusion proteins are secreted as trimeric soluble receptor analogs, which can be used for more efficient neutralization of the biological activities of their naturally occurring trimeric ligands.

Abstract: The present invention relates to a new tumor suppressor, designated Killin. Also described are diagnostic and therapeutic uses of the Killin protein and the killin gene, alone or in combination with traditional cancer therapies.