Abstract: The present disclosure relates in some aspects to immunogenic compositions including recombinant peptides and proteins comprising coronavirus viral antigens and immunogens, e.g., coronavirus S protein peptides. In some aspects, the immunogenic composition comprises a secreted fusion protein comprising a soluble coronavirus viral antigen joined by in-frame fusion to a C-terminal portion of a collagen which is capable of self-trimerization to form a disulfide bond-linked trimeric fusion protein. In some aspects, the immunogenic compositions provided herein are useful for generating an immune response, e.g., for treating or preventing a coronavirus infection. In some aspects, the immunogenic compositions provided herein may be used in a vaccine composition, e.g., as part of a prophylactic and/or therapeutic vaccine. Also provided herein are methods for producing the recombinant peptides and proteins, prophylactic, therapeutic, and/or diagnostic methods, and related kits.

Abstract: Compositions of TNF family of cytokines in covalently linked trimeric forms are disclosed. The resulting fusion proteins are secreted as disulfide bond-linked homotrimers, which are more stable in structure and therapeutically more efficacious than their native counterparts.

Abstract: A motion control system and a motion control method are provided. The motion control method includes: sending a plurality of machining commands to a second controller by a first controller at a cloud; storing the plurality of machining commands in a buffer by the second controller; and operating the machine tool according to the plurality of machining commands stored in the buffer. As such, when poor communication occurs between the first controller and the second controller, the second controller causes the buffer to send a deceleration command to the machine tool so as to cause the machine tool to operate at a reduced speed, thereby avoiding unexpected motion such as sudden shutdown of the machine tool and damage to machined products.

Abstract: A device for dynamically generating numerical controller software of machine tool includes a software function-specification managing unit, a function-module storage unit and a function-module composing unit. The software function-specification managing unit is to produce a text description file describing function modules required by the numerical controller software, and then for performing specification analysis upon the text description file to generate a function module table including the function modules. The function-module storage unit is to memorize and manage the function modules, wherein the function-module storage unit confirms whether or not the function-module storage unit has been furnished with the f function modules required by the numerical controller software. The function-module composing unit is to retrieve the required function modules from the function-module storage unit, and further to set the connection among the function modules to compose the numerical controller software.

Abstract: A device for dynamically generating numerical controller software of machine tool includes a software function-specification managing unit, a function-module storage unit and a function-module composing unit. The software function-specification managing unit is to produce a text description file describing function modules required by the numerical controller software, and then for performing specification analysis upon the text description file to generate a function module table including the function modules. The function-module storage unit is to memorize and manage the function modules, wherein the function-module storage unit confirms whether or not the function-module storage unit has been furnished with the f function modules required by the numerical controller software. The function-module composing unit is to retrieve the required function modules from the function-module storage unit, and further to set the connection among the function modules to compose the numerical controller software.

Abstract: Described herein is a polyurethane foam prepared with certain polytetrahydrofurans and optional polyether polyols. The polyurethane foam is characterized by low hardness increase at low temperature as compared with conventional polyurethane foam, and is suitable for use in products which can be exposed to low temperature such as snow boots.

Abstract: A shift register unit, a driving device, a display device and a driving method are disclosed, The shift register unit includes a first circuit unit and a second circuit unit; the first circuit unit includes an input terminal, a reset terminal, a clock signal terminal, a first voltage terminal, a second voltage terminal and a first output terminal, and is configured to output a first output signal of the shift register unit from the first output terminal; the second circuit unit includes a third voltage terminal, a fourth voltage terminal and a second output terminal, and is configured to output a second output signal of the shift register unit from the second output terminal, at least under the control of the first output signal; and the second output signal and the first output signal are mutually phase-inverted signals.

Abstract: The present disclosure provides a gate drive unit, a driving method thereof and a gate drive circuit. The gate drive unit includes a shift register and a plurality of output control modules. Each of the output control modules is connected to a corresponding clock scanning signal line and a corresponding first scanning signal output terminal, respectively. Each of the output control modules includes a first output control submodule and an output reset submodule. The first output control submodule is connected to a signal output terminal of the shift register, the corresponding clock scanning signal line and the corresponding first scanning signal output terminal, and configured to send a clock scanning signal of the corresponding clock scanning signal line to the corresponding first scanning signal output terminal, under control of a signal outputted by the signal output terminal of the shift register.

Abstract: The present disclosure relates in some aspects to immunogenic compositions including recombinant peptides and proteins comprising coronavirus viral antigens and immunogens, e.g., coronavirus S protein peptides. In some aspects, the immunogenic composition comprises a secreted fusion protein comprising a soluble coronavirus viral antigen joined by in-frame fusion to a C-terminal portion of a collagen which is capable of self-trimerization to form a disulfide bond-linked trimeric fusion protein. In some aspects, the immunogenic compositions provided herein are useful for generating an immune response, e.g., for treating or preventing a coronavirus infection. In some aspects, the immunogenic compositions provided herein may be used in a vaccine composition, e.g., as part of a prophylactic and/or therapeutic vaccine. Also provided herein are methods for producing the recombinant peptides and proteins, prophylactic, therapeutic, and/or diagnostic methods, and related kits.

Abstract: A shift register includes an input circuit, a compensation circuit, an output circuit, a pull-down control circuit, a pull-down circuit, and a reset circuit. During operation of a pixel driving circuit, if a display abnormality occurs in one or more pixels corresponding to the shift register, a compensation signal may be provided by the compensation circuit to a pull-up node according to specific condition of the display abnormality, so as to change a voltage of the pull-up node, and further change a delay time of waveform of the signal passing the switching element in the output circuit connected to the pull-up node.

Abstract: An inner frame of a door or a window is disclosed. The inner frame is disposed at an inner side of a window sash, and is connected between a jamb of the door or the window sash and a door frame or a window frame. The inner frame includes a fixing portion for fixing to the jamb, a water baffle, and a connecting portion for connecting with the door frame or the window frame. One side of the fixing portion is fixed to the jamb, the water baffle is integrally disposed on the other side of the fixing portion opposite to the one side, and the connecting portion is integrally disposed on a side of the water baffle facing away from the fixing portion and is connected to the door frame or the window frame.

Abstract: The present disclosure relates to the field of carbonaceous composite materials, in particular to a silicon-carbon composite material and a preparation method and a use thereof. The silicon-carbon composite material comprises a composite carbon material and nanometer silicon dispersed therein, wherein the composite carbon material is consisting of a graphitic crystal phase and an amorphous carbon phase, wherein the ratio I002/Iamor of the peak intensity I002 of the graphite crystal phase (002) plane relative to the peak intensity Iamor of the amorphous carbon phase as measured by the X-Ray Diffraction (XRD) is within a range of 0.1-40, the graphite crystalline phase is uniformly dispersed in the composite material, the dispersion coefficient ? of the ratio Id/Ig of Id and Ig as measured by Raman data is less than 0.8.

Abstract: A shift register unit, a driving device, a display device and a driving method are disclosed. The shift register unit includes a first circuit unit and a second circuit unit; the first circuit unit includes an input terminal, a reset terminal, a clock signal terminal, a first voltage terminal, a second voltage terminal and a first output terminal, and is configured to output a first output signal of the shift register unit from the first output terminal; the second circuit unit includes a third voltage terminal, a fourth voltage terminal and a second output terminal, and is configured to output a second output signal of the shift register unit from the second output terminal, at least under the control of the first output signal; and the second output signal and the first output signal are mutually phase-inverted signals.

Abstract: A composite carbon material and a preparation method and a use thereof. The composite carbon material comprises a graphite crystal phase and an amorphous carbon phase, wherein the ratio I002/Iamor of the peak intensity I002 of the graphite crystal phase (002) plane relative to the peak intensity Iamor of the amorphous carbon phase as measured by the X-Ray Diffraction (XRD) is within a range of 0.1-40, and the content of the graphite crystal phase is not less than 5 wt %. The composite carbon material has high compressive strength, bending strength and thermal conductivity, and can be used as a heat dissipation material; the composite carbon material can also be used as an anode material of a lithium ion battery such that the lithium ion battery exhibits excellent electrochemical performance.

Abstract: A method for capturing a tool path, applicable to a machine tool having a controller and furnished with a tooling, includes the steps of: obtaining a data update frequency of the controller; calculating a feed rate of the controller, determining whether or not the feed rate is obtained, going to next step if positive, and going to the previous step if negative; reading G-codes of the controller to confirm the feed rate; and, based on the confirmed feed rate, recording machine coordinates transmitted from the controller for synthesizing a tool path file. The tool path file is used for simulation and analysis of machining of the machine tool. In addition, a device for capturing the tool path is also provided.

Abstract: A semiconductor device includes a conductive can include a flat portion and at least one peripheral rim portion extending from an edge of the flat portion, a semiconductor die comprising a first main face and a second main face opposite to the first main face, a first contact pad disposed on the first main face and a second contact pad disposed on the second main face, wherein the first contact pad is electrically connected to the flat portion of the can, an electrical interconnector connected with the second contact pad, and an encapsulant disposed under the semiconductor die so as to surround the electrical interconnector, wherein an external surface of the electrical interconnector is recessed from an external surface of the encapsulant.

Abstract: A modeling method of a cutting force model is provided, including: using a cutting tool to cut a unidirectional fiber reinforced polymer along a circular path; using a measurement member to measure the cutting force on the cutting tool corresponding to the angle between the feeding direction of the cutting tool and the fiber direction of the unidirectional fiber reinforced polymer; and obtaining the functions of the cutting force coefficients in a formula according to the measurement result of the measurement member. With the modeling method, a mechanistic force model can be rapidly established to predict approximate cutting forces of the cutting tool in use.

Abstract: Described herein is a method for producing a PU foam insole, including the following steps of: (1) pouring the raw materials used to form a PU foam into a mould, reacting to obtain a PU sheet, where the height of the mould cavity is from about 1.0 to about 1.6 times of the total thickness of two finished insoles; (2) splitting the PU sheet into two halves in the horizontal direction to obtain two pieces of PU insole material, where one surface of the material has open pores, and the other surface of the material has a skin; and (3) attaching a piece of fabric onto the surface having open pores of the material obtained in step (2). Also described herein is a PU foam insole produced by the method.

Abstract: A non-pneumatic tire may include a polyurethane matrix and expanded thermoplastic elastomer particles. The non-pneumatic tire has 60 to 90 wt. % of the polyurethane matrix and 10 to 40 wt. % of the expanded thermoplastic elastomer particles. The non-pneumatic tire may be produced in a production method. The non-pneumatic tire may be used in a low-speed vehicle.

Abstract: A machining parameter automatic generation system includes a geometric data capturing module, a feature recognition learning network and a machining parameter learning network. The geometric data capturing module captures a geometric shape of a workpiece to generate a candidate feature list. The feature recognition learning network trains the candidate feature list according to a first neural network model to obtain an applicable feature list. The machining parameter learning network trains the applicable feature list and the candidate machining parameter according to a second neural network model to obtain an applicable machining parameter. The applicable machining parameter is used to generate a machining program, and the machining program is read by a machine tool for processing.