Patents by Inventor Peter Andreas

Peter Andreas has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 9015945
    Abstract: A method of forming a flow restriction in a fluid communication system is disclosed. The method comprises the steps of providing a flow restricting section having a cross sectional area and a length, measuring the flow resistivity of the flow restricting section, and modifying the cross sectional area and/or the length of the flow restricting section until a desired flow resistivity of the flow restricting section is obtained. The method provides the possibility of forming a flow restriction in an easy and cost effective manner, and to subsequently adjust the flow resistivity of the flow restriction, thereby obtaining an accurate flow resistivity.
    Type: Grant
    Filed: October 7, 2009
    Date of Patent: April 28, 2015
    Assignee: Flowsion ApS
    Inventors: Kristian Raaby Poulsen, Peter Andreas Rasmussen
  • Patent number: 9018366
    Abstract: The present invention relates to agents and methods that are capable of augmenting NK-mediated killing of target cells by reducing inhibitory KIR signalling without reducing the binding of KIR to HLA-C. As described herein, transduction of negative signaling via KIR, upon binding of KIR to its HLA class I ligand, can involve a ligand-binding induced, conformational reorientation of the KIR molecules allowing interactions to form between adjacent KIRs in specific domains, leading to accelerated clustering. Methods and agents such as monoclonal antibodies for reducing KIR-mediated inhibition of NK cell cytotoxicity without reducing or blocking HLA-binding by, e.g., reducing or blocking dimerization of KIR, are provided.
    Type: Grant
    Filed: January 18, 2013
    Date of Patent: April 28, 2015
    Assignees: Innate Pharma S.A.S, Novo Nordisk A/S
    Inventors: Søren Berg Padkær, Peter Andreas Nicolai Reumert Wagtmann, Pieter Spee, Stefan Zahn, Kristian Kjærgaard, Anders Svensson
  • Patent number: 8981065
    Abstract: Compositions and methods for regulating an immune response in a subject are described. More particularly, described are human antibodies that regulate the activity of NK cells and allow a potentiation of NK cell cytotoxicity in mammalian subjects, and antibodies having antigen-binding properties similar to those of human monoclonal antibody 1-7F9 or 1-4F1. Described also are also fragments and derivatives of such antibodies, as well as pharmaceutical compositions comprising the same and their uses, particularly for use in therapy, to increase NK cell activity or cytotoxicity in subjects.
    Type: Grant
    Filed: July 8, 2013
    Date of Patent: March 17, 2015
    Assignees: Novo Nordisk A/S—Novo Alle, Innate Pharma S.A.S., University of Genoa
    Inventors: Alessandro Moretta, Mariella Della Chiesa, Pascale Andre, Laurent Gauthier, Francois Romagne, Peter Andreas Nicolai Reumert Wagtmann, Ivan Svendsen, Stefan Zahn, Anders Svensson, Matthias Thorolfsson, Soren Berg Padkaer, Kristian Kjaergaard, Pieter Johannes Louis Spee, Michael Wilken
  • Publication number: 20140321486
    Abstract: The present invention relates to a method and a device for the simultaneous compression and characterization of ultrashort laser pulses. An embodiment of the method comprises applying predetermined spectral phases to the pulse to be characterized so as to perform a dispersion scan; applying a nonlinear process to the pulse to be characterized; measuring the resulting signal from the application of the predetermined spectral phases and nonlinear process; applying a numerical iterative algorithm to the measured signal to retrieve the spectral phase of the pulse to be characterized. A few cycle laser pulse may be negatively chirped with a pair of DCM, the controllable amount of positive dispersion may be provided by a pair of glass wedges, one of them being translated for dispersion or phase control, and the frequency spectrum may be measured as well as also frequency resolved the dispersion dependent second-harmonic of the signal being phase modulated.
    Type: Application
    Filed: October 11, 2012
    Publication date: October 30, 2014
    Applicant: UNIVERSIDADE DO PORTO
    Inventors: Miguel Nicolau Da Costa Ribeiro De Miranda, Helder Manuel Paiva Rebelo Cerejo Crespo, Thomas Peter Andreas Fordell, Cord Louis Arnold, Anne L'Huillier
  • Publication number: 20140295187
    Abstract: A composite structure having a number of thermoset resin containing elements and a number of thermoplastic elements and at least one interface between the thermoset resin containing elements and the thermoplastic elements is provided. The thermoset resin containing elements and the thermoplastic elements have functional groups at the interface which bond to each other when the composite structure is cured and the functional groups are independently selected from amines, carboxylic acids, acid anhydrides, oxiranes, and derivatives thereof in their non-bonded condition. Additionally, a blade having such a composite structure is provided.
    Type: Application
    Filed: February 16, 2014
    Publication date: October 2, 2014
    Applicant: SIEMENS AKTIENGESELLSCHAFT
    Inventors: Peter Andreas Lund Jacobsen, Peter Kybelund
  • Publication number: 20140193430
    Abstract: The present invention relates to novel compositions and methods for regulating an immune response in a subject. More particularly, the invention relates to specific antibodies that regulate the activity of NK cells and allow a potentiation of NK cell cytotoxicity in mammalian subjects. The invention also relates to fragments and derivatives of such antibodies, as well as pharmaceutical compositions comprising the same and their uses, particularly in therapy, to increase NK cell activity or cytotoxicity in subjects.
    Type: Application
    Filed: December 13, 2013
    Publication date: July 10, 2014
    Applicants: NOVO NORDISK A/S, UNIVERSITY OF GENOA, BRISTOL-MYERS SQUIBB COMPANY
    Inventors: SØREN BERG PADKJAER, ALESSANDRO MORETTA, MARIELLA DELLA CHIESA, PASCALE ANDRE, LAURENT GAUTHIER, PETER ANDREAS NICOLAI RUMERT WAGTMANN
  • Patent number: 8641365
    Abstract: A rotor of a thermal turbomachine, particularly a gas turbine, is provided. The rotor includes a plurality of individual rotor components that are held together by a tie-bold and combined into a unit. The tie-bolt is supported by the assembly of the surrounding rotor components including the tie-bolt and the rotor disks. A hollow shaft which is made up of two tubular sections and a support wheel further support the rotor.
    Type: Grant
    Filed: February 15, 2008
    Date of Patent: February 4, 2014
    Assignee: Siemens Aktiengesellschaft
    Inventors: Guido Ahaus, Francois Benkler, Ulrich Ehehalt, Harald Hoell, Karsten Kolk, Walter Loch, Harald Nimptsch, Oliver Schneider, Peter-Andreas Schneider, Peter Schröder, Vyacheslav Veitsman
  • Patent number: 8637258
    Abstract: The present invention relates to a method of producing an antibody that cross-reacts with multiple KIR2DL polypeptides and neutralizes the inhibitory activity of such polypeptides.
    Type: Grant
    Filed: June 10, 2010
    Date of Patent: January 28, 2014
    Assignees: Novo Nordisk A/S, University of Genoa, Innate Pharma, S.A.
    Inventors: Soren Berg Padkjaer, Alessandro Moretta, Mariella Della Chiesa, Pascale Andre, Laurent Gauthier, Peter Andreas Nicolai Reumert Wagtmann
  • Publication number: 20140023646
    Abstract: Described are methods of treating viral disease using compounds that block inhibitory NK cell receptors, thereby reducing their inhibition of NK cell cytotoxicity in killing infected target cells. In one embodiment, the compound is an antibody binding, for example, one or more of the human KIR2DL1, KIR2DL2, and KIR2DL3 receptors. In another embodiment, the method further comprises administering a therapeutic antibody or fusion protein which binds an antigen expressed on cells infected with the virus.
    Type: Application
    Filed: October 1, 2013
    Publication date: January 23, 2014
    Applicants: Innate Pharma S.A.S., Novo Norkisk A/S
    Inventors: Peter Andreas, Nicolai, Reumert WAGTMANN, Francois ROMAGNE, Joakim GLAMANN
  • Patent number: 8614307
    Abstract: Compositions and methods for regulating an immune response in a subject are described. More particularly, described are human antibodies that regulate the activity of NK cells and allow a potentiation of NK cell cytotoxicity in mammalian subjects, and antibodies having antigen-binding properties similar to those of human monoclonal antibody 1-7F9 or 1-4F1. Described also are also fragments and derivatives of such antibodies, as well as pharmaceutical compositions comprising the same and their uses, particularly for use in therapy, to increase NK cell activity or cytotoxicity in subjects.
    Type: Grant
    Filed: January 11, 2012
    Date of Patent: December 24, 2013
    Assignees: Novo-Nordisk A/S—Novo Alle, Innate Pharma S.A.S.
    Inventors: Alessandro Moretta, Mariella Della Chiesa, Pascale Andre, Laurant Gauthier, Francois Romagne, Peter Andreas Nicolai Reumert Wagtmann, Ivan Svendsen, Stefan Zahn, Anders Svensson, Matthias Thorolfsson, Soren Berg Padkjaer, Kristian Kjaergaard, Petrus Johannes Loius Spee, Milchael Wilken
  • Publication number: 20130287770
    Abstract: Compositions and methods for regulating an immune response in a subject are described. More particularly, described are human antibodies that regulate the activity of NK cells and allow a potentiation of NK cell cytotoxicity in mammalian subjects, and antibodies having antigen-binding properties similar to those of human monoclonal antibody 1-7F9 or 1-4F1. Described also are also fragments and derivatives of such antibodies, as well as pharmaceutical compositions comprising the same and their uses, particularly for use in therapy, to increase NK cell activity or cytotoxicity in subjects.
    Type: Application
    Filed: July 8, 2013
    Publication date: October 31, 2013
    Inventors: Alessandro Moretta, Mariella Della Chiesa, Pascale Andre, Laurent Gauthier, Francois Romagne, Peter Andreas Nicolai Reumert Wagtmann, Ivan Svendsen, Stefan Zahn, Anders Svensson, Matthias Thorolfsson, Soren Berg Padkaer, Kristian Kjaergaard, Pieter Johannes Loius Spee, Milchael Wilken
  • Patent number: 8551483
    Abstract: Described are methods of treating viral disease using compounds that block inhibitory NK cell receptors, thereby reducing their inhibition of NK cell cytotoxicity in killing infected target cells. In one embodiment, the compound is an antibody binding, for example, one or more of the human KIR2DL1, KIR2DL2, and KIR2DL3 receptors. In another embodiment, the method further comprises administering a therapeutic antibody or fusion protein which binds an antigen expressed on cells infected with the virus.
    Type: Grant
    Filed: January 6, 2006
    Date of Patent: October 8, 2013
    Assignees: Innate Pharma S.A.S., Novo Nordisk A/S
    Inventors: Peter Andreas Nicolai Reumert Wagtmann, Francois Romagne, Joakim Glamann
  • Patent number: 8545171
    Abstract: A rotor of a thermal fluid flow machine, especially a gas turbine, is provided. The rotor includes a plurality of rotor components that are held together by a common tie-bolt that extends through the center of the rotor components. The tie-bolt is fixed in at least one of the rotor components using at least one star spring that surrounds the tie-bolt in a circumferential direction.
    Type: Grant
    Filed: February 15, 2008
    Date of Patent: October 1, 2013
    Assignee: Siemens Aktiengesellschaft
    Inventors: Francois Benkler, Ulrich Ehehalt, Harald Hoell, Uwe Kahlstorf, Karsten Kolk, Walter Loch, Peter-Andreas Schneider
  • Publication number: 20130206226
    Abstract: The invention relates to a photovoltaic cell, comprising a plate shaped substrate of a semiconductor material with a solar face and a connection face, a first volume of the substrate adjacent to the solar face is doted with a first polarity, the second volume is doted with a second polarity and the volumes are separated by a pn-junction, a number of apertures in the substrate extending between both faces and in which a plug has been positioned of which a part is conducting, contact tracks at the solar face of the substrate connected with the first volume and the conducting part of the plug, first contacts at the connection face of the substrate connected with the conducting part of the plug and second contacts located at the connection face of the substrate connected with the second volume, wherein the specific electrical conductivity of the plug decreases from its centre to the contact face with the substrate.
    Type: Application
    Filed: August 23, 2011
    Publication date: August 15, 2013
    Applicant: STICHTING ENERGIEONDERZOEK CENTRUM NEDERLAND
    Inventors: Menno Nicolaas Van Den Donker, Peter Andreas Maria Wijnen
  • Patent number: 8506239
    Abstract: A gas turbine is provided. The gas turbine includes at least one rotor, having rotor blades arranged on the periphery of rotor disks in a plurality of radial planes, and a tie-bolt extending along slots in the rotor disks and holding the rotor disks together as a unit. At least one annular spacer for fixing the position of the tie-bolt in relation to the center line of the rotor disks is also provided. The spacer includes through-openings that are arranged radially in relation to the tie-bolt or to its center line and that extend coaxially.
    Type: Grant
    Filed: February 15, 2008
    Date of Patent: August 13, 2013
    Assignee: Siemens Aktiengesellschaft
    Inventors: Francois Benkler, Ulrich Ehehalt, Harald Hoell, Walter Loch, Peter-Andreas Schneider
  • Publication number: 20130164299
    Abstract: The present invention relates to monoclonal antibodies that are capable of specifically binding to lectin-like transcript 1 (LLT1), to polynucleotides encoding such antibodies and to cells that express such antibodies. Antibodies of the invention have utility in the treatment of autoimmune diseases and cancer, in which LLT1- and CD161-expressing cells play a role in disease pathogenesis.
    Type: Application
    Filed: June 28, 2011
    Publication date: June 27, 2013
    Applicant: C.N.R.S.
    Inventors: Petrus Johannes Louis Spee, Peter Andreas Nicolai Reumert Wagtmann, Stefan Zahn, Elisabeth D. Galsgaard, Birgitte Friedrichsen, Véronique Braud
  • Patent number: 8388970
    Abstract: The present invention relates to agents and methods that are capable of augmenting NK-mediated killing of target cells by reducing inhibitory KIR signalling without reducing the binding of KIR to HLA-C. As described herein, transduction of negative signaling via KIR, upon binding of KIR to its HLA class I ligand, can involve a ligand-binding induced, conformational reorientation of the KIR molecules allowing interactions to form between adjacent KIRs in specific domains, leading to accelerated clustering. Methods and agents such as monoclonal antibodies for reducing KIR-mediated inhibition of NK cell cytotoxicity without reducing or blocking HLA-binding by, e.g., reducing or blocking dimerization of KIR, are provided.
    Type: Grant
    Filed: October 2, 2008
    Date of Patent: March 5, 2013
    Assignees: Novo Nordisk A/S, Innate Pharma S.A.S.
    Inventors: Søren Berg Padkær, Peter Andreas Nicolai Reumert Wagtmann, Pieter Spee, Stefan Zahn, Kristian Kjærgaard, Anders Svensson
  • Publication number: 20120208237
    Abstract: Compositions and methods for regulating an immune response in a subject are described. More particularly, described are human antibodies that regulate the activity of NK cells and allow a potentiation of NK cell cytotoxicity in mammalian subjects, and antibodies having antigen-binding properties similar to those of human monoclonal antibody 1-7F9 or 1-4F1. Described also are also fragments and derivatives of such antibodies, as well as pharmaceutical compositions comprising the same and their uses, particularly for use in therapy, to increase NK cell activity or cytotoxicity in subjects.
    Type: Application
    Filed: January 11, 2012
    Publication date: August 16, 2012
    Applicants: Innate Pharma S.A.S, Novo-Nordisk A/S - Novo Alle
    Inventors: Alessandro Moretta, Mariella Della Chiesa, Pascale Andre, Laurent Gauthier, Francois Romagné, Peter Andreas Nicolai Reumert Wagtmann, Ivan Svendsen, Stefan Zahn, Anders Svensson, Matthias Thórólfsson, Søren Berg Padkær, Kristian Kjaergaard, Pieter Spee, Michael Wilken
  • Patent number: 8119775
    Abstract: Compositions and methods for regulating an immune response in a subject are described. More particularly, described are human antibodies that regulate the activity of NK cells and allow a potentiation of NK cell cytotoxicity in mammalian subjects, and antibodies having antigen-binding properties similar to those of human monoclonal antibody 1-7F9 or 1-4F1. Described also are also fragments and derivatives of such antibodies, as well as pharmaceutical compositions comprising the same and their uses, particularly for use in therapy, to increase NK cell activity or cytotoxicity in subjects.
    Type: Grant
    Filed: October 2, 2008
    Date of Patent: February 21, 2012
    Assignees: University of Genoa, Innate Pharma S.A.S., Novo Nordisk A/S
    Inventors: Alessandro Moretta, Mariella Della Chiesa, Pascale Andre, Laurent Gauthier, Francois Romagné, Peter Andreas Nicolai Reumert Wagtmann, Ivan Svendsen, Stefan Zahn, Anders Svensson, Matthias Thórólfsson, Søren Berg Padkær, Kristian Kjaergaard, Pieter Spee, Michael Wilken
  • Publication number: 20110293561
    Abstract: Compositions comprising anti-KIR antibodies and one or more secondary anti-cancer agents or anti-viral agents and methods of using such combinations (as combination compositions or in separate administration protocols) in the treatment of cancers (e.g., lung cancer) or viral infection (e.g., HIV or HCV infection) are provided.
    Type: Application
    Filed: July 15, 2011
    Publication date: December 1, 2011
    Applicants: INNATE PHARMA S.A.S., NOVO NORDISK A/S
    Inventors: FRANCOIS ROMAGNÉ, Peter Andreas Nicolai Reumert Wagtmann, Joakim Glamann