Abstract: A method of forming a flow restriction in a fluid communication system is disclosed. The method comprises the steps of providing a flow restricting section having a cross sectional area and a length, measuring the flow resistivity of the flow restricting section, and modifying the cross sectional area and/or the length of the flow restricting section until a desired flow resistivity of the flow restricting section is obtained. The method provides the possibility of forming a flow restriction in an easy and cost effective manner, and to subsequently adjust the flow resistivity of the flow restriction, thereby obtaining an accurate flow resistivity.

Abstract: The present invention provides isolated anti-human NKG2D monoclonal antibodies useful for therapeutic applications in humans. Typically, the antibodies are fully human or humanized to minimize the risk for immune responses against the antibodies when administered to a patient. Preferred antibodies include human monoclonal antibodies MS and 21F2. As described herein, other antigen-binding molecules such as, e.g., antigen-binding antibody fragments, antibody derivatives, and multi-specific molecules, can be designed or derived from such antibodies.

Abstract: The present invention relates to novel compositions and methods for regulating an immune response in a subject. More particularly, the invention relates to specific antibodies that regulate the activity of NK cells and allow a potentiation of NK cell cytotoxicity in mammalian subjects. The invention also relates to fragments and derivatives of such antibodies, as well as pharmaceutical compositions comprising the same and their uses, particularly in therapy, to increase NK cell activity or cytotoxicity in subjects.

Abstract: The present invention provides isolated anti-human NKG2D monoclonal antibodies useful for therapeutic applications in humans. Typically, the antibodies are fully human or humanized to minimize the risk for immune responses against the antibodies when administered to a patient. Preferred antibodies include human monoclonal antibodies MS and 21F2. As described herein, other antigen-binding molecules such as, e.g., antigen-binding antibody fragments, antibody derivatives, and multi-specific molecules, can be designed or derived from such antibodies.

Abstract: A novel IgG4 isotype anti-KIR antibody, novel formulations of this and other IgG4 anti-KIR antibodies, and methods of using such formulations are provided. Also described are compositions, formulations, dosages, and administration regimens suitable for NK cell activation and therapeutic applications of anti-KIR antibodies, as well as kits comprising one or more anti-KIR antibodies with instructions for use in treating cancer.

Abstract: A rotor of a thermal turbomachine, particularly a gas turbine, is provided. The rotor includes a plurality of individual rotor components that are held together by a tie-bold and combined into a unit. The tie-bolt is supported by the assembly of the surrounding rotor components including the tie-bolt and the rotor disks. A hollow shaft which is made up of two tubular sections and a support wheel further support the rotor.

Abstract: A gas turbine is provided. The gas turbine includes at least one rotor, having rotor blades arranged on the periphery of rotor disks in a plurality of radial planes, and a tie-bolt extending along slots in the rotor disks and holding the rotor disks together as a unit. At least one annular spacer for fixing the position of the tie-bolt in relation to the center line of the rotor disks is also provided. The spacer includes through-openings that are arranged radially in relation to the tie-bolt or to its center line and that extend coaxially.

Abstract: In a live audio presentation system, a stage rack and a front of house rack are interconnected by a transmission medium that transmits digital audio data and control information between them. Packets of digital audio data and control information are sent at the audio sampling rate. The packets of data are encoded using an encoding technique that provides unique codes that may be detected, thus enabling clock recovery of a clock signal embedded in the data packets. Data packets may include data for error checking. A serial digital transmission medium may be used as the transmission medium. Such a transmission medium uses low voltage signals and supports high bit rates. The system is synchronized by the FOH rack which transmits data to the stage rack according to a local audio sample clock or an external audio sample clock to which it synchronizes. This clock is embedded in data packets sent to the stage rack.

Abstract: A rotor of a thermal fluid flow machine, especially a gas turbine, is provided. The rotor includes a plurality of rotor components that are held together by a common tie-bolt that extends through the center of the rotor components. The tie-bolt is fixed in at least one of the rotor components using at least one star spring that surrounds the tie-bolt in a circumferential direction.

Abstract: The present invention provides isolated anti-human NKG2D monoclonal antibodies useful for therapeutic applications in humans. Typically, the antibodies are fully human or humanized to minimize the risk for immune responses against the antibodies when administered to a patient. Preferred antibodies include human monoclonal antibodies MS and 21F2. As described herein, other antigen-binding molecules such as, e.g., antigen-binding antibody fragments, antibody derivatives, and multi-specific molecules, can be designed or derived from such antibodies.

Abstract: A regulating device for regulating the course of a gas turbine plant has at least one sensor for sensing a measurement variable and for outputting a measurement signal which represents the measurement variable; at least one adjusting system for influencing air and/or fuel supply to a combustion chamber of the gas turbine plant on the basis of a correcting variable; and a regulator connected to the at least one sensor so as to receive the measurement variable and to the at least one adjusting system for outputting the correcting variable, the regulator being designed to determine the correcting variable on the basis of the measurement variable received and its deviation from a pilot variable. At least one sensor is designed to sense the variation in time of at least one burner or combustion chamber parameter as measurement variable.

Abstract: Systems and methods are described in the present disclosure for determining the location and orientation of an object placed on a surface. One such system, among others, includes an optical device physically supported by an object at a fixed position with respect to a reference point of the object. The system also includes a surface upon which the object can be placed. A reference pattern, which is applied to the surface, includes an array of markings visible to the optical device. The array of markings includes encoded location information and orientation information. In addition, the system includes a processing device in communication with the optical device. The processing device is configured to calculate the location and orientation of the reference point of the object with respect to the surface.

Abstract: Compositions comprising anti-KIR antibodies and one or more secondary anti-cancer agents or anti-viral agents and methods of using such combinations (as combination compositions or in separate administration protocols) in the treatment of cancers (e.g., lung cancer) or viral infection (e.g., HIV or HCV infection) are provided.

Abstract: Compositions and methods for regulating an immune response in a subject are described. More particularly, described are human antibodies that regulate the activity of NK cells and allow a potentiation of NK cell cytotoxicity in mammalian subjects, and antibodies having antigen-binding properties similar to those of human monoclonal antibody 1-7F9 or 1-4F1. Described also are also fragments and derivatives of such antibodies, as well as pharmaceutical compositions comprising the same and their uses, particularly for use in therapy, to increase NK cell activity or cytotoxicity in subjects.

Abstract: The present invention relates to agents and methods that are capable of augmenting NK-mediated killing of target cells by reducing inhibitory KIR signalling without reducing the binding of KIR to HLA-C. As described herein, transduction of negative signaling via KIR, upon binding of KIR to its HLA class I ligand, can involve a ligand-binding induced, conformational reorientation of the KIR molecules allowing interactions to form between adjacent KIRs in specific domains, leading to accelerated clustering. Methods and agents such as monoclonal antibodies for reducing KIR-mediated inhibition of NK cell cytotoxicity without reducing or blocking HLA-binding by, e.g., reducing or blocking dimerization of KIR, are provided.

Abstract: Described are methods of treating viral disease using compounds that block inhibitory NK cell receptors, thereby reducing their inhibition of NK cell cytotoxicity in killing infected target cells. In one embodiment, the compound is an antibody binding, for example, one or more of the human KIR2DL1, KIR2DL2, and KIR2DL3 receptors. In another embodiment, the method further comprises administering a therapeutic antibody or fusion protein which binds an antigen expressed on cells infected with the virus.

Abstract: Described is a method of identifying antibodies against hitherto unknown ligands of orphan receptors or other orphan ligands, i.e., receptors or other ligands where the counter-ligand has not yet been identified. The availability of antibodies binding to the unknown ligand significantly facilitates their isolation and characterization, and the identified antibodies can themselves be useful for treating patients with cancer or autoimmune diseases, or other disorders. An exemplary embodiment provides for a method designated Identification of Therapeutic Antibodies by Competitive Screening (ITACS). Described are also fusion proteins comprising a soluble portion of an orphan receptor, such as NKp30, and the Fc portion of an antibody. The fusion proteins typically comprise a Flexible Transmembrane Linker (FTL), i.e., a linker comprising a portion of a transmembrane domain of the orphan receptor.

Abstract: The present invention relates to agents and methods that are capable of augmenting NK-mediated killing of target cells by reducing inhibitory KIR signalling without reducing the binding of KIR to HLA-C. As described herein, transduction of negative signaling via KIR, 5 upon binding of KIR to its HLA class I ligand, can involve a ligand-binding induced, conformational reorientation of the KIR molecules allowing interactions to form between adjacent KIRs in specific domains, leading to accelerated clustering. Methods and agents such as mono-clonal antibodies for reducing KIR-mediated inhibition of NK cell cytotoxicity without reducing or blocking HLA-binding by, e.g., reducing or blocking dimerization of KIR, are provided.

Abstract: Novel fusion proteins that comprise a first portion that corresponds to an antibody-like protein that is specific for an activating receptor on an effector lymphocyte or a variant thereof and a second portion that corresponds to a portion of a cell membrane protein and that binds to a cell-associated target are provided, as are methods of producing such fusion proteins, uses and methods involving such fusion proteins, and compounds and compositions related to such fusion proteins.

Abstract: In a live audio presentation system, a stage rack and a front of house rack are interconnected by a transmission medium that transmits digital audio data and control information between them. Packets of digital audio data and control information are sent at the audio sampling rate. The packets of data are encoded using an encoding technique that provides unique codes that may be detected, thus enabling clock recovery of a clock signal embedded in the data packets. Data packets may include data for error checking. A serial digital transmission medium may be used as the transmission medium. Such a transmission medium uses low voltage signals and supports high bit rates. The system is synchronized by the FOH rack which transmits data to the stage rack according to a local audio sample clock or an external audio sample clock to which it synchronizes. This clock is embedded in data packets sent to the stage rack.