Abstract: The present invention relates to a novel and improved process for preparing (5S)-{[2-(4-carboxyphenyl)ethyl][2-(2-{[3-chloro-4?-(trifluo-romethyl)biphenyl-4-yl]methoxy}phenyl)ethyl]amino}-5,6,7,8-tetrahydroquinoline-2-carboxylic acid of the formula (I) and to novel crystalline forms of it, which is i.a. the pseudopolymorphic form monohydrate I (I-M-I) or the pseudopolymorphic form monohydrate II (I-M-II), furthermore the present invention relates to a novel and selective crystallization process for preparation of the pseudopolymorphic form monohydrate I (I-M-I) or the pseudopolymorphic form monohydrate II (I-M-II), preferably monohydrate I of formula (I-M-I) and to pharmaceutical compositions comprising monohydrate I of formula (I-M-I) and to its use for the treatment and/or prevention of diseases, in particular for the treatment and/or prevention of pulmonary and cardiopulmonary and cardiovascular diseases.

Abstract: In the case of a hydraulic vehicle brake, having a brake caliper (12), having a brake piston (16), having a receiving bore (14) for the brake piston (16), and having a brake piston seal (32) that acts between the brake caliper (12) and the brake piston (16), the brake piston seal (32) is designed as a composite part, with a composite of a base component (34) and a reinforcement insert (36). The reinforcement insert (36) provides the brake piston seal (32) with a degree of elasticity in an axial direction, whereby, after the brake piston (16) has been displaced in the direction of brake pads (22), the brake piston seal (32) displaces the brake piston (16) in the opposite direction.

Abstract: The invention relates to a method for operating a vehicle brake system and to a vehicle brake system, wherein the vehicle brake system comprises at least one hydraulic vehicle brake (10), having a brake caliper (12), having a brake piston (16), having a brake piston seal (20) which is assigned to the brake caliper (12) and which acts between the brake caliper (12) and brake piston (16), having brake pads (22), and having a brake disk (24), in which method a hydraulic brake pressure acting on the brake piston (16) is built up in a manner dependent on a braking command. The brake pressure is furthermore held in a manner dependent on the braking command. If the braking command is withdrawn, the hydraulic brake pressure acting on the brake piston (16) is reduced to a hydraulic intermediate pressure, and the hydraulic intermediate pressure is held for a defined second period of time. The hydraulic brake pressure is subsequently reduced.

Abstract: A hybrid transmission for a vehicle includes a transmission input shaft extending in a transverse direction, at least one countershaft arranged parallel to the transmission input shaft, a clutch device arranged coaxially with respect to the transmission input shaft and which has at least one clutch, and a differential having a differential input gear. A rotational axis of the differential input gear is arranged parallel to the transmission input shaft. The transmission also includes an electric machine having a rotor with a rotor rotational axis arranged parallel to the transmission input shaft and a transmission control device. As viewed in a longitudinal direction perpendicular to the transverse direction, the differential input gear, the transmission input shaft, and a transmission controller including the transmission control device are arranged in succession in the sequence specified.

Abstract: The invention relates to a genetically modified microorganism for making a oligosaccharide, preferably of 3-8 monosaccharide units, more preferably of 3-5 monosaccharide units, particularly a HMO, which comprises one or more genes encoding a sucrose utilization system, so the microorganism can use sucrose as a carbon and energy source.

Abstract: A hybrid transmission for a vehicle includes a transmission input shaft extending in a transverse direction, at least one countershaft arranged parallel to the transmission input shaft, a clutch device arranged coaxially with respect to the transmission input shaft and which has at least one clutch, and a differential having a differential input gear. A rotational axis of the differential input gear is arranged parallel to the transmission input shaft. The transmission also includes an electric machine having a rotor with a rotor rotational axis arranged parallel to the transmission input shaft and a transmission control device. As viewed in a longitudinal direction perpendicular to the transverse direction, the differential input gear, the transmission input shaft, and a transmission controller including the transmission control device are arranged in succession in the sequence specified.

Abstract: A hybrid transmission for a vehicle includes a transmission input shaft extending in a transverse direction, at least one countershaft arranged parallel to the transmission input shaft, a clutch device arranged coaxially with respect to the transmission input shaft and which has at least one clutch, and a differential having a differential input gear. A rotational axis of the differential input gear is arranged parallel to the transmission input shaft. The transmission also includes an electric machine having a rotor with a rotor rotational axis arranged parallel to the transmission input shaft and a transmission control device. As viewed in a longitudinal direction perpendicular to the transverse direction, the differential input gear, the transmission input shaft, and a transmission controller including the transmission control device are arranged in succession in the sequence specified.

Abstract: Herein is reported a method for determining methylation of a promoter nucleic acid operably linked to a nucleic acid encoding a polypeptide and thereby determining the long-term productivity of a cell. Also an aspect is a method for selecting a cell for producing a polypeptide by determining the methylation of the promoter nucleic acid operably linked to the structural gene encoding the polypeptide.

Abstract: The invention relates to a genetically modified microorganism for making a oligosaccharide, preferably of 3-8 monosaccharide units, more preferably of 3-5 monosaccharide units, particularly a HMO, which comprises one or more genes encoding a sucrose utilization system, so the microorganism can use sucrose as a carbon and energy source.

Abstract: Herein is reported a method for determining methylation of a promoter nucleic acid operably linked to a nucleic acid encoding a polypeptide and thereby determining the long-term productivity of a cell. Also an aspect is a method for selecting a cell for producing a polypeptide by determining the methylation of the promoter nucleic acid operably linked to the structural gene encoding the polypeptide.

Abstract: The invention relates to a genetically modified microorganism for making a oligosaccharide, preferably of 3-8 monosaccharide units, more preferably of 3-5 monosaccharide units, particularly a HMO, which comprises one or more genes encoding a sucrose utilization system, so the microorganism can use sucrose as a carbon and energy source.

Abstract: An odor eliminating pet bed assembly for absorbing odors associated with pet beds includes a pet bed that is positionable on a support surface for to have a pet lie thereon. The pet bed has a chamber is integrated therein for receiving an odor absorbing material. A permeable cushion is positioned within the pet bed to have the pet lie thereon when the pet is in the pet bed. The permeable cushion passes the odor absorbing material therethrough. An impermeable cushion is positioned within the pet bed to have the pet lie thereon. The impermeable cushion is comprised of a fluid impermeable material to inhibit the odor absorbing material from passing therethrough.

Abstract: An odor eliminating pet bed assembly for absorbing odors associated with pet beds includes a pet bed that is positionable on a support surface for to have a pet lie thereon. The pet bed has a chamber is integrated therein for receiving an odor absorbing material. A permeable cushion is positioned within the pet bed to have the pet lie thereon when the pet is in the pet bed. The permeable cushion passes the odor absorbing material therethrough. An impermeable cushion is positioned within the pet bed to have the pet lie thereon. The impermeable cushion is comprised of a fluid impermeable material to inhibit the odor absorbing material from passing therethrough.

Abstract: An assistance method for a light control system in a motor vehicle, having a light controller for controlling a lighting unit in the motor vehicle for lighting a motor vehicle environment, a portable unit, at least one communication interface, and an evaluation unit for evaluating signals from the portable unit received via the communication interface. The lighting unit being controllable by the light controller and in accordance with the evaluation of the signals received from the portable unit in a first assistance function, such that at least one light beam emitted by the lighting unit can be positioned as a function of the position of the portable unit. The lighting unit is controlled via the light controller, such that when the first assistance function is switched on, the light beam emitted by the lighting unit automatically tracks the portable unit in accordance with the motion trajectory of the portable unit.

Abstract: The invention relates to a genetically modified microorganism for making a oligosaccharide, preferably of 3-8 monosaccharide units, more preferably of 3-5 monosaccharide units, particularly a HMO, which comprises one or more genes encoding a sucrose utilization system, so the microorganism can use sucrose as a carbon and energy source.

Abstract: The present invention is directed to methods for the separation of a molecule of interest from a solution containing the molecule using dual stage tangential-flow ultrafiltration (“TFF”). In particular, the methods of the invention are directed to the processing of crude feed streams such as conditioned cell culture supernatant to dramatically reduce contaminant and/or impurity levels prior to subsequent, i.e., downstream, refining unit operations. The methods of the invention may be used in the processing of a crude feed stream from biological production systems such as fermentation or other cell culture process, and may further eliminate the need for time consuming impurity precipitation (e.g., pH driven) and/or precipitate filtration processes prior to downstream processes that are sensitive to high impurity loads such as chromatographic unit operations.

Abstract: An assistance method for a light control system in a motor vehicle, having a light controller for controlling a lighting unit in the motor vehicle for lighting a motor vehicle environment, a portable unit, at least one communication interface, and an evaluation unit for evaluating signals from the portable unit received via the communication interface. The lighting unit being controllable by the light controller and in accordance with the evaluation of the signals received from the portable unit in a first assistance function, such that at least one light beam emitted by the lighting unit can be positioned as a function of the position of the portable unit. The lighting unit is controlled via the light controller, such that when the first assistance function is switched on, the light beam emitted by the lighting unit automatically tracks the portable unit in accordance with the motion trajectory of the portable unit.

Abstract: An assistance method for a light control system in a motor vehicle, having a light controller for controlling a lighting unit in the motor vehicle for lighting a motor vehicle environment, a portable unit, at least one communication interface, and an evaluation unit for evaluating signals from the portable unit received via the communication interface. The lighting unit being controllable by the light controller and based on evaluation of the signals received from the portable unit, such that at least one light beam emitted by the lighting unit can be positioned in accordance with signals from the portable unit. A first assistance function manually or automatically switches on, the lighting unit is controlled such that when the first assistance function is switched on, the light beam moves automatically as a function of the portable unit being actuated at a time that follows the switching on of the first assistance function.

Abstract: Systems, methods, and computing devices for building, operating and using map systems with signature-based map caches are disclosed. Based on the desired map properties included in a formatted map request, a map signature can be generated. The map signature can be used to access a signature based map cache to determine whether a map with identical map properties has been previously generated and stored in cache or otherwise available for retrieval. If the map signature exists in the map cache, the corresponding map can be delivered to a map client. If the map signature does not exist in the map cache, then a map can be generated or rendered based on the map properties in the map request. Once the map is generated, it can be saved to the map cache along with associated map signature for future retrieval.

Abstract: Embodiments of the invention relate to an image or raster compression method for a multi-dimensional array of pixels. A user specifies a maximum error allowable per pixel for the compression algorithm. The raster is divided into a number of pixel blocks where each pixel is quantized and bit stuffed based on a number of block statistics including the maximum error allowable. The size of the pixel blocks is limited to two (e.g., 8×8 and 16×16) to save processing time with little difference in compression. A Look-Up Table (LUT) is used instead for certain types of data where it is more efficient.